Longitudinal Patterns of Biomarkers and Chronic Obstructive Lung Disease Evolution (Q3140627): Difference between revisions
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(Created claim: summary (P836): The identification of biomarkers with clinical applicability could help us monitor activity and optimise the management of Chronic Obstructive Pulmonary Disease (COPD). Objectives: 1) To evaluate for two years (3 measures) the temporal evolution of a panel of biomarkers of inflammation and repair in phenotypic characterisation (chronic bronchitis, emphysema and comorbidities) of COPD patients; 2) Evaluate whether the longitudinal patterns of b...) |
(Changed label, description and/or aliases in en: translated_label) |
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Longitudinal Patterns of Biomarkers and Chronic Obstructive Lung Disease Evolution | |||
Revision as of 13:13, 12 October 2021
Project Q3140627 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Longitudinal Patterns of Biomarkers and Chronic Obstructive Lung Disease Evolution |
Project Q3140627 in Spain |
Statements
76,075.0 Euro
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89,500.0 Euro
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85.0 percent
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1 January 2017
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31 March 2020
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FUNDACION CANARIA DE INVESTIGACION SANITARIA (FUNCANIS)
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28°28'10.74"N, 16°15'14.72"W
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38038
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La identificación de biomarcadores con aplicabilidad clínica, podría ayudarnos a monitorizar la actividad y a optimizar el manejo de la Enfermedad Pulmonar Obstructiva Crónica (EPOC). Objetivos: 1) Evaluar durante dos años (3 medidas) la evolución temporal de un panel de biomarcadores de inflamación y reparación en la caracterización fenotípica (bronquitis crónica, enfisema y comorbilidades) de los pacientes con EPOC; 2) Evaluar si los patrones longitudinales de los biomarcadores (PLB= basal y 2 medidas anuales) se asocian con la progresión de la EPOC. Métodos: proyecto encuadrado dentro del estudio multicentrico observacional CHAIN, sobre una cohorte de 959 pacientes (831 con EPOC y 128 fumadores sin EPOC), de los cuales 686 han sido seguidos anualmente al menos dos años y disponemos de seroteca en cada evaluación. Efectuaremos dos tipos de análisis: - Transversal: evaluaremos el PLB en 350 pacientes con EPOC y un grupo control de 75 pacientes fumadores sin EPOC. En el grupo EPOC, analizaremos las correlaciones del PLB con parámetros clínicos y función pulmonar. - Longitudinal (análisis principal): evaluaremos durante al menos cinco años, si los PLB se asocian con declinar acelerado del FEV1 (>40 ml/año), hospitalizaciones y mortalidad. Variables: 1) Clínicas y Función Pulmonar (FEV1, IC/TLC, Kco, PaO2, índice BODE, CAT, comorbilidades, exacerbaciones y mortalidad); 2) Biomarcadores en sangre: a) aplicabilidad clínica (PCR, fibrinógeno, leucocitos y eosinófilos; b) perfil investigador (IL-6, IL-8, CC-16, sRAGE, adiponectina, PARC/CCL18, SFTPD y sirtuina-1). (Spanish)
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The identification of biomarkers with clinical applicability could help us monitor activity and optimise the management of Chronic Obstructive Pulmonary Disease (COPD). Objectives: 1) To evaluate for two years (3 measures) the temporal evolution of a panel of biomarkers of inflammation and repair in phenotypic characterisation (chronic bronchitis, emphysema and comorbidities) of COPD patients; 2) Evaluate whether the longitudinal patterns of biomarkers (PLB = baseline and 2 measures per year) are associated with COPD progression. Methods: a project within the multicenter observational study CHAIN, on a cohort of 959 patients (831 with COPD and 128 smokers without COPD), of which 686 have been followed annually at least two years and we have seroteca in each evaluation. We will carry out two types of analysis: — Cross-sectional: we will evaluate BPL in 350 patients with COPD and a control group of 75 smokers without COPD. In the COPD group, we will analyse the correlations of PLB with clinical parameters and lung function. — Longitudinal (main analysis): we will evaluate for at least five years, if PLB are associated with accelerated decline of FEV1 (>40 ml/year), hospitalisations and mortality. Variables: 1) Clinics and Lung Function (FEV1, IC/TLC, Kco, PaO2, BODE index, CAT, comorbidities, exacerbations and mortality); 2) Blood biomarkers: clinical applicability (PCR, fibrinogen, leukocytes and eosinophils; research profile (IL-6, IL-8, CC-16, Srage, adiponectin, PARC/CCL18, SFTPD and sirtuina-1). (English)
12 October 2021
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Santa Cruz de Tenerife
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Identifiers
PI16_01506
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