SEARCH FOR NEW PARTNERSHIPS BETWEEN VIRUSES AND CANCER FOR THE IDENTIFICATION OF NEW TARGETS FOR DIAGNOSIS, PREVENTION AND ONCOLOGIC THERAPIES (Q3146392): Difference between revisions

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(‎Changed label, description and/or aliases in en: translated_label)
(‎Removed claim: summary (P836): ONE IN THREE PEOPLE IN THE WEST DEVELOP CANCER AND ONE IN FIVE PEOPLE DIE OF CANCER. CANCER IS THEREFORE THE MOST COMMON GENETIC DISEASE, BUT SURPRISINGLY, IT IS ESTIMATED THAT ABOUT 20 % OF ALL CANCER CASES OCCURRING IN THE WORLD COULD BE CAUSED BY VIRUSES AND OTHER MICROORGANISMS. Until NOW, SEIETE VIRUS THAT IS THE CAUSE OF 10-15 % OF ALL cancers, AND WELCOMES MUCH OTHER VIRUS IMPLICED IN CANCER THIS IS ALL FOR DESCUBRIR._x000D_ _x000D_ NEX...)
Property / summary
ONE IN THREE PEOPLE IN THE WEST DEVELOP CANCER AND ONE IN FIVE PEOPLE DIE OF CANCER. CANCER IS THEREFORE THE MOST COMMON GENETIC DISEASE, BUT SURPRISINGLY, IT IS ESTIMATED THAT ABOUT 20 % OF ALL CANCER CASES OCCURRING IN THE WORLD COULD BE CAUSED BY VIRUSES AND OTHER MICROORGANISMS. Until NOW, SEIETE VIRUS THAT IS THE CAUSE OF 10-15 % OF ALL cancers, AND WELCOMES MUCH OTHER VIRUS IMPLICED IN CANCER THIS IS ALL FOR DESCUBRIR._x000D_ _x000D_ NEXT-GENERATION Sequencing DATA (NGS) produced in the framework of several GENOMIC Sequencing PROJECTs of CANCER, they provide an opportunity without precisions to analyse the VIRAL supplement (viroma) of thousands of thousands of people pertaining to different types of CANCER. THIS RESEARCH PROPOSAL WAS BORN WITH THE IDEA OF USING NGS DATA TO DISCOVER NEW PARTNERSHIPS BETWEEN VIRUSES AND CANCER. WE BELIEVE THAT SOME ASSOCIATIONS BETWEEN VIRUSES AND CANCER MAY STILL BE UNDISCOVERED, DUE TO THE LONG TIME BETWEEN THE INFECTION AND THE MALIGNANT TRANSFORMATION AND CANCER IS DIAGNOSED, WHICH IS USUALLY IN THE RANGE OF 15 TO 40 YEARS. THUS, A PATHOGENIC VIRUS COULD HAVE DISAPPEARED FROM THE INFECTED CELLS BEFORE THE TUMOR THAT CAUSED IS DIAGNOSED, MAKING IT IMPOSSIBLE TO IDENTIFY THE RESPONSIBLE VIRUS. HOWEVER, MANY VIRUSES LEAVE TRACES OF THEIR ACTIVITY ON THE GENOME OF CELLS THAT HAVE INFECTED, AND WE ARE CONVINCED THAT SUCH TRACES COULD BE USED TO DETECT PAST VIRAL ACTIVITY DURING THE EVOLUTION OF A TUMOR, EVEN LONG AFTER THOSE VIRUSES DISAPPEARED FROM THE TUMOR; We REFERRED TO THE GENETIC MATERIAL INTEGRATIONS OF THE VIRUS within the NUCLEAR GENOME OF INFECTATED CELLS, something that can be caused by multiple ways during the period of VIRAL INFECTION._x000D_ _x000D_ OUR HIPOTESIS IS THE EXISTENCE OF these virico DNA INTEGRATIONS can be embedded in order to detect the pierced activity of VIRUS in a tumoral class, which could lead us to identify new associations between VIRUS and CANCER. The STUDY OF THESE ASSOCIATIONS Could REVIEW THE EXISTENCE OF NEW VIRUS (VIRUS NOT DESCRITED IN THE KNOW DATA BASES) ASSOCIED TO CANCER._x000D_ _x000D_ THE RESEARCH PROPOSAL THAT WHO IS HAVE OBJECTIVE primary IDENTIFICATION OF NEW SIGNIFICATIVE ASSOCIATIONS BETWEEN VIRUS AND CANCER IN 10700 TUMORAL GENOMS, MEASURE THE ANALISIS OF NGS DATA GENERATE IN THE ENVIRONMENT OF THE INTERNATIONAL CONSORCIONAL GENOME OF CANCER (ICGC) AND CANCER GENOME ATLAS (TCGA). This REPRESENTS THE BASE OF DATA OF CANCER MORE GENERATE JAMAS, AND WE have the opportunity to analyse it due to our Collaborative PAPEL within the ICGC._x000D_ _x000D__x000D_ THE POTENTIAL DISCOVERING OF NEW ASSOCIATIONS BETWEEN VIRUS AND CANCER, and the decommissioning of new poetic virus introduced in oncogenesis, would provide NEW DAYS FOR DIAGNOSTIC, PREVENTION AND TERAPIS OF CANCER. THUS, THIS PROPOSAL REPRESENTS A UNIQUE OPPORTUNITY FOR STATES TO SAVE A LOT OF MONEY ON CANCER TREATMENTS IN THE FUTURE, AND TO IMPROVE THE LIVES OF EUROPEAN CITIZENS AND OUR STATE. IN THIS WAY, THIS PROPOSAL ADDRESSES ONE OF THE SOCIETAL CHALLENGES PROPOSED BY THE EUROPEAN 2020 PROGRAMME AND THE STATE STRATEGY FOR SCIENCE AND TECHNOLOGY. (English)
 
