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(Created claim: summary (P836): THE VIRIC EVOLUTION PLAYS A VITAL ROLE IN THE POSSIBLE ADAPTATION, CHANGE OF HOST, ALTERATION OF VIRULENCE AS WELL AS IN THE EMERGENCE OF NEW VARIANTS DUE TO SPECIFIC MUTATIONS, RECOMBINATION AND GENICAL REARRANGEMENTS. VACCINATION CAN AFFECT THE EVOLUTION OF VIRUSES, ESPECIALLY IN CASES WHERE THEY DO NOT PROVIDE STERILISING PROTECTION, ALLOWING VIRUSES TO EXPLOIT THEIR VARIATION CAPACITY AND MAY CAUSE THE SELECTION OF ESCAPE MUTANTS. THE PORCIN...) |
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| Property / summary | |||||||||||||||
THE VIRIC EVOLUTION PLAYS A VITAL ROLE IN THE POSSIBLE ADAPTATION, CHANGE OF HOST, ALTERATION OF VIRULENCE AS WELL AS IN THE EMERGENCE OF NEW VARIANTS DUE TO SPECIFIC MUTATIONS, RECOMBINATION AND GENICAL REARRANGEMENTS. VACCINATION CAN AFFECT THE EVOLUTION OF VIRUSES, ESPECIALLY IN CASES WHERE THEY DO NOT PROVIDE STERILISING PROTECTION, ALLOWING VIRUSES TO EXPLOIT THEIR VARIATION CAPACITY AND MAY CAUSE THE SELECTION OF ESCAPE MUTANTS. THE PORCINE INFLUENZA VIRUS GENOME CONSISTS OF RNA FOR WHICH HIGH GENETIC VARIABILITY HAS BEEN REPORTED. INACTIVATED VIRUS VACCINATION ALLOWS CONTROL OF THE DISEASE BUT DOES NOT PREVENT REPLICATION. SWINE INFLUENZA VIRUS INFECTION CAUSES ECONOMIC LOSSES IN PIG PRODUCTION AND POSES A THREAT TO PUBLIC HEALTH DUE TO THE RISK OF CAUSING ZOONOTIC INFECTIONS. THE PORCINE POPULATION IS A RESERVOIR OF THE VIRUS AND IS A KEY PLAYER IN THE JUMP OF HOST, FROM BIRDS TO HUMANS, LEADING TO PANDEMICS SUCH AS THE ONE THAT OCCURRED IN 2009. _x000D_ for ALL, as the subject of this project, we intend to deter the MOLECULAR variation of porcinal INFLUENCE VIRUS due to the impact of the new GENERATION Sequence (NGS). THIS MASS SEQUENCING TECHNOLOGY WILL ALLOW US TO IDENTIFY GENETIC VARIANTS, INCLUDING RARE VARIANTS, THAT COULD GO UNNOTICED IN A CONVENTIONAL SEQUENCING (SANGER SEQUENCE). TO THIS END, A STUDY WILL BE CARRIED OUT IN THE FIELD TO DETERMINE THE ROLE OF VACCINATION IN THE DYNAMICS OF QUASISPECIES AND THE APPEARANCE OF NEW VARIANTS. THROUGH AN EXPERIMENTAL INFECTION, THE ABILITY TO ESCAPE THE IMMUNE RESPONSE WILL BE EVALUATED AND THE ROLE OF VACCINATION IN THE GENERATION OF VARIANTS WILL BE ANALYSED. A CONTACT COINFECTION TRIAL WILL ANALYSE THE ABILITY TO GENERATE REARRANGEMENTS IN THIS MODEL AND ITS EVOLUTION OVER TIME. _x000D_ the CONFLUENCE OF MEMBERS OF THE RESEARCH EQUIPMENT TO AUNATE DYSTINTS ASPECTS IN RESEARCH ASSEMBLY ASSEMBLY SYSTEMS, BIOINFORMATION ANALISIS, the EXPERIENCE IN Vaccine DEVELOPMENT FANT TO THE INFLUENCE VIRUS, as well as the knowledge of the porcinal pathology in flange situations, allow to ensure the success of the proposal. _x000D_ DERIVED RESULTS OF THE PROJECT may be of great use for producers in the same way as for pharmactories, as it is deduced from the shares of interests carried by varietal associations of producers and companies to support the product._x000D_ this project will be carried out in the CRESA, INVESTIGATION CENTRE OF THE SINGLE INSTALATIONS OF BIOSEGURITY LEVEL 3, which forms part of the SINGLE SINGLE-Technical INFRASTRUCTURES MAP (ICTS) OF THE MINECO, GOVERNMENT OF SPAIN. (English) | |||||||||||||||
