PHYSIOLOGICAL ROLE OF SHOC2/SUR8 PROTEIN AND STUDY OF ITS INVOLVEMENT IN HUMAN PATHOLOGIES (Q3210579): Difference between revisions

@@ label / el / label / el @@
+ΦΥΣΙΟΛΟΓΙΚΌΣ ΡΌΛΟΣ ΤΗΣ ΠΡΩΤΕΪ́ΝΗΣ SHOC2/SUR8 ΚΑΙ ΜΕΛΈΤΗ ΤΗΣ ΣΥΜΜΕΤΟΧΉΣ ΤΗΣ ΣΕ ΑΝΘΡΏΠΙΝΕΣ ΠΑΘΟΛΟΓΊΕΣ
@@ label / da / label / da @@
+FYSIOLOGISK ROLLE AF SHOC2/SUR8 PROTEIN OG UNDERSØGELSE AF DETS INVOLVERING I MENNESKELIGE PATOLOGIER
@@ label / fi / label / fi @@
+SHOC2/SUR8-PROTEIININ FYSIOLOGINEN ROOLI JA TUTKIMUS SEN OSALLISTUMISESTA IHMISEN PATOLOGIOIHIN
@@ label / mt / label / mt @@
+IR-RWOL FIŻJOLOĠIKU TAL-PROTEINA SHOC2/SUR8 U STUDJU TAL-INVOLVIMENT TAGĦHA FIL-PATOLOĠIJI TAL-BNIEDEM
@@ label / lv / label / lv @@
+SHOC2/SUR8 PROTEĪNA FIZIOLOĢISKĀ LOMA UN PĒTĪJUMS PAR TĀ IESAISTI CILVĒKA PATOLOĢIJĀS
@@ label / sk / label / sk @@
+FYZIOLOGICKÁ ÚLOHA PROTEÍNU SHOC2/SUR8 A ŠTÚDIUM JEHO ÚČASTI NA ĽUDSKÝCH PATOLÓGIÁCH
@@ label / ga / label / ga @@
+RÓL FISEOLAÍOCH PRÓITÉIN SHOC2/SUR8 AGUS STAIDÉAR A DHÉANAMH AR A RANNPHÁIRTÍOCHT I BPAITEOLAÍOCHTAÍ DAONNA
@@ label / cs / label / cs @@
+FYZIOLOGICKÁ ROLE PROTEINU SHOC2/SUR8 A STUDIUM JEHO ZAPOJENÍ DO LIDSKÝCH PATOLOGIÍ
@@ label / pt / label / pt @@
+PAPEL FISIOLÓGICO DA PROTEÍNA SHOC2/SUR8 E ESTUDO DA SUA PARTICIPAÇÃO EM PATOLOGIAS HUMANAS
@@ label / et / label / et @@
+SHOC2/SUR8 PROTEIINI FÜSIOLOOGILINE ROLL JA UURING SELLE OSALEMISE KOHTA INIMESE PATOLOOGIATES
@@ label / hu / label / hu @@
+A SHOC2/SUR8 FEHÉRJE ÉLETTANI SZEREPE ÉS AZ EMBERI PATOLÓGIÁKBAN VALÓ RÉSZVÉTELÉNEK VIZSGÁLATA
@@ label / bg / label / bg @@
+ФИЗИОЛОГИЧНА РОЛЯ НА ПРОТЕИНА SHOC2/SUR8 И ПРОУЧВАНЕ НА УЧАСТИЕТО МУ В ПАТОЛОГИИТЕ ПРИ ЧОВЕКА
@@ label / lt / label / lt @@
+FIZIOLOGINIS SHOC2/SUR8 BALTYMO VAIDMUO IR JO ĮTRAUKIMO Į ŽMOGAUS PATOLOGIJAS TYRIMAS
@@ label / hr / label / hr @@
+FIZIOLOŠKA ULOGA PROTEINA SHOC2/SUR8 I PROUČAVANJE NJEGOVE UKLJUČENOSTI U LJUDSKE PATOLOGIJE
@@ label / sv / label / sv @@
+FYSIOLOGISK ROLL FÖR SHOC2/SUR8-PROTEIN OCH STUDIER AV DESS INBLANDNING I MÄNSKLIGA PATOLOGIER
@@ label / ro / label / ro @@
+ROLUL FIZIOLOGIC AL PROTEINEI SHOC2/SUR8 ȘI STUDIUL IMPLICĂRII SALE ÎN PATOLOGIILE UMANE
@@ label / sl / label / sl @@
+FIZIOLOŠKA VLOGA BELJAKOVINE SHOC2/SUR8 IN ŠTUDIJA NJEGOVE VPLETENOSTI V ČLOVEŠKE PATOLOGIJE
@@ label / pl / label / pl @@
+FIZJOLOGICZNA ROLA BIAŁKA SHOC2/SUR8 I BADANIE JEGO ZAANGAŻOWANIA W PATOLOGIE CZŁOWIEKA
@@ description / bg / description / bg @@
+Проект Q3210579 в Испания
@@ description / hr / description / hr @@
+Projekt Q3210579 u Španjolskoj
@@ description / hu / description / hu @@
+Projekt Q3210579 Spanyolországban
@@ description / cs / description / cs @@
+Projekt Q3210579 ve Španělsku
@@ description / da / description / da @@
+Projekt Q3210579 i Spanien
@@ description / nl / description / nl @@
+Project Q3210579 in Spanje
@@ description / et / description / et @@
+Projekt Q3210579 Hispaanias
@@ description / fi / description / fi @@
+Projekti Q3210579 Espanjassa
@@ description / fr / description / fr @@
+Projet Q3210579 en Espagne
@@ description / de / description / de @@
+Projekt Q3210579 in Spanien
@@ description / el / description / el @@
+Έργο Q3210579 στην Ισπανία
@@ description / ga / description / ga @@
+Tionscadal Q3210579 sa Spáinn
@@ description / it / description / it @@
+Progetto Q3210579 in Spagna
@@ description / lv / description / lv @@
+Projekts Q3210579 Spānijā
@@ description / lt / description / lt @@
+Projektas Q3210579 Ispanijoje
@@ description / mt / description / mt @@
+Proġett Q3210579 fi Spanja
@@ description / pl / description / pl @@
+Projekt Q3210579 w Hiszpanii
@@ description / pt / description / pt @@
+Projeto Q3210579 na Espanha
@@ description / ro / description / ro @@
+Proiectul Q3210579 în Spania
@@ description / sk / description / sk @@
+Projekt Q3210579 v Španielsku
@@ description / sl / description / sl @@
+Projekt Q3210579 v Španiji
@@ description / es / description / es @@
+Proyecto Q3210579 en España
@@ description / sv / description / sv @@
+Projekt Q3210579 i Spanien
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-INSTITUTO DE SALUD CARLOS III DE MADRID (ISCIII)
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-Q3158822
@@ Property / beneficiary: Q3158822 / rank @@
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-Majadahonda
@@ Property / location (string): Majadahonda / rank @@
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-°28'23.02"N, 3°52'20.68"WLatitude 40.473055
Longitude -3.8724138
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-Madrid
@@ Property / contained in NUTS: Madrid / rank @@
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@@ Property / summary @@
+ΑΥΤΌ ΤΟ ΈΡΓΟ ΕΊΝΑΙ Η ΦΥΣΙΚΉ ΣΥΝΈΧΕΙΑ ΤΩΝ ΠΡΟΗΓΟΎΜΕΝΩΝ, ΣΤΗΝ ΟΠΟΊΑ ΕΊΧΑΜΕ ΟΡΊΣΕΙ ΟΡΙΣΜΈΝΕΣ ΠΡΩΤΕΪ́ΝΕΣ ΔΕΣΜΏΝ/ANDAMIUM (ΣΥΜΠΕΡΙΛΑΜΒΑΝΟΜΈΝΩΝ SPRY2 ΚΑΙ SUR8) ΩΣ ΔΙΑΜΟΡΦΩΤΈΣ ΤΗΣ ΚΥΤΤΑΡΙΚΉΣ ΣΗΜΑΤΟΔΌΤΗΣΗΣ, ΜΕ ΕΠΙΠΤΏΣΕΙΣ ΣΤΙΣ ΔΙΑΔΙΚΑΣΊΕΣ ΚΥΤΤΑΡΙΚΟΎ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΎ ΚΑΙ ΔΙΑΦΟΡΟΠΟΊΗΣΗΣ. Η ΠΑΡΟΎΣΑ ΠΡΌΤΑΣΗ ΠΡΟΤΕΊΝΕΙ ΝΑ ΕΠΙΚΥΡΩΘΕΊ/ΝΑ ΕΞΕΤΑΣΤΕΊ Η ΥΠΌΘΕΣΗ ΌΤΙ ΤΟ SUR8 ΜΠΟΡΕΊ ΝΑ ΑΠΟΤΕΛΈΣΕΙ ΒΑΣΙΚΉ ΠΡΩΤΕΪ́ΝΗ ΓΙΑ ΤΗ ΔΙΑΜΌΡΦΩΣΗ ΤΟΥ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΎ ΈΝΑΝΤΙ ΤΩΝ ΕΠΙΛΟΓΏΝ ΔΙΑΦΟΡΟΠΟΊΗΣΗΣ ΤΟΥ ΒΛΑΣΤΟΚΥΤΤΆΡΟΥ/ΣΤΕΛΈΧΟΥΣ ΤΩΝ ΔΙΑΦΌΡΩΝ ΘΗΛΑΣΤΙΚΏΝ ΙΣΤΏΝ, ΜΕ ΠΥΡΗΝΙΚΈΣ ΛΕΙΤΟΥΡΓΊΕΣ ΕΠΙΠΛΈΟΝ ΤΟΥ ΚΥΤΤΑΡΟΠΛΑΣΜΑΤΙΚΟΎ ΡΌΛΟΥ ΤΟΥ ΣΤΗΝ ΕΝΕΡΓΟΠΟΊΗΣΗ ΤΩΝ ΠΡΩΤΕΪΝΏΝ RAF ΚΑΙ ΌΤΙ ΣΕ ΠΑΓΚΌΣΜΙΟ ΕΠΊΠΕΔΟ ΜΠΟΡΕΊ ΝΑ ΠΑΡΈΜΒΕΙ ΣΤΗ ΓΈΝΕΣΗ Ή/ΚΑΙ ΣΤΗΝ ΕΞΈΛΙΞΗ ΕΚΦΥΛΙΣΤΙΚΏΝ ΚΑΙ ΝΕΟΠΛΑΣΜΑΤΙΚΏΝ ΠΑΘΟΛΟΓΙΏΝ. ΤΟ ΈΡΓΟ ΒΑΣΊΖΕΤΑΙ ΣΕ ΠΡΟΗΓΟΎΜΕΝΑ ΣΤΟΙΧΕΊΑ ΤΗΣ ΟΜΆΔΑΣ ΜΑΣ, ΣΤΗΝ ΑΠΌΔΟΣΗ ΤΗΣ ΠΡΩΤΕΪ́ΝΗΣ SUR8 ΣΕ ΚΥΤΤΑΡΙΚΈΣ ΔΙΕΡΓΑΣΊΕΣ ΚΑΙ ΣΤΗ ΔΙΑΦΟΡΟΠΟΊΗΣΗ ΤΩΝ ΙΣΤΏΝ (ΌΠΩΣ Η ΑΝΆΠΤΥΞΗ ΤΟΥ ΔΈΡΜΑΤΟΣ). Σε συνδυασμό με το έργο αυτό επικεντρώνεται στη χορήγηση της φυσιολογικής συνάφειας του SUR8 και της πιθανής εφαρμογής του ως πολυδιάστατου DIANA για καταπληκτικά Μελέτη σε εκφυλιστικές και καρκινικές διεργασίες (ΕΙΔΟΣ ΣΥΓΚΕΝΤΡΩΣΗΣ ΑΝΤΑΓΩΝΙΣΤΙΚΟΤΗΤΑΣ) και ΟΛΟΙ είναι ΣΕ ΣΤΟΧΙΚΑ ΕΠΟΜΕΝΑ:_x000D_ 1.- ΒΕΛΤΙΩΣΗ ΤΗΣ ΜΕΤΑΦΟΡΑΣ ΤΟΥ SUR8 CITOPLASM-NUCLEO (μεκανισμός, ΒΕΛΤΙΩΜΕΝΕΣ ΔΟΜΕΣ ΚΑΙ ΚΑΝΟΝΙΣΜΟΣ), καθώς και το ΧΡΗΜΑΤΙΣΤΙΚΟ SUR8 PAPEL στο NUCLEO και την πιθανή σύνδεσή του με άλλες ΠΡΩΤΕΪΝΕΣ σύνδεσης/προσαρμογής του VIA RAS-ERK που εξακολουθούν να έρχονται στο NUCLEO, όπως KSR1 ΚΑΙ SPRY2._x000D_ _x000D_ 2.- ΑΝΑΛΥΣΗ ΦΥΣΙΚΟΥ ΧΑΡΑΚΤΗΡΑ SUR8 ΣΕ ΖΩΝΗ ΓΙΑ τη χρήση γενετικά τροποποιημένων Ratones ΚΑΙ SUR8 επικύρωση ως ΑΝΤΙ-ογκωματικό DIANA POTENTIAL ΣΤΟ ΤΥΠΟ ΡΑΤΟΝΙΩΝ ΣΤΟ καρκινογόνο QUIMICA ΣΤΟ SKIN ΚΑΙ INTESTINO._x000D__x000D__x000D__x000D__x000D_x000D__x000D__x000D__x000D__x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D__x000D_x000D_x000D_x000D_x000D__x000D_x000D_x000D x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x _x000D_ 3.