RESISTANCE TO SWEET FLAVORS IN OBESITY: RECOVERY THROUGH PHYSICAL EXERCISE AND DIETARY TREATMENT (Q3164146): Difference between revisions
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(Created claim: summary (P836): DUE TO THE SERIOUS HEALTH PROBLEMS IT CAUSES, THE TREATMENT OF OBESITY IS AN URGENT PRIORITY AND A MAJOR CHALLENGE FOR SCIENCE. CURRENTLY THE MOST REALISTIC TREATMENT CONSISTS OF THE CONSUMPTION OF HIPOCALORIC DIETS. HOWEVER, ITS SUCCESS IS REDUCED BECAUSE ITS FOLLOW-UP INVOLVES A GREAT SACRIFICE, IT IS OFTEN ASSOCIATED WITH THE APPEARANCE OF ANXIETY AND COMPENSATORY CHANGES ARE INDUCED PREDISPOSING TO A BOUNCE IN BODY WEIGHT. ON THE OTHER HAND,...) |
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RESISTANCE TO SWEET FLAVORS IN OBESITY: RECOVERY THROUGH PHYSICAL EXERCISE AND DIETARY TREATMENT | |||
Revision as of 17:00, 12 October 2021
Project Q3164146 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | RESISTANCE TO SWEET FLAVORS IN OBESITY: RECOVERY THROUGH PHYSICAL EXERCISE AND DIETARY TREATMENT |
Project Q3164146 in Spain |
Statements
42,955.0 Euro
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85,910.0 Euro
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50.0 percent
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30 December 2016
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29 December 2020
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UNIVERSIDAD AUTONOMA DE BARCELONA
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41°29'27.71"N, 2°8'15.00"E
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08266
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DEBIDO A LOS GRAVES PROBLEMAS DE SALUD QUE ORIGINA, EL TRATAMIENTO DE LA OBESIDAD CONSTITUYE UNA PRIORIDAD URGENTE Y UN IMPORTANTE RETO PARA LA CIENCIA. ACTUALMENTE EL TRATAMIENTO MAS REALISTA CONSISTE EN EL CONSUMO DE DIETAS HIPOCALORICAS. NO OBSTANTE, SU EXITO ES REDUCIDO DEBIDO A QUE SU SEGUIMIENTO IMPLICA UN GRAN SACRIFICO, ESTA ASOCIADO FRECUENTEMENTE A LA APARICION DE ANSIEDAD Y SE INDUCEN CAMBIOS COMPENSATORIOS PREDISPONIENDO A UN REBOTE EN EL PESO CORPORAL. POR OTRO LADO, RESULTADOS PROVENIENTES DE DIFERENTES AMBITOS DE ESTUDIO INDICAN QUE ADEMAS DE UN PROBLEMA NUTRICIONAL, LA OBESIDAD CONLLEVA LA DISREGULACION DE OTRAS FUNCIONES RELACIONADAS CON LOS SISTEMAS SENSORIALES Y DE REFORZAMIENTO CEREBRAL. MAS EN CONCRETO, PARECE QUE CON LA OBESIDAD DISMINUYE LA SENSIBILIDAD AL SABOR DULCE Y EL PODER REFORZANTE DE LOS ALIMENTOS QUE CONTIENEN AZUCARES Y QUE TODO ELLO PODRIA ESTAR MEDIADO POR LA LEPTINA, LA HORMONA ANOREXINEGICA REGULADORA DEL APETITO. DATOS RECIENTES DE NUESTRO GRUPO DE INVESTIGACION MUESTRAN QUE EN UN MODELO ANIMAL DE OBESIDAD INDUCIDA POR DIETA DE CAFETERIA, EL EJERCICIO FISICO DISMINUYE LOS NIVELES CIRCULANTES DE LEPTINA, LO CUAL SUGIERE QUE EL EJERCICIO FISICO PODRIA