TENACIBACULUM MARITIMUM: EPIDEMIOLOGICAL AND GENETIC BASIS STUDY OF THE INFECTIOUS PROCESS IN MARINE FISH? (Q3149723): Difference between revisions
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(Created claim: summary (P836): MARINE TENACIBACULOSIS IS AN ULCERATIVE DISEASE PRODUCED BY FILAMENTARY BACTERIA TENACIBACULUM MARITIMUM.IN THE LAST FEW YEARS, T. MARITIMUM HAS CAUSED MAJOR OUTBREAKS OF DISEASE IN THE CROPS OF TURBOT, SOLE, SEABASS AND SALMON WORLDWIDE CAUSING SERIOUS ECONOMIC LOSSES AND A GREAT CONCERN IN THE AQUACULTURE SECTOR. TO STUDY THE DIFFERENT STRAINS ISOLATED IN THESE LAST YEARS OF THESE HOSTS IN ORDER TO KNOW THE MECHANISMS OF INFECTION OF THE PATHO...) |
(Changed label, description and/or aliases in en: translated_label) |
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TENACIBACULUM MARITIMUM: EPIDEMIOLOGICAL AND GENETIC BASIS STUDY OF THE INFECTIOUS PROCESS IN MARINE FISH? | |||
Revision as of 14:35, 12 October 2021
Project Q3149723 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | TENACIBACULUM MARITIMUM: EPIDEMIOLOGICAL AND GENETIC BASIS STUDY OF THE INFECTIOUS PROCESS IN MARINE FISH? |
Project Q3149723 in Spain |
Statements
154,880.0 Euro
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193,600.0 Euro
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80.0 percent
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1 January 2016
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30 June 2019
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UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
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42°52'49.51"N, 8°32'45.10"W
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15078
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LA TENACIBACULOSIS MARINA ES UNA ENFERMEDAD ULCERATIVA PRODUCIDA POR LA BACTERIA FILAMENTOSA TENACIBACULUM MARITIMUM.EN LOS ULTIMOS AÑOS, T. MARITIMUM HA ORIGINADO IMPORTANTES BROTES DE ENFERMEDAD EN LOS CULTIVOS DE RODABALLO, LENGUADO, LUBINA Y SALMON A NIVEL MUNDIAL OCASIONANDO GRAVES PERDIDAS ECONOMICAS Y UNA GRAN PREOCUPACION EN EL SECTOR ACUICOLA. ABORDAR EL ESTUDIO DE LAS DIFERENTES CEPAS AISLADAS EN ESTOS ULTIMOS AÑOS DE ESTOS HOSPEDADORES CON EL FIN ULTIMO DE CONOCER LOS MECANISMOS DE INFECCION DEL PATOGENO Y PREVENIR BROTES SUCESIVOS DE LA ENFERMEDAD ES LA FINALIDAD DEL PRESENTE PROYECTO. _x000D_ EL TRABAJO ESTA ESTRUCTURADO DESDE UN PUNTO DE VISTA MULTIDISCIPLINAR, INTEGRANDO CONOCIMIENTOS DE MICROBIOLOGIA Y BIOLOGIA MOLECULAR. _x000D_ EL OBJETIVO GENERAL DEL PROYECTO ES: "REALIZAR UN ESTUDIO EPIDEMIOLOGICO DEL PATOGENO BACTERIANO DE PECES MARINOS TENACIBACULUM MARITIMUM Y AVANZAR EN EL CONOCIMIENTO DE SUS MECANISMOS DE VIRULENCIA CON EL FIN DE ESTABLECER Y/O MEJORAR LAS MEDIDAS PREVENTIVAS FRENTE A LAS INFECCIONES QUE CAUSAN IMPORTANTES BROTES DE MORTALIDADES CON UN IMPACTO ECONOMICO NEGATIVO EN LA ACUICULTURA MARINA._x000D_ LOS OBJETIVOS CONCRETOS SON: _x000D_ 1) CARACTERIZACION QUIMIOTAXONOMICA, SEROLOGICA, MOLECULAR Y ANALISIS DE VIRULENCIA DE LAS CEPAS DE T. MARITIMUM AISLADAS EN LOS ULTIMOS AÑOS EN LOS SISTEMAS DE CULTIVO DE RODABALLO, LENGUADO, LUBINA Y SALMON CON EL FIN DE REALIZAR UN ESTUDIO EPIDEMIOLOGICO DEL PATOGENO_x000D_ 2) ANALISIS DEL GENOMA COMPLETO DE UNA CEPA REPRESENTATIVA DE CADA GRUPO ANTIGENICO/MOLECULAR DETECTADO ASOCIADO A MORTALIDADES Y ESTUDIO DE LA EXPRESION DIFERENCIAL DE GENES ENTRE