- ΜΕΛΕΤΗ ΕΚΘΕΣΗΣ και ΘΕΜΑΤΩΝ ΤΡΟΠΟΠΟΙΗΣΕΩΝ SUR8 ΣΤΑ ΔΗΛΩΤΙΚΑ ΚΑΙ ΟΡΓΑΝΑ, ΠΡΩΤΑ ΜΕΤΡΑ ΣΤΟ ΣΥΛΛΟΓΙΟ ΤΟΥ ΔΑΤΟΥ, ΙΣΧΥΡΙΣΜΩΝ ΚΑΙ ΕΞΑΓΩΓΗΣ, υπαρχόντων ΔΙΕΘΝΩΝ ΣΥΝΟΧΩΝ, ΟΠΟΙΕΣ ΑΠΟΤΕΛΕΣΜΑΤΑ θα επικυρωθούν σε άλλους τύπους ΚΛΙΝΙΚΩΝ ΤΥΠΩΝ ΠΑΤΟΛΟΓΙΑΣ. (Greek)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+DETTE PROJEKT ER DEN NATURLIGE FORTSÆTTELSE AF TIDLIGERE, HVOR VI HAVDE DEFINERET VISSE BINDING/ANDAMIUM PROTEINER (HERUNDER SPRY2 OG SUR8) SOM MODULATORER FOR CELLULÆR SIGNALERING, MED KONSEKVENSER FOR PROCESSERNE FOR CELLEPROLIFERATION OG DIFFERENTIERING. I DETTE FORSLAG FORESLÅS DET AT VALIDERE/AFKRÆFTE HYPOTESEN OM, AT SUR8 KAN VÆRE ET CENTRALT PROTEIN TIL MODULERING AF SPREDNINGS-/DIFFERENTIERINGSMULIGHEDERNE FOR STAMCELLER/STAMMER I DE FORSKELLIGE PATTEDYRSVÆV, MED NUKLEARE FUNKTIONER UD OVER DETS CYTOPLASMISKE ROLLE I AKTIVERINGEN AF RAF-PROTEINERNE, OG SOM GLOBALT KAN GRIBE IND I GENESIS OG/ELLER UDVIKLINGEN AF DEGENERATIVE OG NEOPLASMISKE PATOLOGIER. PROJEKTET ER BASERET PÅ TIDLIGERE DATA FRA VORES GRUPPE, PÅ YDEEVNEN AF PROTEIN SUR8 I CELLULÆRE PROCESSER OG PÅ VÆVSDIFFERENTIERING (SÅSOM HUDUDVIKLING). I forbindelse med dette projekt fokuseres der på at fjerne den fysiologiske relevans af SUR8 og dets potentielle anvendelse som en multidimensionel DIANA for fantastiske FUTURES i degenerative og tumorale processer (SPECIALLY IN CANCER COLORRECTAL) og ALLE PÅ OBJEKTIVE NEXTENTS:_x000D_ 1.- STUDY AF SUR8 CITOPLASM-NUCLEO (mekanisme, IMPLEMENTED DOMINIER OG FORORDNING), samt FUNCTIONAL SUR8 PAPEL i NUCLEO og dets mulige forbindelse til andre link/adamage PROTEINS I VIA RAS-ERK, der stadig kommer til NUCLEO, som KSR1 OG SPRY2._x000D_ _x000D_ _x000D_ 2.- ANALISIS AF SUR8 fysiologisk PAPEL I LIVE TIL brug af genetisk modificerede Ratones OG SUR8 validering som en ANTI-tumoral DIANA POTENTIEL I DET TYPE AF Ratoner SOMETID TIL carcinogenese QUIMICA IN SKIN OG INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x_x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___xx000D___xx000D___xx000D___xx000D___ FIRST MEASURES I Silico OF DATOS, SNPS og EXPRESSION BASES, eksisterende INTERNATIONALE KONSORCIER, HVIDS RESULTATER Vil blive valideret i andre CLINICAS TYPES af patologi TYPES. (Danish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+TÄMÄ HANKE ON LUONNOLLINEN JATKOA AIEMMILLE, JOISSA OLIMME MÄÄRITELLEET TIETYT SIDOS/ANDAMIUM-PROTEIINIT (MUKAAN LUKIEN SPRY2 JA SUR8) SOLUSIGNAALIEN MODULAATTOREIKSI, MILLÄ ON VAIKUTUKSIA SOLUJEN LISÄÄNTYMISEEN JA ERIYTYMISEEN. TÄSSÄ EHDOTUKSESSA EHDOTETAAN, ETTÄ VALIDOIDAAN TAI HYLÄTÄÄN OLETTAMUS, ETTÄ SUR8 VOI OLLA KESKEINEN PROTEIINI ERI NISÄKÄSKUDOSTEN KANTASOLUJEN/RUNGON PROLIFERAATIO- JA ERIYTTÄMISVAIHTOEHTOJEN MUKAUTTAMISESSA, SILLÄ YDINTOIMINNOT TÄYDENTÄVÄT SEN SYTOPLASMISTA ROOLIA RAF-PROTEIINIEN AKTIVOINNISSA JA ETTÄ MAAILMANLAAJUISESTI VOIDAAN PUUTTUA GENESIS- JA/TAI RAPPEUTTAVIEN JA KASVAIMISTEN PATOLOGIOIDEN KEHITTYMISEEN. PROJEKTI PERUSTUU RYHMÄMME AIEMPIIN TIETOIHIN, PROTEIINI SUR8:N SUORITUSKYKYYN SOLUPROSESSEISSA JA KUDOSTEN ERIYTYMISEEN (KUTEN IHON KEHITYKSEEN). Yhdessä tässä hankkeessa keskitytään luovuttamaan SUR8:n fysiologinen relevanssi ja sen mahdollinen soveltaminen moniulotteisena DIANA:na erinomaisille rappeutumis- ja tuumoraaliprosesseissa (SPECIALLY IN CANCER COLORRECTAL) ja KAIKKI on PLANT ON OBJECTIVE NEXTENTS:_x000D_ 1. – SUR8 CITOPLASM-NUCLEO (mekanismi, TÄYTÄNTÖT JA ASETUS) sekä NUCLEOn FUNCTIONAL SUR8 PAPEL ja sen mahdollinen yhteys muihin VIA RAS-ERK -linkkiin/vahinkoihin, jotka ovat vielä tulossa NUCLEOon, kuten KSR1 JA SPRY2._x000D_ _x000D_ 2.- ANALISIS OF SUR8 physiologic PAPEL IN LIVE FOR the use of muuntogeeniset Ratones JA SUR8 validointi ANTI-kasvaimena DIANA POTENTIAL IN TÄMÄN TYYPPI Ratonien SOMETID SOMETID syöpää aiheuttavaksi tekijäksi QUIMICA SKIN JA INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D_000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x_x000D_ 3.- KOSKEVAT SUR8-JÄRJESTELMÄT DEGENERATIVIN JA tumoraalisten TUOMIOIDEN TIEDOT, IN silico of DATOS, SNPS ja EXPRESSION BASES, olemassaolevia INTERNATIONAL CONSORCIES, JOTKA RESULTS WILL on validoitu muissa CLINICAS TYPES patologian TYPES. (Finnish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+DAN IL-PROĠETT HUWA L-KONTINWAZZJONI NATURALI TA’ DAWK PREĊEDENTI, FEJN KONNA DDEFINEJNA ĊERTI PROTEINI TA’ BOND/ANDAMIUM (INKLUŻI SPRY2 U SUR8) BĦALA MODULATURI TAS-SINJALAR ĊELLULARI, B’IMPLIKAZZJONIJIET GĦALL-PROĊESSI TAL-PROLIFERAZZJONI U D-DIFFERENZJAZZJONI TAĊ-ĊELLOLI. DIN IL-PROPOSTA TIPPROPONI LI TIVVALIDA/TIRRIFJUTA L-IPOTEŻI LI SUR8 TISTA’ TKUN PROTEINA EWLENIJA BIEX TIMMODULA L-GĦAŻLIET TA’ PROLIFERAZZJONI KONTRA D-DIFFERENZJAZZJONI TAĊ-ĊELLOLA STAMINALI/STEM TAT-TESSUTI MAMMALI DIFFERENTI, B’FUNZJONIJIET NUKLEARI ADDIZZJONALI GĦAR-RWOL ĊITOPLASMIKU TAGĦHA FL-ATTIVAZZJONI TAL-PROTEINI RAF U LI GLOBALMENT TISTA’ TINTERVJENI FIL-ĠENESI U/JEW L-EVOLUZZJONI TA’ PATOLOĠIJI DEĠENERATTIVI U NEOPLAŻMI. IL-PROĠETT HUWA BBAŻAT FUQ DATA PREĊEDENTI MILL-GRUPP TAGĦNA, FUQ IL-PRESTAZZJONI TAL-PROTEINA SUR8 FIL-PROĊESSI ĊELLULARI U FUQ ID-DIFFERENZJAZZJONI TAT-TESSUTI (BĦALL-IŻVILUPP TAL-ĠILDA). Flimkien ma’ dan il-proġett jiffoka fuq it-tqassim tar-rilevanza fiżjoloġika ta’ SUR8 u l-applikazzjoni potenzjali tagħha bħala DIANA multidimensjonali għal FUTUREs terrifici fi proċessi deġenerattivi u tumorali (SPEĊJALI FIL-KORRRETALI TAL-KANĊER) u KOLLHA huwa PLANT DWAR NEXTENTIJIET OBJETTIVI:_x000D_ 1.- STUDY TAL-TRASPORT TA’ SUR8 CITOPLASM-NUCLEO (mekaniżmu, DOMINJONI IMPLEMENTATA U REGOLAMENT), kif ukoll l-APEL SUR8 FUNCTIONAL fil-NUCLEO u l-Konnessjoni Possibbli tagħha għal Link/Adam ieħor PROTEINI TAL-RAS-ERK VIA li għadhom ġejjin għall-NUCLEO, bħala KSR1 U SPRY2._x000D_ _x000D_ _x000D_ 2.- ANALISIS TA’ SUR8 PAPEL fiżjoloġiku IN LIVE GĦALL-użu ta’ Ratones ġenetikament modifikati U SUR8 bħala validazzjoni ANTI-tumorali id-DIANA POTENTIKU F’dan it-tip ta’ Ratoni SOMETID GĦALL-karċinoġeniċità QUIMICA FIL-IKEL U INTESTINO._x000D_x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D___x000D__x000D__x000D___x000D__x000D__x000D___x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D__x000D__x000D___x000D___x000D___x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D__ FIRST MEASURES IN silico TA’ DATOS, SNPS U BASESJONI, eżistenzi ta’ KONSORRIJIET INTERNAZZJONALI, RIŻULTATI LI Jiġi vvalidati fi CLINICAS TYPES oħra tal-patoloġija TYPES. (Maltese)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
