Q3154449 (Q3154449): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): TYPE 1 DIABETES IS, LIKE MOST AUTOIMMUNE DISEASES, A CHRONIC AND SLOW-DEVELOPING PROCESS IN WHICH THE CLINICAL DIAGNOSIS ARRIVES YEARS AFTER SPECIFIC ANTIBODIES OF AUTONTIGENS ARE DETECTED IN PATIENTs’ SERUM. THE CHRONIC NATURE OF THE DISEASE AND THE ACCUMULATION OF ANTIGENICAS TARGETS IN T1D CORRELATES WITH A DYNAMIC RESPONSE OF T CELLS, RESULTING FROM THE RECRUITMENT OF DIFFERENT FUNCTIONAL POPULATIONS OF T CELLS THROUGHOUT THE PROCESS. THE CU...) |
||||||||||||||
| Property / summary | |||||||||||||||
TYPE 1 DIABETES IS, LIKE MOST AUTOIMMUNE DISEASES, A CHRONIC AND SLOW-DEVELOPING PROCESS IN WHICH THE CLINICAL DIAGNOSIS ARRIVES YEARS AFTER SPECIFIC ANTIBODIES OF AUTONTIGENS ARE DETECTED IN PATIENTs’ SERUM. THE CHRONIC NATURE OF THE DISEASE AND THE ACCUMULATION OF ANTIGENICAS TARGETS IN T1D CORRELATES WITH A DYNAMIC RESPONSE OF T CELLS, RESULTING FROM THE RECRUITMENT OF DIFFERENT FUNCTIONAL POPULATIONS OF T CELLS THROUGHOUT THE PROCESS. THE CURRENT VISION OF SELF-REACTIVE T CELLS IS THAT THEY ARE LOW AFFINITY T CELLS FOR ANTIGEN THAT ESCAPE THE T-SELECT AND BECOME PATOGENICAS WHEN ACTIVATED IN SITU. THIS ACTIVATION CAN BE STARTED AND MAINTAINED BY THE GENERATION OF NON-CANONICAL OR NEOLIGANDOS ANTIGENICA TARGETS. THESE RESPONSES ARE GENERALLY CONTROLLED BY DIFFERENT REGULATORY MECHANISMS THAT MAINTAIN TISSUE HOMEOSTASIS. However, an ALTERATION OF THIS DELICATED EQUILIBRIUM can cause pathological products not desired._x000D_ PROPONES that the SPECIFIC CHARACTERISTICS OF THE DIANA TEJIDO PERMIT THE GENERATION OF NEOANTIGENS MEDIENING MECHANISMES DIFERENTIAL PROCESSING OR post-traductional modifications. The ASI GENERATE epitopes are not submitted or submitted inefficiently in the processes of TOLERANCE INDUCTION IN THE TIME._x000D_ In this project we plan to use three different approaches to identify SPECIFIC TECHNICAL MECHANISMS OF INDUCING self-reactivity: (I) COMPARISON OF THE GENERATION OF MHC-I AND II EPITOPES IN THYMUS AND DIANA TISSUE, I.E. LANGERHANS ISLETS; (II) ANALYSIS OF SPECIFIC TISSUE PROCESSING FOR HLA-I LIGANDS; (III) ANALYSIS OF POST-EDUCATIONAL MODIFICATIONS INCLUDING POSFORILACION AND LIPIDACION; (VI) ANALYSIS OF THE EFFECT OF STRESS ON THE LIPID CONTENT OF BETA CELLS. All ANTIGENS _x000D_ SPECIFICS OF TEJID IDENTIFICED will be faced with Tregs, NKT and CELLS T-Effectives with the End of Selecting the Best Molecules FOR IMUNOTERAPEUTIC STRATEGYS OF TOLERANCE INDUCTIONS._x000D_ Expected RESULTS: IDENTIFICATION OF NON-CANONIC PEPTIDES OF AUTOANTIGENS PRESENTED IN