| Property / summary: THE VIRIC EVOLUTION PLAYS A VITAL ROLE IN THE POSSIBLE ADAPTATION, CHANGE OF HOST, ALTERATION OF VIRULENCE AS WELL AS IN THE EMERGENCE OF NEW VARIANTS DUE TO SPECIFIC MUTATIONS, RECOMBINATION AND GENICAL REARRANGEMENTS. VACCINATION CAN AFFECT THE EVOLUTION OF VIRUSES, ESPECIALLY IN CASES WHERE THEY DO NOT PROVIDE STERILISING PROTECTION, ALLOWING VIRUSES TO EXPLOIT THEIR VARIATION CAPACITY AND MAY CAUSE THE SELECTION OF ESCAPE MUTANTS. THE PORCINE INFLUENZA VIRUS GENOME CONSISTS OF RNA FOR WHICH HIGH GENETIC VARIABILITY HAS BEEN REPORTED. INACTIVATED VIRUS VACCINATION ALLOWS CONTROL OF THE DISEASE BUT DOES NOT PREVENT REPLICATION. SWINE INFLUENZA VIRUS INFECTION CAUSES ECONOMIC LOSSES IN PIG PRODUCTION AND POSES A THREAT TO PUBLIC HEALTH DUE TO THE RISK OF CAUSING ZOONOTIC INFECTIONS. THE PORCINE POPULATION IS A RESERVOIR OF THE VIRUS AND IS A KEY PLAYER IN THE JUMP OF HOST, FROM BIRDS TO HUMANS, LEADING TO PANDEMICS SUCH AS THE ONE THAT OCCURRED IN 2009. _x000D_ for ALL, as the subject of this project, we intend to deter the MOLECULAR variation of porcinal INFLUENCE VIRUS due to the impact of the new GENERATION Sequence (NGS). THIS MASS SEQUENCING TECHNOLOGY WILL ALLOW US TO IDENTIFY GENETIC VARIANTS, INCLUDING RARE VARIANTS, THAT COULD GO UNNOTICED IN A CONVENTIONAL SEQUENCING (SANGER SEQUENCE). TO THIS END, A STUDY WILL BE CARRIED OUT IN THE FIELD TO DETERMINE THE ROLE OF VACCINATION IN THE DYNAMICS OF QUASISPECIES AND THE APPEARANCE OF NEW VARIANTS. THROUGH AN EXPERIMENTAL INFECTION, THE ABILITY TO ESCAPE THE IMMUNE RESPONSE WILL BE EVALUATED AND THE ROLE OF VACCINATION IN THE GENERATION OF VARIANTS WILL BE ANALYSED. A CONTACT COINFECTION TRIAL WILL ANALYSE THE ABILITY TO GENERATE REARRANGEMENTS IN THIS MODEL AND ITS EVOLUTION OVER TIME. _x000D_ the CONFLUENCE OF MEMBERS OF THE RESEARCH EQUIPMENT TO AUNATE DYSTINTS ASPECTS IN RESEARCH ASSEMBLY ASSEMBLY SYSTEMS, BIOINFORMATION ANALISIS, the EXPERIENCE IN Vaccine DEVELOPMENT FANT TO THE INFLUENCE VIRUS, as well as the knowledge of the porcinal pathology in flange situations, allow to ensure the success of the proposal. _x000D_ DERIVED RESULTS OF THE PROJECT may be of great use for producers in the same way as for pharmactories, as it is deduced from the shares of interests carried by varietal associations of producers and companies to support the product._x000D_ this project will be carried out in the CRESA, INVESTIGATION CENTRE OF THE SINGLE INSTALATIONS OF BIOSEGURITY LEVEL 3, which forms part of the SINGLE SINGLE-Technical INFRASTRUCTURES MAP (ICTS) OF THE MINECO, GOVERNMENT OF SPAIN. (English) / rank | |||||||||||||||