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@@ Property / summary @@
+ŠIS PROJEKTS IR DABISKS TURPINĀJUMS IEPRIEKŠĒJIEM PROJEKTIEM, KUROS KĀ ŠŪNU SIGNALIZĀCIJAS MODULATORUS MĒS BIJĀM DEFINĒJUŠI NOTEIKTUS SAIŠU/ANDAMIUM PROTEĪNUS (TOSTARP SPRY2 UN SUR8), KAS IETEKMĒ ŠŪNU PROLIFERĀCIJAS UN DIFERENCIĀCIJAS PROCESUS. ŠAJĀ PRIEKŠLIKUMĀ IEROSINĀTS APSTIPRINĀT/ATSAUKT HIPOTĒZI, KA SUR8 VAR BŪT GALVENAIS PROTEĪNS, LAI MODULĒTU PROLIFERĀCIJU SALĪDZINĀJUMĀ AR DAŽĀDU ZĪDĪTĀJU AUDU CILMES ŠŪNU/CILMES CILMES ŠŪNU DIFERENCIĀCIJAS IESPĒJĀM, AR KODOLFUNKCIJĀM PAPILDUS CITOPLAZMAS LOMAI RAF PROTEĪNU AKTIVĒŠANĀ UN KA GLOBĀLI VAR IEJAUKTIES DEĢENERATĪVO UN NEOPLAZMAS PATOLOĢIJU ĢENĒZES UN/VAI ATTĪSTĪBAS PROCESĀ. PROJEKTA PAMATĀ IR MŪSU GRUPAS IEPRIEKŠĒJIE DATI PAR OLBALTUMVIELU SUR8 VEIKTSPĒJU ŠŪNU PROCESOS UN AUDU DIFERENCIĀCIJU (PIEMĒRAM, ĀDAS ATTĪSTĪBU). Saistībā ar šo projektu galvenā uzmanība ir vērsta uz SUR8 fizioloģiskās nozīmes izdalīšanu un tā iespējamo pielietojumu kā daudzdimensiju DIANA drausmīgiem FUTURES mērķiem deģeneratīvos un audzēju procesos (SPECIALLY IN CANCER COLORRECTAL), un visi ir daudzdimensiju NEKŠTENTI:_x000D_ 1.- SUR8 CITOPLASM-NUCLEO TRANSPORTA STUDIJA (mekanisms, IMPLEMENTED DOMINIES UN REGULA), kā arī NUCLEO FUNCTIONAL SUR8 PAPELE un tā iespējamā saikne ar citiem VIA RAS-ERK saišu/bojājumu produktiem, kas joprojām ierodas NUCLEO, kā KSR1 UN SPRY2._x000D_ _x000D_ 2.- ANALISIS SUR8 fizioloģiskās PAPELES VEIKUMIEM par ģenētiski modificētu ratonu un SUR8 validāciju kā ANTI-tumorālu DIANA POTENTIAL IN TYPE Ratonu SOMETID kanceroģenēzes QUIMICA IN SKIN AND INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D__x _x000D_ 3.- STUDY OF EXPRESSION AND POSIBLE MUTATIONS OF SUR8 DEGENERATĪVAJI UN audzēja DISEASES, FIRST MEASURES IN silico OF DATOS, SNPS UN EXPRESSION BASES, esences INTERNATIONAL CONSORCIES, KĀ RESULTES tiks validētas citos CLINICAS TYPES no patoloģijas TYPES. (Latvian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
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+Gregorian
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+TENTO PROJEKT JE PRIRODZENÝM POKRAČOVANÍM PREDCHÁDZAJÚCICH, V KTORÝCH SME DEFINOVALI URČITÉ BOND/ANDAMIUM PROTEÍNY (VRÁTANE SPRY2 A SUR8) AKO MODULÁTORY BUNKOVEJ SIGNALIZÁCIE, ČO MÁ VPLYV NA PROCESY BUNKOVEJ PROLIFERÁCIE A DIFERENCIÁCIE. V TOMTO NÁVRHU SA NAVRHUJE POTVRDIŤ/ODRAZIŤ HYPOTÉZU, ŽE SUR8 MÔŽE BYŤ KĽÚČOVÝM PROTEÍNOM NA MODULÁCIU MOŽNOSTÍ PROLIFERÁCIE VS. DIFERENCIÁCIE KMEŇOVÝCH BUNIEK/STONIEK RÔZNYCH TKANÍV CICAVCOV, S JADROVÝMI FUNKCIAMI, KTORÉ DOPĹŇAJÚ JEHO CYTOPLAZMICKÚ ÚLOHU PRI AKTIVÁCII PROTEÍNOV RAF A KTORÉ MÔŽU GLOBÁLNE ZASAHOVAŤ DO GÉNOVEJ A/ALEBO EVOLÚCIE DEGENERATÍVNYCH A NEOPLAZMICKÝCH PATOLÓGIÍ. PROJEKT JE ZALOŽENÝ NA PREDCHÁDZAJÚCICH ÚDAJOCH Z NAŠEJ SKUPINY, NA VÝKONNOSTI PROTEÍNU SUR8 V BUNKOVÝCH PROCESOCH A NA DIFERENCIÁCII TKANÍV (AKO JE VÝVOJ KOŽE). V spojení s týmto projektom sa tento projekt zameriava na vydanie fyziologickej relevantnosti SUR8 a jeho potenciálnej aplikácie ako multidimenzionálneho DIANA pre úžasné potraviny v degeneratívnych a nádorových procesoch (SPECIALLY IN CANCER COLORRECTAL) a VŠETKO je PLATNÉ NA OBJEKTU:_x000D_ 1.- ŠTUDY DOPRAVY SUR8 CITOPLASM-NUCLEO (mekanizmus, VYKONÁVANÉ DOMINKY A NARIADENIE), ako aj FUNKCTIONAL SUR8 PAPEL v NUCLEO a jeho možné pripojenie na iné prepojenie/adamage PROTEINS VIA RAS-ERK, ktoré stále prichádzajú do NUCLEO, ako KSR1 AND SPRY2._x000D_ _x000D_ 2.- ANALISIS OF SUR8 fyziologický PAPEL IN LIVE na použitie geneticky modifikovaných Ratones A SUR8 validácia ako ANTI-tumorálna DIANA POTENTIAL v tom, že Ratóny SOMETID NA karcinogenézu QUIMICA v SKIN a INTESTINO._x000D__x000D__x000D_x000D__x000D__x000D__x000D__x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D__x _x000D_ 3.- ŠTUDY VÝKLADNÝCH A POSIBLEHO MUTÁCIÍ SUR8 NA DEGENERATÍVNE A nádorové vylučovanie, FIRST MEASURES IN silico of DATOS, SNPS A EXPRESSION BASES, existencií medzinárodných konzorcií, ktorých výsledky budú validované v iných typoch patologických typov CLINICAS. (Slovak)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
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+day
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@@ Property / summary @@
+IS É AN TIONSCADAL SEO LEANÚINT GO NÁDÚRTHA DE NA CINN ROIMHE SEO, INAR SHAINMHÍNÍOMAR PRÓITÉINÍ BANNAÍ/ANDAMIUM ÁIRITHE (LENA N-ÁIRÍTEAR SPRY2 AGUS SUR8) MAR MHODÚLTÓIRÍ COMHARTHAÍOCHTA CEALLACHA, LE HIMPLEACHTAÍ DO PHRÓISIS IOMADAITHE CILLE AGUS DIFREÁLA. BEARTAÍTEAR LEIS AN TOGRA SEO AN HIPITÉIS A BHAILÍOCHTÚ/A BHRÉAGNÚ GUR FÉIDIR LE SUR8 A BHEITH INA PHRÍOMHPHRÓITÉIN CHUN IOMADÚ VS ROGHANNA DIFREÁLA GASCHEALL/GAISTE NA BHFÍOCHÁN MAMACH ÉAGSÚIL A MHODHNÚ, AGUS FEIDHMEANNA NÚICLÉACHA SA BHREIS AR A RÓL CITOPLASMIC I NGNÍOMHACHTÚ PRÓITÉINÍ RAF AGUS GUR FÉIDIR, AR FUD AN DOMHAIN, IDIRGHABHÁIL A DHÉANAMH IN GENESIS AGUS/NÓ IN ÉABHLÓID PAITEOLAÍOCHTAÍ DÍGHINIÚNACHA AGUS NEOPLASMAÍ. TÁ AN TIONSCADAL BUNAITHE AR SHONRAÍ ROIMHE SEO ÓNÁR NGRÚPA, AR FHEIDHMÍOCHT PRÓITÉINE SUR8 I BPRÓISIS CHEALLACHA AGUS AR DHIFREÁIL FÍOCHÁIN (COSÚIL LE FORBAIRT CRAICINN). I gcomhar leis an tionscadal seo díríonn sé ar dháileadh an RELEVANCY fiseolaíocha SUR8 agus a chur i bhfeidhm féideartha mar DIANA iltoiseach do FUTURES terrific i bpróisis díghiniúnacha agus meallacha (SIALACH I gCÚRSAÍ CANCER COLORRECTAL) agus tá ALL PLANT AR NEXTENTS OBJECTIVE:_x000D_ 1.- STIÚRTHÓIREACHT IOMLÁN SUR8 CITOPLASM-NUCLEO (mianachas, Dominies IMPLEMENTED AGUS RIALTAIS), chomh maith leis an PAPEL FUNCTIONAL SUR8 sa NUCLEO agus a Ceangal Féideartha le Nasc/Cosaint Dhamáiste Eile den VIA RAS-ERK atá ag teacht go fóill chuig an NUCLEO, mar KSR1 agus SPRY2._x000D_ _x000D_ 2.- ANALISIS OF SUR8 physiologic PAPEL INIVE D’úsáid Ratones géinmhodhnaithe agus bailíochtú SUR8 mar lannán ANTI-meallach cé gurbh iad Avondale rogha na coitianta tháinig buachaillí GCM le plean agus chuireadar I bhfeidhm é. do__x000D__x000D___x000D___x000D___x000D___x000D___x000D_ 3.- STIÚRTHÓIREACHT MAIDIR LE DATOS, SNPS and EXPRION BASES, atá ann cheana féin de chuid CONSORCIES IDIRNÁISIÚNTA AGUS DÍOLADH MAIDIR LE DHÉANAMH AGUS DHÉANAMH MAIDIR LE DHÉANAMH AGUS DHÉANAMH A DHÉANAMH FÉIDIR LE hAGHAIDH DATOS, SNÁISEANNA AGUS GNÍOMHAÍOCHTAÍ EILEANNA EILEANNA IDIRNÁISIÚNTA, MAIDIR LE DHÉANAMH D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___ (Irish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
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+day
 Before
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@@ Property / summary @@
