RESEARCH ON THE USE OF NEW PSYCHOACTIVE SUBSTANCES THROUGH THE ANALYSIS OF THE PRODUCTS CONSUMED, THE URINE OF POTENTIAL CONSUMERS AND WASTEWATER (Q3152112): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): NEW PSYCHOACTIVE SUBSTANCES (NPS) ARE INCREASINGLY CONSUMED AND POSE A SERIOUS THREAT TO PUBLIC HEALTH. THIS PROJECT PROPOSES A DETAILED RESEARCH THROUGH A GLOBAL APPROACH OF CHEMICAL-ANALYTIC TYPE THAT COVERS SEVERAL AREAS, FROM WHICH INFORMATION CAN BE COLLECTED ON THE CONSUMPTION OF NPS IN SPAIN. _x000D_ _x000D_ the FIRST ENVIRONMENT CONSIDERING CONSUMED PRODUCTS (PASTILLS, HIERBA, ETC), which can be easily accessed by internet and SMART SHO...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
RESEARCH ON THE USE OF NEW PSYCHOACTIVE SUBSTANCES THROUGH THE ANALYSIS OF THE PRODUCTS CONSUMED, THE URINE OF POTENTIAL CONSUMERS AND WASTEWATER | |||
Revision as of 14:50, 12 October 2021
Project Q3152112 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | RESEARCH ON THE USE OF NEW PSYCHOACTIVE SUBSTANCES THROUGH THE ANALYSIS OF THE PRODUCTS CONSUMED, THE URINE OF POTENTIAL CONSUMERS AND WASTEWATER |
Project Q3152112 in Spain |
Statements
27,830.0 Euro
0 references
55,660.0 Euro
0 references
50.0 percent
0 references
1 January 2016
0 references
31 December 2018
0 references
UNIVERSIDAD JAUME I
0 references
39°59'9.71"N, 0°2'15.86"W
0 references
12040
0 references
LAS NUEVAS SUSTANCIAS PSICOACTIVAS (NPS) SON CADA VEZ MAS CONSUMIDAS Y SUPONEN UNA SERIA AMENAZA PARA LA SALUD PUBLICA. EN ESTE PROYECTO SE PROPONE UNA INVESTIGACION DETALLADA A TRAVES DE UNA APROXIMACION GLOBAL DE TIPO QUIMICO-ANALITICO QUE ABARCA VARIOS AMBITOS, A PARTIR DE LOS CUALES SE PUEDE RECABAR INFORMACION SOBRE EL CONSUMO DE NPS EN ESPAÑA. _x000D_ _x000D_ EL PRIMER AMBITO CONSISTE EN ANALIZAR LOS PRODUCTOS CONSUMIDOS (PASTILLAS, HIERBA, ETC), QUE SE PUEDEN ADQUIRIR FACILMENTE A TRAVES DE INTERNET Y SMART SHOPS. LOS CONTINUOS CAMBIOS INTRODUCIDOS EN LA COMPOSICION QUIMICA PARA EVITAR SU DETECCION HACEN NECESARIO EL USO DE ACOPLAMIENTOS CROMATOGRAFIA-ESPECTROMETRIA DE MASAS CON ANALIZADORES DE ALTA RESOLUCION, PUES ESTE ANALISIS NO SE PUEDE ABORDAR DESDE UNA APROXIMACION TIPO TARGET ENFOCANDOLO EXCLUSIVAMENTE HACIA UN LISTADO DE COMPUESTOS DE INTERES, POR LO QUE SE COMPLEMENTARA CON LA BUSQUEDA DE FRAGMENTOS COMUNES. EN ESTA PARTE, SE USARA LC(ESI)-QTOF MS, GC(APCI)-QTOF MS, GC(EI)-TOF MS Y, EN CASO NECESARIO, RMN Y CRISTALOGRAFIA DE RAYOS X. SE RECOPILARA INFORMACION DEL OBSERVATORIO EUROPEO PARA DROGAS Y DROGADICCION (EMCDDA), Y SE TRABAJARA EN COLABORACION CON TIC-TAC, INGLATERRA (DR. RAMSEY), PARA LA DETECCION E IDENTIFICACION DE NPS. _x000D_ _x000D_ EL SEGUNDO AMBITO CONSISTE EN ESTUDIOS SOBRE METABOLITOS DE NPS, A TRAVES DEL ANALISIS DE ORINA DE