Q3144181 (Q3144181): Difference between revisions
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(Created claim: summary (P836): THE PROPOSAL CONSIDERS THE DEVELOPMENT OF DIFFERENT FUNCTIONAL AND COMPOSITE POLYMERIC SYSTEMS, WHICH CAN OFFER ADVANCED SOLUTIONS IN THE FIELD OF REGENERATIVE MEDICINE. IN THIS CONTEXT, THE MAIN OBJECTIVES OF SUB-PROJECT 2 ARE THE DESIGN AND DEVELOPMENT OF BIOACTIVE COATINGS FOR MEDICAL DEVICES OF HIGH HEALTH DEMAND (DENTAL IMPLANTS AND BONE PROTESIS). MORE SPECIFICALLY, THE OBJECTIVES WILL BE, FIRST, THE DEVELOPMENT OF HYBRID SUN-GEL MATERIALS...) |
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| Property / summary | |||||||||||||||
THE PROPOSAL CONSIDERS THE DEVELOPMENT OF DIFFERENT FUNCTIONAL AND COMPOSITE POLYMERIC SYSTEMS, WHICH CAN OFFER ADVANCED SOLUTIONS IN THE FIELD OF REGENERATIVE MEDICINE. IN THIS CONTEXT, THE MAIN OBJECTIVES OF SUB-PROJECT 2 ARE THE DESIGN AND DEVELOPMENT OF BIOACTIVE COATINGS FOR MEDICAL DEVICES OF HIGH HEALTH DEMAND (DENTAL IMPLANTS AND BONE PROTESIS). MORE SPECIFICALLY, THE OBJECTIVES WILL BE, FIRST, THE DEVELOPMENT OF HYBRID SUN-GEL MATERIALS THAT CAN BE APPLIED IN THE FORM OF A COATING ON METALLIC SUBSTRATES (TITANIUM) CAPABLE OF ACTING AS LOCAL CONTROLLED RELEASE VEHICLES OF PHARMACOS WITH HIGH BIOCOMPATIBILITY (BETTER THAN TITANIUM IF POSSIBLE) AFTER APPLICATION IN DENTAL OR BONE PROSTHESIS AND CAPABLE OF PRODUCING OSTEOINDUCTION. A GOOD INTEGRATION OF THE BIOMATERIAL WITH THE SURROUNDING TISSUE IS CRUCIAL FOR THE SUCCESS OF THE IMPLANT/PROTECTION, SO A LARGE HINCAPIE IS MADE IN THE BIOLOGICAL CHARACTERISATION. THE METHODOLOGY WILL CONSIST OF THE SYNTHESIS OF SOL-GEL MIXTURES, SYSTEMATICALLY CONTROLLING THEIR COMPOSITION AND PRESENCE OF FUNCTIONAL GROUPS. SECONDLY, THE DEVELOPMENT OF ADVANCED THERAPIES BASED ON THE LOCAL RELEASE OF PHARMACOS FROM THE DEVELOPED VEHICLES AND THE COMBINATION WITH ACTIVE MOLECULES (PART OF WHICH DEVELOPED IN THIS PROJECT) THAT WILL BE RELEASED IN ORDER TO INCREASE THE FUNCTIONALITY OF THE COATING (OSTEOINDUCCION). FINALLY, AN IMPORTANT WORK WILL BE DONE TO INCREASE THE KNOWLEDGE ABOUT THE DEPOSITION OF PROTEINS IN THE DIFFERENT SURFACE TYPES IN WHICH THE FUNCTIONAL GROUPS AND THE ACTIVE MOLECULES HAVE BEEN SYSTEMATICALLY INCORPORATED, VIA SOL-GEL COATINGS, ALONG WITH THE CORRELATION WITH THE IN VITRO/IN VIVO STUDIES. AN IN-DEPTH STUDY OF PROTEIN ADSORPTION IN DEVELOPED COATINGS WILL BE CONDUCTED TO STUDY MATERIAL-PROTEIN INTERACTIONS IN PROTEIN DEPOSITION TESTS USING A COMBINATION OF DIFFERENT TECHNIQUES: QUARTZ MICROBALANCE TO DETECT THE AMOUNT AND ORIENTATION OF DEPOSITED PROTEINS, ATOMIC FORCE MICROSCOPE AFM TO STUDY ITS CONFIGURATION, SEM COUPLED TO EDAX TO STUDY MORPHOLOGY AND COMPOSITION. AND MASS SPECTROPHOTOMETRY TO STUDY PROTEIN AND ITS QUANTIFICATION ON THE SURFACE OF MATERIALS. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH GROUP OF SUBPROJECT 2 WILL ACTIVELY PARTICIPATE IN A LARGE MULTIDISCIPLINARY TEAM COORDINATED BY DR. JULIO SAN ROMAN WITH MORE THAN 15 YEARS OF EXPERIENCE IN COOPERATIVE PROJECTS. THE COORDINATED AND COMPLEMENTARY MULTIDISCIPLINARY TEAM COVERS ALL THE TASKS AND SPECIALTIES NECESSARY FOR THE DEVELOPMENT OF THE DIFFERENT STAGES AND WORK PACKAGES OF THE PROJECT, SUCH AS THE PREPARATION OF FUNCTIONALISED SYSTEMS, ANALYSIS OF PROPERTIES, CELLULAR BEHAVIOR AND ANIMAL EXPERIMENTATION. (English) | |||||||||||||||
| Property / summary: THE PROPOSAL CONSIDERS THE DEVELOPMENT OF DIFFERENT FUNCTIONAL AND COMPOSITE POLYMERIC SYSTEMS, WHICH CAN OFFER ADVANCED SOLUTIONS IN THE FIELD OF REGENERATIVE MEDICINE. IN THIS CONTEXT, THE MAIN OBJECTIVES OF SUB-PROJECT 2 ARE THE DESIGN AND DEVELOPMENT OF BIOACTIVE COATINGS FOR MEDICAL DEVICES OF HIGH HEALTH DEMAND (DENTAL IMPLANTS AND BONE PROTESIS). MORE SPECIFICALLY, THE OBJECTIVES WILL BE, FIRST, THE DEVELOPMENT OF HYBRID SUN-GEL MATERIALS THAT CAN BE APPLIED IN THE FORM OF A COATING ON METALLIC SUBSTRATES (TITANIUM) CAPABLE OF ACTING AS LOCAL CONTROLLED RELEASE VEHICLES OF PHARMACOS WITH HIGH BIOCOMPATIBILITY (BETTER THAN TITANIUM IF POSSIBLE) AFTER APPLICATION IN DENTAL OR BONE PROSTHESIS AND CAPABLE OF PRODUCING OSTEOINDUCTION. A GOOD INTEGRATION OF THE BIOMATERIAL WITH THE SURROUNDING TISSUE IS CRUCIAL FOR THE SUCCESS OF THE IMPLANT/PROTECTION, SO A LARGE HINCAPIE IS MADE IN THE BIOLOGICAL CHARACTERISATION. THE METHODOLOGY WILL CONSIST OF THE SYNTHESIS OF SOL-GEL MIXTURES, SYSTEMATICALLY CONTROLLING THEIR COMPOSITION AND PRESENCE OF FUNCTIONAL GROUPS. SECONDLY, THE DEVELOPMENT OF ADVANCED THERAPIES BASED ON THE LOCAL RELEASE OF PHARMACOS FROM THE DEVELOPED VEHICLES AND THE COMBINATION WITH ACTIVE MOLECULES (PART OF WHICH DEVELOPED IN THIS PROJECT) THAT WILL BE RELEASED IN ORDER TO INCREASE THE FUNCTIONALITY OF THE COATING (OSTEOINDUCCION). FINALLY, AN IMPORTANT WORK WILL BE DONE TO INCREASE THE KNOWLEDGE ABOUT THE DEPOSITION OF PROTEINS IN THE DIFFERENT SURFACE TYPES IN WHICH THE FUNCTIONAL GROUPS AND THE ACTIVE MOLECULES HAVE BEEN SYSTEMATICALLY INCORPORATED, VIA SOL-GEL COATINGS, ALONG WITH THE CORRELATION WITH THE IN VITRO/IN VIVO STUDIES. AN IN-DEPTH STUDY OF PROTEIN ADSORPTION IN DEVELOPED COATINGS WILL BE CONDUCTED TO STUDY