+TENTO PROJEKT JE PŘIROZENÝM POKRAČOVÁNÍM TĚCH PŘEDCHOZÍCH, VE KTERÝCH JSME DEFINOVALI URČITÉ VAZEBNÍ/ANDAMIUM PROTEINY (VČETNĚ SPRY2 A SUR8) JAKO MODULÁTORY BUNĚČNÉ SIGNALIZACE, S DŮSLEDKY PRO PROCESY BUNĚČNÉ PROLIFERACE A DIFERENCIACE. TENTO NÁVRH NAVRHUJE POTVRDIT/ODMÍTNOUT HYPOTÉZU, ŽE SUR8 MŮŽE BÝT KLÍČOVÝM PROTEINEM PRO MODULACI MOŽNOSTÍ PROLIFERACE VS DIFERENCIACE KMENOVÝCH BUNĚK/STEM RŮZNÝCH TKÁNÍ SAVCŮ, S JADERNÝMI FUNKCEMI, KTERÉ DOPLŇUJÍ JEHO CYTOPLAZMICKOU ROLI PŘI AKTIVACI PROTEINŮ RAF A KTERÉ MOHOU GLOBÁLNĚ ZASAHOVAT DO GENESIS A/NEBO EVOLUCE DEGENERATIVNÍCH A NEOPLAZMATICKÝCH PATOLOGIÍ. PROJEKT JE ZALOŽEN NA PŘEDCHOZÍCH ÚDAJÍCH Z NAŠÍ SKUPINY, NA VÝKONNOSTI PROTEINU SUR8 V BUNĚČNÝCH PROCESECH A NA DIFERENCIACI TKÁNÍ (JAKO JE VÝVOJ KŮŽE). Ve spojení s tímto projektem se zaměřuje na uvolnění fyziologické relevance SUR8 a jeho potenciální aplikace jako multidimenzionální DIANA pro skvělé FUTURY v degenerativních a nádorových procesech (SPECIALLY IN CANCER COLORRECTAL) a ALL je PLANT NA OBJEKTIVNÍCH NEXTENTS:_x000D_ 1.- STUDIE DOPRAVY SUR8 CITOPLASM-NUCLEO (mekanismus, IMPLEMENTED DOMINIES A NAŘÍZENÍ), stejně jako FUNCTIONAL SUR8 PAPEL v NUCLEO a jeho možné spojení s jinými odkazy/adamage PROTEINY VIA RAS-ERK, které stále přicházejí do NUCLEO, jako KSR1 A SPRY2._x000D_ _x000D_ _x000D_ 2.- ANALIZA SUR8 fyziologické PAPEL IN LIVE pro použití geneticky modifikovaných Ratonů A SUR8 validace jako ANTI-tumorální DIANA POTENTIÁL V TYPU Ratones SOMETID K karcinogenezi QUIMICA V SKIN A INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_ x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x _x000D_ 3.- STUDIE EXPRESSIONU A POSIBLNÍ MUTACE SUR8 V DEGENERATIVNÍ A nádorové ZÁVĚRY, FIRST MEASURES IN silico OF DATOS, SNPS A EXPRESSION BASES, existenty INTERNATIONAL CONSORCIES, KTERÉ výsledky budou validovány v jiných KLINICAS TYPŮ patologických. (Czech)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
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+Gregorian
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@@ Property / summary @@
+ESTE PROJECTO É A CONTINUAÇÃO NATURAL DE ONS ANTERIORES, EM QUE DEFINIRAMOS DETERMINADAS PROTEÍNAS DE OBRIGAÇÃO/ANDÂMIO (INCLUINDO SPRY2 E SUR8) COMO MODULATORES DE SINALIZAÇÃO CELULAR, COM IMPLICAÇÕES PARA OS PROCESSOS DE PROLIFERAÇÃO E DIFERENCIAÇÃO CELULARES. A PRESENTE PROPOSTA DE VALIDAR/REFUTAR A HIPOTÉIA DE QUE O SUR8 PODE SER UMA PROTEÍNA-CHAVE PARA MODULAR A PROLIFERAÇÃO VS OPÇÕES DE DIFERENCIAÇÃO DA CÉLULA-CHAVE/STEMA DOS DIFERENTES TECIDOS MAMÍLICOS, COM FUNÇÕES NUCLEARES ADICIONAIS AO SEU PAPEL CITOPLASMICO PARA A ACTIVAÇÃO DAS PROTEÍNAS FUNDAMENTAIS E QUE GLOBALIDADE PODE INTERVENIR EM GENESE E/OU EVOLUÇÃO DE PATOLOGIAS DEGENERATIVAS E NEOPLASMICAS. O PROJECTO É BASEADO EM DADOS ANTERIORES DO NOSSO GRUPO, NO DESEMPENHO DA PROTEÍNA SUR8 EM PROCESSOS CELULARES E NA DIFERENCIAÇÃO DOS TECIDOS (TAL COMO O DESENVOLVIMENTO DA PELE). Em conjunto, este projeto centra-se na dispensação da RELEVANCIA fisiológica do SUR8 e da sua potencial aplicação como um DIANA multidimensional para FUTUROS fantásticos em processos degenerativos e tumorais (especialmente no COLORRECTAL DO CÂNCER) e TODO ESTÁ PLANTO EM NEXTENTES OBJETIVOS:_x000D_ 1.- ESTUDO DO TRANSPORTE DO CITOPLASMA-NUCLEO SUR8 (MECANISMO, DOMÍNIOS IMPLEMENTADOS E REGULAMENTAÇÃO), bem como do PAPEL FUNCIONAL SUR8 no NUCLEO e da sua Possível Ligação a Outras Proteínas de Ligação/Adamagem do VIA RAS-ERK que ainda estão a chegar ao NUCLEO, como KSR1 E SPRY2._x000D_ _x000D_ 2.- ANÁLISE DO SUR8 physiologic PAPEL IN LIVE A utilização de RATONES E SUR8 geneticamente modificados para validação como POTENCIAIS DE DIANA ANTI-TUMORAL NESSE TIPO DE RATONES SOMETIDOS PARA carcinogénese da QUIMICA NA PELE E INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D__x000D_x000D__x000D_x000D__x000D_x000D__x000D__x000D_x000D_x000D_x000D_x000D_x000D__x000D_x000D_x000D_x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D_x000D__x000D___X000D_XD___X000D DE EXPRESSÃO E POSULIDA DE POSSEGULOLOCUDO, DE DE E DE DE E DE A SUPERAÇÃO E DE POSSE DE DE DE DO DO TEMOSOSOSOSOS DO TEMOSSODO, DE E DO TEM DO TEM DE E DO DO TEM DO DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DE E DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM DO TEM TEM DO TEM DO TEM TEM TEM DO TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM TEM T PRIMEIRAS MEDIDAS EM SILICO DE DADOS, SNPS E BASES DE EXPRESSÃO, EXISTENTES DE CONSORCIÊNCIAS INTERNACIONAIS, cujos RESULTADOS SERÃO validados noutros TIPOS CLÍNICOS DE TIPOS DE PATOLOGIA. (Portuguese)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
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++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
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 Before
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+SEE PROJEKT ON LOOMULIK JÄTK EELMISTELE, KUS ME MÄÄRATLESIME TEATUD SIDE-/ANDAMIUM-VALGUD (SH SPRY2 JA SUR8) KUI RAKUSIGNAALI MODULAATORID, MILLEL ON MÕJU RAKKUDE PALJUNEMISELE JA DIFERENTSEERUMISELE. KÄESOLEVAS ETTEPANEKUS TEHAKSE ETTEPANEK KINNITADA/TAGASI LÜKATA HÜPOTEES, ET SUR8 VÕIB OLLA PEAMINE VALK PROLIFERATSIOONI JA IMETAJATE KUDEDE TÜVIRAKKUDE/TÜVEDE DIFERENTSEERIMISVÕIMALUSTE MODULEERIMISEL, MILLEL ON TUUMAFUNKTSIOONID LISAKS TSÜTOPLASMA ROLLILE RAF-VALKUDE AKTIVEERIMISEL NING MIS VÕIB ÜLEMAAILMSELT SEKKUDA GEENIDE JA/VÕI DEGENERATIIVSETE JA KASVAJALISTE PATOLOOGIATE ARENDAMISSE. PROJEKT PÕHINEB MEIE GRUPI VARASEMATEL ANDMETEL, VALGU SUR8 JÕUDLUSEL RAKUPROTSESSIDES JA KUDEDE DIFERENTSEERIMISEL (NT NAHA ARENG). Koos selle projektiga keskendutakse SUR8 füsioloogilise asjakohasuse väljaandmisele ja selle võimalikule rakendamisele mitmemõõtmelise DIANAna suurepäraste FUTURES-i jaoks degeneratiivsetes ja tumoraalsetes protsessides (SPECIALLY IN CANCER COLORRECTAL) ja KÕIK on KOHTA OBJECTIVE NEXTENTS:_x000D_ 1.- SUR8 CITOPLASM-NUCLEO TRANSPORTI (mekanism, IMPLEMENTED DOMINIES JA MÄÄRUS) TRANSPORTI STUDY), samuti FUNCTIONAL SUR8 PAPEL NUCLEOs ja selle võimalik ühendamine muude VIA RAS-ERKi linkide/kohandustega, mis ikka veel tulevad NUCLEOsse, nagu KSR1 JA SPRY2._x000D_ _x000D_ 2.- SUR8 füsioloogilise PAPEL IN LIVE IN LIVE IN LIVE IN LIVE IN LIVE ANTI-kasvajate kasutamine geneetiliselt muundatud rtoonide ja SUR8 valideerimiseks ANTI-kasvajana DIANA POTENTIAL KASUTAMISEKS Ratoonide SOMETID Kantserogenees QUIMICA SKIN JA INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___xx000D___x _x000D_ 3.- SUR8 SUR8 DEGENERATIVE- JA tumoraalsete VALITSUSTE KASUTUSED in silico DATOS, SNPS ja EXPRESSION BASES, olemasents of INTERNATIONAL CONSORCIES, VÕI TULEMID TÜÜBIKINNITUSED TYPESis valideeritud teistes CLINICAS TYPES of patoloogia TYPES. (Estonian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
