Q3156570 (Q3156570): Difference between revisions
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(Created claim: summary (P836): THE MAIN OBJECTIVE OF CHROMYIELD IS TO DEEPEN KNOWLEDGE OF THE MECHANISMS THAT REGULATE THE CONTROL OF THE START OF FLOWERING, A DEVELOPMENT PROCESS WITH A DIRECT IMPACT ON CROP YIELDS. FLOWERING TIME IS ONE OF THE MAJOR DETERMINANTS OF THE PRODUCTION OF SEEDS AND FRUITS; IN FACT AN INAPPROPRIATE FLOWERING TIME HAS AS A DIRECT CONSEQUENCE A REDUCTION IN PRODUCTIVITY. SEVERAL RESEARCH GROUPS, INCLUDING OURS, HAVE CONTRIBUTED TO UNVEILING THE COMP...) |
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THE MAIN OBJECTIVE OF CHROMYIELD IS TO DEEPEN KNOWLEDGE OF THE MECHANISMS THAT REGULATE THE CONTROL OF THE START OF FLOWERING, A DEVELOPMENT PROCESS WITH A DIRECT IMPACT ON CROP YIELDS. FLOWERING TIME IS ONE OF THE MAJOR DETERMINANTS OF THE PRODUCTION OF SEEDS AND FRUITS; IN FACT AN INAPPROPRIATE FLOWERING TIME HAS AS A DIRECT CONSEQUENCE A REDUCTION IN PRODUCTIVITY. SEVERAL RESEARCH GROUPS, INCLUDING OURS, HAVE CONTRIBUTED TO UNVEILING THE COMPLEX GENIC NETWORK THAT PRECISELY REGULATES FLOWERING TIME IN RESPONSE TO INTERNAL AND ENVIRONMENTAL SIGNALS. AMONG THESE REGULATORY MECHANISMS, CHROMATIN REMODELING PROCESSES PLAY A CENTRAL ROLE IN ESTABLISHING THE GENIC EXPRESSION PATTERNS THAT REGULATE THE FLORAL TRANSITION. _x000D_ one OF THE MORE IMPORTANT RETIES TO THE AGRICULTURE IN THE UPDATE IS to GUARANTEE FOOD SECURITY. IMPROVING THE STABILITY AND SUSTAINABILITY OF AGRICULTURAL PRODUCTION REQUIRES INNOVATIVE MECHANISMS THAT ALLOW US TO OBTAIN GREATER VARIABILITY IN AGRONOMIC CHARACTERISTICS OF INTEREST. IN THIS CONTEXT, EPIGENETIC PROCESSES HAVE BEEN PROPOSED AS A NEW STRATEGY FOR CROP IMPROVEMENT. TO BE ABLE TO EXPLOIT THESE MECHANISMS EFFICIENTLY, AN IN-DEPTH KNOWLEDGE OF THE CHROMATIN-MEDIATED REGULATION OF THE AGRONOMIC CHARACTERISTICS ASSOCIATED WITH PRODUCTIVITY IS NECESSARY. FOR THIS REASON, AND IN ORDER TO ADDRESS THE STUDY OF THE ROLE OF THE ORGANISATION OF CHROMATIN IN THE MODULATION OF FLOWERING TIME AND HOW IT INFLUENCES THE PRODUCTIVITY OF CROPS, CHROMYIELD PROPOSES THE USE OF A COMBINATION OF GENETIC, BIOCHEMICAL, MOLECULAR AND GENOMIC APPROACHES FOCUSED ON THE ANALYSIS OF THE PARTICIPATION OF THE ACCETILACION OF HISTONES IN THE CONTROL OF THIS DEVELOPMENT PROCESS. SPECIFICALLY, WE PROPOSE TO ANALYSE THE PARTICIPATION OF THE HISTONE ACETYL TRANSFERASE COMPLEX NUA4 AND IN PARTICULAR ONE OF ITS MOST REPRESENTATIVE SUBUNITS, EPL, IN THE CONTROL OF THE FLORAL TRANSITION. TO DO THIS, WE WILL DISSECT THE GENETIC PATHWAYS THAT MEDIATE THE FUNCTION OF THE EPL