Q3141926 (Q3141926): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): Maternal overnutrition during pregnancy exerts changes in the fetus and increases the risk of developing adult metabolic diseases. Epigenetic modifications, such as DNA methylation, that occur in metabolic programming are little known. This project aims to identify and test the possible reversibility of epigenetic modifications in offspring caused by maternal overnutrition, in particular: 1) Study the methylation profile of the umbilical cord...) |
||||||||||||||
| Property / summary | |||||||||||||||
Maternal overnutrition during pregnancy exerts changes in the fetus and increases the risk of developing adult metabolic diseases. Epigenetic modifications, such as DNA methylation, that occur in metabolic programming are little known. This project aims to identify and test the possible reversibility of epigenetic modifications in offspring caused by maternal overnutrition, in particular: 1) Study the methylation profile of the umbilical cord DNA of a clinical prenatal cohort. Regions differentially methylated in cord tissue of newborns of control mothers and mothers with gestational obesity will be identified and validated by MeDIP-seq and EpiTYPER. The degree of methylation in these regions and their predictive potential for adverse metabolic profile in newborns followed up to 5 years of age (body composition, serum metabolic markers) will be analysed. 2) Study the effects of maternal overnutrition on metabolic programming in a pig animal model. A pig model (suckets born of control bristles and over-fed sows during pregnancy) will be used to validate/replicate the results of the clinical cohort and also to study changes in adipose tissue in animal monitoring. The predictive power of the degree of umbilical cord methylation of changes in prepuberal-age animals will be analysed: body composition, serum metabolic markers and markers in adipose tissue (hypertrophy, inflammation, and DNA methylation). 3) Study the pharmacological reversibility of metabolic programming and associated epigenetic changes in the animal model. The effects of early treatment with metformin in piglets on the possible reversibility of changes in body composition, metabolic markers in serum and markers on adipose tissue (hypertrophy, inflammation, and DNA methylation) will be analysed. (English) | |||||||||||||||
| Property / summary: Maternal overnutrition during pregnancy exerts changes in the fetus and increases the risk of developing adult metabolic diseases. Epigenetic modifications, such as DNA methylation, that occur in metabolic programming are little known. This project aims to identify and test the possible reversibility of epigenetic modifications in offspring caused by maternal overnutrition, in particular: 1) Study the methylation profile of the umbilical cord DNA of a clinical prenatal cohort. Regions differentially methylated in cord tissue of newborns of control mothers and mothers with gestational obesity will be identified and validated by MeDIP-seq and EpiTYPER. The degree of methylation in these regions and their predictive potential for adverse metabolic profile in newborns followed up to 5 years of age (body composition, serum metabolic markers) will be analysed. 2) Study the effects of maternal overnutrition on metabolic programming in a pig animal model. A pig model (suckets born of control bristles and over-fed sows during pregnancy) will be used to validate/replicate the results of the clinical cohort and also to study changes in adipose tissue in animal monitoring. The predictive power of the degree of umbilical cord methylation of changes in prepuberal-age animals will be analysed: body composition, serum metabolic markers and markers in adipose tissue (hypertrophy, inflammation, and DNA methylation). 3) Study the pharmacological reversibility of metabolic programming and associated epigenetic changes in the animal model. The effects of early treatment with metformin in piglets on the possible reversibility of changes in body composition, metabolic markers in serum and markers on adipose tissue (hypertrophy, inflammation, and DNA methylation) will be analysed. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: Maternal overnutrition during pregnancy exerts changes in the fetus and increases the risk of developing adult metabolic diseases. Epigenetic modifications, such as DNA methylation, that occur in metabolic programming are little known. This project aims to identify and test the possible reversibility of epigenetic modifications in offspring caused by maternal overnutrition, in particular: 1) Study the methylation profile of the umbilical cord DNA of a clinical prenatal cohort. Regions differentially methylated in cord tissue of newborns of control mothers and mothers with gestational obesity will be identified and validated by MeDIP-seq and EpiTYPER. The degree of methylation in these regions and their predictive potential for adverse metabolic profile in newborns followed up to 5 years of age (body composition, serum metabolic markers) will be analysed. 