Q3192265 (Q3192265): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): THE EMERGENCE OF MULTI-DRUG-RESISTANT MICROORGANISMS IS ONE OF THE GREATEST THREATS IN THE TREATMENT OF INFECTIOUS DISEASES. TO COMBAT THESE PATHOGENS, IT IS A PRIORITY TO DEVELOP STRATEGIES THAT ENHANCE THE ACTIVITY OF EXISTING ANTIMICROBIAL AGENTS, AND TO IDENTIFY NEW ACTION TARGETS TO FIND NEW COMPOUNDS OF THIS TYPE. THIS WILL INCREASE THE EFFECTIVENESS AND VARIETY OF THE CURRENT AVAILABLE ARSENAL OF ANTIBACTERIALS FOR THE TREATMENT AND ERADI...) |
||||||||||||||
| Property / summary | |||||||||||||||
THE EMERGENCE OF MULTI-DRUG-RESISTANT MICROORGANISMS IS ONE OF THE GREATEST THREATS IN THE TREATMENT OF INFECTIOUS DISEASES. TO COMBAT THESE PATHOGENS, IT IS A PRIORITY TO DEVELOP STRATEGIES THAT ENHANCE THE ACTIVITY OF EXISTING ANTIMICROBIAL AGENTS, AND TO IDENTIFY NEW ACTION TARGETS TO FIND NEW COMPOUNDS OF THIS TYPE. THIS WILL INCREASE THE EFFECTIVENESS AND VARIETY OF THE CURRENT AVAILABLE ARSENAL OF ANTIBACTERIALS FOR THE TREATMENT AND ERADICATION OF THESE PATHOGENS IN HOSPITAL SETTINGS. ONE OF THESE POSSIBLE TARGETS IS CELLULAR MOTILITY, WHOSE RELEVANCE IN THE INFECTIVE PROCESS HAS BEEN WIDELY DESCRIBED. Between BACTERIAN MOTILITY TYPE DIVERSES, Swarming and Twitching, PROMOVED by FLAGELS and PILI OF TYPE IV, RESPECTIVELY, are those who have the greatest transcendence in VIRULENCE._x000D_ ANTERIAL WORKS OF OUR GROUP in SALMONELLA enterica demonstrated that the INTERACTION OF THE PROTEIN RECA (Possitious DNA Reparation System) with the PROTEIN CHEW (which INCLUDs CHEMIOTAXIS HYSTEM HYSTEM TO CHEMIOTAXIS HYSTEM), CONTROL THE Swarming MOVEMENT OF DICHA BACTERIA, by FACILITING THE CORRECTING OF Chemoreceptor COMPLEXS, WHAT WHAT IS IMPRESCINDIBLE FOR MOVEMENT DICHO. _x000D_ Acinetobacter baumannii IS A NEGATIVE GRAM BACTERY WITH A GREAT CAPACITY OF ADQUISITION OF ANTIMICROBIAN RESISTANCE, BEING RESPONSIBLE OF NOSOCOMIAL INFECTIONS that, in some cases, are intractable. THIS BACTERIA LACKS SCOURGES BUT PRESENTS PILI TYPE IV, AND CONSEQUENTLY PERFORMS TWITCHING MOVEMENT. ALTHOUGH ITS MOLECULAR BASES ARE UNKNOWN, THIS MOVEMENT HAS BEEN ASSOCIATED WITH THE COLONISATION OF BIOTIC AND ABIOTIC SURFACES AND ALSO WITH THE ONSET OF THE FORMATION OF BIOPELICULAS, WHICH ARE RESPONSIBLE FOR THEIR PERSISTENCE IN THE HOSPITAL ENVIRONMENT. PREVIOUS DATA FROM OUR GROUP SHOWED THAT THE RECA PROTEIN OF A. BAUMANNII IS INDISPENSABLE FOR THIS BACTERIUM TO BE MOVED BY TWITCHING AND ALSO INTERACTING WITH THE PRODUCT OF THE A1S_2813 GENE, WHICH ENCODES A PROTEIN