Evaluation of bone structural parameters obtained by 3D (3D-Shaper) analysis in patients with type 2 diabetes and their relationship with cardiovascular disease. (Q3149712): Difference between revisions
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Évaluation des paramètres structuraux osseux obtenus par analyse 3D (3D-Shaper) chez les patients atteints de diabète de type 2 et leur relation avec les maladies cardiovasculaires. | |||
Revision as of 16:22, 2 December 2021
Project Q3149712 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Evaluation of bone structural parameters obtained by 3D (3D-Shaper) analysis in patients with type 2 diabetes and their relationship with cardiovascular disease. |
Project Q3149712 in Spain |
Statements
86,000.0 Euro
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107,500.0 Euro
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80.0 percent
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1 January 2019
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31 March 2022
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FUNDACION PARA LA INVESTIGACION BIOSANITARIA DE ANDALUCIA ORIENTAL - ALEJANDRO OTERO
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37°10'24.60"N, 3°35'58.31"W
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18087
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La enfermedad ósea diabética constituye un importante problema clínico y de salud pública por su alta prevalencia y el envejecimiento demográfico. Además, la diabetes mellitus tipo 2 (DM2) se caracteriza por un elevado riesgo de enfermedad cardiovascular (ECV) que está asociada con la fragilidad ósea por factores no bien conocidos. Los mecanismos determinantes de la disminución de la resistencia ósea en la DM2, a pesar de una densidad mineral ósea (DMO) aumentada no se encuentran bien establecidos. Estudios previos, utilizando técnicas complejas, sugieren alteraciones estructurales en el componente cortical y trabecular del tejido óseo de pacientes con DM2 que no son captadas por la densitometría convencional (DXA). Recientemente se ha desarrollado un algoritmo tridimensional mediante análisis 3D (3D-Shaper) que cuantifica la DMO volumétrica trabecular y cortical y la distribución anatómica del grosor cortical utilizando exploraciones de DXA de cadera. Hasta el momento no existen estudios que hayan usado esta técnica 3D-DXA para la evaluación de la fragilidad ósea en pacientes con DM2 ni tampoco se ha analizado la relación entre 3D-DXA y enfermedad cardiovascular en esta población de alto riesgo. El objetivo principal del presente estudio es analizar la relación entre fragilidad ósea, ECV y 3D-DXA en pacientes con DM2. Para ello se ha diseñado un estudio de casos y controles que incluirá 129 pacientes con DM2 (con y sin ECV prevalente) y 129 controles. Nuestra hipótesis es que los valores de 3D-DXA están asociados con la fragilidad ósea y la ECV en pacientes con DM2. (Spanish)
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Diabetic bone disease is a major clinical and public health problem due to its high prevalence and demographic ageing. In addition, type 2 diabetes mellitus (DM2) is characterised by a high risk of cardiovascular disease (CVD) that is associated with bone fragility by unknown factors. The mechanisms determining the decrease in bone resistance in DM2, despite an increased bone mineral density (BMD) are not well established. Previous studies, using complex techniques, suggest structural alterations in the cortical and trabecular component of bone tissue in patients with DM2 that are not captured by conventional densitometry (DXA). A three-dimensional algorithm has recently been developed through 3D (3D-Shaper) analysis that quantifies trabecular and cortical volumetric BMD and anatomical distribution of cortical thickness using hip DXA scans. So far there are no studies using this 3D-DXA technique to evaluate bone fragility in patients with DM2, nor has the relationship between 3D-DXA and cardiovascular disease been analysed in this high-risk population. The main objective of this study is to analyse the relationship between bone fragility, CVD and 3D-DXA in patients with DM2. A case-control study has been designed to include 129 patients with DM2 (with and without prevalent CVD) and 129 controls. Our hypothesis is that 3D-DXA values are associated with bone fragility and CVD in patients with DM2. (English)
12 October 2021
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Granada
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Identifiers
PI18_01235
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