Q3181558 (Q3181558): Difference between revisions
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(Created claim: summary (P836): TYPE 2 DIABETES (DT2) AND OBESITY ARE VERY STRONGLY ASSOCIATED AND ARE A MAJOR HEALTH PROBLEM DUE TO THEIR ALARMINGLY INCREASING PREVALENCE WORLDWIDE. DESPITE THEIR CLINICAL IMPORTANCE, THERE ARE NO EFFECTIVE TREATMENTS AND, IN ADDITION, ANTI-OBESITY PHARMACOS OFTEN HAVE IMPORTANT SIDE EFFECTS DUE TO THEIR ACTIONS AT A SYSTEMIC LEVEL. THUS, NEW AND SAFE APPROACHES ARE NEEDED TO PREVENT AND TREAT THE CURRENT EPIDEMIC OF DT2-OBESITY. OBESITY IS LA...) |
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TYPE 2 DIABETES (DT2) AND OBESITY ARE VERY STRONGLY ASSOCIATED AND ARE A MAJOR HEALTH PROBLEM DUE TO THEIR ALARMINGLY INCREASING PREVALENCE WORLDWIDE. DESPITE THEIR CLINICAL IMPORTANCE, THERE ARE NO EFFECTIVE TREATMENTS AND, IN ADDITION, ANTI-OBESITY PHARMACOS OFTEN HAVE IMPORTANT SIDE EFFECTS DUE TO THEIR ACTIONS AT A SYSTEMIC LEVEL. THUS, NEW AND SAFE APPROACHES ARE NEEDED TO PREVENT AND TREAT THE CURRENT EPIDEMIC OF DT2-OBESITY. OBESITY IS LARGELY DUE TO AN IMBALANCE BETWEEN CONSUMPTION AND ENERGY SPENDING. Therefore, THE DEVELOPMENT OF NEW TERAPEUTIC STRATEGIES INCLUDING the metabolic tax as the INDUCTION OF THE TERMOGENESIS NOT ASSOCIED TO THE MEMBERS FOR THE BROWNING OF THE WAT (WAT) or THE ACTIVATION OF THE ADIPOSO MARRON TEJID (BAT) POTENTIAL FOR THE FUTURE TREATMENT OF OBESITY AND DT2._x000D_ THIS PROJECT PROPOSES TO EVALUATE THE TORENTIAL POTENTIAL FOR DT2 AND OBESITY OF NEW approaches BASED IN THE GENIC TRANSFER TO LIVE MEDIENT VIRAL VECTORS Adenoassociates (AAV) of potential INDUCTORS OF BAT and BROWNING BAT decoupling ACTIVITY PREVENTIFICED: DECOUPLER PROTEIN 1 (UCP1), BONE MORFOGENIC FACTOR 7 (BMP7), FIBROBLAST GROWTH FACTOR 21 (FGF21) AND VENTRICULAR NATRIURETIC PEPTIDE (BNP). IN ADDITION, WITH THE AIM OF IDENTIFYING NEW CANDIDATE FACTORS CAPABLE OF INDUCING WAT BROWNING, ACTIVATING BAT AND/OR IMPROVING GLUCOSE METABOLISM AND TO DEEPEN KNOWLEDGE ABOUT INTERCOMMUNICATION BETWEEN METABOLIC TISSUES INVOLVED IN THESE PROCESSES, THIS PROJECT ALSO PROPOSES TO CARRY OUT AN EXHAUSTIVE TRANSCRIPTOMIC ANALYSIS OF THE EXPRESSION PROFILES OF MRNA, MIRNA AND LNCRNA OF THE WHITE AND BROWN ADIPOSE DEPOSITS AS WELL AS THE LIVER, HEART AND SKELETAL MUSCLE OF COLD-EXPOSED MICE. Following its bioinformatic analysis, THAT 20 FACTORS THAT SUBMITEST RESULTS IN THE BIOINITAL ANALISIS OF THE NUMEROSES ANALISIS bioinformatics will be selected and their capacity to improve the ENERGETIC METABOLISM and GLUCOSE MEDIANING THE TRANSFER TO THE ADIPOSE TRANSFER IN LIVE, harmed, HEART OR SQUELETIC MUSCLE BY VECTORS AAV._x000D_ RESULTS OF THIS STUDY will provide NEW KNOWING ON THE MOLECULAR MECHANISM INVOLUCRED IN THE BROWNING PROCESS AND INTERCOMMUNICATION BETWEEN TEJED METABOLICS KEY AWARD TO ASSESS TO COMPRENDER improving the pathophysiology of OBESITY AND DIABETES AND FACILITING THE DEVELOPMENT OF FUTURES TREATMENTS FOR THESE DISEASES IN HUMANs. (English) | |||||||||||||||
