IMPROVING SELECTIVITY IN TERANOSTICA AND CHEMICAL PROCESSES: NEW MOLECULAR SYSTEMS FOR IMAGING, PHARMACO RELEASE AND CATALYSIS (Q3137482): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): THIS PROJECT PROPOSES THE DEVELOPMENT OF NEW MOLECULAR SYSTEMS WITH POTENTIAL APPLICATION IN IMAGE FOR DIAGNOSIS AND THERAPY AND FOR THE DIRECTED RELEASE OF PHARMACOS. FOR THIS PURPOSE NEW HYBRID PEPTIDES THAT WILL BE STUDIED AS PENETRATING AGENTS IN CELLS (APC) AND PROTOZOA (LEISHMANIA) WILL BE SYNTHESISED. BASED ON THE USE OF CHEMICAL PLATFORMS, NEW LIGANDS THAT CAN COMPLEX GD(III) WILL BE PREPARED AND THEIR PROPERTIES AS CONTRAST AGENTS (AC)...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
IMPROVING SELECTIVITY IN TERANOSTICA AND CHEMICAL PROCESSES: NEW MOLECULAR SYSTEMS FOR IMAGING, PHARMACO RELEASE AND CATALYSIS | |||
Revision as of 12:34, 12 October 2021
Project Q3137482 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | IMPROVING SELECTIVITY IN TERANOSTICA AND CHEMICAL PROCESSES: NEW MOLECULAR SYSTEMS FOR IMAGING, PHARMACO RELEASE AND CATALYSIS |
Project Q3137482 in Spain |
Statements
52,635.0 Euro
0 references
105,270.0 Euro
0 references
50.0 percent
0 references
30 December 2016
0 references
31 December 2020
0 references
UNIVERSIDAD AUTONOMA DE BARCELONA
0 references
42°13'24.28"N, 1°53'31.70"E
0 references
08903
0 references
EN ESTE PROYECTO SE PROPONE EL DESARROLLO DE NUEVOS SISTEMAS MOLECULARES CON POTENCIAL APLICACION EN IMAGEN PARA DIAGNOSIS Y TERAPIA Y PARA LA LA LIBERACION DIRIGIDA DE FARMACOS. PARA ELLO SE SINTETIZARAN NUEVOS PEPTIDOS HIBRIDOS QUE SERAN ESTUDIADOS COMO AGENTES DE PENETRACION EN CELULAS (APC) Y EN PROTOZOOS (LEISHMANIA). EN BASE AL USO PLATAFORMAS QUIMICAS QUIRALES, SE PREPARARAN NUEVOS LIGANDOS QUE PUEDAN COMPLEJAR GD(III) Y SE ESTUDIARAN SUS PROPIEDADES COMO AGENTES DE CONTRASTE (AC) EN RESONANCIA MAGNETICA DE IMAGEN (RMI). LA COMBINACION DE LOS AC CON LOS APC SERVIRA PARA ESTABLECER MODELOS CON POSIBLE APLICACION EN LIBERACION DE FARMACOS GUIADA POR IMAGEN, QUE ES UN INSTRUMENTO DE GRAN UTILIDAD EN TERANOSTICA. ESTA DISCIPLINA SE ENTIENDE COMO EL CAMPO DE LA NANO Y BIOMEDICINA QUE COMBINA DIAGNOSIS Y TERAPIA PERSONALIZADA E IMPLICA, POR TANTO, UNA GRAN SELECTIVIDAD EN PRODUCTOS Y PROCESOS. TAMBIEN SE SINTETIZARAN NUEVOS SURFACTANTES CON EL OBJETIVO FINAL DE PODER SER UTILIZADOS COMO VECTORES NO VIRICOS PARA LA TRANSFECCION CELULAR DE ADN EN TERAPIA GENICA. TODOS ESTOS CAMPOS ENCAJAN EN LA ACCION ESTRATEGICA EN SALUD (RETO EN SALUD, CAMBIO DEMOGRAFICO Y BIENESTAR) CON ESPECIAL ENFASIS EN LAS TECNOLOGIAS DE IMAGEN MEDICA Y EN EL DESARROLLO DE NUEVAS MOLECULAS COMO ARMAS TERAPEUTICAS, ASI COMO MATERIALES AVANZADOS. LOS RESULTADOS ESPERABLES DE ESTAS INVESTIGACIONES TENDRAN REPERCUSION EN LA INDUSTRIA FARMACEUTICA Y TECNOLOGIAS SANITARIAS, LO QUE JUSTIFICA LA INCLUSION DE ESTEVE S.A. COMO EPO DEL PROYECTO. ASIMISMO, SE PROFUNDIZARA EN EL ESTUDIO TEORICO DEL PAPEL DE LOS RIBOZIMAS COMO CATALIZADORES BIOLOGICOS. EN ESPECIAL, SE ESTUDIARA EL RIBOZIMA VHD QUE FUE INICIALMENTE DESCUBIERTO EN EL AGENTE DELTA O VIRUS DE LA HEPATITIS D (VHD), PERO QUE SE ENCUENTRA EN TODOS LOS DOMINIOS DE LA VIDA, INCLUYENDO EL GENOMA HUMANO. POR TANTO, LA COMPRENSION DEL MODO DE ACCION DE ESTAS MOLECULAS TIENE IMPLICACIONES PARA LA SALUD HUMANA Y TAMBIEN PARA EL DISEÑO DE SISTEMAS BIOINSPIRADOS DE UTILIDAD EN CATALISIS QUIMICA. POR ULTIMO, PERO NO MENOS