EPIGENETIC THERAPY FOR THE TREATMENT OF CORONAVIRUS INFECTIONS (Q4201949): Difference between revisions
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(Changed label, description and/or aliases in en: Setting new description) |
(Changed label, description and/or aliases in en, and other parts: Adding English translations) |
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EPIGENETIC THERAPY FOR THE TREATMENT OF CORONAVIRUS INFECTIONS | |||||||||||||||
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BACKGROUND. SARS-COV-2 HAS A SINGLE FILAMENT RNA GENOME. AFTER ENTERING THE TARGET CELL, THE VIRUS BEGINS THE PHASES OF REPLICATION OF ITS GENOME AND SYNTHESIS OF THE NECESSARY PROTEINS. THE EPITHELIAL CELLS OF THE AIRWAY AND THE CELLS OF THE INNATE IMMUNITY (MACROPHAGES) ARE THE MAIN TARGETS OF THE VIRUS. DURING THE REPLICATION OF THE SARS-COV-2 VIRUS, DOUBLE-STRANDED RNA (DSRNA) IS GENERATED, LEADING TO THE ACTIVATION OF VARIOUS DSRNA-SENSING MECHANISMS. THE RESPONSE GENERATED INDUCES THE SYNTHESIS OF INTERFERONS, CHEMOKINES, CYTOKINES AND ON-SITE MIGRATION OF IMMUNE SYSTEM CELLS THAT AMPLIFY AND REFINE THE INITIAL RESPONSE. CORONAVIRUSES EXPRESS PROTEINS THAT ARE ABLE TO INACTIVATE DSRNA-SENSING MECHANISMS, TRIGGERING THE OVERALL DEREGULATION OF THE RESPONSE TO VIRAL INFECTION LEADING TO FURTHER DAMAGE RESULTING FROM EXCESSIVE TISSUE INFLAMMATION AND INEFFECTIVE RESPONSE OF SOME POPS (English) | |||||||||||||||
| Property / summary: BACKGROUND. SARS-COV-2 HAS A SINGLE FILAMENT RNA GENOME. AFTER ENTERING THE TARGET CELL, THE VIRUS BEGINS THE PHASES OF REPLICATION OF ITS GENOME AND SYNTHESIS OF THE NECESSARY PROTEINS. THE EPITHELIAL CELLS OF THE AIRWAY AND THE CELLS OF THE INNATE IMMUNITY (MACROPHAGES) ARE THE MAIN TARGETS OF THE VIRUS. DURING THE REPLICATION OF THE SARS-COV-2 VIRUS, DOUBLE-STRANDED RNA (DSRNA) IS GENERATED, LEADING TO THE ACTIVATION OF VARIOUS DSRNA-SENSING MECHANISMS. THE RESPONSE GENERATED INDUCES THE SYNTHESIS OF INTERFERONS, CHEMOKINES, CYTOKINES AND ON-SITE MIGRATION OF IMMUNE SYSTEM CELLS THAT AMPLIFY AND REFINE THE INITIAL RESPONSE. CORONAVIRUSES EXPRESS PROTEINS THAT ARE ABLE TO INACTIVATE DSRNA-SENSING MECHANISMS, TRIGGERING THE OVERALL DEREGULATION OF THE RESPONSE TO VIRAL INFECTION LEADING TO FURTHER DAMAGE RESULTING FROM EXCESSIVE TISSUE INFLAMMATION AND INEFFECTIVE RESPONSE OF SOME POPS (English) / rank | |||||||||||||||
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| Property / summary: BACKGROUND. SARS-COV-2 HAS A SINGLE FILAMENT RNA GENOME. AFTER ENTERING THE TARGET CELL, THE VIRUS BEGINS THE PHASES OF REPLICATION OF ITS GENOME AND SYNTHESIS OF THE NECESSARY PROTEINS. THE EPITHELIAL CELLS OF THE AIRWAY AND THE CELLS OF THE INNATE IMMUNITY (MACROPHAGES) ARE THE MAIN TARGETS OF THE VIRUS. DURING THE REPLICATION OF THE SARS-COV-2 VIRUS, DOUBLE-STRANDED RNA (DSRNA) IS GENERATED, LEADING TO THE ACTIVATION OF VARIOUS DSRNA-SENSING MECHANISMS. THE RESPONSE GENERATED INDUCES THE SYNTHESIS OF INTERFERONS, CHEMOKINES, CYTOKINES AND ON-SITE MIGRATION OF IMMUNE SYSTEM CELLS THAT AMPLIFY AND REFINE THE INITIAL RESPONSE. CORONAVIRUSES EXPRESS PROTEINS THAT ARE ABLE TO INACTIVATE DSRNA-SENSING MECHANISMS, TRIGGERING THE OVERALL DEREGULATION OF THE RESPONSE TO VIRAL INFECTION LEADING TO FURTHER DAMAGE RESULTING FROM EXCESSIVE TISSUE INFLAMMATION AND INEFFECTIVE RESPONSE OF SOME POPS (English) / qualifier | |||||||||||||||
point in time: 1 February 2022
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Revision as of 06:31, 1 February 2022
Project Q4201949 in Italy
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | EPIGENETIC THERAPY FOR THE TREATMENT OF CORONAVIRUS INFECTIONS |
Project Q4201949 in Italy |
Statements
210,299.02 Euro
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420,598.04 Euro
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50.0 percent
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ISTITUTO EUROPEO DI ONCOLOGIA SRL
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ITALFARMACO S.P.A.