Property / summary: ONE IN THREE PEOPLE IN THE WEST DEVELOP CANCER AND ONE IN FIVE PEOPLE DIE OF CANCER. CANCER IS THEREFORE THE MOST COMMON GENETIC DISEASE, BUT SURPRISINGLY, IT IS ESTIMATED THAT ABOUT 20 % OF ALL CANCER CASES OCCURRING IN THE WORLD COULD BE CAUSED BY VIRUSES AND OTHER MICROORGANISMS. Until NOW, SEIETE VIRUS THAT IS THE CAUSE OF 10-15 % OF ALL cancers, AND WELCOMES MUCH OTHER VIRUS IMPLICED IN CANCER THIS IS ALL FOR DESCUBRIR._x000D_ _x000D_ NEXT-GENERATION Sequencing DATA (NGS) produced in the framework of several GENOMIC Sequencing PROJECTs of CANCER, they provide an opportunity without precisions to analyse the VIRAL supplement (viroma) of thousands of thousands of people pertaining to different types of CANCER. THIS RESEARCH PROPOSAL WAS BORN WITH THE IDEA OF USING NGS DATA TO DISCOVER NEW PARTNERSHIPS BETWEEN VIRUSES AND CANCER. WE BELIEVE THAT SOME ASSOCIATIONS BETWEEN VIRUSES AND CANCER MAY STILL BE UNDISCOVERED, DUE TO THE LONG TIME BETWEEN THE INFECTION AND THE MALIGNANT TRANSFORMATION AND CANCER IS DIAGNOSED, WHICH IS USUALLY IN THE RANGE OF 15 TO 40 YEARS. THUS, A PATHOGENIC VIRUS COULD HAVE DISAPPEARED FROM THE INFECTED CELLS BEFORE THE TUMOR THAT CAUSED IS DIAGNOSED, MAKING IT IMPOSSIBLE TO IDENTIFY THE RESPONSIBLE VIRUS. HOWEVER, MANY VIRUSES LEAVE TRACES OF THEIR ACTIVITY ON THE GENOME OF CELLS THAT HAVE INFECTED, AND WE ARE CONVINCED THAT SUCH TRACES COULD BE USED TO DETECT PAST VIRAL ACTIVITY DURING THE EVOLUTION OF A TUMOR, EVEN LONG AFTER THOSE VIRUSES DISAPPEARED FROM THE TUMOR; We REFERRED TO THE GENETIC MATERIAL INTEGRATIONS OF THE VIRUS within the NUCLEAR GENOME OF INFECTATED CELLS, something that can be caused by multiple ways during the period of VIRAL INFECTION._x000D_ _x000D_ OUR HIPOTESIS IS THE EXISTENCE OF these virico DNA INTEGRATIONS can be embedded in order to detect the pierced activity of VIRUS in a tumoral class, which could lead us to identify new associations between VIRUS and CANCER. The STUDY OF THESE ASSOCIATIONS Could REVIEW THE EXISTENCE OF NEW VIRUS (VIRUS NOT DESCRITED IN THE KNOW DATA BASES) ASSOCIED TO CANCER._x000D_ _x000D_ THE RESEARCH PROPOSAL THAT WHO IS HAVE OBJECTIVE primary IDENTIFICATION OF NEW SIGNIFICATIVE ASSOCIATIONS BETWEEN VIRUS AND CANCER IN 10700 TUMORAL GENOMS, MEASURE THE ANALISIS OF NGS DATA GENERATE IN THE ENVIRONMENT OF THE INTERNATIONAL CONSORCIONAL GENOME OF CANCER (ICGC) AND CANCER GENOME ATLAS (TCGA). This REPRESENTS THE BASE OF DATA OF CANCER MORE GENERATE JAMAS, AND WE have the opportunity to analyse it due to our Collaborative PAPEL within the ICGC._x000D_ _x000D__x000D_ THE POTENTIAL DISCOVERING OF NEW ASSOCIATIONS BETWEEN VIRUS AND CANCER, and the decommissioning of new poetic virus introduced in oncogenesis, would provide NEW DAYS FOR DIAGNOSTIC, PREVENTION AND TERAPIS OF CANCER. THUS, THIS PROPOSAL REPRESENTS A UNIQUE OPPORTUNITY FOR STATES TO SAVE A LOT OF MONEY ON CANCER TREATMENTS IN THE FUTURE, AND TO IMPROVE THE LIVES OF EUROPEAN CITIZENS AND OUR STATE. IN THIS WAY, THIS PROPOSAL ADDRESSES ONE OF THE SOCIETAL CHALLENGES PROPOSED BY THE EUROPEAN 2020 PROGRAMME AND THE STATE STRATEGY FOR SCIENCE AND TECHNOLOGY. (English) / rank
Normal rank
 