IMPORTANTE, SE ESTUDIARAN ESPECIES CON GRAN REACTIVIDAD CONSIDERANDO SU ESTRUCTURA, PROPIEDADES Y APLICACIONES. EN CONCRETO, SE INVESTIGARAN CARBENOS ESTABLES Y SILILENOS COMO LIGANDOS EN COMPLEJOS CON METALES DE TRANSICION, BISILUROS COMO FUENTE DE CARBONO ELEMENTAL Y SILILENOS COMO INTERMEDIOS CLAVE EN CATALISIS NO METALICA. ESTAS TEMATICAS ESTAN PLENAMENTE ALINEADAS CON LA PRIORIDAD EFICIENCIA EN LA UTILIZACION DE RECURSOS Y MATERIAS PRIMAS EN LO QUE SE REFIERE AL DESARROLLO DE NUEVOS PRODUCTOS, TECNOLOGIAS Y PROCESOS QUIMICOS Y BIOLOGICOS, Y DISEÑO DE NUEVOS CATALIZADORES Y BIOCATALIZADORES (RETO EN ACCION SOBRE CAMBIO CLIMATICO Y EFICIENCIA EN LA UTILIZACION DE RECURSOS Y MATERIAS PRIMAS). (Spanish)
0 references
THIS PROJECT PROPOSES THE DEVELOPMENT OF NEW MOLECULAR SYSTEMS WITH POTENTIAL APPLICATION IN IMAGE FOR DIAGNOSIS AND THERAPY AND FOR THE DIRECTED RELEASE OF PHARMACOS. FOR THIS PURPOSE NEW HYBRID PEPTIDES THAT WILL BE STUDIED AS PENETRATING AGENTS IN CELLS (APC) AND PROTOZOA (LEISHMANIA) WILL BE SYNTHESISED. BASED ON THE USE OF CHEMICAL PLATFORMS, NEW LIGANDS THAT CAN COMPLEX GD(III) WILL BE PREPARED AND THEIR PROPERTIES AS CONTRAST AGENTS (AC) IN MAGNETIC IMAGING RESONANCE (RMI) WILL BE STUDIED. THE COMBINATION OF ACS WITH APCS WILL SERVE TO ESTABLISH MODELS WITH POSSIBLE APPLICATION IN PHARMACO RELEASE GUIDED BY IMAGE, WHICH IS A VERY USEFUL INSTRUMENT IN TERANOSTICA. THIS DISCIPLINE IS UNDERSTOOD AS THE FIELD OF NANO AND BIOMEDICINE THAT COMBINES DIAGNOSIS AND PERSONALISED THERAPY AND THEREFORE IMPLIES A GREAT SELECTIVITY IN PRODUCTS AND PROCESSES. NEW SURFACTANTS WILL ALSO BE SYNTHESISED WITH THE ULTIMATE GOAL OF BEING USED AS NON-VIONIC VECTORS FOR CELLULAR DNA TRANSFECCION IN GENIC THERAPY. ALL THESE FIELDS FIT INTO THE STRATEGIC ACTION IN HEALTH (CHALLENGE IN HEALTH, DEMOGRAPHIC CHANGE AND WELL-BEING) WITH SPECIAL EMPHASIS ON MEDICAL IMAGING TECHNOLOGIES AND IN THE DEVELOPMENT OF NEW MOLECULES AS THERAPEUTIC WEAPONS, AS WELL AS ADVANCED MATERIALS. THE EXPECTED RESULTS OF THESE INVESTIGATIONS WILL HAVE AN IMPACT ON THE PHARMACEUTICAL INDUSTRY AND HEALTH TECHNOLOGIES, WHICH JUSTIFIES THE INCLUSION OF ESTEVE S.A. AS THE EPO OF THE PROJECT. IT WILL ALSO DEEPEN THE THEORETICAL STUDY OF THE ROLE OF RIBOZYMES AS BIOLOGICAL CATALYSTS. IN PARTICULAR, RIBOZYME VHD WAS INITIALLY DISCOVERED IN DELTA AGENT OR HEPATITIS D VIRUS (HDV), BUT FOUND IN ALL DOMAINS OF LIFE, INCLUDING THE HUMAN GENOME. THEREFORE, THE UNDERSTANDING OF THE MODE OF ACTION OF THESE MOLECULES HAS IMPLICATIONS FOR HUMAN HEALTH AND ALSO FOR THE DESIGN OF USEFUL BIOINSPIRED SYSTEMS IN CHEMICAL CATALYSIS. FINALLY, BUT NOT LEAST, SPECIES WITH HIGH REACTIVITY WILL BE STUDIED CONSIDERING THEIR STRUCTURE, PROPERTIES AND APPLICATIONS. IN PARTICULAR, STABLE CARBENNES AND SILILENOS WERE INVESTIGATED AS LIGANDS IN COMPLEXES WITH TRANSITION METALS, BISILURS AS A SOURCE OF ELEMENTAL CARBON AND SILILENOS AS KEY INTERMEDIATES IN NON-METALLIC CATALYSIS. THESE THEMES ARE FULLY ALIGNED WITH THE PRIORITY EFFICIENCY IN THE USE OF RESOURCES AND RAW MATERIALS IN TERMS OF THE DEVELOPMENT OF NEW PRODUCTS, TECHNOLOGIES AND CHEMICAL AND BIOLOGICAL PROCESSES, AND THE DESIGN OF NEW CATALYSTS AND BIOCATALYSTS (CHALLENGE IN ACTION ON CLIMATIC CHANGE AND EFFICIENCY IN THE USE OF RESOURCES AND RAW MATERIALS). (English)
12 October 2021
0 references
Sant Julià de Cerdanyola
0 references
Identifiers
CTQ2016-77978-R
0 references