ANALYSIS OF YIN-YANG INTERACTION BETWEEN TP53 AND TP73 IN REPROGRAMMING AND TISSUE ARCHITECTURE: IMPLICATION IN TUMOR ONCOGENESIS (Q3165218): Difference between revisions

@@ label / fr / label / fr @@
+ANALYSE DE L’INTERACTION YIN-YANG ENTRE TP53 ET TP73 DANS LA REPROGRAMMATION ET L’ARCHITECTURE TISSULAIRE: IMPLICATION DANS L’ONCOGÉNÈSE TUMORALE
@@ label / de / label / de @@
+ANALYSE DER YIN-YANG-INTERAKTION ZWISCHEN TP53 UND TP73 IN REPROGRAMMIERUNG UND GEWEBEARCHITEKTUR: IMPLIKATION BEI TUMOR-ONKOGENESE
@@ label / nl / label / nl @@
+ANALYSE VAN YIN-YANG INTERACTIE TUSSEN TP53 EN TP73 IN HERPROGRAMMERING EN WEEFSELARCHITECTUUR: IMPLICATIE BIJ TUMORONCOGENESE
@@ label / it / label / it @@
+ANALISI DELL'INTERAZIONE DI YIN-YANG TRA TP53 E TP73 NELLA RIPROGRAMMAZIONE E NELL'ARCHITETTURA TISSUTALE: IMPLICAZIONE NELL'ONCOGENESI TUMORALE
@@ label / el / label / el @@
+ΑΝΆΛΥΣΗ ΤΗΣ ΑΛΛΗΛΕΠΊΔΡΑΣΗΣ YIN-YANG ΜΕΤΑΞΎ TP53 ΚΑΙ TP73 ΣΤΟΝ ΕΠΑΝΑΠΡΟΓΡΑΜΜΑΤΙΣΜΌ ΚΑΙ ΤΗΝ ΑΡΧΙΤΕΚΤΟΝΙΚΉ ΤΩΝ ΙΣΤΏΝ: ΕΠΙΠΤΏΣΕΙΣ ΣΤΗΝ ΟΓΚΟΓΈΝΕΣΗ ΤΟΥ ΌΓΚΟΥ
@@ label / da / label / da @@
+ANALYSE AF YIN-YANG INTERAKTION MELLEM TP53 OG TP73 I OMPROGRAMMERING OG VÆVSARKITEKTUR: IMPLIKATION I TUMOR ONKOOGENESE
@@ label / fi / label / fi @@
+ANALYYSI YIN-YANGIN VUOROVAIKUTUKSESTA TP53:N JA TP73:N VÄLILLÄ UUDELLEENOHJELMOINTI- JA KUDOSARKKITEHTUURISSA: VAIKUTUS KASVAIMEEN ONCOGENESIS
@@ label / mt / label / mt @@
+ANALIŻI TAL-INTERAZZJONI YIN-YANG BEJN TP53 U TP73 FIR-RIPROGRAMMAR U L-ARKITETTURA TAT-TESSUTI: IMPLIKAZZJONI FL-ONKOĠENESI TAT-TUMUR
@@ label / lv / label / lv @@
+YIN-YANG MIJIEDARBĪBAS ANALĪZE STARP TP53 UN TP73 PĀRPROGRAMMĒŠANĀ UN AUDU ARHITEKTŪRĀ: IETEKME UZ AUDZĒJA ONKOĢENĒZI
@@ label / sk / label / sk @@
+ANALÝZA INTERAKCIE YIN-YANG MEDZI TP53 A TP73 V PREPROGRAMOVANÍ A TKANIVOVEJ ARCHITEKTÚRE: VPLYV NA ONKOGENÉZU NÁDORU
@@ label / ga / label / ga @@
+ANAILÍS AR IDIRGHNÍOMHAÍOCHT CEANN-YANG IDIR TP53 AGUS TP73 IN ATHCHLÁRÚ AGUS AILTIREACHT FÍOCHÁIN: IMPLEACHT IN ONCOGENESIS MEALL
@@ label / cs / label / cs @@
+ANALÝZA INTERAKCE YIN-YANG MEZI TP53 A TP73 V PŘEPROGRAMOVÁNÍ A TKÁŇOVÉ ARCHITEKTUŘE: DŮSLEDKY V NÁDOROVÉ ONKOGENEZE
@@ label / pt / label / pt @@
+ANÁLISE DA INTERACÇÃO YIN-YANG ENTRE TP53 E TP73 NA REPROGRAMAÇÃO E ARQUITETURA DOS TECIDOS: IMPLICAÇÃO NA ONCOGENESE DO TUMOR
@@ label / et / label / et @@
+YIN-YANGI KOOSTOIME ANALÜÜS TP53 JA TP73 VAHEL ÜMBERPROGRAMMEERIMISEL JA KOEARHITEKTUURIS: MÕJU KASVAJA ONKOGENEES
@@ label / hu / label / hu @@
+A TP53 ÉS A TP73 KÖZÖTTI YIN-YANG KÖLCSÖNHATÁS ELEMZÉSE AZ ÁTPROGRAMOZÁS ÉS A SZÖVETI ARCHITEKTÚRA TERÉN: HATÁSA A TUMOR ONKOGENEZIS
@@ label / bg / label / bg @@
+АНАЛИЗ НА ВЗАИМОДЕЙСТВИЕТО НА ИН-ЯНГ МЕЖДУ TP53 И TP73 В ПРЕПРОГРАМИРАНЕТО И ТЪКАННАТА АРХИТЕКТУРА: ПОСЛЕДИЦИ ПРИ ТУМОРНА ОНКОГЕНЕЗА
@@ label / lt / label / lt @@
+YIN-YANG SĄVEIKOS TARP TP53 IR TP73 ANALIZĖ PERPROGRAMUOJANT IR AUDINIŲ ARCHITEKTŪROJE: POVEIKIS NAVIKO ONKOGENEZEI
@@ label / hr / label / hr @@
+ANALIZA INTERAKCIJE YIN-YANG IZMEĐU TP53 I TP73 U REPROGRAMIRANJU I ARHITEKTURI TKIVA: IMPLIKACIJA TUMORA ONKOGENEZE
@@ label / sv / label / sv @@
+ANALYS AV YIN-YANG-INTERAKTIONEN MELLAN TP53 OCH TP73 I OMPROGRAMMERING OCH VÄVNADSARKITEKTUR: KONSEKVENSER FÖR TUMÖRONKOGENES
@@ label / ro / label / ro @@
+ANALIZA INTERACȚIUNII YIN-YANG ÎNTRE TP53 ȘI TP73 ÎN REPROGRAMARE ȘI ARHITECTURA ȚESUTURILOR: IMPLICAȚIA ÎN ONCOGENEZA TUMORII
@@ label / sl / label / sl @@
+ANALIZA INTERAKCIJE YIN-YANG MED TP53 IN TP73 PRI REPROGRAMIRANJU IN TKIVNI ARHITEKTURI: VPLIV NA TUMORSKO ONKOGENEZO
@@ label / pl / label / pl @@
+ANALIZA INTERAKCJI YIN-YANG MIĘDZY TP53 I TP73 W PRZEPROGRAMOWANIU I ARCHITEKTURZE TKANEK: IMPLIKACJA W ONKOGENEZIE NOWOTWORU
@@ description / bg / description / bg @@
+Проект Q3165218 в Испания
