Functional variability of mesenchymal stem cells of adipose tissue (ASCs) after weight loss. Relationship with metafactors linked to the intestinal microbiota. (Q3140035): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): Adipose stem cells (ASCs) are involved in tissue expansion processes and immunomodulatory phenomena that are determinants of obesity and its co-morbidities. The cellular plasticity of ASCs may be influenced by systemic metafactors modulated by the intestinal microbiota (I). Observed changes in the functionality of these cells in obesity and diabetes may persist latent despite weight reduction (RP). OB GENERAL:Evaluar the reversibility of changes...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
Functional variability of mesenchymal stem cells of adipose tissue (ASCs) after weight loss. Relationship with metafactors linked to the intestinal microbiota. | |||
Revision as of 13:03, 12 October 2021
Project Q3140035 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Functional variability of mesenchymal stem cells of adipose tissue (ASCs) after weight loss. Relationship with metafactors linked to the intestinal microbiota. |
Project Q3140035 in Spain |
Statements
56,500.0 Euro
0 references
113,000.0 Euro
0 references
50.0 percent
0 references
1 January 2018
0 references
31 March 2021
0 references
INSTITUTO DE INVESTIGACION BIOMEDICA DE BELLVITGE
0 references
41°21'35.50"N, 2°5'59.24"E
0 references
08101
0 references
Las células madre del tejido adiposo (ASCs) intervienen en los procesos de expansibilidad de dicho tejido y en los fenómenos inmunomoduladores que resultan determinantes en la obesidad y sus co-morbilidades. La plasticidad celular de las ASCs puede estar influenciada por metafactores sistémicos modulados por la microbiota intestinal (MI). Los cambios observados en la funcionalidad de estas células en la obesidad y la diabetes pueden persistir latentes a pesar de la reducción de peso (RP). OB GENERAL:Evaluar la reversibilidad de los cambios en la funcionalidad de las ASCs observados en pacientes obesos y con T2D tras la RP. Hallar un patrón predictivo del comportamiento de las ASCs pre- y post-RP, mediante un análisis comparativo integral de los mecanismos moleculares que regulan la funcionalidad de las ASCs y el análisis de elementos modificables relacionados con la MI.OB SP1:1a: Analizar el efecto de la RP sobre las funciones precursoras, inmunoreguladoras y memoria epigenéticade ASCs en obesos mórbidos tras cirugía bariátrica (CB);1b: Identificar y caracterizar la población de ASCs circulantes pre- y post-CB. Evaluar la capacidad de estas ASCs circulantes de reflejar el patrón de metilación de las ASCsdel SAT pre- y post-RP;1c: Identificación de firmas moleculares específicas asociadas a la reversión total o parcial del comportamiento disfuncional de las ASCs de SAT tras la RP;1d: Evaluar los cambios en diversos factores sistémicos y la composición de la MI, pre- y post-CB;1e: Establecer un patrón predictivo integrando todos los datos que pueda determinar aquellos sujetos susceptibles de revertir la disfuncionalidad de las ASCs. METODOLOGÍA:Estudio prospectivo en pacientes obesos mórbidos sometidos a CB. Estudio de variables analíticas. Estudio de permeabilidad y MI. Estudio funcional y de ómicas de las ASCs pre- y post-RP. Estudioepigenético de ASCs circulantes pre- y post-RP. Análisis estadístico y búsqueda de modelo predictivo. (Spanish)
0 references
Adipose stem cells (ASCs) are involved in tissue expansion processes and immunomodulatory phenomena that are determinants of obesity and its co-morbidities. The cellular plasticity of ASCs may be influenced by systemic metafactors modulated by the intestinal microbiota (I). Observed changes in the functionality of these cells in obesity and diabetes may persist latent despite weight reduction (RP). OB GENERAL:Evaluar the reversibility of changes in the functionality of CSAs observed in obese patients and with T2D after PR. Find a predictive pattern of the behavior of pre- and post-RP ASCs, through a comprehensive comparative analysis of the molecular mechanisms that regulate the functionality of ASCs and the analysis of modifiable elements related to MI.OB SP1:1a: Analyse the effect of PR on precursor, immunoregulatory and epigenetic memory functions of ASCs in obese morbids after bariatric surgery (CB);1b: Identify and characterise the population of pre- and post-CB circulating ASCs. Assess the ability of these circulating ASCs to reflect the methylation pattern of pre- and post-RP ASCs;1c: Identification of specific molecular signatures associated with the total or partial reversal of dysfunctional behaviour of SAT ASCs after PR;1d: Evaluate changes in various systemic factors and the composition of MI, pre- and post-CB;1e: Establish a predictive pattern by integrating all the data that can determine those subjects likely to reverse the dysfunctionality of the ASCs. Metodología:Estudio prospective in obese morbid patients undergoing CB. Study of analytical variables. Permeability and MI study. Functional and omic study of pre- and post-RP ASCs. Epigenetic study of circulating ASCs pre- and post-RP. Statistical analysis and predictive model search. (English)
12 October 2021
0 references
Hospitalet de Llobregat, L'
0 references
Identifiers
PI17_01556
0 references