Q3141518 (Q3141518): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): I. The present draft proposal proposes a sequentiality of the statistics of the operation of the GASTROINTESTINAL TRACT (GIT) with in-live experience, simulations in a model in VITRO, and in a pre-eminent MATEMATIC model (without SILICO) with the primary task of increasing the effectiveness of food management in the CULTIVO OF PECES_x000D_ _x000D_ II. THE PROJECT IS BASED ON TWO PREMISES; A) AN IMPORTANT PART OF PISCICOLA PRODUCTION YIELDS (AND...) |
||||||||||||||
| Property / summary | |||||||||||||||
I. The present draft proposal proposes a sequentiality of the statistics of the operation of the GASTROINTESTINAL TRACT (GIT) with in-live experience, simulations in a model in VITRO, and in a pre-eminent MATEMATIC model (without SILICO) with the primary task of increasing the effectiveness of food management in the CULTIVO OF PECES_x000D_ _x000D_ II. THE PROJECT IS BASED ON TWO PREMISES; A) AN IMPORTANT PART OF PISCICOLA PRODUCTION YIELDS (AND BUSINESS PROFIT) DEPEND ON THE EFFICIENT USE OF NUTRIENTS, ESPECIALLY PROTEIN. In the Mediterranean fish species there is still an important margin of improvement that allows to approximate feed processing INDICES to those of the species of reference, as the Atlantic salmon _x000D_ _x000D_ III. Class NUTRICIONAL EVALUATIONS are based on the provision of INGREDIENT COMBINANCATIONS that are ADECUTED AND VALUE their identity in tests that are essential to my growth, QUANTITATIVE (TOTAL WEIGHT AUMENT) as a QUALITATIVE (proportion of PROTEIN IN FACK)_x000D_ _x000D_ IV. THESE STUDIES ASSUME THAT PROTEIN DIGESTIBILITY VALUES ARE RELIABLE INDICATORS OF ITS BIOAVAILABILITY FOR GROWTH. Apart from the fact that this is highly questionable, there are no plans to support the improvement of the effectiveness of this NUTRIENT’s direct use by means of a better knowledge and potential modification of the agents who are affected by their process in the GIT of PEZ_x000D_ _x000D_ V. it is PLANT that a detailed knowledge of the FACTORS who may have the greatest impact on the effectiveness of the DIGESTION, will serve as a base for modifying different aspectos of INDOLE PRACTICAL that they give as a result of the best before INDICATED _x000D_ _x000D_ VI. THIS APPROACH REGARDS GIT AS A COMPLEX BIOREACTOR WHOSE OPERATION NEEDS TO BE OPTIMISED. In order to do so, it is necessary to understand that suppliers are doing a greater INFLUENCE IN THE NETWORK EFICIENCE OF TRANSFORMATION PROCESSES IN THE SAME AND VALUE THE RESULT OF POSIBLE MODIFICATIONS_x000D_ _x000D_ VII. GIVEN THE COMPLEXITY OF THE PROPOSED STUDY, THIS IS ONLY POSSIBLE THROUGH MODELLING TECHNIQUES. THE WORK PLAN PROPOSES A SEQUENCE THAT STARTS WITH THE COLLECTION OF IN VIVO DATA THAT ALLOWS THE ESTABLISHMENT OF BASIC OPERATIONAL PARAMETERS FOR A GIT IN VITRO REACTOR MODEL. TRIALS WITH THE LATTER UNDER DIFFERENT CONDITIONS WILL IN TURN OFFER SYNTHESISABLE DATA IN A MATHEMATICAL PREDICTIVE MODEL (IN SILICO). FINALLY, OPERATIONAL MODIFICATIONS THAT YIELD THE BEST RESULTS WILL BE VERIFIED IN IN VIVO TESTS. The