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| Property / summary: THE VIRIC EVOLUTION PLAYS A VITAL ROLE IN THE POSSIBLE ADAPTATION, CHANGE OF HOST, ALTERATION OF VIRULENCE AS WELL AS IN THE EMERGENCE OF NEW VARIANTS DUE TO SPECIFIC MUTATIONS, RECOMBINATION AND GENICAL REARRANGEMENTS. VACCINATION CAN AFFECT THE EVOLUTION OF VIRUSES, ESPECIALLY IN CASES WHERE THEY DO NOT PROVIDE STERILISING PROTECTION, ALLOWING VIRUSES TO EXPLOIT THEIR VARIATION CAPACITY AND MAY CAUSE THE SELECTION OF ESCAPE MUTANTS. THE PORCINE INFLUENZA VIRUS GENOME CONSISTS OF RNA FOR WHICH HIGH GENETIC VARIABILITY HAS BEEN REPORTED. INACTIVATED VIRUS VACCINATION ALLOWS CONTROL OF THE DISEASE BUT DOES NOT PREVENT REPLICATION. SWINE INFLUENZA VIRUS INFECTION CAUSES ECONOMIC LOSSES IN PIG PRODUCTION AND POSES A THREAT TO PUBLIC HEALTH DUE TO THE RISK OF CAUSING ZOONOTIC INFECTIONS. THE PORCINE POPULATION IS A RESERVOIR OF THE VIRUS AND IS A KEY PLAYER IN THE JUMP OF HOST, FROM BIRDS TO HUMANS, LEADING TO PANDEMICS SUCH AS THE ONE THAT OCCURRED IN 2009. _x000D_ for ALL, as the subject of this project, we intend to deter the MOLECULAR variation of porcinal INFLUENCE VIRUS due to the impact of the new GENERATION Sequence (NGS). THIS MASS SEQUENCING TECHNOLOGY WILL ALLOW US TO IDENTIFY GENETIC VARIANTS, INCLUDING RARE VARIANTS, THAT COULD GO UNNOTICED IN A CONVENTIONAL SEQUENCING (SANGER SEQUENCE). TO THIS END, A STUDY WILL BE CARRIED OUT IN THE FIELD TO DETERMINE THE ROLE OF VACCINATION IN THE DYNAMICS OF QUASISPECIES AND THE APPEARANCE OF NEW VARIANTS. THROUGH AN EXPERIMENTAL INFECTION, THE ABILITY TO ESCAPE THE IMMUNE RESPONSE WILL BE EVALUATED AND THE ROLE OF VACCINATION IN THE GENERATION OF VARIANTS WILL BE ANALYSED. A CONTACT COINFECTION TRIAL WILL ANALYSE THE ABILITY TO GENERATE REARRANGEMENTS IN THIS MODEL AND ITS EVOLUTION OVER TIME. _x000D_ the CONFLUENCE OF MEMBERS OF THE RESEARCH EQUIPMENT TO AUNATE DYSTINTS ASPECTS IN RESEARCH ASSEMBLY ASSEMBLY SYSTEMS, BIOINFORMATION ANALISIS, the EXPERIENCE IN Vaccine DEVELOPMENT FANT TO THE INFLUENCE VIRUS, as well as the knowledge of the porcinal pathology in flange situations, allow to ensure the success of the proposal. _x000D_ DERIVED RESULTS OF THE PROJECT may be of great use for producers in the same way as for pharmactories, as it is deduced from the shares of interests carried by varietal associations of producers and companies to support the product._x000D_ this project will be carried out in the CRESA, INVESTIGATION CENTRE OF THE SINGLE INSTALATIONS OF BIOSEGURITY LEVEL 3, which forms part of the SINGLE SINGLE-Technical INFRASTRUCTURES MAP (ICTS) OF THE MINECO, GOVERNMENT OF SPAIN. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
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Revision as of 01:00, 13 October 2021
Project Q3207900 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3207900 in Spain |
Statements
114,950.0 Euro
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229,900.0 Euro
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50.0 percent
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30 December 2016
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31 December 2020
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INSTITUTO DE INVESTIGACION Y TECNOLOGIA AGROALIMENTARIAS