TAMBIEN MODULAR LA RESISTENCIA AL SABOR DULCE Y LA DIMINUCION DEL VALOR REFORZANTE DE LOS ALIMENTOS DULCES QUE APARECE EN LA OBESIDAD. ESTE ES EL PUNTO DE PARTIDA Y LA HIPOTESIS PRINCIPAL DEL PRESENTE PROYECTO. EL EQUIPO DE TRABAJO ES INTERDISCIPLINAR Y ALGUNOS DE SUS MIEMBROS HAN TRABAJADO MINUCIOSAMENTE EN UNA DE LAS ESTRATEGIAS TAMBIEN EN AUGE PARA EL TRATAMIENTO DE LA OBESIDAD BASADA EN EL USO DE INGREDIENTES BIOACTIVOS DE ORIGEN NATURAL. MAS EN CONCRETO, HEMOS DEMOSTRADO LOS EFECTOS BENEFICIOSOS DE LOS POLIFENOLES FRENTE A LA OBESIDAD Y PATOLOGIAS RELACIONADAS, INCLUSO ABORDADO LA PROBLEMATICA DE LA OBESIDAD DESDE LA OPTICA DE LA PROGRAMACION METABOLICA. ASI, EL OBJETIVO GENERAL DEL PROYECTO ES DESARROLLAR UNA INTERVENCION BASADA EN EL EJERCICIO FISICO, UNA DIETA SUAVE Y UN INGREDIENTE DE ORIGEN NATURAL, LA OLEUROPEINA, UN POLIFENOL QUE SE ENCUENTRA EN EL ACEITE DE OLIVA EXTRA VIRGEN. PRETENDEMOS EVALUAR LOS EFECTOS DE UNA DIETA SUAVE, DE UNA DIETA SUAVE+EJERCICIO, UNA DIETA SUAVE+OLEUROPEINA, Y DIETA SUAVE+EJERCICIO+OLEUROPEINA ADMINISTRADA A UN MODELO ANIMALE DE OBESIDAD INDUCIDA. ESTOS GRUPOS EXPERIMENTALES SE COMPARARAN CON ANIMALES ALIMENTADOS CON DIETA NORMOLIPIDICA Y CON OTRO GRUPO ALIMENTADO CON DIETA DE CAFETERIA DURANTE TODO EL EXPERIMENTO. ESTE DISEÑO PERMITIRA EVALUAR LOS EFECTOS DE LAS DIFERENTES INTERVENCIONES SOBRE LA SENSIBILIDAD AL SABOR DULCE, EL VALOR REFORZANTE DE ALIMENTOS DULCES, Y LAS FUNCIONES REGULADORAS DE LA LEPTINA. PARA TODO ELLO EVALUAREMOS EN RATAS MACHO Y HEMBRA LAS CONDUCTAS DE LICKING Y DE PREFERENCIA POR SOLUCIONES DULCES DE DOS TIPOS, UN COMPUESTO NATURAL, LA SACAROSA, Y UN EDULCORANTE ARTIFICIAL NO CALORICO, LA SUCRALOSA. SE REALIZARAN SEGUIMIENTOS DE PESO, DE INGESTA Y MUESTREOS DE SANGRE PARA ESTUDIAR LA EVOLUCION DE MARCADORES CLASICOS (GLUCOSA, TRIGLICERIDOS, COLESTEROL, INSULINA). ADEMAS, PARA DETERMINAR LOS NIVELES DE ANSIEDAD DE LOS ANIMALES OBESOS EVALUAREMOS SU CONDUCTA ANSIOSA Y ANALIZAREMOS LA RESPUESTA HORMONAL DEL EJE HPA UNA VEZ RETIRADA LA DIETA DE CAFETERIA. ASI, PRETENDEMOS APORTAR BASES CIENTIFICAS SOLIDAS Y EVALUAR UNA ESTRATEGIA MULTIFACETICA PARA LA ESTABILIZACION DEL TRATAMIENTO DE LA OBESIDAD, AL TIEMPO QUE SE ESTUDIA LA IMPLICACION DE LA LEPTINA EN SUS EFECTOS. (Spanish)
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DUE TO THE SERIOUS HEALTH PROBLEMS IT CAUSES, THE TREATMENT OF OBESITY IS AN URGENT PRIORITY AND A MAJOR CHALLENGE FOR SCIENCE. CURRENTLY THE MOST REALISTIC TREATMENT CONSISTS OF THE CONSUMPTION OF HIPOCALORIC DIETS. HOWEVER, ITS SUCCESS IS REDUCED BECAUSE ITS FOLLOW-UP INVOLVES A GREAT SACRIFICE, IT IS OFTEN ASSOCIATED WITH THE APPEARANCE OF ANXIETY AND COMPENSATORY CHANGES ARE INDUCED PREDISPOSING TO A BOUNCE IN BODY WEIGHT. ON THE OTHER HAND, RESULTS FROM DIFFERENT AREAS OF STUDY INDICATE THAT IN ADDITION TO A NUTRITIONAL