ASSEMBLING OF SUPRAMOLECULAR SYSTEMS AND THEIR INFLUENCE ON CHEMICAL REACTIVITY (Q3187722): Difference between revisions
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(Created claim: summary (P836): THE PROJECT THAT IS REQUESTED PRESENTS A MARKED INTERDISCIPLINARY CHARACTER BECAUSE ITS DEVELOPMENT INVOLVES THEMATIC AREAS AS DIVERSE AS SUPRAMOLECULAR CHEMISTRY, COLLOIDAL CHEMISTRY, ORGANOMETALICA CHEMISTRY AND CHEMICAL KINETICS. THE LAST OBJECTIVE OF THE PROJECT IS THE ACQUISITION AND CHARACTERISATION OF NEW MEANS OF REACTION WITH A DOUBLE DIMENSION: AQUEOUS SYSTEMS AND ANHYDROUS MEDIA. THE NEW AQUEOUS SYSTEMS WILL BE FORMED FROM THE AUTOAGR...) |
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ASSEMBLING OF SUPRAMOLECULAR SYSTEMS AND THEIR INFLUENCE ON CHEMICAL REACTIVITY | |||
Revision as of 20:48, 12 October 2021
Project Q3187722 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | ASSEMBLING OF SUPRAMOLECULAR SYSTEMS AND THEIR INFLUENCE ON CHEMICAL REACTIVITY |
Project Q3187722 in Spain |
Statements
104,544.0 Euro
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130,680.0 Euro
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80.0 percent
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1 January 2015
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30 September 2018
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UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
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42°52'49.51"N, 8°32'45.10"W
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15078
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EL PROYECTO QUE SE SOLICITA PRESENTA UN MARCADO CARACTER INTERDISCIPLINAR PUES SU DESARROLLO IMPLICA AREAS TEMATICAS TAN DIVERSAS COMO LA QUIMICA SUPRAMOLECULAR, QUIMICA COLOIDAL, QUIMICA ORGANOMETALICA Y CINETICA QUIMICA. EL OBJETIVO ULTIMO DEL PROYECTO ES LA OBTENCION Y CARACTERIZACION DE NUEVOS MEDIOS DE REACCION CON UNA DOBLE VERTIENTE: SISTEMAS ACUOSOS Y MEDIOS ANHIDROS. LOS NUEVOS SISTEMAS ACUOSOS SE FORMARAN A PARTIR DE LA AUTOAGREGACION DE ESPECIES SUPRAMOLECULARES CON DIFERENTES NIVELES DE ORGANIZACION: (I) NANOTUBOS; (II) NANOCAPSULAS; (III) MICELAS Y (IV) VESICULAS. LOS NANOTUBOS SE FORMARAN A PARTIR DEL ENSAMBLAJE COVALENTE ENTRE DOS/TRES PILLAR[5]ARENOS Y SU POSTERIOR FUNCIONALIZACION DE MODO QUE SE CONSIGAN ESTRUCTURAS CATIONICAS O ZWITTERIONICAS. LAS NANOCAPSULAS SE FORMARAN A PARTIR DE LA AGREGACION SUPRAMOLECULAR DE DOS O TRES RECEPTORES MACROCICLICOS, GENERALMENTE COMBINACIONES DE CALIXARENOS ANIONICOS Y CATIONICOS CON DERIVADOS ANIONICOS DE CICLODEXTRINAS Y PILLARARENOS CATIONICOS. AMBOS TIPOS DE SISTEMAS, NANOTUBOS Y NANOCAPSULAS, SERAN INVESTIGADOS PARA SU POTENCIAL USO COMO AGENTES ENCAPSULANTES Y TRANSPORTADORES DE IONES. EL OBJETIVO A ALCANZAR ES ENCONTRAR EFECTOS SINERGICOS Y COMPLEMENTARIOS SOBRE LOS PROCESOS DE RECONOCIMIENTO MOLECULAR. EL