ELLAS._x000D_ 3) ANALISIS FUNCIONAL DE GENES CANDIDATOS RELACIONADOS CON LA VIRULENCIA Y CON LA CAPACIDAD DE SUPERVIVENCIA DEL PATOGENO EN EL HOSPEDADOR Y SELECCION Y EVALUACION DE MUTANTES ATENUADOS QUE PUEDAN SER UTILIZADOS COMO POSIBLES CANDIDATOS PARA EL DESARROLLO DE NUEVAS VACUNAS._x000D_ 4) ANALISIS DEL TRANSCRIPTOMA DE PECES INFECTADOS CON CEPAS SALVAJES Y MUTANTES CON EL FIN DE IDENTIFICAR LOS GENES QUE PODRIAN PARTICIPAR EN LOS MECANISMOS DE DEFENSA DE LOS PECES._x000D_ _x000D_ LA CONSECUCION DE ESTOS OBJETIVOS PERMITIRA ESTABLECER LA ESTRUCTURA DE LA POBLACION BASADA EN EL ESTUDIO EPIDEMIOLOGICO Y PROFUNDIZAR EN EL ESTUDIO GENOMICO DE LOS MECANISMOS DE VIRULENCIA DEL PATOGENO DE PECES TENACIBACULUM MARITIMUM CON EL FIN DE DESARROLLAR PRODUCTOS INMUNOLOGICOS QUE PERMITAN PREVENIR BROTES DE MORTALIDAD ASOCIADAS A ESTE MICROORGANISMO EN LOS CULTIVOS MARINOS DE PECES. (Spanish)
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MARINE TENACIBACULOSIS IS AN ULCERATIVE DISEASE PRODUCED BY FILAMENTARY BACTERIA TENACIBACULUM MARITIMUM.IN THE LAST FEW YEARS, T. MARITIMUM HAS CAUSED MAJOR OUTBREAKS OF DISEASE IN THE CROPS OF TURBOT, SOLE, SEABASS AND SALMON WORLDWIDE CAUSING SERIOUS ECONOMIC LOSSES AND A GREAT CONCERN IN THE AQUACULTURE SECTOR. TO STUDY THE DIFFERENT STRAINS ISOLATED IN THESE LAST YEARS OF THESE HOSTS IN ORDER TO KNOW THE MECHANISMS OF INFECTION OF THE PATHOGEN AND TO PREVENT SUCCESSIVE OUTBREAKS OF THE DISEASE IS THE AIM OF THIS PROJECT. _x000D_ the WORKING IS STRUCTURED OF A MULTIDISCIPLINAR VISTA POINT, INTEGRANTED KNOWINGS OF MICROBIOLOGY AND MOLECULAR BIOLOGY. _x000D_ the GENERAL OBJECTIVE OF THE PROJECT IS: “To carry out an epidemiologic stud of the BACTERIAN pathogen of marine fish Tenacibaculum maritimum AND ADVANCED IN THE KNOWING OF YOUR MECHANISMS OF VIRULENCE WITH THE FIN OF STABILITY AND/OR IMPROVEMENTS PREVENTIVE MEASURES FROM THE INFECTIONS THAT WORK IMPORTANT BROUND OF Mortality WITH ECONOMIC IMPACT NEGATIVO IN MARINA ACUICULTURE._x000D_ CONCERNING OBJECTIVES ARE: _x000D_ 1) CHEMIOTAXONOMIC CHARACTERISATION, serological, MOLECULAR AND ANALISIS OF VIRULENCE OF T. maritimum CEPAS IN THE ULTIMY YEARS IN RODABALLO CULTIVO SYSTEMS, LENGUADO, LUBINA AND SALMON WITH THE FINAL OF THE EVERY ANTIGENIC GROUP/MOLECULAR DETECTED ASSOCIATED Mortality AND STUDY OF THE DIFFERENTIAL EXPRESSION OF GENES between them._x000D_ 3) FUNCTIONAL ANALISIS OF CANDIDATE GENES RELATED TO VIRULENCE AND CAPACITY OF SUPERVIVENCE OF the host AND SELECTION AND EVALUATION OF MUTANTS attenuated who may be used as a possible way to develop new VACUNAS._x000D_ 4) of the transcribing of fishes that are affected by saving and maturing ECAs with the end of identifying the GENES that may be involved in the defence mechanisms of the stocks._x000D_ _x000D_ The consecution of these objects will enable the stabilisation of the basic population to be established in Epidemiologic STUDY AND PROFUNDING IN THE GENOMIC STUDY OF THE VIRULEN MECHANISMS OF THE Pathogen OF PECES Tenacibaculum maritimum WITH THE FINANCIAL DEVELOPMENT OF Immunologic PRODUCTS PERMITING PREVENTION BROTS OF MORTALITY ASSOCIED TO THIS micro-organism in the seaside fish stocks. (English)
12 October 2021
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Santiago de Compostela
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Identifiers
AGL2015-63569-R
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