ORIGINALITY of the present project would consist of as much in the approach adopted as in the proposed mode to consecrate and integrate the information required_x000D_ _x000D_ VIII. THE OPERATIONAL ASPECTS OF THE GIT WITH AN IMPACT ON THE BIOACCESSIBILITY OF THE PROTEIN ON WHICH THE PRESENT STUDY WILL FOCUS ARE: A) VARIATIONS IN THE IONIC ENVIRONMENT (PH AND OSMOLARITY), B) RESIDENCE AND TRANSIT TIMES AND C) PROTEASE ACTIVITY IN THE DIFFERENT SECTIONS OF THE DIGESTIVE. The STUDY will be carried out in the Dorada as it SPECIES OF REFERENCE, adapting it also to another specie of interests as is the Senegalese language, which presents a system of INGESTION and DIGESTION TOTALLY DIFFERENTS_x000D_ _x000D_ IX. THE PROTOCOLS AND RESULTS GENERATED WILL MEAN A CHANGE IN THIS TYPE OF STUDIES WITH A SIGNIFICANT REDUCTION OF EXPERIMENTAL ANIMALS AND WILL BENEFIT FEED MANUFACTURERS AND PRODUCERS WITH BETTER DIET ADJUSTMENTS AND (English) | |||||||||||||||
| Property / summary: I. The present draft proposal proposes a sequentiality of the statistics of the operation of the GASTROINTESTINAL TRACT (GIT) with in-live experience, simulations in a model in VITRO, and in a pre-eminent MATEMATIC model (without SILICO) with the primary task of increasing the effectiveness of food management in the CULTIVO OF PECES_x000D_ _x000D_ II. THE PROJECT IS BASED ON TWO PREMISES; A) AN IMPORTANT PART OF PISCICOLA PRODUCTION YIELDS (AND BUSINESS PROFIT) DEPEND ON THE EFFICIENT USE OF NUTRIENTS, ESPECIALLY PROTEIN. In the Mediterranean fish species there is still an important margin of improvement that allows to approximate feed processing INDICES to those of the species of reference, as the Atlantic salmon _x000D_ _x000D_ III. Class NUTRICIONAL EVALUATIONS are based on the provision of INGREDIENT COMBINANCATIONS that are ADECUTED AND VALUE their identity in tests that are essential to my growth, QUANTITATIVE (TOTAL WEIGHT AUMENT) as a QUALITATIVE (proportion of PROTEIN IN FACK)_x000D_ _x000D_ IV. THESE STUDIES ASSUME THAT PROTEIN DIGESTIBILITY VALUES ARE RELIABLE INDICATORS OF ITS BIOAVAILABILITY FOR GROWTH. Apart from the fact that this is highly questionable, there are no plans to support the improvement of the effectiveness of this NUTRIENT’s direct use by means of a better knowledge and potential modification of the agents who are affected by their process in the GIT of PEZ_x000D_ _x000D_ V. it is PLANT that a detailed knowledge of the FACTORS who may have the greatest impact on the effectiveness of the DIGESTION, will serve as a base for modifying different aspectos of INDOLE PRACTICAL that they give as a result of the best before INDICATED _x000D_ _x000D_ VI. THIS APPROACH REGARDS GIT AS A COMPLEX BIOREACTOR WHOSE OPERATION NEEDS TO BE OPTIMISED. In order to do so, it is necessary to understand that suppliers are doing a greater INFLUENCE IN THE NETWORK EFICIENCE OF TRANSFORMATION PROCESSES IN THE SAME AND VALUE THE RESULT OF POSIBLE MODIFICATIONS_x000D_ _x000D_ VII. GIVEN THE COMPLEXITY OF THE PROPOSED STUDY, THIS IS ONLY POSSIBLE THROUGH MODELLING TECHNIQUES. THE WORK PLAN PROPOSES A