Property / summary: ONE IN THREE PEOPLE IN THE WEST DEVELOP CANCER AND ONE IN FIVE PEOPLE DIE OF CANCER. CANCER IS THEREFORE THE MOST COMMON GENETIC DISEASE, BUT SURPRISINGLY, IT IS ESTIMATED THAT ABOUT 20 % OF ALL CANCER CASES OCCURRING IN THE WORLD COULD BE CAUSED BY VIRUSES AND OTHER MICROORGANISMS. Until NOW, SEIETE VIRUS THAT IS THE CAUSE OF 10-15 % OF ALL cancers, AND WELCOMES MUCH OTHER VIRUS IMPLICED IN CANCER THIS IS ALL FOR DESCUBRIR._x000D_ _x000D_ NEXT-GENERATION Sequencing DATA (NGS) produced in the framework of several GENOMIC Sequencing PROJECTs of CANCER, they provide an opportunity without precisions to analyse the VIRAL supplement (viroma) of thousands of thousands of people pertaining to different types of CANCER. THIS RESEARCH PROPOSAL WAS BORN WITH THE IDEA OF USING NGS DATA TO DISCOVER NEW PARTNERSHIPS BETWEEN VIRUSES AND CANCER. WE BELIEVE THAT SOME ASSOCIATIONS BETWEEN VIRUSES AND CANCER MAY STILL BE UNDISCOVERED, DUE TO THE LONG TIME BETWEEN THE INFECTION AND THE MALIGNANT TRANSFORMATION AND CANCER IS DIAGNOSED, WHICH IS USUALLY IN THE RANGE OF 15 TO 40 YEARS. THUS, A PATHOGENIC VIRUS COULD HAVE DISAPPEARED FROM THE INFECTED CELLS BEFORE THE TUMOR THAT CAUSED IS DIAGNOSED, MAKING IT IMPOSSIBLE TO IDENTIFY THE RESPONSIBLE VIRUS. HOWEVER, MANY VIRUSES LEAVE TRACES OF THEIR ACTIVITY ON THE GENOME OF CELLS THAT HAVE INFECTED, AND WE ARE CONVINCED THAT SUCH TRACES COULD BE USED TO DETECT PAST VIRAL ACTIVITY DURING THE EVOLUTION OF A TUMOR, EVEN LONG AFTER THOSE VIRUSES DISAPPEARED FROM THE TUMOR; We REFERRED TO THE GENETIC MATERIAL INTEGRATIONS OF THE VIRUS within the NUCLEAR GENOME OF INFECTATED CELLS, something that can be caused by multiple ways during the period of VIRAL INFECTION._x000D_ _x000D_ OUR HIPOTESIS IS THE EXISTENCE OF these virico DNA INTEGRATIONS can be embedded in order to detect the pierced activity of VIRUS in a tumoral class, which could lead us to identify new associations between VIRUS and CANCER. The STUDY OF THESE ASSOCIATIONS Could REVIEW THE EXISTENCE OF NEW VIRUS (VIRUS NOT DESCRITED IN THE KNOW DATA BASES) ASSOCIED TO CANCER._x000D_ _x000D_ THE RESEARCH PROPOSAL THAT WHO IS HAVE OBJECTIVE primary IDENTIFICATION OF NEW SIGNIFICATIVE ASSOCIATIONS BETWEEN VIRUS AND CANCER IN 10700 TUMORAL GENOMS, MEASURE THE ANALISIS OF NGS DATA GENERATE IN THE ENVIRONMENT OF THE INTERNATIONAL CONSORCIONAL GENOME OF CANCER (ICGC) AND CANCER GENOME ATLAS (TCGA). This REPRESENTS THE BASE OF DATA OF CANCER MORE GENERATE JAMAS, AND WE have the opportunity to analyse it due to our Collaborative PAPEL within the ICGC._x000D_ _x000D__x000D_ THE POTENTIAL DISCOVERING OF NEW ASSOCIATIONS BETWEEN VIRUS AND CANCER, and the decommissioning of new poetic virus introduced in oncogenesis, would provide NEW DAYS FOR DIAGNOSTIC, PREVENTION AND TERAPIS OF CANCER. THUS, THIS PROPOSAL REPRESENTS A UNIQUE OPPORTUNITY FOR STATES TO SAVE A LOT OF MONEY ON CANCER TREATMENTS IN THE FUTURE, AND TO IMPROVE THE LIVES OF EUROPEAN CITIZENS AND OUR STATE. IN THIS WAY, THIS PROPOSAL ADDRESSES ONE OF THE SOCIETAL CHALLENGES PROPOSED BY THE EUROPEAN 2020 PROGRAMME AND THE STATE STRATEGY FOR SCIENCE AND TECHNOLOGY. (English) / qualifier
point in time: 12 October 2021
Timestamp+2021-10-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0
 