@@ description / hr / description / hr @@
+Projekt Q3165218 u Španjolskoj
@@ description / hu / description / hu @@
+Projekt Q3165218 Spanyolországban
@@ description / cs / description / cs @@
+Projekt Q3165218 ve Španělsku
@@ description / da / description / da @@
+Projekt Q3165218 i Spanien
@@ description / nl / description / nl @@
+Project Q3165218 in Spanje
@@ description / et / description / et @@
+Projekt Q3165218 Hispaanias
@@ description / fi / description / fi @@
+Projekti Q3165218 Espanjassa
@@ description / fr / description / fr @@
+Projet Q3165218 en Espagne
@@ description / de / description / de @@
+Projekt Q3165218 in Spanien
@@ description / el / description / el @@
+Έργο Q3165218 στην Ισπανία
@@ description / ga / description / ga @@
+Tionscadal Q3165218 sa Spáinn
@@ description / it / description / it @@
+Progetto Q3165218 in Spagna
@@ description / lv / description / lv @@
+Projekts Q3165218 Spānijā
@@ description / lt / description / lt @@
+Projektas Q3165218 Ispanijoje
@@ description / mt / description / mt @@
+Proġett Q3165218 fi Spanja
@@ description / pl / description / pl @@
+Projekt Q3165218 w Hiszpanii
@@ description / pt / description / pt @@
+Projeto Q3165218 na Espanha
@@ description / ro / description / ro @@
+Proiectul Q3165218 în Spania
@@ description / sk / description / sk @@
+Projekt Q3165218 v Španielsku
@@ description / sl / description / sl @@
+Projekt Q3165218 v Španiji
@@ description / es / description / es @@
+Proyecto Q3165218 en España
@@ description / sv / description / sv @@
+Projekt Q3165218 i Spanien
@@ Property / budget @@
-,700.0 EuroAmount 205,700.0 Euro
Unit Euro
-Amount
+,700.0 Euro
-Unit
+Euro
@@ Property / budget: 205,700.0 Euro / rank @@
-Normal rank
@@ Property / co-financing rate @@
-.0 percentAmount 50.0 percent
Unit percent
-Amount
+.0 percent
-Unit
+percent
@@ Property / co-financing rate: 50.0 percent / rank @@
-Normal rank
@@ Property / EU contribution @@
-,850.0 EuroAmount 102,850.0 Euro
Unit Euro
-Amount
+,850.0 Euro
-Unit
+Euro
@@ Property / EU contribution: 102,850.0 Euro / rank @@
-Normal rank
@@ Property / summary @@
-EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English)
-Normal rank
-point in time: 12 October 2021Timestamp +2021-10-12T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2021-10-12T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / postal code @@
@@ Property / postal code: 24089 / rank @@
-Normal rank
@@ Property / location (string) @@
-León
@@ Property / location (string): León / rank @@
-Normal rank
@@ Property / coordinate location @@
-°38'2.94"N, 5°58'17.11"WLatitude 42.63414505
Longitude -5.97141510454
Precision 1.0E-5
Globe http://www.wikidata.org/entity/Q2
-Latitude
+.63414505
-Longitude
+-5.97141510454
-Precision
+.0E-5
-Globe
+http://www.wikidata.org/entity/Q2
@@ Property / coordinate location: 42°38'2.94"N, 5°58'17.11"W / rank @@
-Normal rank
@@ Property / contained in NUTS @@
-León Province
@@ Property / contained in NUTS: León Province / rank @@
-Normal rank
@@ Property / summary @@
+EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English)
+Normal rank
+point in time: 12 October 2021Timestamp +2021-10-12T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2021-10-12T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
+readability score: 0.2060405799356844Amount 0.2060405799356844
Unit 1
-Amount
+.2060405799356844
 Unit
@@ Property / summary @@