SEQUENCE THAT STARTS WITH THE COLLECTION OF IN VIVO DATA THAT ALLOWS THE ESTABLISHMENT OF BASIC OPERATIONAL PARAMETERS FOR A GIT IN VITRO REACTOR MODEL. TRIALS WITH THE LATTER UNDER DIFFERENT CONDITIONS WILL IN TURN OFFER SYNTHESISABLE DATA IN A MATHEMATICAL PREDICTIVE MODEL (IN SILICO). FINALLY, OPERATIONAL MODIFICATIONS THAT YIELD THE BEST RESULTS WILL BE VERIFIED IN IN VIVO TESTS. The ORIGINALITY of the present project would consist of as much in the approach adopted as in the proposed mode to consecrate and integrate the information required_x000D_ _x000D_ VIII. THE OPERATIONAL ASPECTS OF THE GIT WITH AN IMPACT ON THE BIOACCESSIBILITY OF THE PROTEIN ON WHICH THE PRESENT STUDY WILL FOCUS ARE: A) VARIATIONS IN THE IONIC ENVIRONMENT (PH AND OSMOLARITY), B) RESIDENCE AND TRANSIT TIMES AND C) PROTEASE ACTIVITY IN THE DIFFERENT SECTIONS OF THE DIGESTIVE. The STUDY will be carried out in the Dorada as it SPECIES OF REFERENCE, adapting it also to another specie of interests as is the Senegalese language, which presents a system of INGESTION and DIGESTION TOTALLY DIFFERENTS_x000D_ _x000D_ IX. THE PROTOCOLS AND RESULTS GENERATED WILL MEAN A CHANGE IN THIS TYPE OF STUDIES WITH A SIGNIFICANT REDUCTION OF EXPERIMENTAL ANIMALS AND WILL BENEFIT FEED MANUFACTURERS AND PRODUCERS WITH BETTER DIET ADJUSTMENTS AND (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: I. The present draft proposal proposes a sequentiality of the statistics of the operation of the GASTROINTESTINAL TRACT (GIT) with in-live experience, simulations in a model in VITRO, and in a pre-eminent MATEMATIC model (without SILICO) with the primary task of increasing the effectiveness of food management in the CULTIVO OF PECES_x000D_ _x000D_ II. THE PROJECT IS BASED ON TWO PREMISES; A) AN IMPORTANT PART OF PISCICOLA PRODUCTION YIELDS (AND BUSINESS PROFIT) DEPEND ON THE EFFICIENT USE OF NUTRIENTS, ESPECIALLY PROTEIN. In the Mediterranean fish species there is still an important margin of improvement that allows to approximate feed processing INDICES to those of the species of reference, as the Atlantic salmon _x000D_ _x000D_ III. Class NUTRICIONAL EVALUATIONS are based on the provision of INGREDIENT COMBINANCATIONS that are ADECUTED AND VALUE their identity in tests that are essential to my growth, QUANTITATIVE (TOTAL WEIGHT AUMENT) as a QUALITATIVE (proportion of PROTEIN IN FACK)_x000D_ _x000D_ IV. THESE STUDIES ASSUME THAT PROTEIN DIGESTIBILITY VALUES ARE RELIABLE INDICATORS OF ITS BIOAVAILABILITY FOR GROWTH. Apart from the fact that this is highly questionable, there are no plans to support the improvement of the effectiveness of this NUTRIENT’s direct use by means of a better knowledge and potential modification of the agents who are affected by their process in the GIT of PEZ_x000D_ _x000D_ V. it is PLANT that a detailed knowledge of the FACTORS who may have the greatest impact on the effectiveness of the DIGESTION, will serve as a base for modifying different aspectos of INDOLE PRACTICAL that they give as a result of the best before INDICATED _x000D_ _x000D_ VI. THIS APPROACH REGARDS GIT AS A COMPLEX