APPROVED TO CHEW. In addition to and on the basis of the alternatives in the GENIC EXPRESSION that present BACTERIAAN MUTANTS RESISTENT to rifampicin or streptomycin, we isolate CLONS from A. baumannii RESISTENT TO ANTIIBIOTIC DYCHS WITH IMPORTANT ALTERATIONS IN TWITCHING._x000D_ BY ALL, the GLOBAL OBJECTIVE OF THIS PROJECT IS THE IDENTIFICATION OF NEW MOLECULAR DAYS, RELATED WITH THE Twitching MOVEMENT OF A. baumannii, SUSCEPTIBLES OF BEING THE WHITE OF FUTURES AGENTS chemotherapeutic. FOR THIS PURPOSE, THE COMPONENTS THAT CONTROL AND PARTICIPATE IN THIS MOVEMENT WILL BE IDENTIFIED AND THEIR MOLECULAR BASES, THEIR POSSIBLE RELATIONSHIP WITH THE CHEMOTAXIS SYSTEM AND THEIR IMPACT ON THE VIRULENCE OF THIS PATHOGEN WILL BE STUDIED. TO ADDRESS THIS OBJECTIVE, GENOMIC APPROACHES AND TRANSCRIPTOMICAS WILL BE USED, THE FUNCTIONAL ANALYSIS OF MUTANTS AND THEIR INVOLVEMENT IN VIRULENCE WILL BE PERFORMED, WHILE THE INTERACTION BETWEEN THE PROTEINS OF THE CHEMOTAXIS SYSTEM ASSOCIATED WITH TWITCHING MOVEMENT WILL BE MODELIZATED. LIKEWISE, TO ESTABLISH THE DEGREE OF UNIVERSALITY OF THIS MOVEMENT AND OF THE TARGETS IDENTIFIED, SEARCHES FOR THE GENES OF A. BAUMANNII IDENTIFIED IN THIS PROJECT WILL BE CARRIED OUT IN THE GENOMES OF OTHER BACTERIAL SPECIES THAT ALSO PERFORM TWITCHING MOVEMENT. (English) | |||||||||||||||
| Property / summary: THE EMERGENCE OF MULTI-DRUG-RESISTANT MICROORGANISMS IS ONE OF THE GREATEST THREATS IN THE TREATMENT OF INFECTIOUS DISEASES. TO COMBAT THESE PATHOGENS, IT IS A PRIORITY TO DEVELOP STRATEGIES THAT ENHANCE THE ACTIVITY OF EXISTING ANTIMICROBIAL AGENTS, AND TO IDENTIFY NEW ACTION TARGETS TO FIND NEW COMPOUNDS OF THIS TYPE. THIS WILL INCREASE THE EFFECTIVENESS AND VARIETY OF THE CURRENT AVAILABLE ARSENAL OF ANTIBACTERIALS FOR THE TREATMENT AND ERADICATION OF THESE PATHOGENS IN HOSPITAL SETTINGS. ONE OF THESE POSSIBLE TARGETS IS CELLULAR MOTILITY, WHOSE RELEVANCE IN THE INFECTIVE PROCESS HAS BEEN WIDELY DESCRIBED. Between BACTERIAN MOTILITY TYPE DIVERSES, Swarming and Twitching, PROMOVED by FLAGELS and PILI OF TYPE IV, RESPECTIVELY, are those who have the greatest transcendence in VIRULENCE._x000D_ ANTERIAL WORKS OF OUR GROUP in SALMONELLA enterica demonstrated that the INTERACTION OF THE PROTEIN RECA (Possitious DNA Reparation System) with the PROTEIN CHEW (which INCLUDs CHEMIOTAXIS HYSTEM HYSTEM TO CHEMIOTAXIS HYSTEM), CONTROL THE Swarming MOVEMENT OF DICHA BACTERIA, by FACILITING THE CORRECTING OF Chemoreceptor COMPLEXS, WHAT WHAT IS IMPRESCINDIBLE FOR MOVEMENT DICHO. _x000D_ Acinetobacter