+LE DÉVELOPPEMENT EMBRYONNAIRE ET L’ONCOGÉNÈSE PEUVENT ÊTRE CONSIDÉRÉS COMME LES DEUX FACES D’UNE PIÈCE. LES PROCESSUS DE DÉTERMINATION, DE DIFFÉRENCIATION ET DE MORPHOGÉNÈSE CELLULAIRES, CRUCIAUX AU COURS DU DÉVELOPPEMENT EMBRYONNAIRE, SONT LES MÊMES PROCESSUS QUI SEMBLENT DÉRÉGLEMENTÉS LORS DE LA PROGRESSION TUMORALE ET DE LA MÉTASTASE. Le contrôle de ces procédés est porté à CABO, pour le moins en partie, TRANSCRIPCTION FACTORS en tant que membres de la FAMILY P53._x000D_ L’ANALISSE CONJUNT DES DATAS PROVENENTS DES MULTIPLES DE GROUPE, y compris OURSTRE, REVES UNE INTERACTION YIN-YANGEN ENTRE TP53 ET le TP73 GEN bimodal dans les VARIOS BIOLOGIQUES, ENTRE LA MAINTENANCE DES VILLES Troncal NEURAL OU ANGEGENESIS. LE RÉSULTAT DE L’INTERACTION FONCTIONNELLE ENTRE TP53 ET TP73 EST CONTEXTUEL, PARFOIS SYNERGIQUE ET D’AUTRES, ANTAGONICO. Cette RELATION FONCTIONNELLE ENTRE UNE PAPEL CENTRALE DANS LE DÉVELOPPEMENT EMBRIONAIRE ET L’ARCHITECTURE TISULAIRE ET EST FACILITÉ D’imaginer DES ALTERATIONS DANS LE DÉLICAT DE LA BALANCE DE CE RÈGLEMENT DE CONTRÔLE peut RÉSULTER DANS LE PROGRÈS GÉNÉNIQUE ET DU PROGRÈS tumoral._x000D_Nos hypothèses de travail EST QUE TP73 apporte un PAPEL FUNDAMENTAL DANS L’ÉTABILITÉ DES INTERACTIONS CELLERRES ET DE LA DIFFÉRENCE DU CELL. CETTE FONCTION EST BIMODALE PUISQUE LA RÉPONSE CELLULAIRE RÉSULTANTE DÉPENDRA DE L’EXPRESSION DIFFÉRENTIELLE DES ISOFORMES TA ET DN-P73 ET, PAR CONSÉQUENT, DÉPENDANTE DU CONTEXTE CELLULAIRE. LA RÉGULATION CORRECTE DE CES PROCESSUS CELLULAIRES, MÉDIÉE PAR TP73, EST NÉCESSAIRE ET FONDAMENTALE POUR LE DÉVELOPPEMENT CORRECT DE PROCESSUS BIOLOGIQUEMENT COMPLEXES, TELS QUE LA REPROGRAMMATION DES CELUALS SOMATIQUES ET L’ÉTABLISSEMENT DE LA POLARITÉ TISSULAIRE. _x000D_ pour TOUS, l’OBJECTIVE GÉNÉRALE DE CE PROJET est d’élucider le fonctionnement et les conséquences de l’INTERACTION FONCTIONnelle entre TP53 et TP73 EN PROCESSUS QUE SESENTIAL POUR LE DÉVELOPPEMENT EMBRIONAL, DE L’INICIO ET DU PROGRÈS tumoral: LA REPROGRAMMATION DES CELLULES SOMATIQUES, LA DÉTERMINATION CELLULAIRE ET L’ÉTABLISSEMENT D’UN PLAN DE POLARITÉ CELLULAIRE. TOUS CES PROCESSUS APPAREMMENT DIVERSIFIÉS PARTAGENT UN THÈME CENTRAL: Le RÈGLEMENT DE DÉCLARATION ET LA STABILITÉ DES INTERACTIONS CELULAIRES ADOPTÉES._x000D_ À ÉVALUER CE HIPOTESIS, NOS OBJECTIFS SPÉCIFIQUES NOS OBJECTIFS SPÉCIFIQUES SONT:_x000D_ 1. Caractérisation du MÉCANISME D’ACTION P73, PRESENCE OU Ausence OF P53, dans la reprogrammation de SOMATIC CELLS._x000D_ 2. Étude DE L’INTERACTION FONCTIONNELLE DES P53 et P73 TOUVENT LES MASTERS DU MESODERMICA_x000D_3 Programmes de différenciation. ÉTUDE DE LA FONCTION P73 DANS LA SIGNALISATION DE L’ARCHITECTURE PLANAIRE ET TISSULAIRE DE POLARITÉ CELLULAIRE (French)
+Normal rank
+point in time: 4 December 2021Timestamp +2021-12-04T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2021-12-04T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONALE ENTWICKLUNG UND ONKOGENESE KÖNNEN ALS DIE BEIDEN SEITEN EINER MÜNZE BETRACHTET WERDEN. DIE PROZESSE DER ZELLBESTIMMUNG, DIFFERENZIERUNG UND MORPHOGENESE, DIE WÄHREND DER EMBRYONALEN ENTWICKLUNG ENTSCHEIDEND SIND, SIND DIESELBEN PROZESSE, DIE BEI TUMORPROGRESSION UND METASTASEN DEREGULIERT WERDEN. Die Kontrolle dieser Prozesse wird zu CABO, zumindest teilweise, TRANSCRIPCTION FACTORS als Mitglieder der FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, einschließlich OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 und die TP73 bimodale GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL Troncal CELLS or ANGEGENES. DAS ERGEBNIS DER FUNKTIONALEN INTERAKTION ZWISCHEN TP53 UND TP73 IST KONTEXTUELL, MANCHMAL SYNERGISTISCH UND ANDERE, ANTAGONICO. Diese funcional RELATION BETWEEN ein ZENTRAL PAPEL IN der EMBRIONAR DEVELOPMENT UND der tisularen ARCHITECTURE UND IST FACILY, wie ALTERATIONEN IN der BALANCE DELICATE von dieser CONTROL RED kann sich an GENESIS und Tumor PROGRESS._x000D_Unsere Hypothese arbeiten ist, dass TP73 bringt ein FUNDAMENTAL PAPEL in die Stabilität der CELLER INTERACTIONS UND DIE