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41°29'27.71"N, 2°8'15.00"E
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08266
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LA EVOLUCION VIRICA JUEGA UN PAPEL DE VITAL IMPORTANCIA EN LA POSIBLE ADAPTACION, CAMBIO DE HOSPEDADOR, ALTERACION DE LA VIRULENCIA ASI COMO EN LA EMERGENCIA DE NUEVAS VARIANTES DEBIDO A LAS MUTACIONES PUNTUALES, LA RECOMBINACION Y LOS REORDENAMIENTOS GENICOS. LA VACUNACION PUEDE AFECTAR A LA EVOLUCION DE LOS VIRUS, ESPECIALMENTE EN LOS CASOS EN QUE NO PROPORCIONAN UNA PROTECCION ESTERILIZANTE, PERMITIENDO A LOS VIRUS EXPLOTAR SU CAPACIDAD DE VARIACION Y PUDIENDO ORIGINAR LA SELECCION DE MUTANTES DE ESCAPE. EL GENOMA DEL VIRUS DE INFLUENZA PORCINA ESTA CONSTITUIDO POR RNA PARA EL QUE SE HA DESCRITO UNA ELEVADA VARIABILIDAD GENETICA. LA VACUNACION CON VIRUS INACTIVADO PERMITE CONTROLAR LA ENFERMEDAD AUNQUE NO EVITA LA REPLICACION. LA INFECCION POR EL VIRUS DE INFLUENZA PORCINA ORIGINA PERDIDAS ECONOMICAS EN LA PRODUCCION DE CERDO Y REPRESENTA UNA AMENAZA PARA LA SALUD PUBLICA POR EL RIESGO DE OCASIONAR INFECCIONES ZOONOTICAS. LA POBLACION PORCINA CONSTITUYE UN RESERVORIO DEL VIRUS Y ES PIEZA CLAVE EN EL SALTO DE HOSPEDADOR, DE AVES A HUMANOS, DANDO LUGAR A PANDEMIAS COMO LA OCURRIDA EN 2009. _x000D_ POR TODO ELLO, COMO OBJETIVO DE ESTE PROYECTO, NOS PROPONEMOS DETERMINAR LA VARIACION MOLECULAR DEL VIRUS DE INFLUENZA PORCINA DEBIDO A LA VACUNACION MEDIANTE EL EMPLEO DE LA SECUENCIACION DE NUEVA GENERACION (NGS). ESTA TECNOLOGIA DE SECUENCIACION MASIVA NOS PERMITIRA LA IDENTIFICACION DE VARIANTES GENETICOS, INCLUIDO LOS VARIANTES RAROS, QUE PODRIAN PASAR DESAPERCIBIDOS EN UNA SECUENCIACION CONVENCIONAL (SECUENCIACION DE SANGER). PARA ELLO, SE REALIZARA UN ESTUDIO EN EL CAMPO PARA DETERMINAR EL PAPEL DE LA VACUNACION EN LA DINAMICA DE LAS CUASIESPECIES Y LA APARICION DE NUEVAS VARIANTES. POR MEDIO DE UNA INFECCION EXPERIMENTAL, SE EVALUARA LA CAPACIDAD DE ESCAPAR A LA RESPUESTA INMUNE Y SE ANALIZARA EL PAPEL DE LA VACUNACION EN LA GENERACION DE VARIANTES. EN UN ENSAYO DE COINFECCION POR CONTACTO SE ANALIZARA LA CAPACIDAD DE GENERAR REORDENAMIENTOS EN ESTE MODELO Y SU EVOLUCION A LO LARGO DEL TIEMPO. _x000D_ LA CONFLUENCIA DE LOS MIEMBROS DEL EQUIPO INVESTIGADOR PARA AUNAR DISTINTOS ASPECTOS EN LA INVESTIGACION COMO LOS ESTUDIOS PREVIOS DE EVOLUCION VIRICA EN MULTIPLES SISTEMAS VIRICOS, LOS ANALISIS BIOINFORMATICOS, LA EXPERIENCIA EN DESARROLLOS VACUNALES FRENTE AL VIRUS DE INFLUENZA, ASI COMO EL CONOCIMIENTO DE LA PATOLOGIA PORCINA EN SITUACIONES DE CAMPO, PERMITEN ASEGURAR EL EXITO DE LA PROPUESTA. _x000D_ LOS RESULTADOS DERIVADOS DEL PROYECTO PUEDEN SER DE GRAN UTILIDAD PARA LOS PRODUCTORES AL IGUAL QUE PARA LOS LABORATORIOS FARMACEUTICOS, COMO SE DEDUCE DE LAS CARTAS DE INTERES EMITIDAS POR VARIAS ASOCIACIONES DE PRODUCTORES Y DE COMPAÑIAS PARA APOYAR LA PROPUESTA._x000D_ ESTE PROYECTO SE LLEVARA A CABO EN EL CRESA, CENTRO DE INVESTIGACION QUE DISPONE DE INSTALACIONES DE NIVEL DE BIOSEGURIDAD 3, QUE FORMAN PARTE DEL MAPA DE INFRAESTRUCTURAS CIENTIFICO-TECNICAS SINGULARES (ICTS) DEL MINECO, GOBIERNO DE ESPAÑA. (Spanish)