BIOREACTOR WHOSE OPERATION NEEDS TO BE OPTIMISED. In order to do so, it is necessary to understand that suppliers are doing a greater INFLUENCE IN THE NETWORK EFICIENCE OF TRANSFORMATION PROCESSES IN THE SAME AND VALUE THE RESULT OF POSIBLE MODIFICATIONS_x000D_ _x000D_ VII. GIVEN THE COMPLEXITY OF THE PROPOSED STUDY, THIS IS ONLY POSSIBLE THROUGH MODELLING TECHNIQUES. THE WORK PLAN PROPOSES A SEQUENCE THAT STARTS WITH THE COLLECTION OF IN VIVO DATA THAT ALLOWS THE ESTABLISHMENT OF BASIC OPERATIONAL PARAMETERS FOR A GIT IN VITRO REACTOR MODEL. TRIALS WITH THE LATTER UNDER DIFFERENT CONDITIONS WILL IN TURN OFFER SYNTHESISABLE DATA IN A MATHEMATICAL PREDICTIVE MODEL (IN SILICO). FINALLY, OPERATIONAL MODIFICATIONS THAT YIELD THE BEST RESULTS WILL BE VERIFIED IN IN VIVO TESTS. The ORIGINALITY of the present project would consist of as much in the approach adopted as in the proposed mode to consecrate and integrate the information required_x000D_ _x000D_ VIII. THE OPERATIONAL ASPECTS OF THE GIT WITH AN IMPACT ON THE BIOACCESSIBILITY OF THE PROTEIN ON WHICH THE PRESENT STUDY WILL FOCUS ARE: A) VARIATIONS IN THE IONIC ENVIRONMENT (PH AND OSMOLARITY), B) RESIDENCE AND TRANSIT TIMES AND C) PROTEASE ACTIVITY IN THE DIFFERENT SECTIONS OF THE DIGESTIVE. The STUDY will be carried out in the Dorada as it SPECIES OF REFERENCE, adapting it also to another specie of interests as is the Senegalese language, which presents a system of INGESTION and DIGESTION TOTALLY DIFFERENTS_x000D_ _x000D_ IX. THE PROTOCOLS AND RESULTS GENERATED WILL MEAN A CHANGE IN THIS TYPE OF STUDIES WITH A SIGNIFICANT REDUCTION OF EXPERIMENTAL ANIMALS AND WILL BENEFIT FEED MANUFACTURERS AND PRODUCERS WITH BETTER DIET ADJUSTMENTS AND (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 13:16, 12 October 2021
Project Q3141518 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3141518 in Spain |
Statements
164,560.0 Euro
0 references
205,700.0 Euro
0 references
80.0 percent
0 references
1 January 2015
0 references
30 June 2019
0 references
AGENCIA CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
0 references
36°31'43.28"N, 6°11'24.79"W
0 references
11028
0 references
I. EL PRESENTE PROYECTO PROPONE UNA SECUENCIA DE ESTUDIOS DEL FUNCIONAMIENTO DEL TRACTO GASTROINTESTINAL (GIT) CON EXPERIMENTOS IN VIVO, SIMULACIONES EN UN MODELO IN VITRO, Y EN UN MODELO MATEMATICO PREDICTIVO (IN SILICO) CON EL OBJETO PRINCIPAL DE AUMENTAR LA EFICIENCIA DE DIGESTION DEL ALIMENTO EN EL CULTIVO DE PECES_x000D_ _x000D_ II. EL PROYECTO PARTE DE DOS PREMISAS; A) UNA PARTE IMPORTANTE DE LOS RENDIMIENTOS EN PRODUCCION PISCICOLA (Y DEL BENEFICIO EMPRESARIAL) DEPENDEN DEL USO EFICIENTE DE LOS NUTRIENTES, ESPECIALMENTE DE LA PROTEINA. B) EN LAS ESPECIES PISCICOLAS MEDITERRANEAS HAY TODAVIA UN MARGEN IMPORTANTE DE MEJORA QUE PERMITAN APROXIMAR LOS INDICES DE TRANSFORMACION DEL ALIMENTO A LOS DE LAS ESPECIES DE REFERENCIA, COMO EL SALMON ATLANTICO _x000D_ _x000D_ III. LAS EVALUACIONES NUTRICIONALES CLASICAS SE BASAN EN SUMINISTRAR COMBINACIONES DE INGREDIENTES QUE SE ESTIMAN ADECUADAS Y VALORAR SU IDONEIDAD EN PRUEBAS QUE ESENCIALMENTE