Revision as of 14:59, 12 October 2021

Project Q3146392 in Spain
Language Label Description Also known as
English
SEARCH FOR NEW PARTNERSHIPS BETWEEN VIRUSES AND CANCER FOR THE IDENTIFICATION OF NEW TARGETS FOR DIAGNOSIS, PREVENTION AND ONCOLOGIC THERAPIES
Project Q3146392 in Spain

    Statements

    country
    Spain
    0 references
    EU contribution
    5,476,742.4 Euro
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    budget
    6,845,928.0 Euro
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    co-financing rate
    80.0 percent
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    start time
    16 December 2016
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    end time
    21 September 2018
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    beneficiary name (string)
    UNIVERSIDAD DE VIGO
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    coordinate location

    42°14'15.58"N, 8°43'28.99"W
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    postal code
    36057
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    summary
    UNA DE CADA TRES PERSONAS EN OCCIDENTE DESARROLLAN CANCER Y UNO DE CADA CINCO MUEREN DE DICHA ENFERMEDAD. POR TANTO, EL CANCER ES LA ENFERMEDAD GENETICA MAS COMUN PERO, SORPRENDENTEMENTE, SE ESTIMA QUE ALREDEDOR DEL 20% DE TODOS LOS CASOS DE CANCER QUE OCURREN EN EL MUNDO PODRIAN ESTAR CAUSADOS POR VIRUS Y OTROS MICROORGANISMOS. HASTA AHORA, SE HAN IDENTIFICADO SIETE VIRUS QUE SON LA CAUSA DEL 10-15% DE TODOS LOS CANCERES, Y SE CREE QUE MUCHOS OTROS VIRUS IMPLICADOS EN CANCER ESTAN TODAVIA POR DESCUBRIR._x000D_ _x000D_ LOS DATOS DE NEXT-GENERATION SEQUENCING (NGS) QUE ESTAN SIENDO PRODUCIDOS EN EL MARCO DE VARIOS PROYECTOS DE SECUENCIACION GENOMICA DEL CANCER, PROPORCIONAN UNA OPORTUNIDAD SIN PRECEDENTES PARA ANALIZAR EL COMPLEMENTO VIRAL (VIROMA) DE MILES DE MUESTRAS TUMORALES PERTENECIENTES A DIFERENTES TIPOS DE CANCER. LA PRESENTE PROPUESTA DE INVESTIGACION NACIO CON LA IDEA DE UTILIZAR DATOS DE NGS PARA DESCUBRIR NUEVAS ASOCIACIONES ENTRE VIRUS Y CANCER. CREEMOS QUE ALGUNAS ASOCIACIONES ENTRE VIRUS Y CANCER PODRIAN ESTAR TODAVIA SIN DESCUBRIR, DEBIDO AL LARGO TIEMPO QUE TRANSCURRE DESDE QUE OCURRE LA INFECCION HASTA QUE SE PRODUCE LA TRANSFORMACION MALIGNA Y EL CANCER ES DIAGNOSTICADO, QUE NORMALMENTE ESTA EN EL RANGO DE 15 A 40 AÑOS. ASI, UN VIRUS PATOGENICO PODRIA HABER DESAPARECIDO DE LAS CELULAS INFECTADAS ANTES DE QUE EL TUMOR