KELLEN DIFFERENCATION. DIESE FUNKTION IST BIMODAL, DA DIE RESULTIERENDE ZELLULÄRE REAKTION VOM DIFFERENTIALAUSDRUCK DER ISOFORMEN TA UND DN-P73 ABHÄNGT UND DAHER VOM ZELLULÄREN KONTEXT ABHÄNGIG IST. DIE KORREKTE REGULIERUNG DIESER DURCH TP73 VERMITTELTEN ZELLULÄREN PROZESSE IST NOTWENDIG UND GRUNDLEGEND FÜR DIE KORREKTE ENTWICKLUNG BIOLOGISCH KOMPLEXER PROZESSE, WIE Z. B. DIE NEUPROGRAMMIERUNG SOMATISCHER CELUALS UND DIE BILDUNG VON GEWEBEPOLARITÄT. _x000D_ für ALLE, das GENERAL OBJECTIVE DES PROJEKT ist es, die Funktionsweise und die Folgen der Funcional INTERACTION zwischen TP53 und TP73 zu verdeutlichen. DIE NEUPROGRAMMIERUNG VON SOMATISCHEN ZELLEN, ZELLBESTIMMUNG UND DIE ETABLIERUNG VON ZELLULÄRER POLARITÄT PLANAR. ALL DIESE SCHEINBAR ABWECHSLUNGSREICHEN PROZESSE TEILEN SICH EIN ZENTRALES THEMA: Die VERORDNUNG DER Differenzierung UND DIE STABILITÄT DER ANWENDUNG VON GESCHÄFTIGKEITEN._x000D_ TO EVALUATE DIESER HIPOTESIS, UNSERE SPEZIFISCHE UNSERE SPEZIFISCHEN OBJEKTIVEN ARE:_x000D_ 1. Charakterisierung von P73 ACTION MECHANISM, PRESENCE ODER P53, bei der Neuprogrammierung von SOMATIC CELLS._x000D_ 2. Studie DER funcionalen INTERACTION von P53 und P73, wie Sie MASTERS der MESODERMICA_x000D_3 Differenzierungsprogramme anbieten. UNTERSUCHUNG DER P73-FUNKTION IN DER BESCHILDERUNG DER ZELLULÄREN POLARITÄT PLANAR- UND GEWEBEARCHITEKTUR (German)
+Normal rank
+point in time: 9 December 2021Timestamp +2021-12-09T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2021-12-09T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONALE ONTWIKKELING EN ONCOGENESE KUNNEN WORDEN BESCHOUWD ALS DE TWEE ZIJDEN VAN EEN MUNT. DE PROCESSEN VAN CELBEPALING, DIFFERENTIATIE EN MORFOGENESE, CRUCIAAL TIJDENS EMBRYONALE ONTWIKKELING, ZIJN DEZELFDE PROCESSEN DIE TIJDENS TUMORPROGRESSIE EN METASTASE WORDEN GEDEREGULEERD. De controle van deze processen wordt uitgevoerd naar CABO, althans gedeeltelijk, TRANSCRIPCTION FACTORS als de leden van de FAMILY P53._x000D_ DE ANALISIS CONJUNT VAN PROVENENTE DATAS VAN GROUP MULTIPLES, met inbegrip van OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 EN de TP73 bimodale GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL Troncal CELLS OF ANGEGENESIS. HET RESULTAAT VAN DE FUNCTIONELE INTERACTIE TUSSEN TP53 EN TP73 IS CONTEXTUEEL, SOMS SYNERGISTISCH EN ANDEREN, ANTAGONICO. Deze funcional RELATION BETWEEN A CENTRALE PAPEL IN DE EMBRIONAR ONTWIKKELING EN DE tisulaire ARCHITECTURE EN IS FACILY om zich als ALTERATIONS IN DE BALANCE DELICATIE VAN DIT CONTROLE KAN RESULTEN IN GENESIS EN tumor PROGRESS._x000D_Onze Hypothese werken is DAT TP73 brengt een FUNDAMENTAL PAPEL IN DE STABILITEIT VAN DE CELLER INTERACTIES EN HET CELL DIFFERENCEC. DEZE FUNCTIE IS BIMODAAL OMDAT DE RESULTERENDE CELLULAIRE RESPONS ZAL AFHANGEN VAN DE DIFFERENTIËLE EXPRESSIE VAN DE ISOVORMEN TA EN DN-P73 EN DAAROM AFHANKELIJK IS VAN DE CELLULAIRE CONTEXT. DE JUISTE REGULERING VAN DEZE CELLULAIRE PROCESSEN, GEMEDIEERD DOOR TP73, IS NOODZAKELIJK EN FUNDAMENTEEL VOOR DE JUISTE ONTWIKKELING VAN BIOLOGISCH COMPLEXE PROCESSEN, ZOALS DE HERPROGRAMMERING VAN SOMATISCHE CELUALS EN DE VASTSTELLING VAN WEEFSELPOLARITEIT. _x000D_ voor ALLE, de ALGEMENE OBJECTIE VAN DEZE PROJECT is om de werking en de gevolgen van de funcional INTERACTIE tussen TP53 en TP73 in PROCESSES DAT SESENTIAL VOOR EMBRIONELE ONTWIKKELING, AS VOOR HET INICIO EN tumormatig PROGRESS: HET HERPROGRAMMEREN VAN SOMATISCHE CELLEN, CELBEPALING EN DE VASTSTELLING VAN CELLULAIRE POLARITEITSPLANAR. AL DEZE SCHIJNBAAR DIVERSE PROCESSEN HEBBEN EEN CENTRAAL THEMA: De VERORDENING VAN de differentiatie EN DE STABILITEIT VAN VOLGENDE CELULARY INTERACTIES._x000D_ TO EVALUATE DIS HIPOTESIS, ONZE SPECIFIEKE ONZE SPECIFIEKE OBJECTIEVEN ZIJN:_x000D_ 1. Karakterisering van P73 ACTIE MECHANISM, PRESENCE OF ausence OF P53, bij de herprogrammering van SOMATIC CELLS._x000D_ 2. Studie VAN DE funcional INTERACTIE VAN P53 en P73 ALS JULLIE MASTERS VAN de MESODERMICA_x000D_3 differentiatieprogramma’s. STUDIE VAN P73'S FUNCTIE IN DE BEWEGWIJZERING VAN CELLULAIRE POLARITEIT PLANAIRE EN WEEFSELARCHITECTUUR (Dutch)
