Innovative chemical sets necessary for accurate detection and determination of individual substances in humans using HPLC and LCMS (Q107904): Difference between revisions
Jump to navigation
Jump to search
(Removed claim: summary (P836): The project carried out by ALAB Laboratoria sp. z o.o. in collaboration between the Medical University in Lublin is to carry out research to develop a new high resolution methodology and test kits for precise detection and determination of individual substances in the human body using HPLC and LCMS. The work will result in the completion of the completed HPLC/LCMS kits (test assembly, manual, certificate) dedicated to cytostatic, cardiological...) |
(Created claim: summary (P836): The subject of the project carried out by ALAB Laboratoria sp. z o.o. in cooperation with the Medical University of Lublin is to carry out research works aimed at developing a new high-resolution methodology and chemical sets necessary for precise detection and determination of individual substances in the human body using HPLC and LCMS technology. The result of the work will be ready sets for HPLC and LCMS (reagent kit for analysis, instruction...) |
||||||||||||||
| Property / summary | |||||||||||||||
The subject of the project carried out by ALAB Laboratoria sp. z o.o. in cooperation with the Medical University of Lublin is to carry out research works aimed at developing a new high-resolution methodology and chemical sets necessary for precise detection and determination of individual substances in the human body using HPLC and LCMS technology. The result of the work will be ready sets for HPLC and LCMS (reagent kit for analysis, instruction, certificate) dedicated to the diagnosis of cytostatic, cardiological, antiepileptic drugs and the detection of psychoactive substances (including boosters and drugs). The results of the work will be directly used in the area of clinical toxicology for monitoring drug levels in the blood and drug screenings (including psychoactive substances), Today’s methods of identifying drug poisoning, including psychoactive substances, are mainly based on immunoenzymatic methods such as EMIT, FPIA, kims, CEDIA, immunochromatography (so-called fast cassette or strip tests). The literature emphasises their advantages, which undoubtedly belong to: low cost, short waiting time for the result, no need to purchase expensive apparatus, simplicity of execution, simple visual evaluation of the result, but much less attention is paid to the disadvantages of these methods, including: significantly reduced sensitivity to reference methods, lack of 100 % specificity, which is a frequent cause of falsified results, and the fact that these tests are always targeted at detecting groups of compounds rather than individual substances. In the case of other methods, they are often complicated to interpret, often inconclusive, and the reagents used in these methods usually show a high toxicity (e.g. sodium azide) to the environment, much higher than the substances that will be included in our chromat sets. (English) | |||||||||||||||
| Property / summary: The subject of the project carried out by ALAB Laboratoria sp. z o.o. in cooperation with the Medical University of Lublin is to carry out research works aimed at developing a new high-resolution methodology and chemical sets necessary for precise detection and determination of individual substances in the human body using HPLC and LCMS technology. The result of the work will be ready sets for HPLC and LCMS (reagent kit for analysis, instruction, certificate) dedicated to the diagnosis of cytostatic, cardiological, antiepileptic drugs and the detection of psychoactive substances (including boosters and drugs). The results of the work will be directly used in the area of clinical toxicology for monitoring drug levels in the blood and drug screenings (including psychoactive substances), Today’s methods of identifying drug poisoning, including psychoactive substances, are mainly based on immunoenzymatic methods such as EMIT, FPIA, kims, CEDIA, immunochromatography (so-called fast cassette or strip tests). The literature emphasises their advantages, which undoubtedly belong to: low cost, short waiting time for the result, no need to purchase expensive apparatus, simplicity of execution, simple visual evaluation of the result, but much less attention is paid to the disadvantages of these methods, including: significantly reduced sensitivity to reference methods, lack of 100 % specificity, which is a frequent cause of falsified results, and the fact that these tests are always targeted at detecting groups of compounds rather than individual substances. In the case of other methods, they are often complicated to interpret, often inconclusive, and the reagents used in these methods usually show a high toxicity (e.g. sodium azide) to the environment, much higher than the substances that will be included in our chromat sets. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: The subject of the project carried out by ALAB Laboratoria sp. z o.o. in cooperation with the Medical University of Lublin is to carry out research works aimed at developing a new high-resolution methodology and chemical sets necessary for precise detection and determination of individual substances in the human body using HPLC and LCMS technology. The result of the work will be ready sets for HPLC and LCMS (reagent kit for analysis, instruction, certificate) dedicated to the diagnosis of cytostatic, cardiological, antiepileptic drugs and the detection of psychoactive substances (including boosters and drugs). The results of the work will be directly used in the area of clinical toxicology for monitoring drug levels in the blood and drug screenings (including psychoactive substances), Today’s methods of identifying drug poisoning, including psychoactive substances, are mainly based on immunoenzymatic methods such as EMIT, FPIA, kims, CEDIA, immunochromatography (so-called fast cassette or strip tests). The literature emphasises their advantages, which undoubtedly belong to: low cost, short waiting time for the result, no need to purchase expensive apparatus, simplicity of execution, simple visual evaluation of the result, but much less attention is paid to the disadvantages of these methods, including: significantly reduced sensitivity to reference methods, lack of 100 % specificity, which is a frequent cause of falsified results, and the fact that these tests are always targeted at detecting groups of compounds rather than individual substances. In the case of other methods, they are often complicated to interpret, often inconclusive, and the reagents used in these methods usually show a high toxicity (e.g. sodium azide) to the environment, much higher than the substances that will be included in our chromat sets. (English) / qualifier | |||||||||||||||
point in time: 17 October 2020
| |||||||||||||||
Revision as of 17:15, 17 October 2020
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Innovative chemical sets necessary for accurate detection and determination of individual substances in humans using HPLC and LCMS |
Project in Poland financed by DG Regio |
Statements
2,440,420.0 zloty
0 references
4,979,000.0 zloty
0 references
49.01 percent
0 references
1 August 2016
0 references
31 December 2018
0 references
ALAB LABORATORIA SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ
0 references
52°14'1.3"N, 21°4'17.0"E
0 references
Przedmiotem projektu realizowanego przez firmę ALAB Laboratoria sp. z o.o. we współpracy Uniwersytet Medyczny w Lublinie jest przeprowadzenie prac badawczych, mających na celu opracowanie nowej metodyki wysokorozdzielczej oraz zestawów chemicznych niezbędnych do precyzyjnej detekcji oraz oznaczania poszczególnych substancji w organizmie człowieka z wykorzystaniem technologii HPLC i LCMS. Wynikiem prowadzonych prac będą gotowe zestawy do HPLC i LCMS (zestaw odczynnikowy do analizy, instrukcja, certyfikat) dedykowane diagnostyce leków cytostatycznych, kardiologicznych, przeciwpadaczkowych oraz wykrywaniu substancji psychoaktywnych (w tym dopalaczy oraz narkotyków). Rezultaty prac zostaną bezpośrednio wykorzystane w obszarze toksykologii klinicznej w zakresie monitorowania stężenie leku we krwi oraz skryningów leków (w tym substancji psychoaktywnych), Dzisiejsze sposoby identyfikacji zatruć lekami, w tym substancjami psychoaktywnymi, w głównej mierze opierają się na metodach immunoenzymatycznych, takich jak EMIT, FPIA, KIMS, CEDIA, immunochromatografia (tzw. szybkie testy kasetowe lub paskowe). W literaturze podkreśla się ich zalety do których bez wątpienia należą: niski koszt, krótki czas oczekiwania na wynik, brak konieczności zakupu kosztownej aparatury, prostota wykonania, prosta ocena wizualna wyniku, jednak zdecydowanie mniej uwagi zwraca się na wady wspomnianych metod, do których należą: znacznie ograniczona czułość w odniesieniu do metod referencyjnych, brak 100% specyficzności, będących częstą przyczyną uzyskania zafałszowanych wyników oraz fakt, iż testy te zawsze ukierunkowane są na wykrywanie grup związków, a nie poszczególnych substancji. W przypadku pozostałych metod są one często skomplikowane ich interpretacja nierzadko bywa niejednoznaczna, a odczynniki wykorzystywane w tych metodach zazwyczaj wykazują wysoką toksyczność (np. azydek sodu) dla środowiska, zdecydowanie wyższą niż substancje, które wchodzić będą w skład naszych zestawów chromat. (Polish)
0 references
The subject of the project carried out by ALAB Laboratoria sp. z o.o. in cooperation with the Medical University of Lublin is to carry out research works aimed at developing a new high-resolution methodology and chemical sets necessary for precise detection and determination of individual substances in the human body using HPLC and LCMS technology. The result of the work will be ready sets for HPLC and LCMS (reagent kit for analysis, instruction, certificate) dedicated to the diagnosis of cytostatic, cardiological, antiepileptic drugs and the detection of psychoactive substances (including boosters and drugs). The results of the work will be directly used in the area of clinical toxicology for monitoring drug levels in the blood and drug screenings (including psychoactive substances), Today’s methods of identifying drug poisoning, including psychoactive substances, are mainly based on immunoenzymatic methods such as EMIT, FPIA, kims, CEDIA, immunochromatography (so-called fast cassette or strip tests). The literature emphasises their advantages, which undoubtedly belong to: low cost, short waiting time for the result, no need to purchase expensive apparatus, simplicity of execution, simple visual evaluation of the result, but much less attention is paid to the disadvantages of these methods, including: significantly reduced sensitivity to reference methods, lack of 100 % specificity, which is a frequent cause of falsified results, and the fact that these tests are always targeted at detecting groups of compounds rather than individual substances. In the case of other methods, they are often complicated to interpret, often inconclusive, and the reagents used in these methods usually show a high toxicity (e.g. sodium azide) to the environment, much higher than the substances that will be included in our chromat sets. (English)
17 October 2020
0 references
Identifiers
RPMA.01.02.00-14-5692/16
0 references