QUE CAUSO ES DIAGNOSTICADO, HACIENDO IMPOSIBLE LA IDENTIFICACION DEL VIRUS RESPONSABLE. SIN EMBARGO, MUCHOS VIRUS DEJAN HUELLAS DE SU ACTIVIDAD EN EL GENOMA DE LAS CELULAS QUE HAN INFECTADO, Y NOSOTROS ESTAMOS CONVENCIDOS DE QUE DICHAS HUELLAS PODRIAN SER USADAS PARA DETECTAR LA ACTIVIDAD VIRAL PASADA OCURRIDA A LO LARGO DE LA EVOLUCION DE UN TUMOR, INCLUSO MUCHO TIEMPO DESPUES DE QUE DICHOS VIRUS DESAPARECIERON DEL TUMOR; NOS REFERIMOS A LAS INTEGRACIONES DEL MATERIAL GENETICO DEL VIRUS DENTRO DEL GENOMA NUCLEAR DE LAS CELULAS INFECTADAS, ALGO QUE PUEDE OCURRIR DE MULTIPLES MANERAS DURANTE EL PERIODO DE INFECCION VIRAL._x000D_ _x000D_ NUESTRA HIPOTESIS ES QUE LA EXISTENCIA DE ESTAS INTEGRACIONES DE DNA VIRICO PUEDEN EMPLEARSE PARA DETECTAR LA ACTIVIDAD PASADA DE VIRUS EN UN CLON TUMORAL, LO QUE NOS PODRIA LLEVAR A IDENTIFICAR NUEVAS ASOCIACIONES ENTRE VIRUS Y CANCER. EL ESTUDIO DE ESTAS ASOCIACIONES TAMBIEN PODRIA REVELAR LA EXISTENCIA DE NUEVOS VIRUS (VIRUS NO DESCRITOS EN LAS BASES DE DATOS CONOCIDAS) ASOCIADOS A CANCER._x000D_ _x000D_ LA PROPUESTA DE INVESTIGACION QUE AQUI PRESENTAMOS TIENE COMO OBJETIVO PRINCIPAL LA IDENTIFICACION DE NUEVAS ASOCIACIONES SIGNIFICATIVAS ENTRE VIRUS Y CANCER EN 10.700 GENOMAS TUMORALES, MEDIANTE EL ANALISIS DE DATOS DE NGS GENERADOS EN EL ENTORNO DEL CONSORCIO INTERNACIONAL GENOMA DEL CANCER (ICGC) Y EL CANCER GENOME ATLAS (TCGA). ESTA REPRESENTA LA BASE DE DATOS DE CANCER MAS GRANDE JAMAS GENERADA, Y NOSOTROS TENEMOS LA OPORTUNIDAD DE ANALIZARLA DEBIDO A NUESTRO PAPEL COLABORATIVO DENTRO DEL MARCO DEL ICGC._x000D_ _x000D_ EL POTENCIAL DESCUBRIMIENTO DE NUEVAS ASOCIACIONES ENTRE VIRUS Y CANCER, Y EL DESCUBRIMIENTO DE NUEVOS VIRUS POTENCIALMENTE INVOLUCRADOS EN LA ONCOGENESIS, PROPORCIONARIA NUEVAS DIANAS PARA EL DIAGNOSTICO, PREVENCION Y TERAPIAS DEL CANCER. ASI, ESTA PROPUESTA REPRESENTA UNA OPORTUNIDAD UNICA PARA QUE LOS ESTADOS AHORREN MUCHO DINERO EN TRATAMIENTOS DEL CANCER EN EL FUTURO, Y PARA MEJORAR LA VIDA DE LOS CIUDADANOS EUROPEOS Y DE NUESTRO ESTADO. DE ESTA FORMA, ESTA PROPUESTA ABORDA UNO DE LOS RETOS DE LA SOCIEDAD PROPUESTOS POR EL PROGRAMA EUROPEO 2020 Y LA ESTRATEGIA ESTATAL DE CIENCIA Y TECNOLOGIA. (Spanish)
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    location (string)
    Vigo
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    Identifiers

    Spanish Kohesio ID
    SAF2015-73916-JIN
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