MATERIAL-PROTEIN INTERACTIONS IN PROTEIN DEPOSITION TESTS USING A COMBINATION OF DIFFERENT TECHNIQUES: QUARTZ MICROBALANCE TO DETECT THE AMOUNT AND ORIENTATION OF DEPOSITED PROTEINS, ATOMIC FORCE MICROSCOPE AFM TO STUDY ITS CONFIGURATION, SEM COUPLED TO EDAX TO STUDY MORPHOLOGY AND COMPOSITION. AND MASS SPECTROPHOTOMETRY TO STUDY PROTEIN AND ITS QUANTIFICATION ON THE SURFACE OF MATERIALS. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH GROUP OF SUBPROJECT 2 WILL ACTIVELY PARTICIPATE IN A LARGE MULTIDISCIPLINARY TEAM COORDINATED BY DR. JULIO SAN ROMAN WITH MORE THAN 15 YEARS OF EXPERIENCE IN COOPERATIVE PROJECTS. THE COORDINATED AND COMPLEMENTARY MULTIDISCIPLINARY TEAM COVERS ALL THE TASKS AND SPECIALTIES NECESSARY FOR THE DEVELOPMENT OF THE DIFFERENT STAGES AND WORK PACKAGES OF THE PROJECT, SUCH AS THE PREPARATION OF FUNCTIONALISED SYSTEMS, ANALYSIS OF PROPERTIES, CELLULAR BEHAVIOR AND ANIMAL EXPERIMENTATION. (English) / rank | |||||||||||||||
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| Property / summary: THE PROPOSAL CONSIDERS THE DEVELOPMENT OF DIFFERENT FUNCTIONAL AND COMPOSITE POLYMERIC SYSTEMS, WHICH CAN OFFER ADVANCED SOLUTIONS IN THE FIELD OF REGENERATIVE MEDICINE. IN THIS CONTEXT, THE MAIN OBJECTIVES OF SUB-PROJECT 2 ARE THE DESIGN AND DEVELOPMENT OF BIOACTIVE COATINGS FOR MEDICAL DEVICES OF HIGH HEALTH DEMAND (DENTAL IMPLANTS AND BONE PROTESIS). MORE SPECIFICALLY, THE OBJECTIVES WILL BE, FIRST, THE DEVELOPMENT OF HYBRID SUN-GEL MATERIALS THAT CAN BE APPLIED IN THE FORM OF A COATING ON METALLIC SUBSTRATES (TITANIUM) CAPABLE OF ACTING AS LOCAL CONTROLLED RELEASE VEHICLES OF PHARMACOS WITH HIGH BIOCOMPATIBILITY (BETTER THAN TITANIUM IF POSSIBLE) AFTER APPLICATION IN DENTAL OR BONE PROSTHESIS AND CAPABLE OF PRODUCING OSTEOINDUCTION. A GOOD INTEGRATION OF THE BIOMATERIAL WITH THE SURROUNDING TISSUE IS CRUCIAL FOR THE SUCCESS OF THE IMPLANT/PROTECTION, SO A LARGE HINCAPIE IS MADE IN THE BIOLOGICAL CHARACTERISATION. THE METHODOLOGY WILL CONSIST OF THE SYNTHESIS OF SOL-GEL MIXTURES, SYSTEMATICALLY CONTROLLING THEIR COMPOSITION AND PRESENCE OF FUNCTIONAL GROUPS. SECONDLY, THE DEVELOPMENT OF ADVANCED THERAPIES BASED ON THE LOCAL RELEASE OF PHARMACOS FROM THE DEVELOPED VEHICLES AND THE COMBINATION WITH ACTIVE MOLECULES (PART OF WHICH DEVELOPED IN THIS PROJECT) THAT WILL BE RELEASED IN ORDER TO INCREASE THE FUNCTIONALITY OF THE COATING (OSTEOINDUCCION). FINALLY, AN IMPORTANT WORK WILL BE DONE TO INCREASE THE KNOWLEDGE ABOUT THE DEPOSITION OF PROTEINS IN THE DIFFERENT SURFACE TYPES IN WHICH THE FUNCTIONAL GROUPS AND THE ACTIVE MOLECULES HAVE