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+EZ A PROJEKT A KORÁBBIAK TERMÉSZETES FOLYTATÁSA, AMELYBEN BIZONYOS KÖTÉSI/ANDAMIUM FEHÉRJÉKET (BELEÉRTVE A SPRY2 ÉS SUR8) SEJTJELEK MODULÁTORAKÉNT HATÁROZTUNK MEG, AMI HATÁSSAL VAN A SEJTPROLIFERÁCIÓ ÉS DIFFERENCIÁLÓDÁS FOLYAMATAIRA. EZ A JAVASLAT ANNAK A FELTÉTELEZÉSNEK AZ ÉRVÉNYESÍTÉSÉT/MEGCÁFOLÁSÁT JAVASOLJA, AMELY SZERINT A SUR8 KULCSFONTOSSÁGÚ FEHÉRJE LEHET A KÜLÖNBÖZŐ EMLŐSSZÖVETEK ŐSSEJTJÉNEK/TÖRZSÉNEK DIFFERENCIÁLÁSI LEHETŐSÉGEIHEZ KÉPEST, A RAF FEHÉRJÉK AKTIVÁLÁSÁBAN BETÖLTÖTT CITOPLAZMIKUS SZEREPE MELLETT NUKLEÁRIS FUNKCIÓKKAL, ÉS HOGY GLOBÁLISAN BEAVATKOZHAT A GENESISBE ÉS/VAGY A DEGENERATÍV ÉS NEOPLASMIKUS PATOLÓGIÁK KIALAKULÁSÁBA. A PROJEKT A CSOPORTUNK KORÁBBI ADATAIN, A FEHÉRJE SUR8 SEJTFOLYAMATOKBAN MUTATOTT TELJESÍTMÉNYÉN ÉS A SZÖVETDIFFERENCIÁLÁSON (PÉLDÁUL A BŐRFEJLŐDÉSEN) ALAPUL. Ezzel összefüggésben ez a projekt a SUR8 fiziológiai relevancia kiadására és annak lehetséges, többdimenziós DIANA-ként való alkalmazására összpontosít a degeneratív és tumoros folyamatokban (SPECIALLY IN CANCER COLORRECTAL), és az MINDEN a SUR8 CITOPLASM-NUCLEO (mecanism, IMPLEMENTED DOMINIES ÉS RENDELET) KÖZLEMÉNYE:_x000D_ 1.- STUDY OF TRANSPORTY OF SUR8 CITOPLASM-NUCLEO (mecanism, IMPLEMENTED DOMINIES ÉS RENDELÉS) valamint a NUCLEO-ban lévő FUNCTIONAL SUR8 PAPEL-t és annak lehetséges kapcsolódási pontjait a VIA RAS-ERK-hoz, amelyek még a NUCLEO-ba érkeznek, mint KSR1 ÉS SPRY2._x000D_ _x000D_ 2.- A SUR8 fiziológiai PAPEL ANALISIS OF ANALISIS OF SUR8 fiziológiai PAPEL AZ ÉLETÉBEN a géntechnológiával módosított Ratonok és a SUR8 validálás ANTI-tumorálisként történő felhasználására DIANA POTENTIÁLIS A SKIN ÉS INTESTINO-ban a QUIMICA rákkeltő hatásához szükséges Ratonok TÍPUSA._x000D__x000D__x000D___000D___000D___x000D___000D___000D___x000D___x000D__x000D__x000D__x000D__x000D___x000D___000D___x000D__x000D__x000D__x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D___x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D__000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___ a DATOS, SNPS és EXPRESSION BASES szillikában lévő, nemzetközi CONSORCICIEK létező tagjai, valamint a KERESKEDELMI EREDMÉNYEK más patológiai TYPES-ben validálandók. (Hungarian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
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+ТОЗИ ПРОЕКТ Е ЕСТЕСТВЕНО ПРОДЪЛЖЕНИЕ НА ПРЕДИШНИТЕ, В КОИТО СМЕ ОПРЕДЕЛИЛИ НЯКОИ СВЪРЗВАЩИ/ANDAMIUM ПРОТЕИНИ (ВКЛЮЧИТЕЛНО SPRY2 И SUR8) КАТО МОДУЛАТОРИ НА КЛЕТЪЧНА СИГНАЛИЗАЦИЯ, С ПОСЛЕДИЦИ ЗА ПРОЦЕСИТЕ НА КЛЕТЪЧНА ПРОЛИФЕРАЦИЯ И ДИФЕРЕНЦИАЦИЯ. В НАСТОЯЩОТО ПРЕДЛОЖЕНИЕ СЕ ПРЕДЛАГА ДА СЕ УТВЪРДИ/ОТРЕЧЕ ХИПОТЕЗАТА, ЧЕ SUR8 МОЖЕ ДА БЪДЕ КЛЮЧОВ ПРОТЕИН ЗА МОДУЛИРАНЕ НА ВАРИАНТИТЕ ЗА ПРОЛИФЕРАЦИЯ СПРЯМО ДИФЕРЕНЦИАЦИЯ НА СТВОЛОВИТЕ КЛЕТКИ/СТЪБЛАТА НА РАЗЛИЧНИТЕ ТЪКАНИ НА БОЗАЙНИЦИТЕ, КАТО ЯДРЕНИТЕ ФУНКЦИИ СА В ДОПЪЛНЕНИЕ КЪМ ЦИТОПЛАЗМЕНАТА МУ РОЛЯ В АКТИВИРАНЕТО НА ПРОТЕИНИТЕ RAF И КОИТО В СВЕТОВЕН МАЩАБ МОГАТ ДА СЕ НАМЕСВАТ В ГЕНЕЗИСА И/ИЛИ ЕВОЛЮЦИЯТА НА ДЕГЕНЕРАТИВНИТЕ И НЕОПЛАЗМЕНИТЕ ПАТОЛОГИИ. ПРОЕКТЪТ СЕ ОСНОВАВА НА ПРЕДИШНИ ДАННИ ОТ НАШАТА ГРУПА, НА ЕФЕКТИВНОСТТА НА ПРОТЕИН SUR8 В КЛЕТЪЧНИТЕ ПРОЦЕСИ И НА ТЪКАННАТА ДИФЕРЕНЦИАЦИЯ (КАТО РАЗВИТИЕ НА КОЖАТА). Във връзка с този проект се фокусира върху предоставянето на физиологичната значимост на SUR8 и потенциалното му приложение като многоизмерна ДИАНА за страхотни ФОРТУРИ в дегенеративните и туморните процеси (СПЕЦИАЛНО В КОЛОРЕКТАЛНО) и ВСИЧКИ е ПЛАНАТА НА ОВЕКТИВНИ НЕКСТЕНТИ:_x000D_ 1.- СЪДЪРЖА НА ТРАНСПОРТА НА SUR8 CITOPLASM-NUCLEO (меканизъм, ИЗПЪЛНИТЕЛНИ ДОМИНИИ И РЕГЛАМЕНТ), както и FUNCTIONAL SUR8 PAPEL в NUCLEO и неговата възможна връзка с други връзки/административни продукти на VIA RAS-ERK, които все още идват към NUCLEO, като KSR1 И SPRY2._x000D_ _x000D_ 2.- АНАЛИЗ НА SUR8 физиологичният PAPEL IN LIVE за използването на генетично модифицирани ратони и SUR8 валидиране като анти-туморален DIANA POTENTIAL В този вид на ратони, които са предназначени за карциногенезата QUIMICA в SKIN и INTESTINO._x000D__x000D_x000D__x000D_x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D_x000D__x000D_x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x000D___x000D__x000D_x000D__x000D__x000D__x000D__x000D_x000D__x000D_x000D___x000D__x000D__x000D__x000D_x000D__x000D___x000DD_x000D__x000DD___x000DD___x000DD___x000D__x000D___x000D___x000D_ първите стъпки в силико на Датос, SNPS и EXPRESSION BASES, съществуващи от международни КОНСОРЦИИ, които ще бъдат валидирани в други CLINICAS TYPES OF Patology TYPES. (Bulgarian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
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+ŠIS PROJEKTAS YRA NATŪRALUS ANKSTESNIŲ TĘSINYS, KURIAME MES NUSTATĖME TAM TIKRUS JUNGTIES/ANDAMIUM BALTYMUS (ĮSKAITANT SPRY2 IR SUR8) KAIP KORINIO SIGNALO MODULIATORIUS, TURINČIUS ĮTAKOS LĄSTELIŲ PROLIFERACIJOS IR DIFERENCIACIJOS PROCESAMS. ŠIAME PASIŪLYME SIŪLOMA PATVIRTINTI (ATMESTI) HIPOTEZĘ, KAD SUR8 GALI BŪTI PAGRINDINIS BALTYMAS, GALINTIS MODULIUOTI ĮVAIRIŲ ŽINDUOLIŲ AUDINIŲ KAMIENINIŲ LĄSTELIŲ IR (ARBA) KAMIENINIŲ LĄSTELIŲ DIFERENCIACIJOS GALIMYBES, KURIŲ BRANDUOLINĖS FUNKCIJOS PAPILDO CITOPLAZMINĮ VAIDMENĮ AKTYVINANT RAF BALTYMUS, IR KAD VISAME PASAULYJE GALI KIŠTIS Į GENEZĘ IR (ARBA) DEGENERACINIŲ IR NAVIKINIŲ PATOLOGIJŲ RAIDĄ. PROJEKTAS GRINDŽIAMAS ANKSTESNIAIS MŪSŲ GRUPĖS DUOMENIMIS, BALTYMŲ SUR8 NAŠUMU LĄSTELIŲ PROCESUOSE IR AUDINIŲ DIFERENCIACIJA (PVZ., ODOS VYSTYMUSI). Kartu šis projektas orientuotas į fiziologinį SUR8 aktualumą ir jo galimą taikymą kaip daugiamatį DIANA, skirtą siaubingiems degeneracinių ir navikų procesams (SPECIALLY in CANCER COLORRECTAL) ir VISI yra PLANT OBJECTIVE NEXTENTS:_x000D_ 1.- SUR8 CITOPLASM-NUCLEO TRANSPORTO (mekanizmas, ĮGYVENDINTI DOMINIAI IR REGLAMENTAS) STUDIJA, taip pat FUNCTIONAL SUR8 PAPEL į NUCLEO ir jo galimą ryšį su kitais VIA RAS-ERK ryšiais/žalingais produktais, kurie vis dar atvyksta į NUCLEO, kaip KSR1 IR SPRY2._x000D_ _x000D_ 2.- SUR8 fiziologinio PAPELIO PRIEŽIŪROS PRIEŽIŪRA, naudojant genetiškai modifikuotus Ratonus ir SUR8 kaip ANTI-tumoralinį patvirtinimą DIANA POTENTIAL, KAD TIPAS Ratones SOMETID KONTROLĖ KUIMIKA SKYRIUS ir INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D__x000D__x000D___x000D___ X000D___x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x_x _x000D___x _x000D__3.- IŠPRENDIMŲ IR NUOMONIŲ VYRIAUSYBIŲ IŠLAIDŲ VYRIAUSYBĖ IR NAUDOJIMO PAVADINIMAS, pagrindinės PASIŪLYMAI DATOS, SNPS IR EXPRESIJOS DALIŲ, egzistavusių INTERNATIONAL CONSORCIES, KURIOS REZULTATAI bus patvirtinti kitose patologijos TYPOS CLINICAS TYPES. (Lithuanian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