+Normal rank
+point in time: 17 December 2021Timestamp +2021-12-17T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2021-12-17T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+LO SVILUPPO EMBRIONALE E L'ONCOGENESI POSSONO ESSERE CONSIDERATI COME LE DUE FACCE DI UNA MONETA. I PROCESSI DI DETERMINAZIONE CELLULARE, DIFFERENZIAZIONE E MORFOGENESI, CRUCIALI DURANTE LO SVILUPPO EMBRIONALE, SONO GLI STESSI PROCESSI CHE APPAIONO DEREGOLAMENTATI DURANTE LA PROGRESSIONE DEL TUMORE E LA METASTASI. Il controllo di questi processi viene portato a CABO, per lo meno in parte, TRASCRIZIONE FACTORS come membri della FAMILY P53._x000D_ IL CONGETTO ANALISI DEI DATI PROVENENTI DI MULTIPLE DI GRUPPO, compreso il OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 E il TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, come la MAINTENANCE DI CELLS NEURAL Troncal O ANGENESIS. IL RISULTATO DELL'INTERAZIONE FUNZIONALE TRA TP53 E TP73 È CONTESTUALE, A VOLTE SINERGICO E ALTRI, ANTAGONICO. Questa RELAZIONE Funcionale tra un PAPEL CENTRALE NELLO SVILUPPO EMBRIONARIO E L'ARCHITECTURA Tisulare ed è FACILY to Imaginare AS ALTERATIONS NEL DELICATO DI BALANCE DELICATO DI QUESTO RED CONTROLLO può derivare in GENESIS e PROGRESS tumorale._x000D_La nostra ipotesi è che il TP73 porta un PAPEL FONDAMENTALE NELLA STABILITA DELLE INTERACTIONI CELLER E LA DIFFERENCAZIONE CELLA. QUESTA FUNZIONE È BIMODALE IN QUANTO LA RISPOSTA CELLULARE RISULTANTE DIPENDERÀ DALL'ESPRESSIONE DIFFERENZIALE DELLE ISOFORME TA E DN-P73 E, QUINDI, DIPENDERÀ DAL CONTESTO CELLULARE. LA CORRETTA REGOLAZIONE DI QUESTI PROCESSI CELLULARI, MEDIATA DAL TP73, È NECESSARIA E FONDAMENTALE PER IL CORRETTO SVILUPPO DI PROCESSI BIOLOGICAMENTE COMPLESSI, COME LA RIPROGRAMMAZIONE DEI CELUALS SOMATICI E L'INSTAURAZIONE DELLA POLARITÀ TISSUTALE. _x000D_ per TUTTI, l'OBIETTIVO GENERALE DI QUESTO PROGETTO è quello di chiarire il funzionamento e le conseguenze dell'Interazione funcionale tra il TP53 e il TP73 nei processi che richiedono lo sviluppo EMBRIONAL, come per l'INICIO e il PROGRESSO tumorale: LA RIPROGRAMMAZIONE DELLE CELLULE SOMATICHE, LA DETERMINAZIONE CELLULARE E LA DETERMINAZIONE DELLA POLARITÀ CELLULARE PLANARE. TUTTI QUESTI PROCESSI APPARENTEMENTE DIVERSI CONDIVIDONO UN TEMA CENTRALE: Il REGOLAMENTO DELLA DISPONIBILITA‘E LA STABILITA' DELLE INTERAZIONI CELULARIA ADOTTATE._x000D_ PER VALUTARE QUESTO HIPOTESI, NOSTRI SPECIFICI I NOSTRI OBIETTIVI SPECIFICI:_x000D_ 1. Caratterizzazione di P73 ACTION MECHANISM, PRESENCE O ausence OF P53, nella riprogrammazione delle CELLS SOMATIC._x000D_ 2. Studio DELL'INTERAZIONE Funcionale di P53 e P73 COME DEI MASTERS DI MESODERMICA_x000D_3 Programmi di Differenziazione. STUDIO DELLA FUNZIONE P73 NELLA SEGNALETICA DI POLARITÀ CELLULARE PLANARE E ARCHITETTURA TISSUTALE (Italian)
+Normal rank