BEEN SYSTEMATICALLY INCORPORATED, VIA SOL-GEL COATINGS, ALONG WITH THE CORRELATION WITH THE IN VITRO/IN VIVO STUDIES. AN IN-DEPTH STUDY OF PROTEIN ADSORPTION IN DEVELOPED COATINGS WILL BE CONDUCTED TO STUDY MATERIAL-PROTEIN INTERACTIONS IN PROTEIN DEPOSITION TESTS USING A COMBINATION OF DIFFERENT TECHNIQUES: QUARTZ MICROBALANCE TO DETECT THE AMOUNT AND ORIENTATION OF DEPOSITED PROTEINS, ATOMIC FORCE MICROSCOPE AFM TO STUDY ITS CONFIGURATION, SEM COUPLED TO EDAX TO STUDY MORPHOLOGY AND COMPOSITION. AND MASS SPECTROPHOTOMETRY TO STUDY PROTEIN AND ITS QUANTIFICATION ON THE SURFACE OF MATERIALS. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH GROUP OF SUBPROJECT 2 WILL ACTIVELY PARTICIPATE IN A LARGE MULTIDISCIPLINARY TEAM COORDINATED BY DR. JULIO SAN ROMAN WITH MORE THAN 15 YEARS OF EXPERIENCE IN COOPERATIVE PROJECTS. THE COORDINATED AND COMPLEMENTARY MULTIDISCIPLINARY TEAM COVERS ALL THE TASKS AND SPECIALTIES NECESSARY FOR THE DEVELOPMENT OF THE DIFFERENT STAGES AND WORK PACKAGES OF THE PROJECT, SUCH AS THE PREPARATION OF FUNCTIONALISED SYSTEMS, ANALYSIS OF PROPERTIES, CELLULAR BEHAVIOR AND ANIMAL EXPERIMENTATION. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 14:00, 12 October 2021
Project Q3144181 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3144181 in Spain |
Statements
33,880.0 Euro
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67,760.0 Euro
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50.0 percent
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1 January 2015
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30 September 2018
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UNIVERSIDAD JAUME I
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39°59'9.71"N, 0°2'15.86"W
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12040
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LA PROPUESTA CONSIDERA EL DESARROLLO DE DIFERENTES SISTEMAS POLIMERICOS FUNCIONALES Y COMPOSITES, QUE PUEDEN OFRECER SOLUCIONES AVANZADAS EN EL CAMPO DE LA MEDICINA REGENERATIVA. EN ESTE CONTEXTO, LOS OBJETIVOS PRINCIPALES DEL SUBPROYECTO 2 SON EL DISEÑO Y DESARROLLO DE RECUBRIMIENTOS BIOACTIVOS PARA DISPOSITIVOS MEDICOS DE GRAN DEMANDA SANITARIA (IMPLANTES DENTALES Y PROTESIS DE HUESO). MAS ESPECIFICAMENTE, LOS OBJETIVOS SERAN, PRIMERAMENTE, EL DESARROLLO DE MATERIALES SOL-GEL HIBRIDOS QUE PUEDAN APLICARSE EN FORMA DE RECUBRIMIENTO SOBRE SUSTRATOS METALICOS (TITANIO) CAPACES DE ACTUAR COMO VEHICULOS LOCALES DE LIBERACION CONTROLADA DE FARMACOS CON ALTA BIOCOMPATIBILIDAD (MEJOR QUE LA DEL TITANIO SI ES POSIBLE) TRAS APLICARSE