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+OVAJ PROJEKT JE PRIRODNI NASTAVAK PRETHODNIH, U KOJEM SMO DEFINIRALI ODREĐENE VEZE/ANDAMIUM PROTEINE (UKLJUČUJUĆI SPRY2 I SUR8) KAO MODULATORE STANIČNE SIGNALIZACIJE, S IMPLIKACIJAMA ZA PROCESE PROLIFERACIJE STANICA I DIFERENCIJACIJE. OVIM SE PRIJEDLOGOM PREDLAŽE POTVRĐIVANJE/ODBIJANJE HIPOTEZE DA SUR8 MOŽE BITI KLJUČNI PROTEIN ZA MODULIRANJE MOGUĆNOSTI PROLIFERACIJE U ODNOSU NA MOGUĆNOSTI DIFERENCIJACIJE MATIČNIH STANICA/STABLJIKA RAZLIČITIH TKIVA SISAVACA, PRI ČEMU SE NUKLEARNE FUNKCIJE DODAJU NJEGOVOJ CITOPLAZMIČKOJ ULOZI U AKTIVIRANJU PROTEINA RAF-A I DA SE GLOBALNO MOŽE INTERVENIRATI U POSTANKU I/ILI RAZVOJU DEGENERATIVNIH I NEOPLAZMIČKIH PATOLOGIJA. PROJEKT SE TEMELJI NA PRETHODNIM PODACIMA IZ NAŠE GRUPE, NA PERFORMANSAMA PROTEINA SUR8 U STANIČNIM PROCESIMA I NA DIFERENCIJACIJI TKIVA (KAO ŠTO JE RAZVOJ KOŽE). U vezi s ovim projektom fokusira se na oslobađanje fiziološke relevantnosti SUR8 i njegove potencijalne primjene kao multidimenzionalne DIANA za sjajne FUTURE u degenerativne i tumorske procese (SPECIALLY IN CANCER COLORRECTAL), a sve je PLANT ON OBJEKTIVE NEXTENTS:_x000D_ 1.- STUDY OF THE TRANSPORT OF SUR8 CITOPLASM-NUCLEO (mekanizam, IMPLEMENTED DOMINIES AND UREDBA), kao i FUNCTIONAL SUR8 PAPEL u NUCLEO-u i njegovoj mogućoj vezi s drugim vezama/prilagodbama VIA RAS-ERK-a koji još uvijek dolaze u NUCLEO, kao KSR1 AND SPRY2._x000D_ _x000D_ 2.- ANALIZA SUR8 fiziološkog PAPELA U LIVE za korištenje genetski modificiranih Ratones AND SUR8 validacija kao ANTI-tumoral DIANA POTENTIAL U tom trenutku Ratones SOMETID TO carcinogenesis QUIMICA U SKIN AND INTESTINO._x000D__x000D__x000D___x000D___x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D__x000D___x000D___x000D__x000D__x000D__x000D__x000D___x000D___x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D_ 3.- STUDIJA IZVJEŠĆA I PITANJA SUR8 U DEGENERATIVE I tumorskim DISEASES, FIRST MJERE U Silico of DATOS, SNPS I EXPRESSION BASES, Postojeće Internacionalne ZEMLJIŠTE, KOJE REZULTATI će biti potvrđeni u drugim CLINICAS TYPES od patologije TYPES. (Croatian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
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+DETTA PROJEKT ÄR DEN NATURLIGA FORTSÄTTNING AV TIDIGARE, DÄR VI HADE DEFINIERAT VISSA BOND/ANDAMIUM PROTEINER (INKLUSIVE SPRY2 OCH SUR8) SOM MODULATORER AV CELLULÄR SIGNALERING, MED KONSEKVENSER FÖR PROCESSERNA FÖR CELLPROLIFERATION OCH DIFFERENTIERING. I DETTA FÖRSLAG FÖRESLÅS ATT MAN VALIDERAR/AVVISAR HYPOTESEN ATT SUR8 KAN VARA ETT VIKTIGT PROTEIN FÖR ATT MODULERA SPRIDNINGSALTERNATIVEN JÄMFÖRT MED DIFFERENTIERINGSALTERNATIVEN FÖR STAMCELLEN/STAMMEN I DE OLIKA DÄGGDJURSVÄVNADERNA, MED NUKLEÄRA FUNKTIONER UTÖVER DESS CYTOPLASMISKA ROLL NÄR DET GÄLLER ATT AKTIVERA RAF-PROTEINERNA OCH SOM GLOBALT KAN INGRIPA I GENESIS OCH/ELLER UTVECKLING AV DEGENERATIVA OCH NEOPLASMISKA PATOLOGIER. PROJEKTET BYGGER PÅ TIDIGARE DATA FRÅN VÅR GRUPP, PÅ PRESTANDA AV PROTEIN SUR8 I CELLULÄRA PROCESSER OCH PÅ VÄVNADSDIFFERENTIERING (SÅSOM HUDUTVECKLING). Samtidigt fokuserar detta projekt på att sprida den fysiologiska relevansen av SUR8 och dess potentiella tillämpning som ett multidimensionellt DIANA för fantastiska FUTURES i degenerativa och tumorala processer (SPECIALLY IN CANCER COLORRECTAL) och ALLA är PÅ OBJEKTIV NEXTENTS:_x000D_ 1.- STUDY OF THE TRANSPORT OF SUR8 CITOPLASM-NUCLEO (mekanism, GENOMFÖRANDE DOMINIES OCH FÖRORDNING), samt FUNCTIONAL SUR8 PAPEL i NUCLEO och dess möjliga anslutning till andra länkar/skador av VIA RAS-ERK som fortfarande kommer till NUCLEO, som KSR1 OCH SPRY2._x000D_ _x000D_ 2.- ANALISIS OF SUR8 fysiologiskt PAPEL I LIVE FÖR DEN användning av genetiskt modifierade Ratones OCH SUR8 validering som en ANTI-tumoral DIANA POTENTIAL I DETTA TYP AV Ratoner SOMETID TILL carcinogenes QUIMICA I SKIN OCH INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D_x000D_x000D_x000D__x000D__x000D_x000D_x000D_x000D_x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000_x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D__x000D_ 3.- STUDY OF EXPRESSION OCH POSIBLE MUTATIONER AV SUR8 I DEGENERATIVE OCH tumorala DISEASER, FIRST MEASURES I silico of DATOS, SNPS and EXPRESSION BASES, finns i INTERNATIONAL CONSORCIES, WHICH RESULTATS kommer att valideras i andra KLINICAS-TYPES av patologi TYPES. (Swedish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
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 Before
 After
@@ Property / summary @@
+ACEST PROIECT ESTE CONTINUAREA NATURALĂ A CELOR ANTERIOARE, ÎN CARE AM DEFINIT ANUMITE LEGĂTURI/PROTEINEANDAMIUM (INCLUSIV SPRY2 ȘI SUR8) CA MODULATORI AI SEMNALIZĂRII CELULARE, CU IMPLICAȚII PENTRU PROCESELE DE PROLIFERARE ȘI DIFERENȚIERE CELULARĂ. PREZENTA PROPUNERE PROPUNE VALIDAREA/REFUTAREA IPOTEZEI CONFORM CĂREIA SUR8 POATE FI O PROTEINĂ CHEIE PENTRU MODULAREA OPȚIUNILOR DE PROLIFERARE FAȚĂ DE CELE DE DIFERENȚIERE ALE DIFERITELOR ȚESUTURI DE MAMIFERE, CU FUNCȚII NUCLEARE SUPLIMENTARE FAȚĂ DE ROLUL SĂU CITOPLASMIC ÎN ACTIVAREA PROTEINELOR RAF ȘI CARE, LA NIVEL MONDIAL, POT INTERVENI ÎN GENEZA ȘI/SAU EVOLUȚIA PATOLOGIILOR DEGENERATIVE ȘI NEOPLASMICE. PROIECTUL SE BAZEAZĂ PE DATELE ANTERIOARE ALE GRUPULUI NOSTRU, PE PERFORMANȚA PROTEINEI SUR8 ÎN PROCESELE CELULARE ȘI PE DIFERENȚIEREA ȚESUTURILOR (CUM AR FI DEZVOLTAREA PIELII). În conjuncție, acest proiect se concentrează pe distribuirea relevanței fiziologice a SUR8 și a aplicării sale potențiale ca DIANA multidimensională pentru FUTURES terifiante în procesele degenerative și tumorale (SPECIALLY IN CANCER COLORRECTAL) și ALL este PLANT PE NEXTENȚII OBJECTIVE:_x000D_ 1.- STUDIA TRANSPORTULUI SUR8 CITOPLASM-NUCLEO (mecanism, DOMINII IMPLEMENTATE ȘI REGULAMENT), precum și PAPEL FUNCTIONAL SUR8 în NUCLEO și posibila sa conexiune la alte legături/protocoluri ale VIA RAS-ERK care încă vin la NUCLEO, ca KSR1 ȘI SPRY2._x000D_ _x000D_ _x000D_ 2.- ANALISIS OF SUR8 PAPEL fiziologic ÎN LIVE PENTRU utilizarea ratonelor modificate genetic ȘI validarea SUR8 ca DIANA ANTI-tumorale POTENTIAL ÎN CĂ TIMPUL Ratonelor SOMETID LA carcinogeneza QUIMICA ÎN SKIN ȘI INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D_x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D_x000D__x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_x000D_ x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D__x_x000D_ 3.