+point in time: 16 January 2022Timestamp +2022-01-16T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-01-16T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+Η ΕΜΒΡΥΪΚΉ ΑΝΆΠΤΥΞΗ ΚΑΙ Η ΟΓΚΟΓΈΝΕΣΗ ΜΠΟΡΟΎΝ ΝΑ ΘΕΩΡΗΘΟΎΝ ΩΣ ΟΙ ΔΎΟ ΌΨΕΙΣ ΕΝΌΣ ΝΟΜΊΣΜΑΤΟΣ. ΟΙ ΔΙΑΔΙΚΑΣΊΕΣ ΠΡΟΣΔΙΟΡΙΣΜΟΎ ΤΩΝ ΚΥΤΤΆΡΩΝ, ΔΙΑΦΟΡΟΠΟΊΗΣΗΣ ΚΑΙ ΜΟΡΦΟΓΈΝΕΣΗΣ, ΖΩΤΙΚΉΣ ΣΗΜΑΣΊΑΣ ΚΑΤΆ ΤΗ ΔΙΆΡΚΕΙΑ ΤΗΣ ΕΜΒΡΥΪΚΉΣ ΑΝΆΠΤΥΞΗΣ, ΕΊΝΑΙ ΟΙ ΊΔΙΕΣ ΔΙΑΔΙΚΑΣΊΕΣ ΠΟΥ ΕΜΦΑΝΊΖΟΝΤΑΙ ΑΠΟΡΡΥΘΜΙΣΜΈΝΕΣ ΚΑΤΆ ΤΗ ΔΙΆΡΚΕΙΑ ΤΗΣ ΕΞΈΛΙΞΗΣ ΤΟΥ ΌΓΚΟΥ ΚΑΙ ΤΗΣ ΜΕΤΆΣΤΑΣΗΣ. Ο έλεγχος των διαδικασιών αυτών πραγματοποιείται στην CABO, τουλάχιστον εν μέρει, στους ΔΡΑΣΤΗΡΙΟΤΗΤΕΣ ΔΙΑΜΕΤΑΚΟΜΙΣΗΣ ως μέλη του ΟΙΚΟΓΕΝΕΙΟΥ P53._x000D_ ΤΟ ΣΥΜΒΟΥΛΙΟ ΑΝΑΛΥΣΗΣ ΠΑΡΟΧΩΝ ΔΑΤΑΣ ΤΗΣ ΟΜΑΔΑΣ MULTIPLES, συμπεριλαμβανομένου του OURSTER, ΑΝΑΘΕΣΙΖΕΙ ΕΝΑΝ-YANG INTERACTION BETWEEN TP53 και το TP73 διτροπικό ΓΕΝ ΣΤΟ ΒΙΟΛΟΓΙΚΟ CONTEXT VARIOS, ΩΣ ΤΗ ΔΙΑΧΕΙΡΙΣΗ ΝΕΡΟΥ ΤΡΟΝΤΚ ΚΕΛΛΩΝ Ή ΑΝΓΕΓΕΝΗΣ. ΤΟ ΑΠΟΤΈΛΕΣΜΑ ΤΗΣ ΛΕΙΤΟΥΡΓΙΚΉΣ ΑΛΛΗΛΕΠΊΔΡΑΣΗΣ ΜΕΤΑΞΎ TP53 ΚΑΙ TP73 ΕΊΝΑΙ ΣΥΜΦΡΑΖΌΜΕΝΟ, ΜΕΡΙΚΈΣ ΦΟΡΈΣ ΣΥΝΕΡΓΙΣΤΙΚΌ ΚΑΙ ΆΛΛΑ, ANTAGONICO. Αυτή η funcional ΣΧΕΤΙΚΑ ΜΕ ΤΟ ΚΕΝΤΡΙΚΟ ΧΑΡΑΚΤΗΡΙΣΤΙΚΟ ΣΤΗΝ ΕΜΠΟΡΙΚΗ ΑΝΑΠΤΥΞΗ ΚΑΙ ΤΗ ΘΕΣΜΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΚΑΙ ΕΙΝΑΙ ΟΙΚΟΓΕΝΕΙΑ ΝΑ ΦΑΝΕΙ ΝΑ ΕΝΑΛΛΑΣΣΕΤΑΙ ΣΕ ΕΝΑΛΛΑΣΣΟΜΕΝΟ ΣΤΗ ΔΕΛΤΙΟ ΙΣΤΟΣΕΛΙΔΑ ΤΟΥ ΚΟΚΚΙΝΟΥ ΕΛΕΓΧΟΥ ΜΕ ΤΟ ΓΕΝΕΣΙΣ ΚΑΙ ΟΡΘΙΚΟ ΠΡΟΓΡΑΜΜΑ._x000D_Η υποθετική μας εργασία είναι αυτή η TP73 Φέρνει ένα Ταμείο ΠΡΟΒΛΕΨΗ ΣΤΗ ΣΤΑΘΕΡΟΠΟΙΗΣΗ ΤΩΝ ΚΑΛΛΙΕΡΓΕΙΩΝ ΚΑΙ ΤΗΣ ΔΙΑΧΕΙΡΙΣΗΣ ΚΑΛΛΙΕΡΓΕΙΑΣ. Η ΣΥΝΆΡΤΗΣΗ ΑΥΤΉ ΕΊΝΑΙ ΔΙΤΡΟΠΙΚΉ, ΔΕΔΟΜΈΝΟΥ ΌΤΙ Η ΠΡΟΚΎΠΤΟΥΣΑ ΚΥΤΤΑΡΙΚΉ ΑΠΌΚΡΙΣΗ ΘΑ ΕΞΑΡΤΗΘΕΊ ΑΠΌ ΤΗ ΔΙΑΦΟΡΙΚΉ ΈΚΦΡΑΣΗ ΤΩΝ ΙΣΟΜΟΡΦΏΝ TA ΚΑΙ DN-P73 ΚΑΙ, ΩΣ ΕΚ ΤΟΎΤΟΥ, ΕΞΑΡΤΆΤΑΙ ΑΠΌ ΤΟ ΚΥΤΤΑΡΙΚΌ ΠΛΑΊΣΙΟ. Η ΟΡΘΉ ΡΎΘΜΙΣΗ ΑΥΤΏΝ ΤΩΝ ΚΥΤΤΑΡΙΚΏΝ ΔΙΕΡΓΑΣΙΏΝ, ΜΕ ΤΗ ΜΕΣΟΛΆΒΗΣΗ ΤΟΥ TP73, ΕΊΝΑΙ ΑΠΑΡΑΊΤΗΤΗ ΚΑΙ ΘΕΜΕΛΙΏΔΗΣ ΓΙΑ ΤΗΝ ΟΡΘΉ ΑΝΆΠΤΥΞΗ ΒΙΟΛΟΓΙΚΆ ΠΟΛΎΠΛΟΚΩΝ ΔΙΕΡΓΑΣΙΏΝ, ΌΠΩΣ Ο ΕΠΑΝΑΠΡΟΓΡΑΜΜΑΤΙΣΜΌΣ ΤΩΝ ΣΩΜΑΤΙΚΏΝ CELUALS ΚΑΙ Ο ΚΑΘΟΡΙΣΜΌΣ ΠΟΛΙΚΌΤΗΤΑΣ ΤΩΝ ΙΣΤΏΝ. _x000D_ για ΟΛΟΥΣ, ο ΓΕΝΙΚΟΣ ΣΤΟΧΟΣ του ΠΑΡΟΝΤΟΣ ΕΡΓΟΥ είναι να αποσαφηνίσει τη λειτουργία και τις συνέπειες της διαδραστικής διαδραστικότητας μεταξύ του TP53 και του TP73 σε ΔΙΑΔΙΚΑΣΙΕΣ ΠΟΥ ΠΡΟΒΛΕΠΟΝΤΑΙ ΣΕ ΕΜΠΟΡΙΚΗ ΑΝΑΠΤΥΞΗ, ΩΣ ΓΙΑ ΤΟ ΙΝΙΚΙΟ ΚΑΙ ΤΟ ΟΡΙΚΟ ΠΡΟΓΡΑΜΜΑ: Ο ΕΠΑΝΑΠΡΟΓΡΑΜΜΑΤΙΣΜΌΣ ΤΩΝ ΣΩΜΑΤΙΚΏΝ ΚΥΤΤΆΡΩΝ, Ο ΠΡΟΣΔΙΟΡΙΣΜΌΣ ΤΩΝ ΚΥΤΤΆΡΩΝ ΚΑΙ Ο ΠΡΟΣΔΙΟΡΙΣΜΌΣ ΤΗΣ ΚΥΤΤΑΡΙΚΉΣ ΠΟΛΙΚΌΤΗΤΑΣ. ΌΛΕΣ ΑΥΤΈΣ ΟΙ ΦΑΙΝΟΜΕΝΙΚΆ ΔΙΑΦΟΡΕΤΙΚΈΣ ΔΙΑΔΙΚΑΣΊΕΣ ΜΟΙΡΆΖΟΝΤΑΙ ΈΝΑ ΚΕΝΤΡΙΚΌ ΘΈΜΑ: Ο ΚΑΝΟΝΙΣΜΟΣ ΤΗΣ διαφοροποιησησ και ΤΗΣ ΣΤΑΘΕΡΟΠΟΙΗΣΗΣ των ΕΚΔΗΛΩΜΕΝΩΝ ΣΥΜΒΑΣΕΩΝ ΜΑΣ._x000D_ για την ΑΞΙΟΛΟΓΗΣΗ ΤΗΣ ΙΣΠΟΤΕΣΗΣ, ΤΩΝ ΕΙΔΙΚΩΝ ΣΤΟΧΩΝ ΜΑΣ ΤΩΝ ΕΙΔΙΚΩΝ ΣΤΟΧΩΝ ΜΑΣ ΕΙΝΑΙ:_x000D_ 1. Χαρακτηρισμός του P73 ACTION MECHANISM, PRESENCE OR Ausence OF P53, στον επαναπρογραμματισμό των SOMATIC CELLS._x000D_ 2. ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΧΕΙΡΗΣΙΑΚΗΣ ΔΙΑΔΡΑΣΗΣ των P53 και P73 ΩΣ ΝΑ ΛΑΜΒΑΝΕΤΕ ΣΥΝΕΡΓΑΤΕΣ των ΠΡΟΓΡΑΜΜΑΤΩΝ ΔΙΑΦΟΡΩΣΗΣ MESODERMICA_x000D_3. ΜΕΛΈΤΗ ΤΗΣ ΛΕΙΤΟΥΡΓΊΑΣ ΤΟΥ P73 ΣΤΗ ΣΉΜΑΝΣΗ ΤΗΣ ΚΥΤΤΑΡΙΚΉΣ ΠΟΛΙΚΌΤΗΤΑΣ ΕΠΊΠΕΔΗΣ ΑΡΧΙΤΕΚΤΟΝΙΚΉΣ ΚΑΙ ΤΗΣ ΑΡΧΙΤΕΚΤΟΝΙΚΉΣ ΙΣΤΟΎ (Greek)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONISK UDVIKLING OG ONKOOGENESE KAN BETRAGTES SOM DE TO SIDER AF EN MØNT. PROCESSERNE MED CELLEBESTEMMELSE, DIFFERENTIERING OG MORFOGENESE, AFGØRENDE UNDER EMBRYONISK UDVIKLING, ER DE SAMME PROCESSER, DER VISES DEREGULERET UNDER TUMORPROGRESSION OG METASTASE. Kontrollen med disse processer varetages i det mindste delvis af CABO som medlemmer af FAMILY P53._x000D_ ANALISIS KONJUNT AF PROVENENT DATAS AF GROUP MULTIPLES, herunder OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 OG TP73 bimodal GEN I BIOLOGIC CONTEXT VARIOS, AS MAINTENANCE OF NEURAL Troncal CELLS ELLER ANGEGENESIS. RESULTATET AF DEN FUNKTIONELLE INTERAKTION MELLEM TP53 OG TP73 ER KONTEKSTUEL, UNDERTIDEN SYNERGISTISK OG ANDRE, ANTAGONICO. Denne funcionale RELATION skal give en CENTRAL PAPEL i EMBRIONAR DEVELOPMENT OG den tisulære ARCHITECTURE og er FACILY at forestille sig som ALTERATIONER i BALANCE DELICATE af denne KONTROL RED KAN RESULTAT I GENESIS OG tumoral PROGRESS._x000D_Vores hypotese arbejder er det, at TP73 Bringer en FUNDAMENTAL PAPELEL i STABILITY af CELLER INTERACTIONS OG CELLIFFERENCECATION. DENNE FUNKTION ER BIMODAL, DA DEN RESULTERENDE CELLULÆRE RESPONS VIL AFHÆNGE AF DET DIFFERENTIEREDE UDTRYK AF ISOFORMERNE TA OG DN-P73 OG DERFOR