CONSUMIDORES. SE COLABORARA CON LA UNIDAD DE PATOLOGIA DUAL GRAVE (HOSPITAL PROVINCIAL DE CASTELLON), LAS UNIDADES DE CONDUCTAS ADICTIVAS DE LA COMUNIDAD VALENCIANA, Y EL INSTITUTO DE INVESTIGACIONES MEDICAS (HOSPITAL DEL MAR). SE PRETENDE IDENTIFICAR LOS PRINCIPALES METABOLITOS EXCRETADOS EN LA ORINA, CON EL FIN DE HACER UN SEGUIMIENTO DEL CONSUMO DE NPS A TRAVES DEL ANALISIS DE ESTOS BIOMARCADORES (COMPUESTO INALTERADO O METABOLITO). LA INVESTIGACION SE COMPLEMENTARA CON EXPERIENCIAS CON MICROSOMAS HEPATICOS HUMANOS REALIZADOS EN LA UNIV AMBERES (DR. COVACI), Y LA UNIV SAARLAND (DR. MAURER). LA IDENTIFICACION DE METABOLITOS SE REALIZARA POR LC-QTOF MS. EN FUNCION DE LA DISPONIBILIDAD DE PATRONES DE REFERENCIA, SE DESARROLLARAN TAMBIEN METODOS CUANTITATIVOS, BASADOS EN LC-MS/MS TRIPLE CUADRUPOLO, PARA EL ANALISIS DE ORINA DE CONSUMIDORES. _x000D_ _x000D_ EL TERCER AMBITO SERA EL ANALISIS DE AGUAS RESIDUALES URBANAS, CON EL FIN DE ESTIMAR EL CONSUMO DE NPS (SEWAGE-BASED EPIDEMIOLOGY, SBE). ESTA ES UNA LINEA PRIORITARIA DE NUESTRO GRUPO EN LA QUE MANTENEMOS AMPLIA COLABORACION INTERNACIONAL (UNIV. BATH, NIVA (NORUEGA), INSTITUTO MARIO NEGRI (ITALIA) Y KWR (PAISES BAJOS)), QUE HA DEMOSTRADO SU UTILIDAD PARA DROGAS ¿CLASICAS¿, COMO COCAINA, CANNABIS Y ANFETAMINAS. SE REALIZARA UNA BUSQUEDA DE BIOMARCADORES, PREVIAMENTE IDENTIFICADOS EN ORINA DE CONSUMIDORES, EN MUESTRAS DE INFLUENTE URBANO TOMADAS EN FINES DE SEMANA, FESTIVIDADES, O EVENTOS DIVERSOS, EN LOS QUE EL CONSUMO DE DROGAS ES MAYOR. LA BUSQUEDA DE NPS SE HARA MEDIANTE SCREENING POR LC-QTOF MS, SOBRE UNA LISTA DE NUMEROSOS CANDIDATOS, Y MEDIANTE LC-MS/MS, PARA COMPUESTOS PARA LOS QUE SE HAYA DESARROLLADO METODOLOGIA ANALITICA CUANTITATIVA._x000D_ _x000D_ MEDIANTE LA COMBINACION DE ESTOS TRES AMBITOS Y CON EL USO DE DIFERENTES TECNICAS ANALITICAS (LC Y GC, ACOPLADAS A MS DE ALTA Y BAJA RESOLUCION), SE OBTENDRA INFORMACION COMPLEMENTARIA SOBRE EL CONSUMO DE NPS. EL PROYECTO SE CENTRA EN LA POBLACION ESPAÑOLA, PERO LA COLABORACION INTERNACIONAL EN ESTE CAMPO FACILITARA LA OBTENCION DE DATOS SOBRE CONSUMOS EN OTROS PAISES, LO QUE PERMITIRA ANTICIPAR POSIBLES TENDENCIAS. (Spanish)
0 references
NEW PSYCHOACTIVE SUBSTANCES (NPS) ARE INCREASINGLY CONSUMED AND POSE A SERIOUS THREAT TO PUBLIC HEALTH. THIS PROJECT PROPOSES A DETAILED RESEARCH THROUGH A GLOBAL APPROACH OF CHEMICAL-ANALYTIC TYPE THAT COVERS SEVERAL AREAS, FROM WHICH INFORMATION CAN BE COLLECTED ON THE CONSUMPTION OF NPS IN SPAIN. _x000D_ _x000D_ the FIRST ENVIRONMENT CONSIDERING CONSUMED PRODUCTS (PASTILLS, HIERBA, ETC), which can be easily accessed by internet and SMART SHOPS. THE CONTINUOUS CHANGES INTRODUCED IN THE CHEMICAL COMPOSITION TO AVOID DETECTION MAKE IT NECESSARY TO USE CHROMATOGRAPH-SPECTROMETRY MASS COUPLINGS