PROBLEM, OBESITY ENTAILS THE DISREGUATION OF OTHER FUNCTIONS RELATED TO SENSORY AND CEREBRAL STRENGTHENING SYSTEMS. MORE SPECIFICALLY, IT SEEMS THAT WITH OBESITY DECREASES THE SENSITIVITY TO THE SWEET TASTE AND THE STRENGTHENING POWER OF FOODS CONTAINING SUGARS AND THAT ALL THIS COULD BE MEDIATED BY LEPTIN, THE HORMONE ANOREXINEGIC REGULATING APPETITE. RECENT DATA FROM OUR RESEARCH GROUP SHOW THAT IN AN ANIMAL MODEL OF OBESITY INDUCED BY COFFEE DIET, PHYSICAL EXERCISE DECREASES THE CIRCULATING LEVELS OF LEPTIN, WHICH SUGGESTS THAT PHYSICAL EXERCISE COULD ALSO MODULATE THE RESISTANCE TO THE SWEET TASTE AND THE DIMINUCTION OF THE REINFORCING VALUE OF SWEET FOODS THAT APPEARS IN OBESITY. THIS IS THE STARTING POINT AND THE MAIN SCENARIO OF THIS PROJECT. THE TEAM IS INTERDISCIPLINARY AND SOME OF ITS MEMBERS HAVE WORKED CLOSELY ON ONE OF THE BOOMING STRATEGIES FOR THE TREATMENT OF OBESITY BASED ON THE USE OF NATURALLY OCCURRING BIOACTIVE INGREDIENTS. MORE SPECIFICALLY, WE HAVE DEMONSTRATED THE BENEFICIAL EFFECTS OF POLYPHENOLS AGAINST OBESITY AND RELATED PATHOLOGIES, EVEN ADDRESSING THE PROBLEM OF OBESITY FROM THE OPTIC OF METABOLIC PROGRAMMING. THUS, THE GENERAL OBJECTIVE OF THE PROJECT IS TO DEVELOP AN INTERVENTION BASED ON PHYSICAL EXERCISE, A MILD DIET AND AN INGREDIENT OF NATURAL ORIGIN, OLEUROPEIN, A POLYPHENOL FOUND IN EXTRA VIRGIN OLIVE OIL. WE INTEND TO EVALUATE THE EFFECTS OF A MILD DIET, A MILD DIET+EXERCISE, A MILD DIET+OLEUROPEIN, AND GENTLE DIET+EXERCISE+OLEUROPEIN ADMINISTERED TO AN ANIMAL MODEL OF INDUCED OBESITY. THESE EXPERIMENTAL GROUPS WILL BE COMPARED WITH ANIMALS FED NORMOLIPIDICA DIET AND ANOTHER GROUP FED COFFEE DIET THROUGHOUT THE EXPERIMENT. THIS DESIGN WILL MAKE IT POSSIBLE TO EVALUATE THE EFFECTS OF THE DIFFERENT INTERVENTIONS ON THE SENSITIVITY TO THE SWEET TASTE, THE REINFORCING VALUE OF SWEET FOODS, AND THE REGULATORY FUNCTIONS OF LEPTIN. FOR ALL THIS WE WILL EVALUATE IN MALE AND FEMALE RATS LICKING BEHAVIORS AND PREFERABLY BY SWEET SOLUTIONS OF TWO TYPES, A NATURAL COMPOUND, THE SUCROSE, AND AN ARTIFICIAL NON CALORIC SWEETENER, THE SUCRALOSE. WEIGHT, INTAKE AND BLOOD SAMPLING WILL BE MONITORED TO STUDY THE EVOLUTION OF CLASSICAL MARKERS (GLUCOSE, TRIGLYCERIDES, CHOLESTEROL, INSULIN). IN ADDITION, TO DETERMINE THE ANXIETY LEVELS OF OBESE ANIMALS WE WILL EVALUATE THEIR ANXIOUS BEHAVIOR AND ANALYSE THE HORMONAL RESPONSE OF THE HPA AXIS ONCE THE COFFEE DIET HAS BEEN REMOVED. THUS, WE INTEND TO PROVIDE SOLID SCIENTIFIC BASES AND EVALUATE A MULTIFACETED STRATEGY FOR STABILISING THE TREATMENT OF OBESITY, WHILE STUDYING THE IMPLICATION OF LEPTIN IN ITS EFFECTS. (English)
12 October 2021
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Cerdanyola del Vallès
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Identifiers
PSI2016-77234-R
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