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THE VIRIC EVOLUTION PLAYS A VITAL ROLE IN THE POSSIBLE ADAPTATION, CHANGE OF HOST, ALTERATION OF VIRULENCE AS WELL AS IN THE EMERGENCE OF NEW VARIANTS DUE TO SPECIFIC MUTATIONS, RECOMBINATION AND GENICAL REARRANGEMENTS. VACCINATION CAN AFFECT THE EVOLUTION OF VIRUSES, ESPECIALLY IN CASES WHERE THEY DO NOT PROVIDE STERILISING PROTECTION, ALLOWING VIRUSES TO EXPLOIT THEIR VARIATION CAPACITY AND MAY CAUSE THE SELECTION OF ESCAPE MUTANTS. THE PORCINE INFLUENZA VIRUS GENOME CONSISTS OF RNA FOR WHICH HIGH GENETIC VARIABILITY HAS BEEN REPORTED. INACTIVATED VIRUS VACCINATION ALLOWS CONTROL OF THE DISEASE BUT DOES NOT PREVENT REPLICATION. SWINE INFLUENZA VIRUS INFECTION CAUSES ECONOMIC LOSSES IN PIG PRODUCTION AND POSES A THREAT TO PUBLIC HEALTH DUE TO THE RISK OF CAUSING ZOONOTIC INFECTIONS. THE PORCINE POPULATION IS A RESERVOIR OF THE VIRUS AND IS A KEY PLAYER IN THE JUMP OF HOST, FROM BIRDS TO HUMANS, LEADING TO PANDEMICS SUCH AS THE ONE THAT OCCURRED IN 2009. _x000D_ for ALL, as the subject of this project, we intend to deter the MOLECULAR variation of porcinal INFLUENCE VIRUS due to the impact of the new GENERATION Sequence (NGS). THIS MASS SEQUENCING TECHNOLOGY WILL ALLOW US TO IDENTIFY GENETIC VARIANTS, INCLUDING RARE VARIANTS, THAT COULD GO UNNOTICED IN A CONVENTIONAL SEQUENCING (SANGER SEQUENCE). TO THIS END, A STUDY WILL BE CARRIED OUT IN THE FIELD TO DETERMINE THE ROLE OF VACCINATION IN THE DYNAMICS OF QUASISPECIES AND THE APPEARANCE OF NEW VARIANTS. THROUGH AN EXPERIMENTAL INFECTION, THE ABILITY TO ESCAPE THE IMMUNE RESPONSE WILL BE EVALUATED AND THE ROLE OF VACCINATION IN THE GENERATION OF VARIANTS WILL BE ANALYSED. A CONTACT COINFECTION TRIAL WILL ANALYSE THE ABILITY TO GENERATE REARRANGEMENTS IN THIS MODEL AND ITS EVOLUTION OVER TIME. _x000D_ the CONFLUENCE OF MEMBERS OF THE RESEARCH EQUIPMENT TO AUNATE DYSTINTS ASPECTS IN RESEARCH ASSEMBLY ASSEMBLY SYSTEMS, BIOINFORMATION ANALISIS, the EXPERIENCE IN Vaccine DEVELOPMENT FANT TO THE INFLUENCE VIRUS, as well as the knowledge of the porcinal pathology in flange situations, allow to ensure the success of the proposal. _x000D_ DERIVED RESULTS OF THE PROJECT may be of great use for producers in the same way as for pharmactories, as it is deduced from the shares of interests carried by varietal associations of producers and companies to support the product._x000D_ this project will be carried out in the CRESA, INVESTIGATION CENTRE OF THE SINGLE INSTALATIONS OF BIOSEGURITY LEVEL 3, which forms part of the SINGLE SINGLE-Technical INFRASTRUCTURES MAP (ICTS) OF THE MINECO, GOVERNMENT OF SPAIN. (English)
13 October 2021
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Cerdanyola del Vallès
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Identifiers
AGL2016-75280-R
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