Characterisation of circulating exosomes and immunological markers of HIV-1 infected patients with natural infection control (elite controllers) (Q3150051): Difference between revisions
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(Created claim: summary (P836): Circulating exosomes play an important role in many cellular processes and in many pathologies, harboring molecules such as microRNAs that are very promising candidates for use as biomarkers. There are many papers on the role of miRNAs in the field of HIV-1 infection, showing that the altered expression of these molecules plays a fundamental role in the disease. However, very few studies have been conducted in HIV-1 infected patients with natura...) |
(Changed label, description and/or aliases in fr: translated_label) |
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Caractérisation des exosomes circulants et marqueurs immunologiques des patients infectés par le VIH-1 avec contrôle naturel des infections (contrôleurs d’élite) | |||
Revision as of 16:42, 2 December 2021
Project Q3150051 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Characterisation of circulating exosomes and immunological markers of HIV-1 infected patients with natural infection control (elite controllers) |
Project Q3150051 in Spain |
Statements
31,000.0 Euro
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62,000.0 Euro
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50.0 percent
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1 January 2019
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31 March 2022
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL RAMON Y CAJAL
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40°25'0.12"N, 3°42'12.89"W
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28079
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Los exosomas circulantes tienen un papel importante en muchos procesos celulares y en muchas patologías, albergando moléculas como los microRNAs que son candidatos muy prometedores para su uso como biomarcadores. Hay muchos trabajos sobre el papel de los miRNAs en el ámbito de la infección por el VIH-1 demostrándose que la expresión alterada de estas moléculas desempeña un papel fundamental en la enfermedad. Sin embargo, son muy pocos los estudios realizados en pacientes infectados por el VIH-1 que presentan un control natural de la infección en ausencia de tratamiento antirretroviral (controladores de élite), los cuales representan una prevalencia muy baja (1-5%). El presente proyecto analizará el potencial de los exosomas circulantes y los microRNAs como biomarcadores para el diagnóstico y pronóstico de progresión en pacientes controladores de élite y su eventual utilización como diana terapéutica. Además, se asociarán a parámetros inmunofenotípicos, de la inmunidad innata y adquirida, y de citocinas solubles. (Spanish)
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Circulating exosomes play an important role in many cellular processes and in many pathologies, harboring molecules such as microRNAs that are very promising candidates for use as biomarkers. There are many papers on the role of miRNAs in the field of HIV-1 infection, showing that the altered expression of these molecules plays a fundamental role in the disease. However, very few studies have been conducted in HIV-1 infected patients with natural infection control in the absence of antiretroviral therapy (elite controllers), which represent a very low prevalence (1-5 %). This project will analyse the potential of circulating exosomes and microRNAs as biomarkers for the diagnosis and prognosis of progression in elite controlling patients and their possible use as a therapeutic target. In addition, they will be associated with immunophenotypic parameters, innate and acquired immunity, and soluble cytokines. (English)
12 October 2021
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Madrid
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Identifiers
PI18_01151
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