Q3143503 (Q3143503): Difference between revisions
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(Created claim: summary (P836): Cardiovascular diseases cause high morbidity and mortality in developed countries. Associated risk factors such as inflammatory and autoimmune diseases increase the incidence of these pathologies, including atherosclerotic coronary disease. This disease is defined as a chronic inflammatory process of the vascular wall. In the last 10 years, the peptidyl-prolylcis-transisomerase protein family (PPIases) has been associated with inflammation assoc...) |
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Cardiovascular diseases cause high morbidity and mortality in developed countries. Associated risk factors such as inflammatory and autoimmune diseases increase the incidence of these pathologies, including atherosclerotic coronary disease. This disease is defined as a chronic inflammatory process of the vascular wall. In the last 10 years, the peptidyl-prolylcis-transisomerase protein family (PPIases) has been associated with inflammation associated with various heart and vascular diseases including atherosclerosis. Within this group of proteins, cyclophyllins seem to play a fundamental role both in the development and evolution of atheroma plaque, which makes them interesting therapeutic targets. Of the four isoforms that have so far been related to cardiovascular diseases, the most studied is cyclophylline A and its Emprim CD147 receptor whose levels begin to increase before any clinical manifestation. In this project the profile of these four isoforms will be determined in samples from patients with acute and chronic atherosclerotic coronary artery disease and with/without associated risk factors in order to establish new biomarkers related to this disease. In addition, the effect of modulation of these proteins will be studied with a group of molecules that have previously shown activity. These initially asylated molecules of Spongionellagracilis sponge, called gracilins, have served as guiding molecules for the synthesis of active analogues. Both gracillin and synthetic analogues have a high affinity for cyclophyllins A and D and lack of in vitro and in vivo toxicity, making them suitable for studies in both asylated cells and animal models in order to develop new therapeutic strategies for atherosclerosis. (English) | |||||||||||||||
| Property / summary: Cardiovascular diseases cause high morbidity and mortality in developed countries. Associated risk factors such as inflammatory and autoimmune diseases increase the incidence of these pathologies, including atherosclerotic coronary disease. This disease is defined as a chronic inflammatory process of the vascular wall. In the last 10 years, the peptidyl-prolylcis-transisomerase protein family (PPIases) has been associated with inflammation associated with various heart and vascular diseases including atherosclerosis. Within this group of proteins, cyclophyllins seem to play a fundamental role both in the development and evolution of atheroma plaque, which makes them interesting therapeutic targets. Of the four isoforms that have so far been related to cardiovascular diseases, the most studied is cyclophylline A and its Emprim CD147 receptor whose levels begin to increase before any clinical manifestation. In this project the profile of these four isoforms will be determined in samples from patients with acute and chronic atherosclerotic coronary artery disease and with/without associated risk factors in order to establish new biomarkers related to this disease. In addition, the effect of modulation of these proteins will be studied with a group of molecules that have previously shown activity. These initially asylated molecules of Spongionellagracilis sponge, called gracilins, have served as guiding molecules for the synthesis of active analogues. Both gracillin and synthetic analogues have a high affinity for cyclophyllins A and D and lack of in vitro and in vivo toxicity, making them suitable for studies in both asylated cells and animal models in order to develop new therapeutic strategies for atherosclerosis. (English) / rank | |||||||||||||||
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| Property / summary: Cardiovascular diseases cause high morbidity and mortality in developed countries. Associated risk factors such as inflammatory and autoimmune diseases increase the incidence of these pathologies, including atherosclerotic coronary disease. This disease is defined as a chronic inflammatory process of the vascular wall. In the last 10 years, the peptidyl-prolylcis-transisomerase protein family (PPIases) has been associated with inflammation associated with various heart and vascular diseases including atherosclerosis. Within this group of proteins, cyclophyllins seem to play a fundamental role both in the development and evolution of atheroma plaque, which makes them interesting therapeutic targets. Of the four isoforms that have so far been related to cardiovascular diseases, the most studied is cyclophylline A and its Emprim CD147 receptor whose levels begin to increase before any clinical manifestation. In this project the profile of these four isoforms will be determined in samples from patients with acute and chronic atherosclerotic coronary artery disease and with/without associated risk factors in order to establish new biomarkers related to this disease. In addition, the effect of modulation of these proteins will be studied with a group of molecules that have previously shown activity. These initially asylated molecules of Spongionellagracilis sponge, called gracilins, have served as guiding molecules for the synthesis of active analogues. Both gracillin and synthetic analogues have a high affinity for cyclophyllins A and D and lack of in vitro and in vivo toxicity, making them suitable for studies in both asylated cells and animal models in order to develop new therapeutic strategies for atherosclerosis. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:29, 12 October 2021