EN PROTESIS DENTALES O DE HUESO Y CAPACES DE PRODUCIR OSTEOINDUCCION. UNA BUENA INTEGRACION DEL BIOMATERIAL CON EL TEJIDO CIRCUNDANTE ES CRUCIAL PARA EL EXITO DEL IMPLANTE/PROTESIS, POR LO QUE SE HARA UN GRAN HINCAPIE EN LA CARACTERIZACION BIOLOGICA. LA METODOLOGIA CONSISTIRA EN LA SINTESIS DE MEZCLAS SOL-GEL, CONTROLANDO SISTEMATICAMENTE SU COMPOSICION Y PRESENCIA DE GRUPOS FUNCIONALES. EN SEGUNDO LUGAR, EL DESARROLLO DE TERAPIAS AVANZADAS BASADAS EN LA LIBERACION LOCAL DE FARMACOS A PARTIR DE LOS VEHICULOS DESARROLLADOS Y LA COMBINACION CON MOLECULAS ACTIVAS (PARTE DE ELLAS DESARROLLADAS EN ESTE PROYECTO) QUE SERAN LIBERADAS CON EL FIN DE AUMENTAR LA FUNCIONALIDAD DEL RECUBRIMIENTO (OSTEOINDUCCION). FINALMENTE, SE REALIZARA UN IMPORTANTE TRABAJO PARA INCREMENTAR EL CONOCIMIENTO ACERCA DE LA DEPOSICION DE PROTEINAS EN LOS DIFERENTES TIPOS DE SUPERFICIE EN LOS QUE LOS GRUPOS FUNCIONALES Y LAS MOLECULAS ACTIVAS HAYAN SIDO SISTEMATICAMENTE INCORPORADOS, VIA RECUBRIMIENTOS SOL-GEL, JUNTO A LA CORRELACION CON LOS ESTUDIOS IN VITRO/IN VIVO. UN ESTUDIO EN PROFUNDIDAD DE LA ADSORCION DE PROTEINAS EN LOS RECUBRIMIENTOS DESARROLLADOS SE LLEVARA A CABO PARA ESTUDIAR LAS INTERACCIONES MATERIAL-PROTEINA EN TESTS DE DEPOSICION DE PROTEINAS UTILIZANDO UNA COMBINACION DE DIFERENTES TECNICAS: MICROBALANZA DE CUARZO PARA DETECTAR LA CANTIDAD Y ORIENTACION DE LAS PROTEINAS DEPOSITADAS, MICROSCOPIO DE FUERZA ATOMICA ¿ AFM PARA ESTUDIAR SU CONFIGURACION, SEM ACOPLADO A EDAX PARA ESTUDIAR LA MORFOLOGIA Y COMPOSICION. Y ESPECTROFOTOMETRIA DE MASAS PARA ESTUDIAR LA PROTEINA Y SU CUANTIFICACION EN LA SUPERFICIE DE LOS MATERIALES. PARA CUMPLIR ESTOS OBJETIVOS, EL GRUPO DE INVESTIGACION DEL SUBPROYECTO 2 PARTICIPARA ACTIVAMENTE EN UN GRAN EQUIPO MULTIDISCIPLINAR COORDINADO POR EL DR. JULIO SAN ROMAN CON MAS DE 15 AÑOS DE EXPERIENCIA EN PROYECTOS COOPERATIVOS. EL EQUIPO MULTIDISCIPLINAR COORDINADO Y COMPLEMENTARIO CUBRE TODAS LAS TAREAS Y ESPECIALIDADES NECESARIAS PARA EL DESARROLLO DE LAS DIFERENTES ETAPAS Y PAQUETES DE TRABAJO DEL PROYECTO, COMO SON LA PREPARACION DE SISTEMAS FUNCIONALIZADOS, ANALISIS DE PROPIEDADES, COMPORTAMIENTO CELULAR Y EXPERIMENTACION ANIMAL. (Spanish)
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THE PROPOSAL CONSIDERS THE DEVELOPMENT OF DIFFERENT FUNCTIONAL AND COMPOSITE POLYMERIC SYSTEMS, WHICH CAN OFFER ADVANCED SOLUTIONS IN THE FIELD OF REGENERATIVE MEDICINE. IN THIS CONTEXT, THE MAIN OBJECTIVES OF SUB-PROJECT 2 ARE THE DESIGN AND DEVELOPMENT OF BIOACTIVE COATINGS FOR MEDICAL DEVICES OF HIGH HEALTH DEMAND (DENTAL IMPLANTS AND BONE PROTESIS). MORE