baumannii IS A NEGATIVE GRAM BACTERY WITH A GREAT CAPACITY OF ADQUISITION OF ANTIMICROBIAN RESISTANCE, BEING RESPONSIBLE OF NOSOCOMIAL INFECTIONS that, in some cases, are intractable. THIS BACTERIA LACKS SCOURGES BUT PRESENTS PILI TYPE IV, AND CONSEQUENTLY PERFORMS TWITCHING MOVEMENT. ALTHOUGH ITS MOLECULAR BASES ARE UNKNOWN, THIS MOVEMENT HAS BEEN ASSOCIATED WITH THE COLONISATION OF BIOTIC AND ABIOTIC SURFACES AND ALSO WITH THE ONSET OF THE FORMATION OF BIOPELICULAS, WHICH ARE RESPONSIBLE FOR THEIR PERSISTENCE IN THE HOSPITAL ENVIRONMENT. PREVIOUS DATA FROM OUR GROUP SHOWED THAT THE RECA PROTEIN OF A. BAUMANNII IS INDISPENSABLE FOR THIS BACTERIUM TO BE MOVED BY TWITCHING AND ALSO INTERACTING WITH THE PRODUCT OF THE A1S_2813 GENE, WHICH ENCODES A PROTEIN APPROVED TO CHEW. In addition to and on the basis of the alternatives in the GENIC EXPRESSION that present BACTERIAAN MUTANTS RESISTENT to rifampicin or streptomycin, we isolate CLONS from A. baumannii RESISTENT TO ANTIIBIOTIC DYCHS WITH IMPORTANT ALTERATIONS IN TWITCHING._x000D_ BY ALL, the GLOBAL OBJECTIVE OF THIS PROJECT IS THE IDENTIFICATION OF NEW MOLECULAR DAYS, RELATED WITH THE Twitching MOVEMENT OF A. baumannii, SUSCEPTIBLES OF BEING THE WHITE OF FUTURES AGENTS chemotherapeutic. FOR THIS PURPOSE, THE COMPONENTS THAT CONTROL AND PARTICIPATE IN THIS MOVEMENT WILL BE IDENTIFIED AND THEIR MOLECULAR BASES, THEIR POSSIBLE RELATIONSHIP WITH THE CHEMOTAXIS SYSTEM AND THEIR IMPACT ON THE VIRULENCE OF THIS PATHOGEN WILL BE STUDIED. TO ADDRESS THIS OBJECTIVE, GENOMIC APPROACHES AND TRANSCRIPTOMICAS WILL BE USED, THE FUNCTIONAL ANALYSIS OF MUTANTS AND THEIR INVOLVEMENT IN VIRULENCE WILL BE PERFORMED, WHILE THE INTERACTION BETWEEN THE PROTEINS OF THE CHEMOTAXIS SYSTEM ASSOCIATED WITH TWITCHING MOVEMENT WILL BE MODELIZATED. LIKEWISE, TO ESTABLISH THE DEGREE OF UNIVERSALITY OF THIS MOVEMENT AND OF THE TARGETS IDENTIFIED, SEARCHES FOR THE GENES OF A. BAUMANNII IDENTIFIED IN THIS PROJECT WILL BE CARRIED OUT IN THE GENOMES OF OTHER BACTERIAL SPECIES THAT ALSO PERFORM TWITCHING MOVEMENT. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: THE EMERGENCE OF MULTI-DRUG-RESISTANT MICROORGANISMS IS ONE OF THE GREATEST THREATS IN THE TREATMENT OF INFECTIOUS DISEASES. TO COMBAT THESE PATHOGENS, IT IS A PRIORITY TO DEVELOP STRATEGIES THAT ENHANCE THE ACTIVITY OF EXISTING ANTIMICROBIAL AGENTS, AND TO IDENTIFY NEW ACTION TARGETS TO FIND NEW COMPOUNDS OF THIS TYPE. THIS WILL INCREASE THE EFFECTIVENESS AND VARIETY OF THE CURRENT AVAILABLE ARSENAL OF ANTIBACTERIALS FOR THE