ESTABLECIMIENTO DE NUEVOS TIPOS DE INTERACCIONES HOST:GUEST POTENCIARA SU POSIBLE USO EN CATALISIS SUPRAMOLECULAR MEDIANTE LA ESTABILIZACION DE INTERMEDIOS Y/O ESTADOS DE TRANSICION._x000D_ LA FORMACION DE ESTRUCTURAS SUPRAMOLECULARES DE MAYOR TAMAÑO Y COMPLEJIDAD (MICELAS Y/O VESICULAS) TENDRA LUGAR A PARTIR DE DOS VIAS BIEN DIFERENCIADAS: (A) AUTOAGREGACION DE RECEPTORES MACROCICLICOS MODIFICADOS HIDROFOBICAMENTE Y (B) AUTOAGREGACION DE COMPLEJOS SUPRAMOLECULARES. EN EL PRIMER CASO LOS SISTEMAS ESTARAN CARACTERIZADOS POR LA EXISTENCIA DE DOS POSICIONES DE SOLUBILIZACION BIEN DIFERENCIADAS: LA CAVIDAD DEL RECEPTOR MACROCICLICO Y EL CORE DE LA MICELA/VESICULA. LA TRANSFERENCIA DEL GUEST DESDE UNA A OTRA POSICION DE SOLUBILIZACION, EN RESPUESTA A ESTIMULOS EXTERNOS, CONSTITUIRA UN OBJETIVO BASICO DEL ESTUDIO. LA PRINCIPAL CARACTERISTICA DE LOS AGREGADOS FORMADOS POR ENSAMBLAJE DE COMPLEJOS SUPRAMOLECULARES RADICA EN LA REVERSIBILIDAD DEL PROCESO DE FORMACION DE COMPLEJOS. DE ESTE MODO LA UTILIZACION DE ESTIMULOS EXTERNOS QUE MODIFIQUE LA FORMACION DEL COMPLEJO SUPRAMOLECULAR TAMBIEN ALTERARA LA FORMACION DE LA MICELA Y/O VESICULA. LA POSIBILIDAD DE DESTRUCCION DEL AGREGADO EN RESPUESTA A ESTIMULOS EXTERNOS ES DE LA MAXIMA IMPORTANCIA HABIDA CUENTA LA UTILIZACION DE ESTOS SISTEMAS EN PROCESOS DE ENCAPSULACION Y/O LIBERACION DE DROGAS._x000D_ EN LA REALIZACION DEL PRESENTE PROYECTO SE CONTEMPLA EL DESARROLLO Y EVALUACION DE UN NUEVO TIPO DE LIGANDOS QUIRALES PARA COMPUESTOS ORGANOLITICOS CON EL OBJETIVO DE CONSEGUIR LA FORMACION ENANTIOSELECTIVA DE ANIONES. DICHOS LIGANDOS PRESENTAN LA CAPACIDAD DE ENCAPSULAR N-BULI DE UN MODO SIN PRECEDENTES DE TAL MODO QUE ELIMINAN SU CAPACIDAD REACTIVA. LAS PROPIEDADES BASICAS/NUCLEOFILAS DEL N-BULI SE VUELVEN A PONER DE MANIFIESTO SI AL SISTEMA SE LE AÑADEN DOS TIPOS DE SUSTANCIAS COMPETITIVAS: LIGANDOS QUE COMPITAN POR EL ORGANOLITICO (TMEDA, HMPA, ETC.) O ESPECIES QUE COMPITAN POR LAS POSICIONES DEL LIGANDO QUIRAL (LICLO4, ETC.). LA UTILIZACION DE ESTA FAMILIA DE LIGANDOS QUIRALES PERMITIRA ENCAPSULAR Y/O LIBERAR EL REACTIVO ORGANOLITICO A VOLUNTAD AL TIEMPO QUE SE PRETENDE MODIFICAR LA REACTIVIDAD DE ORGANOLITICOS BIDENTADOS. (Spanish)
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THE PROJECT THAT IS REQUESTED PRESENTS A MARKED INTERDISCIPLINARY CHARACTER BECAUSE ITS DEVELOPMENT INVOLVES THEMATIC AREAS AS DIVERSE AS SUPRAMOLECULAR CHEMISTRY, COLLOIDAL CHEMISTRY, ORGANOMETALICA CHEMISTRY AND CHEMICAL KINETICS. THE LAST OBJECTIVE OF THE PROJECT IS THE ACQUISITION AND CHARACTERISATION OF NEW MEANS OF REACTION WITH A DOUBLE DIMENSION: AQUEOUS SYSTEMS AND ANHYDROUS MEDIA. THE NEW AQUEOUS SYSTEMS WILL BE FORMED FROM THE AUTOAGREGACION OF SUPRAMOLECULAR SPECIES WITH DIFFERENT LEVELS OF ORGANISATION: (I) NANOTUBES; (II) NANOCAPSULAS; (III) MICELLES AND (IV) VESICULAS. THE NANOTUBES WILL BE FORMED FROM THE COVALENT