GENES AND HOW THEY CONTROL THE GENIC EXPRESSION DURING THE FLORAL TRANSITION. ON THE OTHER HAND, WE WILL UNVEIL THE MOLECULAR MECHANISMS THAT MEDIATE THE ROLE OF THESE PROTEINS BY IDENTIFYING THE PROTEIN COMPLEXES WHERE THEY ARE PRESENT AS WELL AS THE GENICAS NETWORKS THAT CONTROL IN THE FLORAL TRANSITION. FINALLY, WE PROPOSE TO ELUCIDATE THE PARTICIPATION OF THIS NUA4 COMPLEX IN THE CHROMATIN REMODELING PROCESSES AND HOW THESE CORRELATE WITH ALTERATIONS IN THE CHARACTERISTICS OF DEVELOPMENT RELATED TO PRODUCTIVITY. ALL THESE APPROACHES WILL BE USED IN THE STUDY OF TWO RELATED SPECIES OF THE BRASSICACEAE FAMILY, THE MODEL SPECIES ARABIDOPSIS THALIANA AND THE CULTIVATION OF RAPESEED (BRASSICA NAPUS), WHICH WILL FACILITATE THE TRANSFER OF THE RESULTS BETWEEN THE TWO SPECIES AND THEIR APPLICATION TO OTHER CROPS OF BRASSICA OF AGRONOMIC INTEREST. CHROMYIELD HAS BEEN DESIGNED TO ADDRESS THE PROBLEM OF FOOD SAFETY, AND WILL PROVIDE TOOLS THAT CONTRIBUTE TO THE PRODUCTION OF NEW VARIETIES WITH DIFFERENT REQUIREMENTS OVER FLOWERING TIME. FINALLY, THE PARTICIPATION IN CHROMYIELD OF TWO SEED COMPANIES, NPZI AND SYNGENTA, AND THEIR INTEREST IN THE PROPOSAL WILL GUARANTEE THE TRANSFER TO THE SECTOR OF ANY RELEVANT COMMERCIAL RESULTS DEVELOPED IN THE FRAMEWORK OF THIS PROJECT. (English) | |||||||||||||||
| Property / summary: THE MAIN OBJECTIVE OF CHROMYIELD IS TO DEEPEN KNOWLEDGE OF THE MECHANISMS THAT REGULATE THE CONTROL OF THE START OF FLOWERING, A DEVELOPMENT PROCESS WITH A DIRECT IMPACT ON CROP YIELDS. FLOWERING TIME IS ONE OF THE MAJOR DETERMINANTS OF THE PRODUCTION OF SEEDS AND FRUITS; IN FACT AN INAPPROPRIATE FLOWERING TIME HAS AS A DIRECT CONSEQUENCE A REDUCTION IN PRODUCTIVITY. SEVERAL RESEARCH GROUPS, INCLUDING OURS, HAVE CONTRIBUTED TO UNVEILING THE COMPLEX GENIC NETWORK THAT PRECISELY REGULATES FLOWERING TIME IN RESPONSE TO INTERNAL AND ENVIRONMENTAL SIGNALS. AMONG THESE REGULATORY MECHANISMS, CHROMATIN REMODELING PROCESSES PLAY A CENTRAL ROLE IN ESTABLISHING THE GENIC EXPRESSION PATTERNS THAT REGULATE THE FLORAL TRANSITION. _x000D_ one OF THE MORE IMPORTANT RETIES TO THE AGRICULTURE IN THE UPDATE IS to GUARANTEE FOOD SECURITY. IMPROVING THE STABILITY AND SUSTAINABILITY OF AGRICULTURAL PRODUCTION REQUIRES INNOVATIVE MECHANISMS THAT ALLOW US TO OBTAIN GREATER VARIABILITY IN AGRONOMIC CHARACTERISTICS OF INTEREST. IN THIS CONTEXT, EPIGENETIC PROCESSES HAVE BEEN PROPOSED AS A NEW STRATEGY FOR CROP IMPROVEMENT. TO BE ABLE TO EXPLOIT THESE MECHANISMS EFFICIENTLY, AN IN-DEPTH KNOWLEDGE OF THE CHROMATIN-MEDIATED REGULATION OF THE AGRONOMIC CHARACTERISTICS ASSOCIATED WITH PRODUCTIVITY IS NECESSARY. FOR