2) Study the effects of maternal overnutrition on metabolic programming in a pig animal model. A pig model (suckets born of control bristles and over-fed sows during pregnancy) will be used to validate/replicate the results of the clinical cohort and also to study changes in adipose tissue in animal monitoring. The predictive power of the degree of umbilical cord methylation of changes in prepuberal-age animals will be analysed: body composition, serum metabolic markers and markers in adipose tissue (hypertrophy, inflammation, and DNA methylation). 3) Study the pharmacological reversibility of metabolic programming and associated epigenetic changes in the animal model. The effects of early treatment with metformin in piglets on the possible reversibility of changes in body composition, metabolic markers in serum and markers on adipose tissue (hypertrophy, inflammation, and DNA methylation) will be analysed. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 13:25, 12 October 2021
Project Q3141926 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3141926 in Spain |
Statements
81,125.0 Euro
0 references
162,250.0 Euro
0 references
50.0 percent
0 references
1 January 2017
0 references
31 March 2020
0 references
FUNDACION INSTITUTO DE INVESTIGACION BIOMEDICA DE GERONA
0 references
41°58'45.48"N, 2°49'11.78"E
0 references
17079
0 references
La sobrenutrición materna durante la gestación ejerce cambios en el feto y aumenta el riesgo de desarrollar enfermedades metabólicas del adulto. Las modificaciones epigenéticas, tales como metilación del DNA, que se producen en la programación metabólica son poco conocidas. Este proyecto pretende identificar y testar la posible reversibilidad de las modificaciones epigenéticas en la descendencia causadas por sobrenutrición materna, en particular: 1) Estudiar el perfil de metilación del DNA en cordón umbilical de una cohorte prenatal clínica. Las regiones diferencialmente metiladas en tejido de cordón de recién nacidos de madres control y de madres con obesidad gestacional se identificarán y validarán mediante MeDIP-seq y EpiTYPER. Se analizará el grado de metilación en dichas regiones y su potencial predictor de perfil metabólico adverso en los recién nacidos seguidos hasta los 5 años de edad (composición corporal, marcadores metabólicos en suero). 2) Estudiar los efectos de la sobrenutrición materna en la programación metabólica en un modelo animal porcino. Se utilizará un modelo porcino (lechones nacidos de cerdas control y de cerdas sobrealimentadas durante la gestación) para validar/replicar los resultados de la cohorte clínica y estudiar además cambios en el tejido adiposo en el seguimiento de los animales. Se analizará el poder predictor del grado de metilación en cordón umbilical de los cambios en los animales en edad prepuberal: composición corporal, marcadores metabólicos en suero y marcadores en tejido adiposo (hipertrofia, inflamación y metilación de DNA). 3) Estudiar la reversibilidad farmacológica de la programación metabólica y cambios epigenéticos asociados en el modelo animal. Se analizarán los efectos del tratamiento precoz con metformina en los lechones sobre la posible reversibilidad de los cambios de composición corporal, marcadores metabólicos en suero y marcadores en tejido adiposo (hipertrofia, inflamación y metilación del DNA). (Spanish)
0 references
Maternal overnutrition during pregnancy exerts changes in the fetus and increases the risk of developing adult metabolic diseases. Epigenetic modifications, such as DNA methylation, that occur in metabolic programming are little known. This project aims to identify and test the possible reversibility of epigenetic modifications in offspring caused by maternal overnutrition, in particular: 1) Study the methylation profile of the umbilical cord DNA of a clinical prenatal cohort. Regions differentially methylated in cord tissue of newborns of control mothers and mothers with gestational obesity will be identified and validated by MeDIP-seq and EpiTYPER. The degree of methylation in these regions and their predictive potential for adverse metabolic profile in newborns followed up to 5 years of age (body composition, serum metabolic markers) will be analysed. 2) Study the effects of maternal overnutrition on metabolic programming in a pig animal model. A pig model (suckets born of control bristles and over-fed sows during pregnancy) will be used to validate/replicate the results of the clinical cohort and also to study changes in adipose tissue in animal monitoring. The predictive power of the degree of umbilical cord methylation of changes in prepuberal-age animals will be analysed: body composition, serum metabolic markers and markers in adipose tissue (hypertrophy, inflammation, and DNA methylation). 3) Study the pharmacological reversibility of metabolic programming and associated epigenetic changes in the animal model. The effects of early treatment with metformin in piglets on the possible reversibility of changes in body composition, metabolic markers in serum and markers on adipose tissue (hypertrophy, inflammation, and DNA methylation) will be analysed. (English)
12 October 2021
0 references
Girona
0 references
Identifiers
PI16_01335
0 references