- STUDIA EXPRESSION ȘI MUTAȚII POSIBLE ale SUR8 în DISEAZELE DEGENERATIVE ȘI tumorale, în primul rând, în silico de DATOS, SNPS ȘI BASES EXPRESSION, existente ale CONSORCIEI INTERNATIONALE, CARE REZULTATE VA fi validate în alte CLINICAS Tipuri de patologie. (Romanian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+TA PROJEKT JE NARAVNO NADALJEVANJE PREJŠNJIH, V KATEREM SMO OPREDELILI DOLOČENE VEZI/ANDAMIUM PROTEINE (VKLJUČNO S SPRY2 IN SUR8) KOT MODULATORJE CELIČNEGA SIGNALA, KAR VPLIVA NA PROCESE CELIČNE PROLIFERACIJE IN DIFERENCIACIJE. TA PREDLOG PREDLAGA, DA SE POTRDI/ZAVRNE HIPOTEZA, DA JE LAHKO SUR8 KLJUČNI PROTEIN ZA MODULACIJO PROLIFERACIJE V PRIMERJAVI Z MOŽNOSTMI DIFERENCIACIJE MATIČNIH CELIC/STEBLA RAZLIČNIH TKIV SESALCEV, Z JEDRSKIMI FUNKCIJAMI, KI DOPOLNJUJEJO NJEGOVO CITOPLAZMIČNO VLOGO PRI AKTIVIRANJU BELJAKOVIN RAF, IN DA LAHKO GLOBALNO POSEGAJO V GENEZO IN/ALI RAZVOJ DEGENERATIVNIH IN NEOPLAZEMSKIH PATOLOGIJ. PROJEKT TEMELJI NA PREJŠNJIH PODATKIH NAŠE SKUPINE, O UČINKOVITOSTI PROTEINA SUR8 V CELIČNIH PROCESIH IN NA DIFERENCIACIJI TKIV (KOT JE RAZVOJ KOŽE). V povezavi s tem projektom se osredotoča na odpravo fiziološke ustreznosti SUR8 in njegove potencialne uporabe kot večdimenzionalna DIANA za čudovite FUTURES v degenerativnih in tumorskih procesih (SPECIALLY IN CANCER COLORRECTAL) in VSE je PLANT OBJEKTIVNI NEXTENTI:_x000D_ 1.- STUDIJA TRANSPORTA SUR8 CITOPLASM-NUCLEO (mekanizem, IMPLEMENTED DOMINIES IN UREDBA), kot tudi FUNCTIONAL SUR8 PAPEL v NUCLEO in njegova možna povezava z drugimi povezavami/prilagoditvenimi PROTEINAMI VIA RAS-ERK, ki še vedno prihajajo v NUCLEO, kot KSR1 IN SPRY2._x000D_ _x000D_ _x000D_ 2.- ANALISIS SUR8 fiziološkega PAPELJA V ŽIVALI ZA uporabo gensko spremenjenih ratonov in validacije SUR8 kot ANTI-tumoralne DIANA POTENTIALNA VRSTA VRSTA Ratonov SOMETID ZA karcinogenezo QUIMICA V SKLICU IN INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D_ 3.- STUDIJA IZVAJANJA IN POSIBLE MUTACIJE V DEGENERATIVNIH IN tumorskih DIMES, PRVE MERITVE V silico DATOS, SNPS IN IZVAJANJE BASES, ki obstajajo iz INTERNATIONAL CONSORCIES, KI JIH RESULTI, ki jih je treba validirati v drugih CLINICAS TYPES patologije. (Slovenian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+TEN PROJEKT JEST NATURALNĄ KONTYNUACJĄ POPRZEDNICH, W KTÓRYCH ZDEFINIOWALIŚMY PEWNE BIAŁKA WIĄZANIA/ANDAMIUM (W TYM SPRY2 I SUR8) JAKO MODULATORY SYGNALIZACJI KOMÓRKOWEJ, CO MA WPŁYW NA PROCESY PROLIFERACJI I RÓŻNICOWANIA KOMÓREK. W NINIEJSZYM WNIOSKU PROPONUJE SIĘ ZATWIERDZENIE/ODRZUCENIE HIPOTEZY, ZGODNIE Z KTÓRĄ SUR8 MOŻE BYĆ KLUCZOWYM BIAŁKIEM DO MODULACJI PROLIFERACJI W PORÓWNANIU Z WARIANTAMI RÓŻNICOWANIA KOMÓREK MACIERZYSTYCH/STEMÓW RÓŻNYCH TKANEK SSAKÓW, Z FUNKCJAMI JĄDROWYMI DODATKOWYMI W STOSUNKU DO ICH ROLI CYTOPLAZMATYCZNEJ W AKTYWACJI BIAŁEK RAF ORAZ ŻE NA CAŁYM ŚWIECIE MOŻE INTERWENIOWAĆ W GENEZĘ I/LUB EWOLUCJĘ PATOLOGII ZWYRODNIENIOWYCH I NOWOTWOROWYCH. PROJEKT OPIERA SIĘ NA WCZEŚNIEJSZYCH DANYCH Z NASZEJ GRUPY, NA WYDAJNOŚCI BIAŁKA SUR8 W PROCESACH KOMÓRKOWYCH ORAZ NA RÓŻNICOWANIU TKANEK (TAKICH JAK ROZWÓJ SKÓRY). W związku z tym projekt ten koncentruje się na dostarczeniu fizjologicznego znaczenia SUR8 i jego potencjalnemu zastosowaniu jako wielowymiarowej DIANA dla wspaniałych FUTURESów w procesach zwyrodnieniowych i nowotworowych (SPECIALLY IN CANCER COLORRECTAL) i WSZYSTKIE JEST WSZYSTKIE NA NEXTENTY:_x000D_ 1.- STUDY TRANSPORTU SUR8 CITOPLASM-NUCLEO (mekanizm, WMPLEMENTED DOMINIES I ROZPORZĄDZENIE), jak również FUNKCJA SUR8 PAPEL w NUCLEO i jego możliwe połączenie z innymi profilami łącza/adamażu VIA RAS-ERK, które nadal przychodzą do NUCLEO, jako KSR1 I SPRY2._x000D_ _x000D_ 2.- ANALIZA PAPEL fizjologiczny SUR8 w ŻYWIE do stosowania genetycznie zmodyfikowanych ratonów i walidacji SUR8 jako ANTI-tumoral DIANA POTENTYCZNA W TYM TYPU Ratonów SOMETID NA rakotwórczość QUIMICA W SKIN I INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D_x000D__x000D__x000D__x000D__x000000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D__x000D__x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D___x000D_ pierwsze ŚRODKI w silico DATOS, SNPS I EXPRESSION BASES, istniej±ce konsorcj?w miêdzynarodowych, uwzglêdnione wyniki bêd± walidowane w innych typach CLINICAS TYPÓW patologicznych. (Polish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / beneficiary @@
+Carlos III Health Institute
@@ Property / beneficiary: Carlos III Health Institute / rank @@
+Normal rank
@@ Property / beneficiary name (string) @@
+INSTITUTO DE SALUD CARLOS III
@@ Property / beneficiary name (string): INSTITUTO DE SALUD CARLOS III / rank @@
+Normal rank
@@ Property / location (string) @@
+Majadahonda
@@ Property / location (string): Majadahonda / rank @@
+Normal rank
@@ Property / postal code @@
@@ Property / postal code: 28200 / rank @@
+Normal rank
@@ Property / contained in NUTS @@
+Madrid
@@ Property / contained in NUTS: Madrid / rank @@
+Normal rank
@@ Property / contained in NUTS: Madrid / qualifier @@
+inferred from: postal code
@@ Property / contained in Local Administrative Unit @@
+San Lorenzo de El Escorial
+Normal rank
+inferred from: postal code
@@ Property / coordinate location @@
+°35'43.73"N, 4°8'38.40"WLatitude 40.595483781653
Longitude -4.1439984505657
Precision 1.0E-5
Globe http://www.wikidata.org/entity/Q2
-Latitude
+.595483781653
-Longitude
+-4.1439984505657
-Precision
+.0E-5
-Globe
+http://www.wikidata.org/entity/Q2
@@ Property / coordinate location: 40°35'43.73"N, 4°8'38.40"W / rank @@
+Normal rank
@@ Property / coordinate location: 40°35'43.73"N, 4°8'38.40"W / qualifier @@
+inferred from: postal code
@@ Property / budget @@
+,300.0 EuroAmount 278,300.0 Euro
Unit Euro
-Amount
+,300.0 Euro
-Unit
+Euro
@@ Property / budget: 278,300.0 Euro / rank @@
+Preferred rank
@@ Property / EU contribution @@
+,534.34 EuroAmount 151,534.34 Euro
Unit Euro
-Amount
+,534.34 Euro
-Unit
+Euro
@@ Property / EU contribution: 151,534.34 Euro / rank @@
+Preferred rank
@@ Property / co-financing rate @@
+.45 percentAmount 54.45 percent
Unit percent
-Amount
+.45 percent
-Unit
+percent
@@ Property / co-financing rate: 54.45 percent / rank @@
+Normal rank
@@ Property / date of last update @@
+December 2023Timestamp +2023-12-21T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2023-12-21T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / date of last update: 21 December 2023 / rank @@
+Normal rank