TREATMENT AND ERADICATION OF THESE PATHOGENS IN HOSPITAL SETTINGS. ONE OF THESE POSSIBLE TARGETS IS CELLULAR MOTILITY, WHOSE RELEVANCE IN THE INFECTIVE PROCESS HAS BEEN WIDELY DESCRIBED. Between BACTERIAN MOTILITY TYPE DIVERSES, Swarming and Twitching, PROMOVED by FLAGELS and PILI OF TYPE IV, RESPECTIVELY, are those who have the greatest transcendence in VIRULENCE._x000D_ ANTERIAL WORKS OF OUR GROUP in SALMONELLA enterica demonstrated that the INTERACTION OF THE PROTEIN RECA (Possitious DNA Reparation System) with the PROTEIN CHEW (which INCLUDs CHEMIOTAXIS HYSTEM HYSTEM TO CHEMIOTAXIS HYSTEM), CONTROL THE Swarming MOVEMENT OF DICHA BACTERIA, by FACILITING THE CORRECTING OF Chemoreceptor COMPLEXS, WHAT WHAT IS IMPRESCINDIBLE FOR MOVEMENT DICHO. _x000D_ Acinetobacter baumannii IS A NEGATIVE GRAM BACTERY WITH A GREAT CAPACITY OF ADQUISITION OF ANTIMICROBIAN RESISTANCE, BEING RESPONSIBLE OF NOSOCOMIAL INFECTIONS that, in some cases, are intractable. THIS BACTERIA LACKS SCOURGES BUT PRESENTS PILI TYPE IV, AND CONSEQUENTLY PERFORMS TWITCHING MOVEMENT. ALTHOUGH ITS MOLECULAR BASES ARE UNKNOWN, THIS MOVEMENT HAS BEEN ASSOCIATED WITH THE COLONISATION OF BIOTIC AND ABIOTIC SURFACES AND ALSO WITH THE ONSET OF THE FORMATION OF BIOPELICULAS, WHICH ARE RESPONSIBLE FOR THEIR PERSISTENCE IN THE HOSPITAL ENVIRONMENT. PREVIOUS DATA FROM OUR GROUP SHOWED THAT THE RECA PROTEIN OF A. BAUMANNII IS INDISPENSABLE FOR THIS BACTERIUM TO BE MOVED BY TWITCHING AND ALSO INTERACTING WITH THE PRODUCT OF THE A1S_2813 GENE, WHICH ENCODES A PROTEIN APPROVED TO CHEW. In addition to and on the basis of the alternatives in the GENIC EXPRESSION that present BACTERIAAN MUTANTS RESISTENT to rifampicin or streptomycin, we isolate CLONS from A. baumannii RESISTENT TO ANTIIBIOTIC DYCHS WITH IMPORTANT ALTERATIONS IN TWITCHING._x000D_ BY ALL, the GLOBAL OBJECTIVE OF THIS PROJECT IS THE IDENTIFICATION OF NEW MOLECULAR DAYS, RELATED WITH THE Twitching MOVEMENT OF A. baumannii, SUSCEPTIBLES OF BEING THE WHITE OF FUTURES AGENTS chemotherapeutic. FOR THIS PURPOSE, THE COMPONENTS THAT CONTROL AND PARTICIPATE IN THIS MOVEMENT WILL BE IDENTIFIED AND THEIR MOLECULAR BASES, THEIR POSSIBLE RELATIONSHIP WITH THE CHEMOTAXIS SYSTEM AND THEIR IMPACT ON THE VIRULENCE OF THIS PATHOGEN WILL BE STUDIED. TO ADDRESS THIS OBJECTIVE, GENOMIC APPROACHES AND TRANSCRIPTOMICAS WILL BE USED, THE FUNCTIONAL ANALYSIS OF MUTANTS AND THEIR INVOLVEMENT IN VIRULENCE WILL BE PERFORMED, WHILE THE INTERACTION BETWEEN THE PROTEINS OF THE CHEMOTAXIS SYSTEM ASSOCIATED WITH TWITCHING MOVEMENT WILL BE MODELIZATED. LIKEWISE, TO ESTABLISH THE DEGREE OF UNIVERSALITY OF THIS MOVEMENT AND OF THE TARGETS IDENTIFIED, SEARCHES FOR THE GENES OF A. BAUMANNII IDENTIFIED IN THIS PROJECT WILL BE CARRIED OUT IN THE GENOMES OF OTHER BACTERIAL SPECIES THAT ALSO PERFORM TWITCHING MOVEMENT. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