THIS REASON, AND IN ORDER TO ADDRESS THE STUDY OF THE ROLE OF THE ORGANISATION OF CHROMATIN IN THE MODULATION OF FLOWERING TIME AND HOW IT INFLUENCES THE PRODUCTIVITY OF CROPS, CHROMYIELD PROPOSES THE USE OF A COMBINATION OF GENETIC, BIOCHEMICAL, MOLECULAR AND GENOMIC APPROACHES FOCUSED ON THE ANALYSIS OF THE PARTICIPATION OF THE ACCETILACION OF HISTONES IN THE CONTROL OF THIS DEVELOPMENT PROCESS. SPECIFICALLY, WE PROPOSE TO ANALYSE THE PARTICIPATION OF THE HISTONE ACETYL TRANSFERASE COMPLEX NUA4 AND IN PARTICULAR ONE OF ITS MOST REPRESENTATIVE SUBUNITS, EPL, IN THE CONTROL OF THE FLORAL TRANSITION. TO DO THIS, WE WILL DISSECT THE GENETIC PATHWAYS THAT MEDIATE THE FUNCTION OF THE EPL GENES AND HOW THEY CONTROL THE GENIC EXPRESSION DURING THE FLORAL TRANSITION. ON THE OTHER HAND, WE WILL UNVEIL THE MOLECULAR MECHANISMS THAT MEDIATE THE ROLE OF THESE PROTEINS BY IDENTIFYING THE PROTEIN COMPLEXES WHERE THEY ARE PRESENT AS WELL AS THE GENICAS NETWORKS THAT CONTROL IN THE FLORAL TRANSITION. FINALLY, WE PROPOSE TO ELUCIDATE THE PARTICIPATION OF THIS NUA4 COMPLEX IN THE CHROMATIN REMODELING PROCESSES AND HOW THESE CORRELATE WITH ALTERATIONS IN THE CHARACTERISTICS OF DEVELOPMENT RELATED TO PRODUCTIVITY. ALL THESE APPROACHES WILL BE USED IN THE STUDY OF TWO RELATED SPECIES OF THE BRASSICACEAE FAMILY, THE MODEL SPECIES ARABIDOPSIS THALIANA AND THE CULTIVATION OF RAPESEED (BRASSICA NAPUS), WHICH WILL FACILITATE THE TRANSFER OF THE RESULTS BETWEEN THE TWO SPECIES AND THEIR APPLICATION TO OTHER CROPS OF BRASSICA OF AGRONOMIC INTEREST. CHROMYIELD HAS BEEN DESIGNED TO ADDRESS THE PROBLEM OF FOOD SAFETY, AND WILL PROVIDE TOOLS THAT CONTRIBUTE TO THE PRODUCTION OF NEW VARIETIES WITH DIFFERENT REQUIREMENTS OVER FLOWERING TIME. FINALLY, THE PARTICIPATION IN CHROMYIELD OF TWO SEED COMPANIES, NPZI AND SYNGENTA, AND THEIR INTEREST IN THE PROPOSAL WILL GUARANTEE THE TRANSFER TO THE SECTOR OF ANY RELEVANT COMMERCIAL RESULTS DEVELOPED IN THE FRAMEWORK OF THIS PROJECT. (English) / rank | |||||||||||||||
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| Property / summary: THE MAIN OBJECTIVE OF CHROMYIELD IS TO DEEPEN KNOWLEDGE OF THE MECHANISMS THAT REGULATE THE CONTROL OF THE START OF FLOWERING, A DEVELOPMENT PROCESS WITH A DIRECT IMPACT ON CROP YIELDS. FLOWERING TIME IS ONE OF THE MAJOR DETERMINANTS OF THE PRODUCTION OF SEEDS AND FRUITS; IN FACT AN INAPPROPRIATE FLOWERING TIME HAS AS A DIRECT CONSEQUENCE A REDUCTION IN PRODUCTIVITY. SEVERAL RESEARCH GROUPS, INCLUDING OURS, HAVE CONTRIBUTED TO UNVEILING THE COMPLEX GENIC NETWORK THAT PRECISELY REGULATES FLOWERING TIME IN RESPONSE TO INTERNAL AND ENVIRONMENTAL SIGNALS. AMONG THESE REGULATORY MECHANISMS, CHROMATIN REMODELING PROCESSES PLAY A CENTRAL ROLE IN ESTABLISHING THE GENIC EXPRESSION PATTERNS THAT REGULATE THE FLORAL TRANSITION. _x000D_ one OF THE MORE IMPORTANT RETIES TO THE AGRICULTURE IN THE UPDATE IS to GUARANTEE FOOD SECURITY. IMPROVING THE STABILITY AND SUSTAINABILITY OF AGRICULTURAL PRODUCTION REQUIRES INNOVATIVE MECHANISMS THAT ALLOW US TO OBTAIN GREATER VARIABILITY IN AGRONOMIC CHARACTERISTICS OF INTEREST. IN THIS CONTEXT, EPIGENETIC PROCESSES HAVE BEEN PROPOSED AS A NEW STRATEGY FOR CROP IMPROVEMENT. TO BE ABLE TO EXPLOIT THESE MECHANISMS EFFICIENTLY, AN IN-DEPTH KNOWLEDGE OF THE CHROMATIN-MEDIATED REGULATION OF THE AGRONOMIC CHARACTERISTICS ASSOCIATED WITH PRODUCTIVITY IS NECESSARY. FOR THIS REASON, AND IN ORDER TO ADDRESS THE STUDY OF THE ROLE OF THE ORGANISATION OF CHROMATIN IN THE MODULATION OF FLOWERING TIME AND HOW IT INFLUENCES THE PRODUCTIVITY OF CROPS, CHROMYIELD PROPOSES THE USE OF A COMBINATION OF GENETIC, BIOCHEMICAL, MOLECULAR AND GENOMIC APPROACHES FOCUSED ON THE ANALYSIS OF THE PARTICIPATION OF THE ACCETILACION OF HISTONES IN THE CONTROL OF THIS DEVELOPMENT PROCESS. SPECIFICALLY, WE PROPOSE TO ANALYSE THE PARTICIPATION OF THE HISTONE ACETYL TRANSFERASE COMPLEX NUA4 AND IN PARTICULAR ONE OF ITS MOST REPRESENTATIVE SUBUNITS, EPL, IN THE CONTROL OF THE FLORAL TRANSITION. TO DO THIS, WE WILL DISSECT THE GENETIC PATHWAYS THAT MEDIATE THE FUNCTION OF THE EPL GENES AND HOW THEY CONTROL THE GENIC EXPRESSION DURING THE FLORAL TRANSITION. ON THE OTHER HAND, WE WILL UNVEIL THE MOLECULAR MECHANISMS THAT MEDIATE THE ROLE OF THESE PROTEINS BY IDENTIFYING THE PROTEIN COMPLEXES WHERE THEY ARE PRESENT AS WELL AS THE GENICAS NETWORKS THAT CONTROL IN THE FLORAL TRANSITION. FINALLY, WE PROPOSE TO ELUCIDATE THE PARTICIPATION OF THIS NUA4 COMPLEX IN THE CHROMATIN REMODELING PROCESSES AND HOW THESE CORRELATE WITH ALTERATIONS IN THE CHARACTERISTICS OF DEVELOPMENT RELATED TO PRODUCTIVITY. ALL THESE APPROACHES WILL BE USED IN THE STUDY OF TWO RELATED SPECIES OF THE BRASSICACEAE FAMILY, THE MODEL SPECIES ARABIDOPSIS THALIANA AND THE CULTIVATION OF RAPESEED (BRASSICA NAPUS), WHICH WILL FACILITATE THE TRANSFER OF THE RESULTS BETWEEN THE TWO SPECIES AND THEIR APPLICATION TO OTHER CROPS OF BRASSICA OF AGRONOMIC INTEREST. CHROMYIELD HAS BEEN DESIGNED TO ADDRESS THE PROBLEM OF FOOD SAFETY, AND WILL PROVIDE TOOLS THAT CONTRIBUTE TO THE PRODUCTION OF NEW VARIETIES WITH DIFFERENT REQUIREMENTS OVER FLOWERING TIME. FINALLY, THE PARTICIPATION IN CHROMYIELD OF TWO SEED COMPANIES, NPZI AND SYNGENTA, AND THEIR INTEREST IN THE PROPOSAL WILL GUARANTEE THE TRANSFER TO THE SECTOR OF ANY RELEVANT COMMERCIAL RESULTS DEVELOPED IN THE FRAMEWORK OF THIS PROJECT. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:16, 12 October 2021
Project Q3156570 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3156570 in Spain |
Statements
166,375.0 Euro
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332,750.0 Euro
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50.0 percent
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30 December 2016
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31 December 2020
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INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA
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40°26'4.74"N, 3°48'53.39"W
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28115
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EL PRINCIPAL OBJETIVO DE CHROMYIELD ES PROFUNDIZAR EN EL CONOCIMIENTO DE LOS MECANISMOS QUE REGULAN EL CONTROL DEL INICIO DE LA FLORACION, UN PROCESO DE DESARROLLO CON UN IMPACTO DIRECTO EN EL RENDIMIENTO DE LOS CULTIVOS. EL TIEMPO DE FLORACION ES UNO DE LOS MAYORES DETERMINANTES DE LA PRODUCCION DE SEMILLAS Y FRUTOS; DE HECHO UN TIEMPO DE FLORACION INAPROPIADO TIENE COMO CONSECUENCIA DIRECTA UNA REDUCCION EN LA PRODUCTIVIDAD. VARIOS GRUPOS DE INVESTIGACION, INCLUIDO EL NUESTRO, HAN CONTRIBUIDO A DESVELAR LA COMPLEJA RED GENICA QUE REGULA DE FORMA PRECISA EL TIEMPO DE FLORACION EN RESPUESTA A SEÑALES INTERNAS Y AMBIENTALES. ENTRE ESTOS MECANISMOS REGULADORES, LOS PROCESOS DE REMODELACION DE LA CROMATINA JUEGAN UN PAPEL CENTRAL EN ESTABLECER LOS PATRONES DE EXPRESION GENICA QUE REGULAN LA TRANSICION FLORAL. _x000D_ UNO DE LOS RETOS MAS IMPORTANTES A LOS QUE SE ENFRENTA LA AGRICULTURA EN LA ACTUALIDAD ES GARANTIZAR LA SEGURIDAD ALIMENTARIA. LA MEJORA DE LA ESTABILIDAD Y SOSTENIBILIDAD DE LA PRODUCCION AGRICOLA REQUIERE DE MECANISMOS INNOVADORES QUE NOS PERMITAN OBTENER UNA MAYOR VARIABILIDAD EN CARACTERES AGRONOMICOS DE INTERES. EN ESE CONTEXTO, LOS PROCESOS EPIGENETICOS HAN SIDO PROPUESTOS COMO UNA NUEVA ESTRATEGIA PARA LA MEJORA DE CULTIVOS. PARA PODER EXPLOTAR DE FORMA EFICIENTE DICHOS MECANISMOS SE NECESITA UN CONOCIMIENTO EN PROFUNDIDAD DE LA REGULACION MEDIADA POR CROMATINA DE LOS CARACTERES AGRONOMICOS ASOCIADOS A PRODUCTIVIDAD. POR ELLO, Y CON EL FIN DE ABORDAR EL ESTUDIO DEL PAPEL DE LA ORGANIZACION DE LA CROMATINA EN LA MODULACION DEL TIEMPO DE FLORACION Y COMO INFLUYE EN LA PRODUCTIVIDAD DE LOS CULTIVOS, EN CHROMYIELD SE PROPONE EL USO DE UNA COMBINACION DE APROXIMACIONES GENETICAS, BIOQUIMICAS, MOLECULARES Y GENOMICAS CENTRADAS EN EL ANALISIS DE LA PARTICIPACION DE LA ACETILACION DE HISTONAS EN EL CONTROL DE ESTE PROCESO DEL DESARROLLO. ESPECIFICAMENTE, PROPONEMOS ANALIZAR LA PARTICIPACION DEL COMPLEJO HISTONA ACETIL TRANSFERASA NUA4 Y EN CONCRETO DE UNA DE SUS SUBUNIDADES MAS REPRESENTATIVAS, EPL, EN EL CONTROL DE LA TRANSICION FLORAL. PARA ELLO, DISECCIONAREMOS LAS VIAS GENETICAS QUE MEDIAN LA FUNCION DE LOS GENES EPL Y COMO CONTROLAN LA EXPRESION GENICA DURANTE LA TRANSICION FLORAL. POR OTRA PARTE, DESVELAREMOS LOS MECANISMOS MOLECULARES QUE MEDIAN EL PAPEL DE ESTAS PROTEINAS MEDIANTE LA IDENTIFICACION DE LOS COMPLEJOS PROTEICOS DONDE ESTAN PRESENTES ASI COMO DE LAS REDES GENICAS QUE CONTROLAN EN LA TRANSICION FLORAL. FINALMENTE, PROPONEMOS ELUCIDAR LA PARTICIPACION DE ESTE COMPLEJO NUA4 EN LOS PROCESOS DE REMODELACION DE CROMATINA Y COMO ESTOS CORRELACIONAN CON ALTERACIONES EN LOS CARACTERES DE DESARROLLO RELACIONADOS CON PRODUCTIVIDAD. TODAS ESTAS APROXIMACIONES SE USARAN EN EL ESTUDIO DE DOS ESPECIES RELACIONADAS DE LA FAMILIA BRASSICACEAE, LA ESPECIE MODELO ARABIDOPSIS THALIANA Y EL CULTIVO DE LA COLZA (BRASSICA NAPUS), LO QUE FACILITARA LA TRANSFERENCIA DE LOS RESULTADOS ENTRE AMBAS ESPECIES Y SU APLICACION A OTROS CULTIVOS DE BRASSICA DE INTERES AGRONOMICO. CHROMYIELD HA SIDO DISEÑADO PARA AFRONTAR EL PROBLEMA DE LA SEGURIDAD ALIMENTARIA, Y PROPORCIONARA HERRAMIENTAS QUE CONTRIBUYAN A LA PRODUCCION DE NUEVAS VARIEDADES CON DISTINTOS REQUERIMIENTOS EN EL TIEMPO DE FLORACION. FINALMENTE, LA PARTICIPACION EN CHROMYIELD DE DOS COMPAÑIAS DE SEMILLAS, NPZI AND SYNGENTA, Y SU INTERES EN LA PROPUESTA GARANTIZARA LA TRANSFERENCIA AL SECTOR DE CUALQUIER RESULTADO COMERCIAL RELEVANTE DESARROLLADO EN EL MARCO DE ESTE PROYECTO. (Spanish)
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THE MAIN OBJECTIVE OF CHROMYIELD IS TO DEEPEN KNOWLEDGE OF THE MECHANISMS THAT REGULATE THE CONTROL OF THE START OF FLOWERING, A DEVELOPMENT PROCESS WITH A DIRECT IMPACT ON CROP YIELDS. FLOWERING TIME IS ONE OF THE MAJOR DETERMINANTS OF THE PRODUCTION OF SEEDS AND FRUITS; IN FACT AN INAPPROPRIATE FLOWERING TIME HAS AS A DIRECT CONSEQUENCE A REDUCTION IN PRODUCTIVITY. SEVERAL RESEARCH GROUPS, INCLUDING OURS, HAVE CONTRIBUTED TO UNVEILING THE COMPLEX GENIC NETWORK THAT PRECISELY REGULATES FLOWERING TIME IN RESPONSE TO INTERNAL AND ENVIRONMENTAL SIGNALS. AMONG THESE REGULATORY MECHANISMS, CHROMATIN REMODELING PROCESSES PLAY A CENTRAL ROLE IN ESTABLISHING THE GENIC EXPRESSION PATTERNS THAT REGULATE THE FLORAL TRANSITION. _x000D_ one OF THE MORE IMPORTANT RETIES TO THE AGRICULTURE IN THE UPDATE IS to GUARANTEE FOOD SECURITY. IMPROVING THE STABILITY AND SUSTAINABILITY