AFHÆNGIG AF DEN CELLULÆRE KONTEKST. DEN KORREKTE REGULERING AF DISSE CELLULÆRE PROCESSER, DER FORMIDLES AF TP73, ER NØDVENDIG OG GRUNDLÆGGENDE FOR EN KORREKT UDVIKLING AF BIOLOGISK KOMPLEKSE PROCESSER, SÅSOM OMPROGRAMMERING AF SOMATISKE CELUALS OG ETABLERING AF VÆVSPOLARITET. _x000D_ for ALL, GENERAL OBJECTIVE AF DENNE PROJEKT er at belyse funktionen og konsekvenserne af den funcional INTERACTION mellem TP53 og TP73 I PROCESSES DET SESENTIAL FOR EMBRIONAL UVELOPMENT, SOM FOR INICIO OG tumoral PROGRESS: OMPROGRAMMERING AF SOMATISKE CELLER, CELLEBESTEMMELSE OG ETABLERING AF CELLULÆR POLARITETSPLANAR. ALLE DISSE TILSYNELADENDE FORSKELLIGARTEDE PROCESSER HAR ET CENTRALT TEMA: Ændrings- OG STABILITYEN FOR VEDTAGET CELULARY INTERACTIONS._x000D_ FOR DENNE HIPOTESIS, vores SPECIFIKKE OPLYSNINGER ARE:_x000D_ 1. Karakterisering af P73 ACTION MECHANISM, PRESENCE ELLER ausence OF P53, i omprogrammeringen af SOMATIC CELLS._x000D_ 2. Undersøgelse af den funcional INTERACTION AF P53 og P73, da du får MESODERMICA_x000D_3 Differentiationsprogrammer. UNDERSØGELSE AF P73'S FUNKTION I SKILTNING AF CELLULÆR POLARITET PLANAR OG VÆV ARKITEKTUR (Danish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+ALKION KEHITYSTÄ JA ONKOGENEESIA VOIDAAN PITÄÄ KOLIKON MOLEMPINA PUOLINA. SOLUJEN MÄÄRITYS-, ERILAISTUMIS- JA MORFOGENEESIPROSESSIT, JOTKA OVAT RATKAISEVAN TÄRKEITÄ ALKION KEHITYKSEN AIKANA, OVAT SAMAT PROSESSIT, JOTKA NÄYTTÄVÄT OLEVAN SÄÄNTELEMÄTTÖMIÄ KASVAIMEN ETENEMISEN JA ETÄPESÄKKEEN AIKANA. Näiden prosessien valvonta siirretään ainakin osittain CABO:lle, mukaan lukien TRANSCRIPCTION FACTORS PERHEEN P53._x000D_ ANALISIS CONJUNT OF PROJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, mukaan lukien OURSTER, VASTAA YIN-YANG INTERACTION BETWEEN TP53 ja TP73 bimodaalinen GEN IN BIOLOGIC CONTEXT VARIOS, kuten NEURAL Troncal CELLS OR ANGEGENESIS. TP53:N JA TP73:N TOIMINNALLISEN VUOROVAIKUTUKSEN TULOS ON KONTEKSTUAALINEN, JOSKUS SYNERGISTINEN JA MUUT, ANTAGONICO. Tämä hauskanpito tulee VAHVISTAA A CENTRAL PAPEL in the EMBRIONAR DEVELOPMENT JA Tisular ARCHITECTURE JA ON FACILY kuvitella AS ALTERATIONS TÄMÄT TÄMÄN KÄYTETTÄVÄT KÄYTTÖT TÄMÄN KANSSA GENESIS- JA tumoral PROGRESS._x000D_Meidän Hypothesis toimii IS THAT TP73 Brings CELLERIN TOIMINTA JA KÄYTTÖJÄRJESTELMÄN VALVONTA KÄYTTÖJÄRJESTELMÄ. TÄMÄ FUNKTIO ON BIMODAALINEN, KOSKA TULOKSENA SAATU SOLUVASTE RIIPPUU ISOMUOTOJEN TA:N JA DN-P73:N EROILMAISUSTA JA SIKSI RIIPPUU SOLUKONTEKSTISTA. NÄIDEN TP73:N VÄLITTÄMIEN SOLUPROSESSIEN OIKEA SÄÄNTELY ON VÄLTTÄMÄTÖNTÄ JA OLENNAISTA BIOLOGISESTI MONIMUTKAISTEN PROSESSIEN ASIANMUKAISEN KEHITYKSEN KANNALTA, KUTEN SOMAATTISTEN CELUALS-YHDISTEIDEN UUDELLEENOHJELMOINTI JA KUDOSTEN POLARITEETIN MUODOSTUMINEN. _x000D_ KAIKILLE, YLEINEN OBJECTIVE tämän PROJECTIN on selvittää toimintaa ja seurauksia välillä TP53 ja TP73 välinen funcional INTERACTION TP53 ja TP73 PROCESSES TEHTÄVÄ TÄMÄN EMBRIONAL DEVELOPMENT, AS TIICIO JA Tumoral PROGRESS: SOMAATTISTEN SOLUJEN UUDELLEENOHJELMOINTI, SOLUJEN MÄÄRITTÄMINEN JA SOLUN POLARITEETTITASON MÄÄRITTÄMINEN. KAIKILLA NÄILLÄ NÄENNÄISESTI MONIMUOTOISILLA PROSESSEILLA ON KESKEINEN TEEMA: Eriyttämisen ASETUS JA VALVONTA HYVÄKSYNNÄ TÄMÄN HIPOTESIS- JA VALVONTAVIESTELMÄN HYVÄKSYNNÄN HYVÄKSYNNÄN KÄYTTÄMÄN KÄYTTÖÖN TARJOITUKSEN TARJOITUKSEN TUOTTEIDEN TARJOITUKSEN TUOTTEIDEN TARKOITUS:_x000D_ 1. Luonnehdinta P73 TOIMINTA MECHANISM, PRESENCE TAI Ausence OF P53, uudelleenohjelmointi SOMATIC CELLS._x000D_ 2. P53:n ja P73:n välisen yhteistyön tutkimus MESODERMICA_x000D_3 -eriyttämisohjelmista. TUTKIMUS P73: N TOIMINNASTA SOLUN NAPAISUUDEN JA KUDOSARKKITEHTUURIN MERKEISSÄ (Finnish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+L-IŻVILUPP EMBRIJONIKU U L-ONKOĠENESI JISTGĦU JITQIESU