Q3137651 (Q3137651): Difference between revisions
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(Created claim: summary (P836): The main objective of this study is to identify alterations in peripheral markers of systemic inflammation and bacterial translocation in three groups of 40 subjects each: patients with bipolar disorder and schizophrenia and healthy subjects. The project will also determine the relationship between adherence to the Mediterranean diet/life style and inflammatory markers and bacterial translocation in both patient groups. As secondary objectives w...) |
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The main objective of this study is to identify alterations in peripheral markers of systemic inflammation and bacterial translocation in three groups of 40 subjects each: patients with bipolar disorder and schizophrenia and healthy subjects. The project will also determine the relationship between adherence to the Mediterranean diet/life style and inflammatory markers and bacterial translocation in both patient groups. As secondary objectives we consider evaluating the role of abuse substances in the intestinal flora, bacterial translocation and peripheral inflammation; determine the relationship between the degree of adherence to the Mediterranean diet/life style and the overall and neurocognitive functioning of patients; compare the composition of the intestinal microbiota (percentage of bacteria composition) and the possible existence of dysbiosis in patients with bipolar disorder, patients with schizophrenia and healthy controls. For this we propose a cross-sectional observational study with case-control design in which the adherence to the Mediterranean diet/life style, intestinal dysbiosis, markers of bacterial translocation and parameters of inflammation, oxidative stress and neurotrophins will be evaluated in a single visit. During the same visit, a clinical, neurocognitive and functional evaluation of the subjects will be performed. (English) | |||||||||||||||
| Property / summary: The main objective of this study is to identify alterations in peripheral markers of systemic inflammation and bacterial translocation in three groups of 40 subjects each: patients with bipolar disorder and schizophrenia and healthy subjects. The project will also determine the relationship between adherence to the Mediterranean diet/life style and inflammatory markers and bacterial translocation in both patient groups. As secondary objectives we consider evaluating the role of abuse substances in the intestinal flora, bacterial translocation and peripheral inflammation; determine the relationship between the degree of adherence to the Mediterranean diet/life style and the overall and neurocognitive functioning of patients; compare the composition of the intestinal microbiota (percentage of bacteria composition) and the possible existence of dysbiosis in patients with bipolar disorder, patients with schizophrenia and healthy controls. For this we propose a cross-sectional observational study with case-control design in which the adherence to the Mediterranean diet/life style, intestinal dysbiosis, markers of bacterial translocation and parameters of inflammation, oxidative stress and neurotrophins will be evaluated in a single visit. During the same visit, a clinical, neurocognitive and functional evaluation of the subjects will be performed. (English) / rank | |||||||||||||||
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| Property / summary: The main objective of this study is to identify alterations in peripheral markers of systemic inflammation and bacterial translocation in three groups of 40 subjects each: patients with bipolar disorder and schizophrenia and healthy subjects. The project will also determine the relationship between adherence to the Mediterranean diet/life style and inflammatory markers and bacterial translocation in both patient groups. As secondary objectives we consider evaluating the role of abuse substances in the intestinal flora, bacterial translocation and peripheral inflammation; determine the relationship between the degree of adherence to the Mediterranean diet/life style and the overall and neurocognitive functioning of patients; compare the composition of the intestinal microbiota (percentage of bacteria composition) and the possible existence of dysbiosis in patients with bipolar disorder, patients with schizophrenia and healthy controls. For this we propose a cross-sectional observational study with case-control design in which the adherence to the Mediterranean diet/life style, intestinal dysbiosis, markers of bacterial translocation and parameters of inflammation, oxidative stress and neurotrophins will be evaluated in a single visit. During the same visit, a clinical, neurocognitive and functional evaluation of the subjects will be performed. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 12:35, 12 October 2021
Project Q3137651 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3137651 in Spain |
Statements
30,500.0 Euro
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61,000.0 Euro
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50.0 percent
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1 January 2017
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31 March 2021
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FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS
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42°50'47.44"N, 2°40'20.64"W
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01059
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El objetivo principal del presente estudio es identificar alteraciones en marcadores periféricos de inflamación sistémica y traslocación bacteriana en tres grupos de 40 sujetos cada uno: pacientes con trastorno bipolar y esquizofrenia y sujetos sanos. Asímismo el proyecto determinará la relación entre la adherencia a la dieta/ estilo de vida mediterráneo y los marcadores inflamatorios y de traslocación bacteriana en ambos grupos de pacientes. Como objetivos secundarios nos planteamos evaluar el papel del consumo de sustancias de abuso en la flora intestinal, en la traslocación bacteriana y en la inflamación periférica; determinar la relación entre el grado de adherencia a la dieta/ estilo de vida mediterráneo y el funcionamiento global y neurocognitivo de los pacientes; comparar la composición de la microbiota intestinal (porcentaje de composición de bacterias) y la posible existencia de disbiosis en pacientes con trastorno bipolar, pacientes con esquizofrenia y controles sanos. Para ello planteamos un estudio observacional transversal con diseño caso-control en el que se evaluará en una sola visita la adherencia a la dieta/estilo de vida mediterráneo, disbiosis intestinal, marcadores de traslocación bacteriana y parámetros de inflamación, estrés oxidativo y neurotrofinas. En la misma visita se realizará una evaluación clínica, neurocognitiva y funcional de los sujetos. (Spanish)
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The main objective of this study is to identify alterations in peripheral markers of systemic inflammation and bacterial translocation in three groups of 40 subjects each: patients with bipolar disorder and schizophrenia and healthy subjects. The project will also determine the relationship between adherence to the Mediterranean diet/life style and inflammatory markers and bacterial translocation in both patient groups. As secondary objectives we consider evaluating the role of abuse substances in the intestinal flora, bacterial translocation and peripheral inflammation; determine the relationship between the degree of adherence to the Mediterranean diet/life style and the overall and neurocognitive functioning of patients; compare the composition of the intestinal microbiota (percentage of bacteria composition) and the possible existence of dysbiosis in patients with bipolar disorder, patients with schizophrenia and healthy controls. For this we propose a cross-sectional observational study with case-control design in which the adherence to the Mediterranean diet/life style, intestinal dysbiosis, markers of bacterial translocation and parameters of inflammation, oxidative stress and neurotrophins will be evaluated in a single visit. During the same visit, a clinical, neurocognitive and functional evaluation of the subjects will be performed. (English)
12 October 2021
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Vitoria-Gasteiz
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Identifiers
PI16_01164
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