| Property / summary: TYPE 2 DIABETES (DT2) AND OBESITY ARE VERY STRONGLY ASSOCIATED AND ARE A MAJOR HEALTH PROBLEM DUE TO THEIR ALARMINGLY INCREASING PREVALENCE WORLDWIDE. DESPITE THEIR CLINICAL IMPORTANCE, THERE ARE NO EFFECTIVE TREATMENTS AND, IN ADDITION, ANTI-OBESITY PHARMACOS OFTEN HAVE IMPORTANT SIDE EFFECTS DUE TO THEIR ACTIONS AT A SYSTEMIC LEVEL. THUS, NEW AND SAFE APPROACHES ARE NEEDED TO PREVENT AND TREAT THE CURRENT EPIDEMIC OF DT2-OBESITY. OBESITY IS LARGELY DUE TO AN IMBALANCE BETWEEN CONSUMPTION AND ENERGY SPENDING. Therefore, THE DEVELOPMENT OF NEW TERAPEUTIC STRATEGIES INCLUDING the metabolic tax as the INDUCTION OF THE TERMOGENESIS NOT ASSOCIED TO THE MEMBERS FOR THE BROWNING OF THE WAT (WAT) or THE ACTIVATION OF THE ADIPOSO MARRON TEJID (BAT) POTENTIAL FOR THE FUTURE TREATMENT OF OBESITY AND DT2._x000D_ THIS PROJECT PROPOSES TO EVALUATE THE TORENTIAL POTENTIAL FOR DT2 AND OBESITY OF NEW approaches BASED IN THE GENIC TRANSFER TO LIVE MEDIENT VIRAL VECTORS Adenoassociates (AAV) of potential INDUCTORS OF BAT and BROWNING BAT decoupling ACTIVITY PREVENTIFICED: DECOUPLER PROTEIN 1 (UCP1), BONE MORFOGENIC FACTOR 7 (BMP7), FIBROBLAST GROWTH FACTOR 21 (FGF21) AND VENTRICULAR NATRIURETIC PEPTIDE (BNP). IN ADDITION, WITH THE AIM OF IDENTIFYING NEW CANDIDATE FACTORS CAPABLE OF INDUCING WAT BROWNING, ACTIVATING BAT AND/OR IMPROVING GLUCOSE METABOLISM AND TO DEEPEN KNOWLEDGE ABOUT INTERCOMMUNICATION BETWEEN METABOLIC TISSUES INVOLVED IN THESE PROCESSES, THIS PROJECT ALSO PROPOSES TO CARRY OUT AN EXHAUSTIVE TRANSCRIPTOMIC ANALYSIS OF THE EXPRESSION PROFILES OF MRNA, MIRNA AND LNCRNA OF THE WHITE AND BROWN ADIPOSE DEPOSITS AS WELL AS THE LIVER, HEART AND SKELETAL MUSCLE OF COLD-EXPOSED MICE. Following its bioinformatic analysis, THAT 20 FACTORS THAT SUBMITEST RESULTS IN THE BIOINITAL ANALISIS OF THE NUMEROSES ANALISIS bioinformatics will be selected and their capacity to improve the ENERGETIC METABOLISM and GLUCOSE MEDIANING THE TRANSFER TO THE ADIPOSE TRANSFER IN LIVE, harmed, HEART OR SQUELETIC MUSCLE BY VECTORS AAV._x000D_ RESULTS OF THIS STUDY will provide NEW KNOWING ON THE MOLECULAR MECHANISM INVOLUCRED IN THE BROWNING PROCESS AND INTERCOMMUNICATION BETWEEN TEJED METABOLICS KEY AWARD TO ASSESS TO COMPRENDER improving the pathophysiology of OBESITY AND DIABETES AND FACILITING THE DEVELOPMENT OF FUTURES TREATMENTS FOR THESE DISEASES IN HUMANs. (English) / rank | |||||||||||||||