SPECIFICALLY, THE OBJECTIVES WILL BE, FIRST, THE DEVELOPMENT OF HYBRID SUN-GEL MATERIALS THAT CAN BE APPLIED IN THE FORM OF A COATING ON METALLIC SUBSTRATES (TITANIUM) CAPABLE OF ACTING AS LOCAL CONTROLLED RELEASE VEHICLES OF PHARMACOS WITH HIGH BIOCOMPATIBILITY (BETTER THAN TITANIUM IF POSSIBLE) AFTER APPLICATION IN DENTAL OR BONE PROSTHESIS AND CAPABLE OF PRODUCING OSTEOINDUCTION. A GOOD INTEGRATION OF THE BIOMATERIAL WITH THE SURROUNDING TISSUE IS CRUCIAL FOR THE SUCCESS OF THE IMPLANT/PROTECTION, SO A LARGE HINCAPIE IS MADE IN THE BIOLOGICAL CHARACTERISATION. THE METHODOLOGY WILL CONSIST OF THE SYNTHESIS OF SOL-GEL MIXTURES, SYSTEMATICALLY CONTROLLING THEIR COMPOSITION AND PRESENCE OF FUNCTIONAL GROUPS. SECONDLY, THE DEVELOPMENT OF ADVANCED THERAPIES BASED ON THE LOCAL RELEASE OF PHARMACOS FROM THE DEVELOPED VEHICLES AND THE COMBINATION WITH ACTIVE MOLECULES (PART OF WHICH DEVELOPED IN THIS PROJECT) THAT WILL BE RELEASED IN ORDER TO INCREASE THE FUNCTIONALITY OF THE COATING (OSTEOINDUCCION). FINALLY, AN IMPORTANT WORK WILL BE DONE TO INCREASE THE KNOWLEDGE ABOUT THE DEPOSITION OF PROTEINS IN THE DIFFERENT SURFACE TYPES IN WHICH THE FUNCTIONAL GROUPS AND THE ACTIVE MOLECULES HAVE BEEN SYSTEMATICALLY INCORPORATED, VIA SOL-GEL COATINGS, ALONG WITH THE CORRELATION WITH THE IN VITRO/IN VIVO STUDIES. AN IN-DEPTH STUDY OF PROTEIN ADSORPTION IN DEVELOPED COATINGS WILL BE CONDUCTED TO STUDY MATERIAL-PROTEIN INTERACTIONS IN PROTEIN DEPOSITION TESTS USING A COMBINATION OF DIFFERENT TECHNIQUES: QUARTZ MICROBALANCE TO DETECT THE AMOUNT AND ORIENTATION OF DEPOSITED PROTEINS, ATOMIC FORCE MICROSCOPE AFM TO STUDY ITS CONFIGURATION, SEM COUPLED TO EDAX TO STUDY MORPHOLOGY AND COMPOSITION. AND MASS SPECTROPHOTOMETRY TO STUDY PROTEIN AND ITS QUANTIFICATION ON THE SURFACE OF MATERIALS. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH GROUP OF SUBPROJECT 2 WILL ACTIVELY PARTICIPATE IN A LARGE MULTIDISCIPLINARY TEAM COORDINATED BY DR. JULIO SAN ROMAN WITH MORE THAN 15 YEARS OF EXPERIENCE IN COOPERATIVE PROJECTS. THE COORDINATED AND COMPLEMENTARY MULTIDISCIPLINARY TEAM COVERS ALL THE TASKS AND SPECIALTIES NECESSARY FOR THE DEVELOPMENT OF THE DIFFERENT STAGES AND WORK PACKAGES OF THE PROJECT, SUCH AS THE PREPARATION OF FUNCTIONALISED SYSTEMS, ANALYSIS OF PROPERTIES, CELLULAR BEHAVIOR AND ANIMAL EXPERIMENTATION. (English)
12 October 2021
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Castellón de la Plana/Castelló de la Plana
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Identifiers
MAT2014-51918-C2-2-R
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