Role of uremic toxins of intestinal origin in vascular calcifications and cardiovascular events of patients with chronic kidney disease (Q3149469): Difference between revisions
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(Removed claim: summary (P836): The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study wi...) |
(Created claim: summary (P836): The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study will...) |
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The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study will include 451 patients over a 3-year period. Determinations A study of trimethylamine (TMA) and trimethylamine-N-oxide (TMA), p-cresyl sulfate (PCS) and 3-indoxyl sulfate (IS), plasma soluble Klotho and FGF23 will be carried out at the beginning and after inclusion of the patients in faeces of the intestinal microbiota. At the beginning at 12, 18, 24.30 and 36 months. It is performed by eco-doppler, determination of the intimate-medium thickness in carotide and measurement of vascular calcifications; as well as the appearance of cardiovascular events, in the periods mentioned above. Renal function, demographic and comorbidity variables shall be collected. A descriptive, bivariate statistical analysis (Wilcoxon test, chi-square test, Spearman correlation test), and ROC curve analysis will be performed. The purpose of the study is to discover whether uremic toxins from the intestinal microbiota in patients with chronic kidney disease play a role in the cardiovascular events and calcifications that occur in these patients. As well as discovering the ways by which these processes occur. (English) | |||||||||||||||
| Property / summary: The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study will include 451 patients over a 3-year period. Determinations A study of trimethylamine (TMA) and trimethylamine-N-oxide (TMA), p-cresyl sulfate (PCS) and 3-indoxyl sulfate (IS), plasma soluble Klotho and FGF23 will be carried out at the beginning and after inclusion of the patients in faeces of the intestinal microbiota. At the beginning at 12, 18, 24.30 and 36 months. It is performed by eco-doppler, determination of the intimate-medium thickness in carotide and measurement of vascular calcifications; as well as the appearance of cardiovascular events, in the periods mentioned above. Renal function, demographic and comorbidity variables shall be collected. A descriptive, bivariate statistical analysis (Wilcoxon test, chi-square test, Spearman correlation test), and ROC curve analysis will be performed. The purpose of the study is to discover whether uremic toxins from the intestinal microbiota in patients with chronic kidney disease play a role in the cardiovascular events and calcifications that occur in these patients. As well as discovering the ways by which these processes occur. (English) / rank | |||||||||||||||
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| Property / summary: The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study will include 451 patients over a 3-year period. Determinations A study of trimethylamine (TMA) and trimethylamine-N-oxide (TMA), p-cresyl sulfate (PCS) and 3-indoxyl sulfate (IS), plasma soluble Klotho and FGF23 will be carried out at the beginning and after inclusion of the patients in faeces of the intestinal microbiota. At the beginning at 12, 18, 24.30 and 36 months. It is performed by eco-doppler, determination of the intimate-medium thickness in carotide and measurement of vascular calcifications; as well as the appearance of cardiovascular events, in the periods mentioned above. Renal function, demographic and comorbidity variables shall be collected. A descriptive, bivariate statistical analysis (Wilcoxon test, chi-square test, Spearman correlation test), and ROC curve analysis will be performed. The purpose of the study is to discover whether uremic toxins from the intestinal microbiota in patients with chronic kidney disease play a role in the cardiovascular events and calcifications that occur in these patients. As well as discovering the ways by which these processes occur. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:10, 12 October 2021
Project Q3149469 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Role of uremic toxins of intestinal origin in vascular calcifications and cardiovascular events of patients with chronic kidney disease |
Project Q3149469 in Spain |
Statements
40,800.0 Euro
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51,000.0 Euro
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80.0 percent
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1 January 2019
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31 March 2022
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FUNDACION PARA LA INVESTIGACION BIOSANITARIA DE ANDALUCIA ORIENTAL - ALEJANDRO OTERO
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37°10'24.60"N, 3°35'58.31"W
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18087
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El objetivo principal del estudio es averiguar si existe una relación entre los niveles de p-cresil sulfato (PCS), indoxil sulfato (IS), trimetilamina N-óxido (TMAO), Klotho y FGF23 y la morbilidad asociada a la insuficiencia renal crónica. Diseño del estudio Es un estudio observacional prospectivo que se realiza en pacientes con enfermedad renal crónica en estadios III, IV , V y en en tratamiento renal sustitutivo, hemodiálisis y diálisis peritoneal. En el estudio se incluirán 451 pacientes en un periodo de 3 años. Determinaciones Se realizará al inicio y tras la inclusión de los pacientes un estudio en heces de la microbiota intestinal, mediante análisis metagenómico, se realizará determinaciones de trimetilamina (TMA) y trimetilamina-N-óxido (TMAO), p-cresil sulfato (PCS) y 3-indoxil sulfato (IS), Klotho soluble en plasma y FGF23. Al inicio a los 12, 18, 24,30 y36 meses. Se realizara mediante eco-doppler, determinación del grosor intima-media en carótida y medición de calcificaciones vasculares; así como la aparición de los eventos cardiovasculares, en los periodos anteriormente referidos. Se recogerán variables de función renal, datos demográficos y de comorbilidad. Se realizará un análisis estadístico descriptivo, bivariante (test Wilcoxon, chi-cuadrado, test de correlación de Spearman), y análisis de curvas ROC. La finalidad del estudio es descubrir si las toxinas urémicas procedentes de la microbiota intestinal en los pacientes con enfermedad renal crónica, juegan un papel en los eventos y las calcificaciones cardiovasculares que se producen en estos pacientes. Así como descubrir cuáles son las vías por las que se producen estos procesos. (Spanish)
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The main objective of the study is to find out if there is a relationship between levels of p-cresyl sulfate (PCS), indoxyl sulfate (IS), trimethylamine N-oxide (TMAO), Klotho and FGF23 and morbidity associated with chronic renal failure. Study Design This prospective observational study is conducted in patients with stage III, IV, V chronic kidney disease and in replacement renal treatment, haemodialysis and peritoneal dialysis. The study will include 451 patients over a 3-year period. Determinations A study of trimethylamine (TMA) and trimethylamine-N-oxide (TMA), p-cresyl sulfate (PCS) and 3-indoxyl sulfate (IS), plasma soluble Klotho and FGF23 will be carried out at the beginning and after inclusion of the patients in faeces of the intestinal microbiota. At the beginning at 12, 18, 24.30 and 36 months. It is performed by eco-doppler, determination of the intimate-medium thickness in carotide and measurement of vascular calcifications; as well as the appearance of cardiovascular events, in the periods mentioned above. Renal function, demographic and comorbidity variables shall be collected. A descriptive, bivariate statistical analysis (Wilcoxon test, chi-square test, Spearman correlation test), and ROC curve analysis will be performed. The purpose of the study is to discover whether uremic toxins from the intestinal microbiota in patients with chronic kidney disease play a role in the cardiovascular events and calcifications that occur in these patients. As well as discovering the ways by which these processes occur. (English)
12 October 2021
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Granada
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Identifiers
PI18_01715
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