| |||||||||||||||
Revision as of 23:41, 12 October 2021
Project Q3192265 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3192265 in Spain |
Statements
84,700.0 Euro
0 references
169,400.0 Euro
0 references
50.0 percent
0 references
30 December 2016
0 references
29 December 2020
0 references
UNIVERSIDAD AUTONOMA DE BARCELONA
0 references
41°29'27.71"N, 2°8'15.00"E
0 references
08266
0 references
LA EMERGENCIA DE MICROORGANISMOS MULTIRRESISTENTES ES UNA DE LAS MAYORES AMENAZAS DEL TRATAMIENTO DE LAS ENFERMEDADES INFECCIOSAS. PARA LUCHAR CONTRA ESTOS PATOGENOS RESULTA PRIORITARIO DESARROLLAR ESTRATEGIAS QUE POTENCIEN LA ACTIVIDAD DE LOS AGENTES ANTIMICROBIANOS EXISTENTES, E IDENTIFICAR NUEVAS DIANAS DE ACCION PARA ENCONTRAR NUEVOS COMPUESTOS DE ESTE TIPO. ELLO INCREMENTARA LA EFICACIA Y LA VARIEDAD DEL ACTUAL ARSENAL DISPONIBLE DE ANTIBACTERIANOS PARA EL TRATAMIENTO Y LA ERRADICACION DE DICHOS PATOGENOS EN AMBIENTES HOSPITALARIOS. UNA DE ESTAS POSIBLES DIANAS ES LA MOTILIDAD CELULAR, CUYA RELEVANCIA EN EL PROCESO INFECTIVO HA SIDO AMPLIAMENTE DESCRITA. ENTRE LOS DIVERSOS TIPOS DE MOTILIDAD BACTERIANA, EL MOVIMIENTO EN ENJAMBRE (SWARMING) Y EL DE EXTENSION-RETRACCION (TWITCHING), PROMOVIDOS POR FLAGELOS Y PILI DEL TIPO IV, RESPECTIVAMENTE, SON LOS QUE TIENEN MAYOR TRANSCENDENCIA EN VIRULENCIA._x000D_ ANTERIORES TRABAJOS DE NUESTRO GRUPO EN SALMONELLA ENTERICA DEMOSTRARON QUE LA INTERACCION DE LA PROTEINA RECA (REGULADOR POSITIVO DEL SISTEMA DE REPARACION SOS DEL DNA) CON LA PROTEINA CHEW (QUE ANCLA LA HISTIDINA QUINASA DEL SISTEMA DE QUIMIOTAXIS A LOS QUIMIORRECEPTORES), CONTROLA EL MOVIMIENTO SWARMING DE DICHA BACTERIA, FACILITANDO EL CORRECTO ENSAMBLAJE DE LOS COMPLEJOS DE QUIMIORRECEPTORES, LO CUAL ES IMPRESCINDIBLE PARA DICHO MOVIMIENTO. _x000D_ ACINETOBACTER BAUMANNII ES UNA BACTERIA GRAM NEGATIVA CON UNA GRAN CAPACIDAD DE ADQUISICION DE RESISTENCIAS A ANTIMICROBIANOS, SIENDO RESPONSABLE DE INFECCIONES NOSOCOMIALES QUE, EN ALGUNOS CASOS, RESULTAN INTRATABLES. ESTA BACTERIA CARECE DE FLAGELOS PERO PRESENTA PILI DEL TIPO IV, Y CONSECUENTEMENTE, REALIZA MOVIMIENTO TWITCHING. AUNQUE SE DESCONOCEN SUS BASES MOLECULARES, ESTE MOVIMIENTO SE HA ASOCIADO CON LA COLONIZACION DE SUPERFICIES