WITH HIGH RESOLUTION ANALYSERS, SINCE THIS ANALYSIS CANNOT BE APPROACHED FROM A TARGET-TYPE APPROACH FOCUSING EXCLUSIVELY ON A LIST OF COMPOUNDS OF INTEREST, SO IT WILL BE COMPLEMENTED BY THE SEARCH FOR COMMON FRAGMENTS. IN THIS PART, LC(ESI)-QTOF MS, GC(APCI)-QTOF MS, GC(EI)-TOF MS AND, IF NECESSARY, RMN AND X-RAY CRYSTALLOGRAPHY WILL BE COLLECTED FROM THE EUROPEAN MONITORING CENTRE FOR DRUGS AND DRUG ADDICTION (EMCDDA), AND WILL WORK IN COLLABORATION WITH TIC-TAC, ENGLAND (DR. RAMSEY), FOR THE DETECTION AND IDENTIFICATION OF NPS. _x000D_ _x000D_ the ENVIRONMENT SECOND CONSISES IN STUDIES ON NPS METABOLITS, WITH THE ORINE ANALISIS OF CONSUMERERS. COLLABORATION WILL BE CARRIED OUT WITH THE SEVERE DUAL PATHOLOGY UNIT (PROVINCIAL HOSPITAL OF CASTELLON), THE ADDICTIVE BEHAVIOR UNITS OF THE VALENCIAN COMMUNITY, AND THE INSTITUTE FOR MEDICAL RESEARCH (HOSPITAL DEL MAR). THE AIM IS TO IDENTIFY THE MAIN METABOLITES EXCRETED IN THE URINE, IN ORDER TO MONITOR THE CONSUMPTION OF NPS THROUGH THE ANALYSIS OF THESE BIOMARKERS (UNALTERED COMPOUND OR METABOLITE). THE RESEARCH WILL BE COMPLEMENTED BY EXPERIENCES WITH HUMAN HEPATIC MICROSOMES PERFORMED IN UNIV ANTWERP (DR. COVACI), AND UNIV SAARLAND (DR. MAURER). METABOLITE IDENTIFICATION WILL BE PERFORMED BY LC-QTOF MS. DEPENDING ON THE AVAILABILITY OF REFERENCE STANDARDS, QUANTITATIVE METHODS, BASED ON LC-MS/MS TRIPLE QUADRUPLE, WILL ALSO BE DEVELOPED FOR THE ANALYSIS OF CONSUMER URINE. _x000D_ _x000D_ the THIRD AMBITO will be URBAN RESIDUAL WATER ANALISIS, with the end of NPS CONSUMPTION (SEWAGE-BASED EPIDEMIOLOGY, SBE). THIS IS A PRIORITY LINE OF OUR GROUP IN WHICH WE MAINTAIN EXTENSIVE INTERNATIONAL COLLABORATION (UNIV. BATH, NIVA (NORWAY), MARIO NEGRI INSTITUTE (ITALY) AND KWR (NETHERLANDS), WHICH HAS DEMONSTRATED ITS USEFULNESS FOR CLASSIC DRUGS, SUCH AS COCAINE, CANNABIS AND AMPHETAMINES. A SEARCH WILL BE MADE FOR BIOMARKERS, PREVIOUSLY IDENTIFIED IN THE URINE OF CONSUMERS, IN SAMPLES OF URBAN INFLUENT TAKEN AT WEEKENDS, FESTIVITIES, OR VARIOUS EVENTS, IN WHICH THE USE OF DRUGS IS GREATER. The NPS SEARCH WILL BE MEDIANT SCREENING BY LC-QTOF MS, ON A LIST OF NUMEROSOS CANDIDATES, AND MEDIANT LC-MS/MS, FOR COMPOSES FOR THE DEVELOPMENT FOR THE QUANTITATIVE ANALITATIVE METODOLOGY._x000D_ _x000D_ of these three AMBITS AND THE USE OF TECHNICAL DIFFERENTS (LC and GC, coupled to MS High and Low RESOLUTION), COMPLEMENTARY INFORMATION ON NPS CONSUMPTION THE PROJECT FOCUSES ON THE SPANISH POPULATION, BUT THE INTERNATIONAL COLLABORATION IN THIS FIELD WILL FACILITATE THE COLLECTION OF DATA ON CONSUMPTION IN OTHER COUNTRIES, ALLOWING TO ANTICIPATE POSSIBLE TRENDS. (English)
12 October 2021
0 references
Castellón de la Plana/Castelló de la Plana
0 references
Identifiers
CTQ2015-65603-P
0 references