Project Q3143503 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3143503 in Spain |
Statements
17,600.0 Euro
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22,000.0 Euro
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80.0 percent
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1 January 2017
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31 March 2020
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
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43°2'46.39"N, 7°28'26.36"W
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27028
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Las enfermedades cardiovasculares son causa de una alta morbilidad y mortalidad en los países desarrollados. Factores de riesgo asociado como enfermedades inflamatorias y autoinmunes incrementan la incidencia de estas patologías, entre las que destaca la enfermedad coronaria aterosclerótica. Esta enfermedad se define como un proceso inflamatorio crónico de la pared vascular. En los últimos 10 años, la familia de proteínas peptidil-prolilcis-transisomerasas (PPIasas) se ha relacionado con la inflamación asociada a diversas enfermedades cardíacas y vasculares incluyendo la aterosclerosis. Dentro de este grupo de proteínas, las ciclofilinas parecen despeñar un papel fundamental tanto en el desarrollo como en la evolución de la placa de ateroma, lo que las convierte en interesantes dianas terapéuticas. De las cuatro isoformas que hasta el momento se han relacionado con las enfermedades cardiovasculares, la más estudiada es la ciclofilina A y su receptor EMPRIM CD147 cuyos niveles comienzan a aumentar antes de cualquier manifestación clínica. En el presente proyecto se determinará el perfil de estas cuatro isoformas en muestras de pacientes con enfermedad coronaria aterosclerótica aguda y crónica y con/sin factores de riesgo asociados con el fin de establecer nuevos biomarcadores relacionados con esta enfermedad. Además se estudiará el efecto de la modulación de estas proteínas con un grupo de moléculas que previamente han mostrado actividad. Estas moléculas asiladas inicialmente de la esponja Spongionellagracilis, llamadas gracilinas han servido como moléculas guía para la síntesis de análogos activos. Tanto las gracilinas como los análogos sintéticos presentan alta afinidad por las ciclofilinas A y D y ausencia de toxicidad in vitro e in vivo por lo que son moléculas idóneas para estudios tanto en células asiladas como en modelos animales con el fin de desarrollar nuevas estrategias terapéuticas para la aterosclerosis. (Spanish)
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Cardiovascular diseases cause high morbidity and mortality in developed countries. Associated risk factors such as inflammatory and autoimmune diseases increase the incidence of these pathologies, including atherosclerotic coronary disease. This disease is defined as a chronic inflammatory process of the vascular wall. In the last 10 years, the peptidyl-prolylcis-transisomerase protein family (PPIases) has been associated with inflammation associated with various heart and vascular diseases including atherosclerosis. Within this group of proteins, cyclophyllins seem to play a fundamental role both in the development and evolution of atheroma plaque, which makes them interesting therapeutic targets. Of the four isoforms that have so far been related to cardiovascular diseases, the most studied is cyclophylline A and its Emprim CD147 receptor whose levels begin to increase before any clinical manifestation. In this project the profile of these four isoforms will be determined in samples from patients with acute and chronic atherosclerotic coronary artery disease and with/without associated risk factors in order to establish new biomarkers related to this disease. In addition, the effect of modulation of these proteins will be studied with a group of molecules that have previously shown activity. These initially asylated molecules of Spongionellagracilis sponge, called gracilins, have served as guiding molecules for the synthesis of active analogues. Both gracillin and synthetic analogues have a high affinity for cyclophyllins A and D and lack of in vitro and in vivo toxicity, making them suitable for studies in both asylated cells and animal models in order to develop new therapeutic strategies for atherosclerosis. (English)
12 October 2021
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Lugo
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Identifiers
PI16_01816
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