BIOTICAS Y ABIOTICAS Y TAMBIEN CON EL INICIO DE LA FORMACION DE BIOPELICULAS, LAS CUALES SON RESPONSABLES DE SU PERSISTENCIA EN EL ENTORNO HOSPITALARIO. DATOS PREVIOS DE NUESTRO GRUPO MOSTRARON QUE LA PROTEINA RECA DE A. BAUMANNII ES INDISPENSABLE PARA QUE DICHA BACTERIA PUEDA DESPLAZARSE POR TWITCHING Y TAMBIEN QUE INTERACCIONA CON EL PRODUCTO DEL GEN A1S_2813, QUE CODIFICA UNA PROTEINA HOMOLOGA A CHEW. ADEMAS Y EN BASE A LAS ALTERACIONES EN LA EXPRESION GENICA QUE PRESENTAN MUTANTES BACTERIANOS RESISTENTES A RIFAMPICINA O A ESTREPTOMICINA, AISLAMOS CLONES DE A. BAUMANNII RESISTENTES A DICHOS ANTIBIOTICOS CON ALTERACIONES IMPORTANTES EN TWITCHING._x000D_ POR TODO ELLO, EL OBJETIVO GLOBAL DE ESTE PROYECTO ES LA IDENTIFICACION DE POSIBLES NUEVAS DIANAS MOLECULARES, RELACIONADAS CON EL MOVIMIENTO TWITCHING DE A. BAUMANNII, SUSCEPTIBLES DE SER EL BLANCO DE FUTUROS AGENTES QUIMIOTERAPEUTICOS. PARA ELLO, SE IDENTIFICARAN LOS COMPONENTES QUE CONTROLAN Y PARTICIPAN EN ESTE MOVIMIENTO Y SE ESTUDIARAN SUS BASES MOLECULARES, SU POSIBLE RELACION CON EL SISTEMA DE QUIMIOTAXIS Y SU IMPACTO EN LA VIRULENCIA DE ESTE PATOGENO. PARA ABORDAR ESTE OBJETIVO SE USARAN APROXIMACIONES GENOMICAS Y TRANSCRIPTOMICAS, SE REALIZARA EL ANALISIS FUNCIONAL DE MUTANTES Y SU IMPLICACION EN LA VIRULENCIA, A LA VEZ QUE SE MODELIZARA LA INTERACCION ENTRE LAS PROTEINAS DEL SISTEMA DE QUIMIOTAXIS ASOCIADAS AL MOVIMIENTO TWITCHING. ASIMISMO, PARA ESTABLECER EL GRADO DE UNIVERSALIDAD DE ESTE MOVIMIENTO Y DE LAS DIANAS QUE SE IDENTIFIQUEN, SE REALIZARAN BUSQUEDAS DE LOS GENES DE A. BAUMANNII IDENTIFICADOS EN ESTE PROYECTO EN LOS GENOMAS DE OTRAS ESPECIES BACTERIANAS QUE TAMBIEN REALICEN MOVIMIENTO TWITCHING. (Spanish)
0 references
THE EMERGENCE OF MULTI-DRUG-RESISTANT MICROORGANISMS IS ONE OF THE GREATEST THREATS IN THE TREATMENT OF INFECTIOUS DISEASES. TO COMBAT THESE PATHOGENS, IT IS A PRIORITY TO DEVELOP STRATEGIES THAT ENHANCE THE ACTIVITY OF EXISTING ANTIMICROBIAL AGENTS, AND TO IDENTIFY NEW ACTION TARGETS TO FIND NEW COMPOUNDS OF THIS TYPE. THIS WILL INCREASE THE EFFECTIVENESS AND VARIETY OF THE CURRENT AVAILABLE ARSENAL OF ANTIBACTERIALS FOR THE TREATMENT AND ERADICATION OF THESE PATHOGENS IN HOSPITAL SETTINGS. ONE OF THESE POSSIBLE TARGETS IS CELLULAR MOTILITY, WHOSE RELEVANCE IN THE INFECTIVE PROCESS HAS BEEN WIDELY DESCRIBED. Between BACTERIAN MOTILITY TYPE DIVERSES, Swarming and Twitching, PROMOVED by FLAGELS and PILI OF TYPE IV, RESPECTIVELY, are those who have the greatest transcendence in VIRULENCE._x000D_ ANTERIAL WORKS OF OUR GROUP in SALMONELLA enterica demonstrated that the INTERACTION OF THE PROTEIN RECA (Possitious DNA Reparation System) with the PROTEIN CHEW (which INCLUDs CHEMIOTAXIS HYSTEM HYSTEM TO CHEMIOTAXIS HYSTEM), CONTROL THE Swarming MOVEMENT OF DICHA BACTERIA, by FACILITING THE CORRECTING OF Chemoreceptor COMPLEXS, WHAT WHAT IS IMPRESCINDIBLE FOR MOVEMENT DICHO. _x000D_ Acinetobacter baumannii IS A NEGATIVE GRAM BACTERY WITH A GREAT CAPACITY OF ADQUISITION OF ANTIMICROBIAN RESISTANCE, BEING RESPONSIBLE OF NOSOCOMIAL INFECTIONS that, in some cases, are intractable. THIS BACTERIA LACKS SCOURGES BUT PRESENTS PILI TYPE IV, AND CONSEQUENTLY PERFORMS TWITCHING MOVEMENT. ALTHOUGH ITS MOLECULAR BASES ARE UNKNOWN, THIS MOVEMENT HAS BEEN ASSOCIATED WITH THE COLONISATION OF BIOTIC AND ABIOTIC SURFACES AND ALSO WITH THE ONSET OF THE FORMATION OF BIOPELICULAS, WHICH ARE RESPONSIBLE FOR THEIR PERSISTENCE IN THE HOSPITAL ENVIRONMENT. PREVIOUS DATA FROM OUR GROUP SHOWED THAT THE RECA PROTEIN OF A. BAUMANNII IS INDISPENSABLE FOR THIS BACTERIUM TO BE MOVED BY TWITCHING AND ALSO INTERACTING WITH THE PRODUCT OF THE A1S_2813 GENE, WHICH ENCODES A PROTEIN APPROVED TO CHEW. In addition to and on the basis of the alternatives in the GENIC EXPRESSION that present BACTERIAAN MUTANTS RESISTENT to rifampicin or streptomycin, we isolate CLONS from A. baumannii RESISTENT TO ANTIIBIOTIC DYCHS WITH IMPORTANT ALTERATIONS IN TWITCHING._x000D_ BY ALL, the GLOBAL OBJECTIVE OF THIS PROJECT IS THE IDENTIFICATION OF NEW MOLECULAR DAYS, RELATED WITH THE Twitching MOVEMENT OF A. baumannii, SUSCEPTIBLES OF BEING THE WHITE OF FUTURES AGENTS chemotherapeutic. FOR THIS PURPOSE, THE COMPONENTS THAT CONTROL AND PARTICIPATE IN THIS MOVEMENT WILL BE IDENTIFIED AND THEIR MOLECULAR BASES, THEIR POSSIBLE RELATIONSHIP WITH THE CHEMOTAXIS SYSTEM AND THEIR IMPACT ON THE VIRULENCE OF THIS PATHOGEN WILL BE STUDIED. TO ADDRESS THIS OBJECTIVE, GENOMIC APPROACHES AND TRANSCRIPTOMICAS WILL BE USED, THE FUNCTIONAL ANALYSIS OF MUTANTS AND THEIR INVOLVEMENT IN VIRULENCE WILL BE PERFORMED, WHILE THE INTERACTION BETWEEN THE PROTEINS OF THE CHEMOTAXIS SYSTEM ASSOCIATED WITH TWITCHING MOVEMENT WILL BE MODELIZATED. LIKEWISE, TO ESTABLISH THE DEGREE OF UNIVERSALITY OF THIS MOVEMENT AND OF THE TARGETS IDENTIFIED, SEARCHES FOR THE GENES OF A. BAUMANNII IDENTIFIED IN THIS PROJECT WILL BE CARRIED OUT IN THE GENOMES OF OTHER BACTERIAL SPECIES THAT ALSO PERFORM TWITCHING MOVEMENT. (English)
13 October 2021
0 references
Cerdanyola del Vallès
0 references
Identifiers
BIO2016-77011-R
0 references