MIDEN CRECIMIENTO, TANTO CUANTITATIVO (AUMENTO DE PESO TOTAL) COMO CUALITATIVO (PROPORCION DE PROTEINA EN CARCASA)_x000D_ _x000D_ IV. TALES ESTUDIOS ASUMEN QUE LOS VALORES DE DIGESTIBILIDAD DE PROTEINA SON INDICADORES FIABLES DE SU BIODISPONIBILIDAD PARA CRECIMIENTO. APARTE DE QUE ESTO ES ALTAMENTE CUESTIONABLE, NO EXISTEN APENAS ESTUDIOS QUE PLANTEEN LA MEJORA DE LA EFICIENCIA DEL USO DIGESTIVO DE ESTE NUTRIENTE MEDIANTE UN MEJOR CONOCIMIENTO Y POSIBLE MODIFICACION DE LOS FACTORES QUE INFLUYEN EN SU PROCESADO EN EL GIT DEL PEZ_x000D_ _x000D_ V. SEGUN ESTO, SE PLANTEA QUE UN CONOCIMIENTO DETALLADO DE LOS FACTORES QUE MAYOR IMPACTO PUEDEN TENER EN LA EFICIENCIA DE LA DIGESTION, SERVIRAN DE BASE PARA MODIFICAR DISTINTOS ASPECTOS DE INDOLE PRACTICA QUE DEN COMO RESULTADO LA MEJORA ANTES INDICADA _x000D_ _x000D_ VI. ESTE ENFOQUE CONSIDERA EL GIT COMO UN BIORREACTOR COMPLEJO CUYO FUNCIONAMIENTO ES PRECISO OPTIMIZAR. PARA ELLO SE PRECISA ENTENDER QUE FACTORES EJERCEN UNA MAYOR INFLUENCIA EN LA EFICIENCIA NETA DE LOS PROCESOS DE TRANSFORMACION QUE OCURREN EN EL MISMO Y VALORAR EL RESULTADO DE POSIBLES MODIFICACIONES_x000D_ _x000D_ VII. DADA LA COMPLEJIDAD DEL ESTUDIO PROPUESTO, ESTO SOLO ES POSIBLE MEDIANTE TECNICAS DE MODELIZACION. EL PLAN DE TRABAJO PROPONE UNA SECUENCIA QUE SE INICIA CON LA OBTENCION DE DATOS IN VIVO QUE PERMITAN ESTABLECER PARAMETROS OPERACIONALES BASICOS PARA UN MODELO DE REACTOR IN VITRO DE GIT. LOS ENSAYOS CON ESTE ULTIMO BAJO DIFERENTES CONDICIONES OFRECERAN A SU VEZ OFRECER DATOS SINTETIZABLES EN UN MODELO MATEMATICO PREDICTIVO (IN SILICO). POR ULTIMO, LAS MODIFICACIONES OPERATIVAS QUE DEN LOS MEJORES RESULTADOS SE COMPROBARAN EN ENSAYOS IN VIVO. LA ORIGINALIDAD DEL PRESENTE PROYECTO CONSISTIRIA TANTO EN EL ENFOQUE ADOPTADO COMO EN EL MODO PROPUESTO PARA CONSEGUIR E INTEGRAR LA INFORMACION REQUERIDA_x000D_ _x000D_ VIII. LOS ASPECTOS OPERATIVOS DEL GIT CON REPERCUSION EN LA BIOACCESIBILIDAD DE LA PROTEINA EN QUE SE CENTRARA EL PRESENTE ESTUDIO SON: A) VARIACIONES EN EL AMBIENTE IONICO (PH Y OSMOLARIDAD), B) TIEMPOS DE RESIDENCIA Y TRANSITO Y C) ACTIVIDAD DE LAS PROTEASAS EN LAS DIFERENTES SECCIONES DEL DIGESTIVO. EL ESTUDIO SE REALIZARA EN LA DORADA COMO ESPECIE DE REFERENCIA, ADAPTANDOLO TAMBIEN A OTRA ESPECIE DE INTERES COMO ES EL LENGUADO SENEGALES, QUE PRESENTA UN SISTEMA DE INGESTION Y DIGESTION TOTALMENTE DIFERENTES_x000D_ _x000D_ IX. LOS PROTOCOLOS Y RESULTADOS GENERADOS SIGNIFICARAN UN CAMBIO EN ESTE TIPO DE ESTUDIOS CON UNA SIGNIFICATIVA REDUCCION DE LOS ANIMALES DE EXPERIMENTACION Y BENEFICIARAN A FABRICANTES DE PIENSOS Y PRODUCTORES CON MEJORES AJUSTES DE DIETAS Y (Spanish)
0 references