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ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL'EMILIA ROMAGNA "BRUNO UBERTINI"
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ISTITUTO SUPERIORE DI SANITÃ
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BACKGROUND. IL VIRUS SARS-COV-2 POSSIEDE UN GENOMA A RNA A SINGOLO FILAMENTO. DOPO LÂ INGRESSO NELLA CELLULA BERSAGLIO, IL VIRUS INIZIA LE FASI DI REPLICAZIONE DEL SUO GENOMA E DI SINTESI DELLE PROTEINE NECESSARIE. LE CELLULE EPITELIALI DELLE VIE AEREE E LE CELLULE DELLA IMMUNITÃ INNATA (MACROFAGI) SONO I PRINCIPALI BERSAGLI DEL VIRUS. DURANTE LA REPLICAZIONE DEL VIRUS SARS-COV-2, VIENE GENERATO RNA A DOPPIA ELICA (DOUBLE-STRANDED RNA, DSRNA) CHE PORTA ALLÂ ATTIVAZIONE DI VARI MECCANISMI DI DSRNA-SENSING. LA RISPOSTA GENERATA INDUCE LA SINTESI DI INTERFERONI, CHEMOCHINE, CITOCHINE E LA MIGRAZIONE IN LOCO DI CELLULE DEL SISTEMA IMMUNITARIO CHE AMPLIFICANO E PERFEZIONANO LA RISPOSTA INIZIALE. I CORONAVIRUS ESPRIMONO PROTEINE CHE SONO IN GRADO DI INATTIVARE I MECCANISMI DI DSRNA-SENSING, INNESCANDO LA DEREGOLAZIONE COMPLESSIVA DELLA RISPOSTA ALLÂ INFEZIONE VIRALE CHE PORTA AD UN ULTERIORE DANNO CHE DERIVA DALLÂ ECCESSIVA INFIAMMAZIONE DEI TESSUTI E DALLA INEFFICACE RISPOSTA DI ALCUNE POP (Italian)
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BACKGROUND. SARS-COV-2 HAS A SINGLE FILAMENT RNA GENOME. AFTER ENTERING THE TARGET CELL, THE VIRUS BEGINS THE PHASES OF REPLICATION OF ITS GENOME AND SYNTHESIS OF THE NECESSARY PROTEINS. THE EPITHELIAL CELLS OF THE AIRWAY AND THE CELLS OF THE INNATE IMMUNITY (MACROPHAGES) ARE THE MAIN TARGETS OF THE VIRUS. DURING THE REPLICATION OF THE SARS-COV-2 VIRUS, DOUBLE-STRANDED RNA (DSRNA) IS GENERATED, LEADING TO THE ACTIVATION OF VARIOUS DSRNA-SENSING MECHANISMS. THE RESPONSE GENERATED INDUCES THE SYNTHESIS OF INTERFERONS, CHEMOKINES, CYTOKINES AND ON-SITE MIGRATION OF IMMUNE SYSTEM CELLS THAT AMPLIFY AND REFINE THE INITIAL RESPONSE. CORONAVIRUSES EXPRESS PROTEINS THAT ARE ABLE TO INACTIVATE DSRNA-SENSING MECHANISMS, TRIGGERING THE OVERALL DEREGULATION OF THE RESPONSE TO VIRAL INFECTION LEADING TO FURTHER DAMAGE RESULTING FROM EXCESSIVE TISSUE INFLAMMATION AND INEFFECTIVE RESPONSE OF SOME POPS (English)
1 February 2022
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CINISELLO BALSAMO
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MILANO
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BRESCIA
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