Latest revision as of 23:16, 9 October 2024

Project Q3210579 in Spain

Language	Label	Description	Also known as
English	PHYSIOLOGICAL ROLE OF SHOC2/SUR8 PROTEIN AND STUDY OF ITS INVOLVEMENT IN HUMAN PATHOLOGIES	Project Q3210579 in Spain

Statements

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151,534.34 Euro

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budget

278,300.0 Euro

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co-financing rate

54.45 percent

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start time

30 December 2016

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end time

29 December 2020

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beneficiary name (string)

INSTITUTO DE SALUD CARLOS III

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beneficiary

Carlos III Health Institute

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intervention field

Research and innovation activities in public research centres and centres of competence including networking

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programme

Multi-regional Spain - ERDF

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fund

European Regional Development Fund

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coordinate location

40°35'43.73"N, 4°8'38.40"W

inferred from

postal code

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postal code

28200

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summary

ESTE PROYECTO ES LA CONTINUACION NATURAL DE OTROS ANTERIORES, EN LOS QUE HABIAMOS DEFINIDO A CIERTAS PROTEINAS DE ENLACE/ANDAMIO (INCLUYENDO SPRY2 Y SUR8) COMO MODULADORES DE LA SEÑALIZACION CELULAR, CON IMPLICACIONES EN LOS PROCESOS DE PROLIFERACION Y DIFERENCIACION CELULAR. LA PRESENTE PROPUESTA PLANTEA VALIDAR/REFUTAR LA HIPOTESIS DE QUE SUR8 PUEDE SER UNA PROTEINA CLAVE PARA MODULAR LAS OPCIONES PROLIFERACION VS DIFERENCIACION DE LAS CELULAS TRONCALES/STEM DE LOS DISTINTOS TEJIDOS DE MAMIFEROS, CON FUNCIONES NUCLEARES ADICIONALES A SU PAPEL CITOPLASMICO EN LA ACTIVACION DE LAS PROTEINAS RAF Y QUE GLOBALMENTE PUEDE INTERVENIR EN LA GENESIS Y/O EVOLUCION DE PATOLOGIAS DEGENERATIVAS Y NEOPLASICAS. EL PROYECTO SE BASA EN DATOS PREVIOS DE NUESTRO GRUPO, SOBRE LA ACTUACION DE LA PROTEINA SUR8 EN PROCESOS CELULARES Y EN LA DIFERENCIACION DE TEJIDOS (COMO EL DESARROLLO DE LA PIEL). EN CONJUNTO ESTE PROYECTO SE ENFOCA EN DISCERNIR LA RELEVANCIA FISIOLOGICA DE SUR8 Y SU POTENCIAL APLICABILIDAD COMO DIANA MOLECULAR PARA FUTURAS TERAPIAS EN PROCESOS DEGENERATIVOS Y TUMORALES (ESPECIALMENTE EN CANCER COLORRECTAL) Y TODO ELLO SE PLANTEA SOBRE LOS SIGUIENTES OBJETIVOS:_x000D_ 1.- ESTUDIO DEL TRANSPORTE DE SUR8 CITOPLASMA-NUCLEO (MECANISMO, DOMINIOS IMPLICADOS Y REGULACION), ASI COMO EL PAPEL FUNCIONAL DE SUR8 EN EL NUCLEO Y SU POSIBLE CONEXION CON OTRAS PROTEINAS DE ENLACE/ANDAMIO DE LA VIA RAS-ERK QUE TAMBIEN VAN AL NUCLEO, COMO KSR1 Y SPRY2._x000D_ _x000D_ 2.- ANALISIS DEL PAPEL FISIOLOGICO DE SUR8 IN VIVO MEDIANTE EL USO DE RATONES MODIFICADOS GENETICAMENTE Y VALIDACION DE SUR8 COMO UNA POTENCIAL DIANA ANTI-TUMORAL EN ESE TIPO DE RATONES SOMETIDOS A CARCINOGENESIS QUIMICA EN PIEL E INTESTINO._x000D_ _x000D_ 3.- ESTUDIO DE LA EXPRESION Y POSIBLES MUTACIONES DE SUR8 EN ENFERMEDADES DEGENERATIVAS Y TUMORALES, PRIMERO MEDIANTE UN ANALISIS IN SILICO DE LAS DISTINTAS BASES DE DATOS, DE SNPS Y DE EXPRESION, EXISTENTES DE LOS CONSORCIOS INTERNACIONALES, CUYOS RESULTADOS SE VALIDARAN LUEGO EN MUESTRAS CLINICAS DE TIPOS CONCRETOS DE PATOLOGIAS. (Spanish)

0 references

THIS PROJECT IS THE NATURAL CONTINUATION OF PREVIOUS ONES, IN WHICH WE HAD DEFINED CERTAIN BOND/ANDAMIUM PROTEINS (INCLUDING SPRY2 AND SUR8) AS MODULATORS OF CELLULAR SIGNALING, WITH IMPLICATIONS FOR THE PROCESSES OF CELL PROLIFERATION AND DIFFERENTIATION. THE PRESENT PROPOSAL PROPOSES TO VALIDATE/REFUTE THE HYPOTHESIS THAT SUR8 CAN BE A KEY PROTEIN FOR MODULATING THE PROLIFERATION VS DIFFERENTIATION OPTIONS OF THE STEM CELL/STEM OF THE DIFFERENT MAMMAL TISSUES, WITH NUCLEAR FUNCTIONS ADDITIONAL TO ITS CYTOPLASMIC ROLE IN ACTIVATING THE RAF PROTEINS AND THAT GLOBALLY CAN INTERVENE IN GENESIS AND/OR EVOLUTION OF DEGENERATIVE AND NEOPLASMIC PATHOLOGIES. THE PROJECT IS BASED ON PREVIOUS DATA FROM OUR GROUP, ON THE PERFORMANCE OF PROTEIN SUR8 IN CELLULAR PROCESSES AND ON TISSUE DIFFERENTIATION (SUCH AS SKIN DEVELOPMENT). In conjunction this project focuses on dispensing the physiological RELEVANCY of SUR8 and its potential application as a multi-dimensional DIANA for terrific FUTURES in degenerative and tumoral processes (SPECIALLY IN CANCER COLORRECTAL) and ALL is PLANT ON OBJECTIVE NEXTENTS:_x000D_ 1.- STUDY OF THE TRANSPORT OF SUR8 CITOPLASM-NUCLEO (MECANISM, IMPLEMENTED DOMINIES AND REGULATION), as well as the FUNCTIONAL SUR8 PAPEL in the NUCLEO and its Possible Connection to Other Link/Adamage PROTEINS OF THE VIA RAS-ERK that are still coming to the NUCLEO, as KSR1 AND SPRY2._x000D_ _x000D_ 2.- ANALISIS OF SUR8 physiologic PAPEL IN LIVE FOR THE use of genetically modified RATONES AND SUR8 validation as an ANTI-TUMORAL DIANA POTENTIAL IN THAT TYPE OF RATONES SOMETID TO carcinogenesis QUIMICA IN SKIN AND INTESTINO._x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D__x000D___x000D___x000D___x000D_____x000D___x _x000D_ 3.- STUDY OF EXPRESSION AND POSIBLE MUTATIONS OF SUR8 IN DEGENERATIVE AND TUMORAL DISEASES, FIRST MEASURES IN SILICO OF DATOS, SNPS AND EXPRESSION BASES, EXISTENTS OF INTERNATIONAL CONSORCIES, WHICH RESULTS WILL be validated in other CLINICAS TYPES OF PATOLOGY TYPES. (English)

PHYSIOLOGICAL ROLE OF SHOC2/SUR8 PROTEIN AND STUDY OF ITS INVOLVEMENT IN HUMAN PATHOLOGIES (Q3210579): Difference between revisions

Latest revision as of 23:16, 9 October 2024

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