ASSEMBLY BETWEEN TWO/THREE PILLAR[5]ARENES AND THEIR SUBSEQUENT FUNCIONALISATION SO THAT CATIONIC OR ZWITTERIONIC STRUCTURES ARE ACHIEVED. NANOCAPSULAS SHALL BE FORMED FROM THE SUPRAMOLECULAR AGGREGATION OF TWO OR THREE MACROCYCLIC RECEPTORS, USUALLY COMBINATIONS OF ANIONIC CALIXARENS AND CYSTICS WITH CYCLODEXTRIN ANIONIC DERIVATIVES AND CYLINDRICAL PILLARARENES. BOTH TYPES OF SYSTEMS, NANOTUBES AND NANOCAPSULAS, WILL BE INVESTIGATED FOR POTENTIAL USE AS ENCAPSULATING AGENTS AND ION CONVEYORS. THE GOAL TO BE ACHIEVED IS TO FIND SYNERGISTIC AND COMPLEMENTARY EFFECTS ON MOLECULAR RECOGNITION PROCESSES. The STABILITY OF NEW INTERACTION TYPES HOST:GUEST will enhance their potential use in supramolecular CATALISIS by stabilising INTERMEDIAMENTS AND/OR TRANSICATION STATES._x000D_ THE FORMATION OF SUMMOLLEcular STRUCTURES OF MAY SIZE AND COMPLEJITY (micellas AND/OR VESICULS) TENDS TO PARTY OF DIFERENTY TEATURES: (A) AUTOAGREGACTION OF MODIFIED MACROCYCLIC RECEPTORS HIDROFOBICALY AND (B) AUTOAGREGACTION OF SUPRAMOLECULAR COMPLEXES. IN THE FIRST CASE THE SYSTEMS WILL BE CHARACTERISED BY THE EXISTENCE OF TWO WELL-DIFFERENTIATED SOLUBILISATION POSITIONS: THE CAVITY OF THE MACROCICLICO RECEPTOR AND THE CORE OF THE MICELLA/VESSEL. THE TRANSFER OF THE GUEST FROM ONE TO ANOTHER POSITION OF SOLUBILISATION, IN RESPONSE TO EXTERNAL STIMULI, WILL CONSTITUTE A BASIC OBJECTIVE OF THE STUDY. THE MAIN FEATURE OF AGGREGATES FORMED BY ASSEMBLING SUPRAMOLECULAR COMPLEXES LIES IN THE REVERSIBILITY OF THE COMPLEX FORMATION PROCESS. IN THIS WAY THE USE OF EXTERNAL STIMULI THAT MODIFIES THE FORMATION OF THE SUPRAMOLECULAR COMPLEX WILL ALSO ALTER THE FORMATION OF THE MICELLA AND/OR VESICULA. The POSIBILITY OF DESTRACTION OF THE AGREED IN RESPONSE TO EXTERNAL STIMPORTANCE IS OF THE MAXIMUM IMPORTANCE ACCOUNTING THE USE OF THESE SYSTEMS IN THE PROJECT PROCESSING AND/or DROGAS FREEDOM._x000D_ IN THE RELATED PROJECT OF THE DEVELOPMENT CONTACTING THE DEVELOPMENT and evaluation of a new type of chiral ligans for organic compounds with the OBJECTIVE OF CONSEGURE THE Anti-oselective ANION FORMATION. THESE LIGANDS PRESENT THE ABILITY TO ENCAPSULATE N-BULI IN AN UNPRECEDENTED WAY SO THAT THEY ELIMINATE THEIR REACTIVE CAPACITY. THE BASIC/NUCLEOPHILS PROPERTIES OF N-BULI ARE AGAIN REVEALED IF TWO TYPES OF COMPETITIVE SUBSTANCES ARE ADDED TO THE SYSTEM: LIGANDS THAT COMPETE FOR THE ORGANOLITICO (TMEDA, HMPA, ETC.) OR SPECIES THAT COMPETE FOR THE POSITIONS OF THE CHIRAL LIGAND (LICLO4, ETC.). THE USE OF THIS FAMILY OF CHIRAL LIGANDS WILL ALLOW TO ENCAPSULATE AND/OR RELEASE THE ORGANOLITICO REAGENT AT WILL WHILE AIMING TO MODIFY THE REACTIVITY OF BIDENT ORGANOLITICS. (English)
12 October 2021
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Santiago de Compostela
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Identifiers
CTQ2014-55208-P
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