BĦALA Ż-ŻEWĠ NAĦAT TA’ MUNITA. IL-PROĊESSI TAD-DETERMINAZZJONI TAĊ-ĊELLOLI, ID-DIFFERENZJAZZJONI U L-MORFOĠENISI, KRUĊJALI MATUL L-IŻVILUPP EMBRIJONIKU, HUMA L-ISTESS PROĊESSI LI JIDHRU DEREGOLATI MATUL IL-PROGRESSJONI TAT-TUMUR U L-METASTASI. Il-kontroll ta ‘dawn il-proċessi jitwettaq biex CABO, għall-inqas parzjalment, FACTORS TRANSCRIPCTION bħala l-membri tal-FAMILY P53._x000D_ IL-KONJUNT ANALISIS TA ‘DATAJIET PROVENENT TA’ MULTIPLI GROUP, inklużi OURSTER, REVES A INTERACTION YIN-YANG BETWEEN TP53 U l-ĠEN bimodali TP73 F’KONTEXTI BIOLOGIC VARIOS, AS THE MAINTENANCE OF NEURron Tcal CELLSGE ORGEN. IR-RIŻULTAT TAL-INTERAZZJONI FUNZJONALI BEJN TP53 U TP73 HUWA KUNTESTWALI, XI KULTANT SINERĠISTIKU U OĦRAJN, ANTAGONICO. Din il-Funcional RELATION għandha TITĦA PAPEL ĊENTRALI FIL-DEVELOPMENT EMBRJONIAR U L-ARCHITECTURA tisulari U hija FACILY biex timaginate AS ALTERATIONS fid-DELIKAT TAL-KONTROLLU RED RESULT F’ĠEŻ U PROGRESS Tumorali._x000D_Our Hypothesis li jaħdmu TP73 Brings a PAPEL FUNDAMENTAL FL-ISTABILITÀ ta ‘l-INTERAZZJONIJIET KELLER U L-IFFERENCECATION ELL. DIN IL-FUNZJONI HIJA BIMODALI PERESS LI R-RISPONS ĊELLULARI LI JIRRIŻULTA JIDDEPENDI FUQ L-ESPRESSJONI DIFFERENZJALI TAL-ISOFORMI TA U DN-P73 U, GĦALHEKK, JIDDEPENDI FUQ IL-KUNTEST ĊELLULARI. IR-REGOLAMENTAZZJONI KORRETTA TA’ DAWN IL-PROĊESSI ĊELLULARI, MEDJATA MINN TP73, HIJA MEĦTIEĠA U FUNDAMENTALI GĦALL-IŻVILUPP KORRETT TA’ PROĊESSI BIJOLOĠIKAMENT KUMPLESSI, BĦALL-IPPROGRAMMAR MILL-ĠDID TA’ CELUALS SOMATIĊI U L-ISTABBILIMENT TA’ POLARITÀ TAT-TESSUTI. _x000D_ għal KOLLHA, l-OBJETTIVA ĠENERALI TA’ DIN IL-PROJETTIVA hija li jiġu ċċarati l-funzjonament u l-konsegwenzi ta’ l-INTERACTION funcional bejn TP53 u TP73 FIL-PROĊESSIVI LI GĦALL-ŻVILUPP EMBRIJONALI, KIF GĦALL-INIKIO U l-PROGRESS Tumorali: L-IPPROGRAMMAR MILL-ĠDID TA’ ĊELLOLI SOMATIĊI, ID-DETERMINAZZJONI TAĊ-ĊELLOLI U L-ISTABBILIMENT TA’ PLANAR TAL-POLARITÀ ĊELLULARI. DAWN IL-PROĊESSI KOLLHA LI JIDHRU DIFFERENTI GĦANDHOM TEMA ĊENTRALI: Ir-REGOLAMENT TA’ Differenza U L-ISTABILITÀ TA’ INTERAZZJONIJIET KELULARJI AOPTIĊI._x000D_ Biex JAGĦMEL HIPOTESIS, OUR SPEĊIFIĊI OUR OUR SPEĊIFIĊI ARE:_x000D_ 1. Karatterizzazzjoni ta’ P73 AZZJONI MECHANISM, PRESENCE JEW Awżenza TA’ P53, fir-riprogrammar ta’ SOMATIC CELLS._x000D_ 2. Studju ta ‘l-INTERACTION funcional ta’ P53 u P73 AS DO You GET MASTERS TAL-MESODERMICA_x000D_3 Programmi ta ‘Differenzjazzjoni. STUDJU TAL-FUNZJONI P73‘S FIS-SINJALAR TAL-PJANAR TAL-POLARITÀ ĊELLULARI U L-ARKITETTURA TAT-TESSUTI (Maltese)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRIONĀLO ATTĪSTĪBU UN ONKOĢENĒZI VAR UZSKATĪT PAR MONĒTAS ABĀM PUSĒM. ŠŪNU NOTEIKŠANAS, DIFERENCIĀCIJAS UN MORFOĢENĒZES PROCESI, KAS IR BŪTISKI EMBRIONĀLĀS ATTĪSTĪBAS LAIKĀ, IR TIE PAŠI PROCESI, KAS AUDZĒJA PROGRESĒŠANAS UN METASTĀZES LAIKĀ PARĀDĀS NEREGULĒTI. Šo procesu kontrole tiek veikta CABO, vismaz daļēji, TRANSCRIPCTION FACTORS kā FAMILY P53._x000D_ ANALISIS CONJUNT OF GROUP MULTIPLES PROVENENTDATAS, tostarp OURSTER, REGULES A YIN-YANG INTERACTION BETWEEN TP53 un TP73 bimodālo GEN BIOLOGIC CONTEXT VARIOS, kā arī NEURAL Troncal CELLS vai ANGEGENESIS MAINTENANCE. FUNKCIONĀLĀS MIJIEDARBĪBAS REZULTĀTS STARP TP53 UN TP73 IR KONTEKSTUĀLS, DAŽKĀRT SINERĢISKS UN CITI, ANTAGONICO. Šī funcional ATLAUKUMS BETWEEN CENTRAL PAPELAS EMBRIONAR DEVELOPMENT UN tisular ARCHITECTURE UN IS FACILY imaginate AS ALTERATIONS BALANCE DELICATE of THIS CONTROL RED CAN RESULT ĢENESIS UN audzēja PROGRESS._x000D_Mūsu Hipotēzes darba IS TP73 Brings a FUNDAMENTAL PAPELS PALĪDZĪBAS STABILITY OF THE CELLER INTERACTIONS UN CELL DIFFERENCECATION. ŠĪ FUNKCIJA IR BIMODĀLA, JO IEGŪTĀ ŠŪNU ATBILDES REAKCIJA BŪS ATKARĪGA NO IZOFORMU TA UN DN-P73 DIFERENCIĀLĀS IZPAUSMES UN TĀDĒJĀDI BŪS ATKARĪGA NO ