Q3136698 (Q3136698): Difference between revisions
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(Created claim: summary (P836): Food allergy is a pathology that affects 8 % of the child population in industrialised countries. Among the most prevalent foods for consultation in the Allergology services are milk and egg. The pathogenesis of allergy to cow’s milk proteins, as well as the acquisition of oral tolerance is very complex and not exactly known. However, it is believed that the dineral bacteria with which we live in our intestine (as a whole called intestinal mic...) |
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Food allergy is a pathology that affects 8 % of the child population in industrialised countries. Among the most prevalent foods for consultation in the Allergology services are milk and egg. The pathogenesis of allergy to cow’s milk proteins, as well as the acquisition of oral tolerance is very complex and not exactly known. However, it is believed that the dineral bacteria with which we live in our intestine (as a whole called intestinal microbiota), may be playing a very important role in this regard. The microbiota is known to be necessary for the induction of tolerance to antigens and more and more studies suggest that an altered composition of the intestinal microbiota or dysbiosis may result in a local and systemic alteration of the immune response to certain food allergens. Since primary colonisation of these bacteria occurs maternally, our hypothesis suggests that there may be a longitudinal influence, transmitted from mothers to children, on the composition of the intestinal microbiota that could be directly related to the development of cow’s milk protein allergy in infants. For this we propose to study, from a genomic and metabolomic point of view (at the level of the metabolites they produce), the intestinal microbiota present in the feces of infants, their mothers and their grandmothers. (English) | |||||||||||||||
| Property / summary: Food allergy is a pathology that affects 8 % of the child population in industrialised countries. Among the most prevalent foods for consultation in the Allergology services are milk and egg. The pathogenesis of allergy to cow’s milk proteins, as well as the acquisition of oral tolerance is very complex and not exactly known. However, it is believed that the dineral bacteria with which we live in our intestine (as a whole called intestinal microbiota), may be playing a very important role in this regard. The microbiota is known to be necessary for the induction of tolerance to antigens and more and more studies suggest that an altered composition of the intestinal microbiota or dysbiosis may result in a local and systemic alteration of the immune response to certain food allergens. Since primary colonisation of these bacteria occurs maternally, our hypothesis suggests that there may be a longitudinal influence, transmitted from mothers to children, on the composition of the intestinal microbiota that could be directly related to the development of cow’s milk protein allergy in infants. For this we propose to study, from a genomic and metabolomic point of view (at the level of the metabolites they produce), the intestinal microbiota present in the feces of infants, their mothers and their grandmothers. (English) / rank | |||||||||||||||
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| Property / summary: Food allergy is a pathology that affects 8 % of the child population in industrialised countries. Among the most prevalent foods for consultation in the Allergology services are milk and egg. The pathogenesis of allergy to cow’s milk proteins, as well as the acquisition of oral tolerance is very complex and not exactly known. However, it is believed that the dineral bacteria with which we live in our intestine (as a whole called intestinal microbiota), may be playing a very important role in this regard. The microbiota is known to be necessary for the induction of tolerance to antigens and more and more studies suggest that an altered composition of the intestinal microbiota or dysbiosis may result in a local and systemic alteration of the immune response to certain food allergens. Since primary colonisation of these bacteria occurs maternally, our hypothesis suggests that there may be a longitudinal influence, transmitted from mothers to children, on the composition of the intestinal microbiota that could be directly related to the development of cow’s milk protein allergy in infants. For this we propose to study, from a genomic and metabolomic point of view (at the level of the metabolites they produce), the intestinal microbiota present in the feces of infants, their mothers and their grandmothers. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:46, 12 October 2021
Project Q3136698 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3136698 in Spain |
Statements
56,000.0 Euro
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112,000.0 Euro
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50.0 percent
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1 January 2018
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31 March 2021
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FUNDACION INVESTIGACION BIOMEDICA DEL HOSPITAL NIÑO JESUS
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40°25'0.12"N, 3°42'12.89"W
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28079
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La alergia alimentaria es una patología que afecta al 8% de la población infantil en países industrializados. Entre los alimentos más prevalentes motivo de consulta en los servicios de Alergología están la leche y el huevo. La patogénesis de la alergia a las proteínas de la leche de vaca, así como la adquisición de tolerancia oral es muy compleja y no se conoce con exactitud. No obstante, se cree que las bacterias comensales con las que convivimos en nuestro intestino (en su conjunto denominadas microbiota intestinal), pudieran estar jugando un papel muy importante en este sentido. Se sabe que la microbiota es necesaria para la inducción de tolerancia a los antígenos y cada vez son más los estudios que sugieren que una composición alterada de la microbiota intestinal o disbiosis, pudiera resultar en una alteración local y sistémica de la respuesta inmune a determinados alérgenos alimentarios. Puesto que la colonización primaria de estas bacterias ocurre por vía materna, nuestra hipótesis sugiere que pudiera existir una influencia longitudinal, transmitida de madres a hijos, en la composición de la microbiota intestinal que pudiera estar directamente relacionada con el desarrollo a la alergia a proteínas de la leche de vaca en lactantes. Para ello proponemos estudiar, desde un punto de vista genómico y metabolómico (a nivel de los metabolitos que producen), la microbiota intestinal presente en las heces de lactantes, sus madres y sus abuelas. (Spanish)
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Food allergy is a pathology that affects 8 % of the child population in industrialised countries. Among the most prevalent foods for consultation in the Allergology services are milk and egg. The pathogenesis of allergy to cow’s milk proteins, as well as the acquisition of oral tolerance is very complex and not exactly known. However, it is believed that the dineral bacteria with which we live in our intestine (as a whole called intestinal microbiota), may be playing a very important role in this regard. The microbiota is known to be necessary for the induction of tolerance to antigens and more and more studies suggest that an altered composition of the intestinal microbiota or dysbiosis may result in a local and systemic alteration of the immune response to certain food allergens. Since primary colonisation of these bacteria occurs maternally, our hypothesis suggests that there may be a longitudinal influence, transmitted from mothers to children, on the composition of the intestinal microbiota that could be directly related to the development of cow’s milk protein allergy in infants. For this we propose to study, from a genomic and metabolomic point of view (at the level of the metabolites they produce), the intestinal microbiota present in the feces of infants, their mothers and their grandmothers. (English)
12 October 2021
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Madrid
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Identifiers
PI17_01087
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