ISLETS, EITHER BY POST-TRANSLATIONAL MODIFICATIONS OR SPECIFIC TISSUE PROCESSING. Identification OF NATURAL LIPIDS MODIFICED BY THE CELLER STRES IN BETA CELLS;._x000D_ RISKS: Difficulty TO OBJECTIVE DATA due to the LIMITATION OF THE SARS._x000D_ BENEFITS: ANY AUTOANTIGENICO LIGAND IDENTIFIED FROM HUMAN ISLETS WILL BE OF INTEREST FOR THE STUDY OF THE AUTOIMMUNE PROCESS IN T1D AND, IN PARTICULAR, THOSE GENERATED AS A RESULT OF THE SPECIFIC CHARACTERISTICS OF THE DIANA TISSUE AND THEREFORE NOT PRESENTED IN THE THYMUS. THESE DATA HAVE THE POTENTIAL TO IMPROVE PERSONALISED IMMUNOTHERAPIES FOR PATIENTS WITH T1D. THE LAST OBJECTIVE OF THIS PROPOSAL WILL BE THE IDENTIFICATION OF LIPID-PEPTIDO CONJUGATES CAPABLE OF MODULATING THE SPECIFIC RESPONSES OF T CELLS THROUGH THE ACTIVATION OF NKT CELLS. (English) | |||||||||||||||
| Property / summary: TYPE 1 DIABETES IS, LIKE MOST AUTOIMMUNE DISEASES, A CHRONIC AND SLOW-DEVELOPING PROCESS IN WHICH THE CLINICAL DIAGNOSIS ARRIVES YEARS AFTER SPECIFIC ANTIBODIES OF AUTONTIGENS ARE DETECTED IN PATIENTs’ SERUM. THE CHRONIC NATURE OF THE DISEASE AND THE ACCUMULATION OF ANTIGENICAS TARGETS IN T1D CORRELATES WITH A DYNAMIC RESPONSE OF T CELLS, RESULTING FROM THE RECRUITMENT OF DIFFERENT FUNCTIONAL POPULATIONS OF T CELLS THROUGHOUT THE PROCESS. THE CURRENT VISION OF SELF-REACTIVE T CELLS IS THAT THEY ARE LOW AFFINITY T CELLS FOR ANTIGEN THAT ESCAPE THE T-SELECT AND BECOME PATOGENICAS WHEN ACTIVATED IN SITU. THIS ACTIVATION CAN BE STARTED AND MAINTAINED BY THE GENERATION OF NON-CANONICAL OR NEOLIGANDOS ANTIGENICA TARGETS. THESE RESPONSES ARE GENERALLY CONTROLLED BY DIFFERENT REGULATORY MECHANISMS THAT MAINTAIN TISSUE HOMEOSTASIS. However, an ALTERATION OF THIS DELICATED EQUILIBRIUM can cause pathological products not desired._x000D_ PROPONES that the SPECIFIC CHARACTERISTICS OF THE DIANA TEJIDO PERMIT THE GENERATION OF NEOANTIGENS MEDIENING MECHANISMES DIFERENTIAL PROCESSING OR post-traductional modifications. The ASI GENERATE epitopes are not submitted or submitted inefficiently in the processes of TOLERANCE INDUCTION IN THE TIME._x000D_ In this project we plan to use three different approaches to identify SPECIFIC TECHNICAL MECHANISMS OF INDUCING self-reactivity: (I) COMPARISON OF THE GENERATION OF MHC-I AND II EPITOPES IN THYMUS AND DIANA TISSUE, I.E. LANGERHANS ISLETS; (II) ANALYSIS OF SPECIFIC TISSUE PROCESSING FOR HLA-I LIGANDS; (III) ANALYSIS OF POST-EDUCATIONAL MODIFICATIONS INCLUDING POSFORILACION AND LIPIDACION; (VI) ANALYSIS OF THE EFFECT OF STRESS ON THE LIPID CONTENT OF BETA CELLS. All ANTIGENS _x000D_ SPECIFICS OF TEJID IDENTIFICED will be faced with Tregs, NKT and CELLS T-Effectives with the End of Selecting the Best Molecules FOR IMUNOTERAPEUTIC STRATEGYS OF TOLERANCE INDUCTIONS._x000D_ Expected RESULTS: IDENTIFICATION OF NON-CANONIC PEPTIDES OF AUTOANTIGENS PRESENTED IN ISLETS, EITHER BY POST-TRANSLATIONAL MODIFICATIONS OR SPECIFIC TISSUE PROCESSING. Identification OF NATURAL LIPIDS MODIFICED BY THE CELLER STRES IN BETA CELLS;._x000D_ RISKS: Difficulty TO OBJECTIVE DATA due to the LIMITATION OF THE SARS._x000D_ BENEFITS: ANY AUTOANTIGENICO LIGAND IDENTIFIED FROM HUMAN ISLETS WILL BE OF INTEREST FOR THE STUDY OF THE AUTOIMMUNE PROCESS IN T1D AND, IN PARTICULAR, THOSE GENERATED AS A RESULT OF THE SPECIFIC CHARACTERISTICS OF THE DIANA TISSUE AND THEREFORE NOT PRESENTED IN THE THYMUS. THESE DATA HAVE THE POTENTIAL TO IMPROVE PERSONALISED IMMUNOTHERAPIES FOR PATIENTS WITH T1D. THE LAST OBJECTIVE OF THIS PROPOSAL WILL BE THE IDENTIFICATION OF LIPID-PEPTIDO CONJUGATES CAPABLE OF MODULATING THE SPECIFIC RESPONSES OF T CELLS THROUGH THE ACTIVATION OF NKT CELLS. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: TYPE 1 DIABETES IS, LIKE MOST AUTOIMMUNE DISEASES, A CHRONIC AND SLOW-DEVELOPING PROCESS IN WHICH THE CLINICAL DIAGNOSIS ARRIVES YEARS AFTER SPECIFIC ANTIBODIES OF AUTONTIGENS ARE DETECTED IN PATIENTs’ SERUM. THE CHRONIC NATURE OF THE DISEASE AND THE ACCUMULATION OF ANTIGENICAS TARGETS IN T1D CORRELATES WITH A DYNAMIC RESPONSE OF T CELLS, RESULTING FROM THE RECRUITMENT OF DIFFERENT FUNCTIONAL POPULATIONS OF T CELLS THROUGHOUT THE PROCESS. THE CURRENT VISION OF SELF-REACTIVE T CELLS IS THAT THEY ARE LOW AFFINITY T CELLS FOR ANTIGEN THAT ESCAPE THE T-SELECT AND BECOME PATOGENICAS WHEN ACTIVATED IN SITU. THIS ACTIVATION CAN BE STARTED AND MAINTAINED BY THE GENERATION OF NON-CANONICAL OR NEOLIGANDOS ANTIGENICA TARGETS. THESE RESPONSES ARE GENERALLY CONTROLLED BY DIFFERENT REGULATORY MECHANISMS THAT MAINTAIN TISSUE HOMEOSTASIS. However, an ALTERATION OF THIS DELICATED EQUILIBRIUM can cause pathological products not desired._x000D_ PROPONES that the SPECIFIC CHARACTERISTICS OF THE DIANA TEJIDO PERMIT THE GENERATION OF NEOANTIGENS MEDIENING MECHANISMES DIFERENTIAL PROCESSING OR post-traductional modifications. The ASI GENERATE epitopes are not submitted or submitted inefficiently in the processes of TOLERANCE INDUCTION IN THE TIME._x000D_ In this project we plan to use three different approaches to identify SPECIFIC TECHNICAL MECHANISMS OF INDUCING self-reactivity: (I) COMPARISON OF THE GENERATION OF MHC-I AND II EPITOPES IN THYMUS AND DIANA TISSUE, I.E. LANGERHANS ISLETS; (II) ANALYSIS OF SPECIFIC TISSUE PROCESSING FOR HLA-I LIGANDS; (III) ANALYSIS OF POST-EDUCATIONAL MODIFICATIONS INCLUDING POSFORILACION AND LIPIDACION; (VI) ANALYSIS OF THE EFFECT OF STRESS ON THE LIPID CONTENT OF BETA CELLS. All ANTIGENS _x000D_ SPECIFICS OF TEJID IDENTIFICED will be faced with Tregs, NKT and CELLS T-Effectives with the End of Selecting the Best Molecules FOR IMUNOTERAPEUTIC STRATEGYS OF TOLERANCE INDUCTIONS._x000D_ Expected RESULTS: IDENTIFICATION OF NON-CANONIC PEPTIDES OF AUTOANTIGENS PRESENTED IN ISLETS, EITHER BY POST-TRANSLATIONAL MODIFICATIONS OR SPECIFIC TISSUE PROCESSING. Identification OF NATURAL LIPIDS MODIFICED BY THE CELLER STRES IN BETA CELLS;._x000D_ RISKS: Difficulty TO OBJECTIVE DATA due to the LIMITATION OF THE SARS._x000D_ BENEFITS: ANY AUTOANTIGENICO LIGAND IDENTIFIED FROM HUMAN ISLETS WILL BE OF INTEREST FOR THE STUDY OF THE AUTOIMMUNE PROCESS IN T1D AND, IN PARTICULAR, THOSE GENERATED AS A RESULT OF THE SPECIFIC CHARACTERISTICS OF THE DIANA TISSUE AND THEREFORE NOT PRESENTED IN THE THYMUS. THESE DATA HAVE THE POTENTIAL TO IMPROVE PERSONALISED IMMUNOTHERAPIES FOR PATIENTS WITH T1D. THE LAST OBJECTIVE OF THIS PROPOSAL WILL BE THE IDENTIFICATION OF LIPID-PEPTIDO CONJUGATES CAPABLE OF MODULATING THE SPECIFIC RESPONSES OF T CELLS THROUGH THE ACTIVATION OF NKT CELLS. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 15:39, 12 October 2021
Project Q3154449 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3154449 in Spain |
Statements
151,250.0 Euro
0 references
302,500.0 Euro
0 references
50.0 percent
0 references
1 January 2016
0 references
30 June 2019
0 references
UNIVERSIDAD AUTONOMA DE BARCELONA
0 references
42°13'24.28"N, 1°53'31.70"E
0 references
08903
0 references
LA DIABETES TIPO 1 ES, COMO LA MAYORIA DE LAS ENFERMEDADES AUTOINMUNES, UN PROCESO CRONICO Y DE DESARROLLO LENTO EN EL QUE EL DIAGNOSTICO CLINICO LLEGA AÑOS DESPUES QUE SE DETECTEN ANTICUERPOS ESPECIFICOS DE AUTONTIGENOS EN EL SUERO DE LOS PACIENTES. LA NATURALEZA CRONICA DE LA ENFERMEDAD Y LA ACUMULACION DE DIANAS ANTIGENICAS EN LA T1D SE CORRELACIONA CON UNA RESPUESTA DINAMICA DE CELULAS T, RESULTADO DEL RECLUTAMIENTO DE DIFERENTES POBLACIONES FUNCIONALES DE CELULAS T A LO LARGO DEL PROCESO. LA VISION ACTUAL SOBRE LAS CELULAS T AUTORREACTIVAS ES QUE SON CELULAS T DE BAJA AFINIDAD POR EL ANTIGENO QUE ESCAPAN DE LA SELECCION TIMICA Y SE CONVIERTEN EN PATOGENICAS AL ACTIVARSE IN SITU. ESTA ACTIVACION SE PUEDE INICIAR Y MANTENER POR LA GENERACION DE DIANAS ANTIGENICAS NO CANONICAS O NEOLIGANDOS. ESTAS RESPUESTAS SON CONTROLADAS GENERALMENTE POR DIFERENTES MECANISMOS DE REGULACION QUE MANTIENEN LA HOMEOSTASIS DEL TEJIDO. SIN EMBARGO, UNA ALTERACION DE ESTE DELICADO EQUILIBRIO PUEDE CONDUCIR A PROCESOS PATOLOGICOS NO DESEADOS._x000D_ PROPONEMOS QUE LAS CARACTERISTICAS ESPECIFICAS DEL TEJIDO DIANA PERMITEN LA GENERACION DE NEOANTIGENOS MEDIANTE MECANISMOS DE PROCESAMIENTO DIFERENCIALES O MODIFICACIONES POSTRADUCCIONALES. LOS EPITOPOS ASI GENERADOS NO SE PRESENTAN O SE PRESENTAN INEFICIENTEMENTE EN LOS PROCESOS DE INDUCCION DE TOLERANCIA EN EL TIMO._x000D_ EN ESTE PROYECTO NOS PROPONEMOS USAR TRES ENFOQUES DIFERENTES PARA IDENTIFICAR LOS MECANISMOS ESPECIFICOS DE TEJIDO CAPACES DE INDUCIR AUTORREACTIVIDAD: (I) COMPARACION DE LA GENERACION DE EPITOPOS DE MHC-I Y II EN EL TIMO Y EN EL TEJIDO DIANA, ES DECIR, LOS ISLOTES DE LANGERHANS; (II) ANALISIS DEL PROCESAMIENTO ESPECIFICO DE TEJIDO PARA LIGANDOS DE HLA-I; (III) ANALISIS DE MODIFICACIONES POSTRADUCCIONALES INCLUYENDO FOSFORILACION Y LIPIDACION; (VI) ANALISIS DEL EFECTO DEL ESTRES SOBRE EL CONTENIDO LIPIDICO DE LAS CELULAS BETA. TODOS LOS ANTIGENOS _x000D_ ESPECIFICOS DE TEJIDO IDENTIFICADOS SE ENFRENTARAN A TREGS, NKT Y CELULAS T EFECTORAS CON EL FIN DE SELECCIONAR LAS MEJORES MOLECULAS PARA ESTRATEGIAS INMUNOTERAPEUTICAS DE INDUCCION DE TOLERANCIA._x000D_ RESULTADOS ESPERADOS: IDENTIFICACION DE PEPTIDOS NO CANONICOS DE AUTOANTIGENOS PRESENTADOS EN LOS ISLOTES, YA SEA POR MODIFICACIONES POSTRADUCCIONALES O PROCESAMIENTO ESPECIFICO DE TEJIDO. IDENTIFICACION DE LOS LIPIDOS NATURALES MODIFICADOS POR EL ESTRES CELULAR EN CELULAS BETA;._x000D_ RIESGOS: DIFICULTAD PARA OBTENER DATOS SUFICIENTES DEBIDO A LA LIMITACION DE LAS MUESTRAS._x000D_ BENEFICIOS: CUALQUIER LIGANDO AUTOANTIGENICO IDENTIFICADO A PARTIR DE ISLOTES HUMANOS SERA DE INTERES PARA EL ESTUDIO DEL PROCESO AUTOINMUNE EN T1D Y, EN PARTICULAR, LOS GENERADOS COMO CONSECUENCIA DE LAS CARACTERISTICAS ESPECIFICAS DEL TEJIDO DIANA Y, POR TANTO, NO PRESENTADOS EN EL TIMO. ESTOS DATOS TIENEN EL POTENCIAL DE MEJORAR LAS INMUNOTERAPIAS PERSONALIZADAS PARA PACIENTES CON T1D. EL OBJETIVO ULTIMO DE ESTA PROPUESTA SERA LA IDENTIFICACION DE CONJUGADOS LIPIDO-PEPTIDO CAPACES DE MODULAR LAS RESPUESTAS ESPECIFICAS DE CELULAS T A TRAVES DE LA ACTIVACION DE CELULAS NKT. (Spanish)
0 references