I. The present draft proposal proposes a sequentiality of the statistics of the operation of the GASTROINTESTINAL TRACT (GIT) with in-live experience, simulations in a model in VITRO, and in a pre-eminent MATEMATIC model (without SILICO) with the primary task of increasing the effectiveness of food management in the CULTIVO OF PECES_x000D_ _x000D_ II. THE PROJECT IS BASED ON TWO PREMISES; A) AN IMPORTANT PART OF PISCICOLA PRODUCTION YIELDS (AND BUSINESS PROFIT) DEPEND ON THE EFFICIENT USE OF NUTRIENTS, ESPECIALLY PROTEIN. In the Mediterranean fish species there is still an important margin of improvement that allows to approximate feed processing INDICES to those of the species of reference, as the Atlantic salmon _x000D_ _x000D_ III. Class NUTRICIONAL EVALUATIONS are based on the provision of INGREDIENT COMBINANCATIONS that are ADECUTED AND VALUE their identity in tests that are essential to my growth, QUANTITATIVE (TOTAL WEIGHT AUMENT) as a QUALITATIVE (proportion of PROTEIN IN FACK)_x000D_ _x000D_ IV. THESE STUDIES ASSUME THAT PROTEIN DIGESTIBILITY VALUES ARE RELIABLE INDICATORS OF ITS BIOAVAILABILITY FOR GROWTH. Apart from the fact that this is highly questionable, there are no plans to support the improvement of the effectiveness of this NUTRIENT’s direct use by means of a better knowledge and potential modification of the agents who are affected by their process in the GIT of PEZ_x000D_ _x000D_ V. it is PLANT that a detailed knowledge of the FACTORS who may have the greatest impact on the effectiveness of the DIGESTION, will serve as a base for modifying different aspectos of INDOLE PRACTICAL that they give as a result of the best before INDICATED _x000D_ _x000D_ VI. THIS APPROACH REGARDS GIT AS A COMPLEX BIOREACTOR WHOSE OPERATION NEEDS TO BE OPTIMISED. In order to do so, it is necessary to understand that suppliers are doing a greater INFLUENCE IN THE NETWORK EFICIENCE OF TRANSFORMATION PROCESSES IN THE SAME AND VALUE THE RESULT OF POSIBLE MODIFICATIONS_x000D_ _x000D_ VII. GIVEN THE COMPLEXITY OF THE PROPOSED STUDY, THIS IS ONLY POSSIBLE THROUGH MODELLING TECHNIQUES. THE WORK PLAN PROPOSES A SEQUENCE THAT STARTS WITH THE COLLECTION OF IN VIVO DATA THAT ALLOWS THE ESTABLISHMENT OF BASIC OPERATIONAL PARAMETERS FOR A GIT IN VITRO REACTOR MODEL. TRIALS WITH THE LATTER UNDER DIFFERENT CONDITIONS WILL IN TURN OFFER SYNTHESISABLE DATA IN A MATHEMATICAL PREDICTIVE MODEL (IN SILICO). FINALLY, OPERATIONAL MODIFICATIONS THAT YIELD THE BEST RESULTS WILL BE VERIFIED IN IN VIVO TESTS. The ORIGINALITY of the present project would consist of as much in the approach adopted as in the proposed mode to consecrate and integrate the information required_x000D_ _x000D_ VIII. THE OPERATIONAL ASPECTS OF THE GIT WITH AN IMPACT ON THE BIOACCESSIBILITY OF THE PROTEIN ON WHICH THE PRESENT STUDY WILL FOCUS ARE: A) VARIATIONS IN THE IONIC ENVIRONMENT (PH AND OSMOLARITY), B) RESIDENCE AND TRANSIT TIMES AND C) PROTEASE ACTIVITY IN THE DIFFERENT SECTIONS OF THE DIGESTIVE. The STUDY will be carried out in the Dorada as it SPECIES OF REFERENCE, adapting it also to another specie of interests as is the Senegalese language, which presents a system of INGESTION and DIGESTION TOTALLY DIFFERENTS_x000D_ _x000D_ IX. THE PROTOCOLS AND RESULTS GENERATED WILL MEAN A CHANGE IN THIS TYPE OF STUDIES WITH A SIGNIFICANT REDUCTION OF EXPERIMENTAL ANIMALS AND WILL BENEFIT FEED MANUFACTURERS AND PRODUCERS WITH BETTER DIET ADJUSTMENTS AND (English)
12 October 2021
0 references
Puerto Real
0 references
Identifiers
AGL2014-52888-R
0 references