OF AGRICULTURAL PRODUCTION REQUIRES INNOVATIVE MECHANISMS THAT ALLOW US TO OBTAIN GREATER VARIABILITY IN AGRONOMIC CHARACTERISTICS OF INTEREST. IN THIS CONTEXT, EPIGENETIC PROCESSES HAVE BEEN PROPOSED AS A NEW STRATEGY FOR CROP IMPROVEMENT. TO BE ABLE TO EXPLOIT THESE MECHANISMS EFFICIENTLY, AN IN-DEPTH KNOWLEDGE OF THE CHROMATIN-MEDIATED REGULATION OF THE AGRONOMIC CHARACTERISTICS ASSOCIATED WITH PRODUCTIVITY IS NECESSARY. FOR THIS REASON, AND IN ORDER TO ADDRESS THE STUDY OF THE ROLE OF THE ORGANISATION OF CHROMATIN IN THE MODULATION OF FLOWERING TIME AND HOW IT INFLUENCES THE PRODUCTIVITY OF CROPS, CHROMYIELD PROPOSES THE USE OF A COMBINATION OF GENETIC, BIOCHEMICAL, MOLECULAR AND GENOMIC APPROACHES FOCUSED ON THE ANALYSIS OF THE PARTICIPATION OF THE ACCETILACION OF HISTONES IN THE CONTROL OF THIS DEVELOPMENT PROCESS. SPECIFICALLY, WE PROPOSE TO ANALYSE THE PARTICIPATION OF THE HISTONE ACETYL TRANSFERASE COMPLEX NUA4 AND IN PARTICULAR ONE OF ITS MOST REPRESENTATIVE SUBUNITS, EPL, IN THE CONTROL OF THE FLORAL TRANSITION. TO DO THIS, WE WILL DISSECT THE GENETIC PATHWAYS THAT MEDIATE THE FUNCTION OF THE EPL GENES AND HOW THEY CONTROL THE GENIC EXPRESSION DURING THE FLORAL TRANSITION. ON THE OTHER HAND, WE WILL UNVEIL THE MOLECULAR MECHANISMS THAT MEDIATE THE ROLE OF THESE PROTEINS BY IDENTIFYING THE PROTEIN COMPLEXES WHERE THEY ARE PRESENT AS WELL AS THE GENICAS NETWORKS THAT CONTROL IN THE FLORAL TRANSITION. FINALLY, WE PROPOSE TO ELUCIDATE THE PARTICIPATION OF THIS NUA4 COMPLEX IN THE CHROMATIN REMODELING PROCESSES AND HOW THESE CORRELATE WITH ALTERATIONS IN THE CHARACTERISTICS OF DEVELOPMENT RELATED TO PRODUCTIVITY. ALL THESE APPROACHES WILL BE USED IN THE STUDY OF TWO RELATED SPECIES OF THE BRASSICACEAE FAMILY, THE MODEL SPECIES ARABIDOPSIS THALIANA AND THE CULTIVATION OF RAPESEED (BRASSICA NAPUS), WHICH WILL FACILITATE THE TRANSFER OF THE RESULTS BETWEEN THE TWO SPECIES AND THEIR APPLICATION TO OTHER CROPS OF BRASSICA OF AGRONOMIC INTEREST. CHROMYIELD HAS BEEN DESIGNED TO ADDRESS THE PROBLEM OF FOOD SAFETY, AND WILL PROVIDE TOOLS THAT CONTRIBUTE TO THE PRODUCTION OF NEW VARIETIES WITH DIFFERENT REQUIREMENTS OVER FLOWERING TIME. FINALLY, THE PARTICIPATION IN CHROMYIELD OF TWO SEED COMPANIES, NPZI AND SYNGENTA, AND THEIR INTEREST IN THE PROPOSAL WILL GUARANTEE THE TRANSFER TO THE SECTOR OF ANY RELEVANT COMMERCIAL RESULTS DEVELOPED IN THE FRAMEWORK OF THIS PROJECT. (English)
12 October 2021
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Pozuelo de Alarcón
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Identifiers
BIO2016-77559-R
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