TYPE 1 DIABETES IS, LIKE MOST AUTOIMMUNE DISEASES, A CHRONIC AND SLOW-DEVELOPING PROCESS IN WHICH THE CLINICAL DIAGNOSIS ARRIVES YEARS AFTER SPECIFIC ANTIBODIES OF AUTONTIGENS ARE DETECTED IN PATIENTs’ SERUM. THE CHRONIC NATURE OF THE DISEASE AND THE ACCUMULATION OF ANTIGENICAS TARGETS IN T1D CORRELATES WITH A DYNAMIC RESPONSE OF T CELLS, RESULTING FROM THE RECRUITMENT OF DIFFERENT FUNCTIONAL POPULATIONS OF T CELLS THROUGHOUT THE PROCESS. THE CURRENT VISION OF SELF-REACTIVE T CELLS IS THAT THEY ARE LOW AFFINITY T CELLS FOR ANTIGEN THAT ESCAPE THE T-SELECT AND BECOME PATOGENICAS WHEN ACTIVATED IN SITU. THIS ACTIVATION CAN BE STARTED AND MAINTAINED BY THE GENERATION OF NON-CANONICAL OR NEOLIGANDOS ANTIGENICA TARGETS. THESE RESPONSES ARE GENERALLY CONTROLLED BY DIFFERENT REGULATORY MECHANISMS THAT MAINTAIN TISSUE HOMEOSTASIS. However, an ALTERATION OF THIS DELICATED EQUILIBRIUM can cause pathological products not desired._x000D_ PROPONES that the SPECIFIC CHARACTERISTICS OF THE DIANA TEJIDO PERMIT THE GENERATION OF NEOANTIGENS MEDIENING MECHANISMES DIFERENTIAL PROCESSING OR post-traductional modifications. The ASI GENERATE epitopes are not submitted or submitted inefficiently in the processes of TOLERANCE INDUCTION IN THE TIME._x000D_ In this project we plan to use three different approaches to identify SPECIFIC TECHNICAL MECHANISMS OF INDUCING self-reactivity: (I) COMPARISON OF THE GENERATION OF MHC-I AND II EPITOPES IN THYMUS AND DIANA TISSUE, I.E. LANGERHANS ISLETS; (II) ANALYSIS OF SPECIFIC TISSUE PROCESSING FOR HLA-I LIGANDS; (III) ANALYSIS OF POST-EDUCATIONAL MODIFICATIONS INCLUDING POSFORILACION AND LIPIDACION; (VI) ANALYSIS OF THE EFFECT OF STRESS ON THE LIPID CONTENT OF BETA CELLS. All ANTIGENS _x000D_ SPECIFICS OF TEJID IDENTIFICED will be faced with Tregs, NKT and CELLS T-Effectives with the End of Selecting the Best Molecules FOR IMUNOTERAPEUTIC STRATEGYS OF TOLERANCE INDUCTIONS._x000D_ Expected RESULTS: IDENTIFICATION OF NON-CANONIC PEPTIDES OF AUTOANTIGENS PRESENTED IN ISLETS, EITHER BY POST-TRANSLATIONAL MODIFICATIONS OR SPECIFIC TISSUE PROCESSING. Identification OF NATURAL LIPIDS MODIFICED BY THE CELLER STRES IN BETA CELLS;._x000D_ RISKS: Difficulty TO OBJECTIVE DATA due to the LIMITATION OF THE SARS._x000D_ BENEFITS: ANY AUTOANTIGENICO LIGAND IDENTIFIED FROM HUMAN ISLETS WILL BE OF INTEREST FOR THE STUDY OF THE AUTOIMMUNE PROCESS IN T1D AND, IN PARTICULAR, THOSE GENERATED AS A RESULT OF THE SPECIFIC CHARACTERISTICS OF THE DIANA TISSUE AND THEREFORE NOT PRESENTED IN THE THYMUS. THESE DATA HAVE THE POTENTIAL TO IMPROVE PERSONALISED IMMUNOTHERAPIES FOR PATIENTS WITH T1D. THE LAST OBJECTIVE OF THIS PROPOSAL WILL BE THE IDENTIFICATION OF LIPID-PEPTIDO CONJUGATES CAPABLE OF MODULATING THE SPECIFIC RESPONSES OF T CELLS THROUGH THE ACTIVATION OF NKT CELLS. (English)
12 October 2021
0 references
Sant Julià de Cerdanyola
0 references
Identifiers
SAF2015-66399-R
0 references