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| Property / summary: TYPE 2 DIABETES (DT2) AND OBESITY ARE VERY STRONGLY ASSOCIATED AND ARE A MAJOR HEALTH PROBLEM DUE TO THEIR ALARMINGLY INCREASING PREVALENCE WORLDWIDE. DESPITE THEIR CLINICAL IMPORTANCE, THERE ARE NO EFFECTIVE TREATMENTS AND, IN ADDITION, ANTI-OBESITY PHARMACOS OFTEN HAVE IMPORTANT SIDE EFFECTS DUE TO THEIR ACTIONS AT A SYSTEMIC LEVEL. THUS, NEW AND SAFE APPROACHES ARE NEEDED TO PREVENT AND TREAT THE CURRENT EPIDEMIC OF DT2-OBESITY. OBESITY IS LARGELY DUE TO AN IMBALANCE BETWEEN CONSUMPTION AND ENERGY SPENDING. Therefore, THE DEVELOPMENT OF NEW TERAPEUTIC STRATEGIES INCLUDING the metabolic tax as the INDUCTION OF THE TERMOGENESIS NOT ASSOCIED TO THE MEMBERS FOR THE BROWNING OF THE WAT (WAT) or THE ACTIVATION OF THE ADIPOSO MARRON TEJID (BAT) POTENTIAL FOR THE FUTURE TREATMENT OF OBESITY AND DT2._x000D_ THIS PROJECT PROPOSES TO EVALUATE THE TORENTIAL POTENTIAL FOR DT2 AND OBESITY OF NEW approaches BASED IN THE GENIC TRANSFER TO LIVE MEDIENT VIRAL VECTORS Adenoassociates (AAV) of potential INDUCTORS OF BAT and BROWNING BAT decoupling ACTIVITY PREVENTIFICED: DECOUPLER PROTEIN 1 (UCP1), BONE MORFOGENIC FACTOR 7 (BMP7), FIBROBLAST GROWTH FACTOR 21 (FGF21) AND VENTRICULAR NATRIURETIC PEPTIDE (BNP). IN ADDITION, WITH THE AIM OF IDENTIFYING NEW CANDIDATE FACTORS CAPABLE OF INDUCING WAT BROWNING, ACTIVATING BAT AND/OR IMPROVING GLUCOSE METABOLISM AND TO DEEPEN KNOWLEDGE ABOUT INTERCOMMUNICATION BETWEEN METABOLIC TISSUES INVOLVED IN THESE PROCESSES, THIS PROJECT ALSO PROPOSES TO CARRY OUT AN EXHAUSTIVE TRANSCRIPTOMIC ANALYSIS OF THE EXPRESSION PROFILES OF MRNA, MIRNA AND LNCRNA OF THE WHITE AND BROWN ADIPOSE DEPOSITS AS WELL AS THE LIVER, HEART AND SKELETAL MUSCLE OF COLD-EXPOSED MICE. Following its bioinformatic analysis, THAT 20 FACTORS THAT SUBMITEST RESULTS IN THE BIOINITAL ANALISIS OF THE NUMEROSES ANALISIS bioinformatics will be selected and their capacity to improve the ENERGETIC METABOLISM and GLUCOSE MEDIANING THE TRANSFER TO THE ADIPOSE TRANSFER IN LIVE, harmed, HEART OR SQUELETIC MUSCLE BY VECTORS AAV._x000D_ RESULTS OF THIS STUDY will provide NEW KNOWING ON THE MOLECULAR MECHANISM INVOLUCRED IN THE BROWNING PROCESS AND INTERCOMMUNICATION BETWEEN TEJED METABOLICS KEY AWARD TO ASSESS TO COMPRENDER improving the pathophysiology of OBESITY AND DIABETES AND FACILITING THE DEVELOPMENT OF FUTURES TREATMENTS FOR THESE DISEASES IN HUMANs. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 20:37, 12 October 2021
Project Q3181558 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3181558 in Spain |
Statements
266,200.0 Euro
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532,400.0 Euro
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50.0 percent
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1 January 2015
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31 December 2017
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UNIVERSIDAD AUTONOMA DE BARCELONA
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42°13'24.28"N, 1°53'31.70"E
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08903
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LA DIABETES TIPO 2 (DT2) Y LA OBESIDAD ESTAN MUY FUERTEMENTE ASOCIADAS Y SON UN IMPORTANTE PROBLEMA DE SALUD DEBIDO A SU ALARMANTEMENTE CRECIENTE PREVALENCIA A NIVEL MUNDIAL. A PESAR DE SU IMPORTANCIA CLINICA, NO EXISTEN TRATAMIENTOS EFECTIVOS Y, ADEMAS, LOS FARMACOS ANTI-OBESIDAD FRECUENTEMENTE PRESENTAN IMPORTANTES EFECTOS SECUNDARIOS POR SUS ACCIONES A NIVEL SISTEMICO. ASI, SE NECESITAN APROXIMACIONES NUEVAS Y SEGURAS PARA PREVENIR Y TRATAR LA ACTUAL EPIDEMIA DE DT2-OBESIDAD. LA OBESIDAD SE DEBE EN GRAN MEDIDA A UN DESEQUILIBRIO ENTRE EL CONSUMO Y EL GASTO ENERGETICO. POR LO TANTO, EL DESARROLLO DE NUEVAS ESTRATEGIAS TERAPEUTICAS ENFOCADAS A INCREMENTAR LA TASA METABOLICA TALES COMO LA INDUCCION DE LA TERMOGENESIS NO ASOCIADA A TEMBLOR MEDIANTE EL BROWNING DEL TEJIDO ADIPOSO BLANCO (WAT) O LA ACTIVACION DEL TEJIDO ADIPOSO MARRON (BAT) PRESENTARIAN UN GRAN POTENCIAL PARA EL FUTURO TRATAMIENTO DE LA OBESIDAD Y LA DT2._x000D_ ESTE PROYECTO PROPONE EVALUAR EL POTENCIAL TERAPEUTICO PARA LA DT2 Y LA OBESIDAD DE NUEVAS APROXIMACIONES BASADAS EN LA TRANSFERENCIA GENICA A TEJIDO ADIPOSO IN VIVO MEDIANTE VECTORES VIRALES ADENOASOCIADOS (AAV) DE POTENTES INDUCTORES DE LA ACTIVIDAD DESACOPLADORA DEL BAT Y BROWNING DEL WAT PREVIAMENTE IDENTIFICADOS: PROTEINA DESACOPLADORA 1 (UCP1), FACTOR MORFOGENICO DEL HUESO 7 (BMP7), FACTOR DE CRECIMIENTO DEL FIBROBLASTO 21 (FGF21) Y PEPTIDO NATRIURETICO VENTRICULAR (BNP). ADEMAS, CON EL OBJETIVO DE IDENTIFICAR NUEVOS FACTORES CANDIDATOS CAPACES DE INDUCIR EL BROWNING DEL WAT, LA ACTIVACION DEL BAT Y/O LA MEJORA DEL METABOLISMO DE LA GLUCOSA Y PARA AHONDAR EN EL CONOCIMIENTO SOBRE LA INTERCOMUNICACION ENTRE TEJIDOS METABOLICOS INVOLUCRADOS EN ESTOS PROCESOS, ESTE PROYECTO TAMBIEN PROPONE REALIZAR UN EXHAUSTIVO ANALISIS TRANSCRIPTOMICO DE LOS PERFILES DE EXPRESION DE MRNA, MIRNA Y LNCRNA DE LOS DEPOSITOS ADIPOSOS BLANCOS Y MARRONES ASI COMO DEL HIGADO, CORAZON Y MUSCULO ESQUELETICO DE RATONES EXPUESTOS AL FRIO. TRAS SU ANALISIS BIOINFORMATICO, AQUELLOS 20 FACTORES QUE PRESENTEN LOS RESULTADOS MAS ROBUSTOS TRAS LOS NUMEROSOS ANALISIS BIOINFORMATICOS, SERAN SELECCIONADOS Y SE EVALUARA IN VIVO SU HABILIDAD PARA MEJORAR EL METABOLISMO ENERGETICO Y DE LA GLUCOSA MEDIANTE SU TRANSFERENCIA AL TEJIDO ADIPOSO, HIGADO, CORAZON O MUSCULO ESQUELETICO POR MEDIO DE VECTORES AAV._x000D_ LOS RESULTADOS DE ESTE ESTUDIO PROVEERAN NUEVO CONOCIMIENTO SOBRE LOS MECANISMOS MOLECULARES INVOLUCRADOS EN EL PROCESO DE BROWNING Y LA INTERCOMUNICACION ENTRE TEJIDOS METABOLICOS CLAVE AYUDANDO ASI A COMPRENDER MEJOR LA FISIOPATOLOGIA DE LA OBESIDAD Y LA DIABETES Y FACILITANDO EL DESARROLLO DE FUTUROS TRATAMIENTOS PARA ESTAS ENFERMEDADES EN HUMANOS. (Spanish)
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TYPE 2 DIABETES (DT2) AND OBESITY ARE VERY STRONGLY ASSOCIATED AND ARE A MAJOR HEALTH PROBLEM DUE TO THEIR ALARMINGLY INCREASING PREVALENCE WORLDWIDE. DESPITE THEIR CLINICAL IMPORTANCE, THERE ARE NO EFFECTIVE TREATMENTS AND, IN ADDITION, ANTI-OBESITY PHARMACOS OFTEN HAVE IMPORTANT SIDE EFFECTS DUE TO THEIR ACTIONS AT A SYSTEMIC LEVEL. THUS, NEW AND SAFE APPROACHES ARE NEEDED TO PREVENT AND TREAT THE CURRENT EPIDEMIC OF DT2-OBESITY. OBESITY IS LARGELY DUE TO AN IMBALANCE BETWEEN CONSUMPTION AND ENERGY SPENDING. Therefore, THE DEVELOPMENT OF NEW TERAPEUTIC STRATEGIES INCLUDING the metabolic tax as the INDUCTION OF THE TERMOGENESIS NOT ASSOCIED TO THE MEMBERS FOR THE BROWNING OF THE WAT (WAT) or THE ACTIVATION OF THE ADIPOSO MARRON TEJID (BAT) POTENTIAL FOR THE FUTURE TREATMENT OF OBESITY AND DT2._x000D_ THIS PROJECT PROPOSES TO EVALUATE THE TORENTIAL POTENTIAL FOR DT2 AND OBESITY OF NEW approaches BASED IN THE GENIC TRANSFER TO LIVE MEDIENT VIRAL VECTORS Adenoassociates (AAV) of potential INDUCTORS OF BAT and BROWNING BAT decoupling ACTIVITY PREVENTIFICED: DECOUPLER PROTEIN 1 (UCP1), BONE MORFOGENIC FACTOR 7 (BMP7), FIBROBLAST GROWTH FACTOR 21 (FGF21) AND VENTRICULAR NATRIURETIC PEPTIDE (BNP). IN ADDITION, WITH THE AIM OF IDENTIFYING NEW CANDIDATE FACTORS CAPABLE OF INDUCING WAT BROWNING, ACTIVATING BAT AND/OR IMPROVING GLUCOSE METABOLISM AND TO DEEPEN KNOWLEDGE ABOUT INTERCOMMUNICATION BETWEEN METABOLIC TISSUES INVOLVED IN THESE PROCESSES, THIS PROJECT ALSO PROPOSES TO CARRY OUT AN EXHAUSTIVE TRANSCRIPTOMIC ANALYSIS OF THE EXPRESSION PROFILES OF MRNA, MIRNA AND LNCRNA OF THE WHITE AND BROWN ADIPOSE DEPOSITS AS WELL AS THE LIVER, HEART AND SKELETAL MUSCLE OF COLD-EXPOSED MICE. Following its bioinformatic analysis, THAT 20 FACTORS THAT SUBMITEST RESULTS IN THE BIOINITAL ANALISIS OF THE NUMEROSES ANALISIS bioinformatics will be selected and their capacity to improve the ENERGETIC METABOLISM and GLUCOSE MEDIANING THE TRANSFER TO THE ADIPOSE TRANSFER IN LIVE, harmed, HEART OR SQUELETIC MUSCLE BY VECTORS AAV._x000D_ RESULTS OF THIS STUDY will provide NEW KNOWING ON THE MOLECULAR MECHANISM INVOLUCRED IN THE BROWNING PROCESS AND INTERCOMMUNICATION BETWEEN TEJED METABOLICS KEY AWARD TO ASSESS TO COMPRENDER improving the pathophysiology of OBESITY AND DIABETES AND FACILITING THE DEVELOPMENT OF FUTURES TREATMENTS FOR THESE DISEASES IN HUMANs. (English)
12 October 2021
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Sant Julià de Cerdanyola
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Identifiers
SAF2014-54866-R
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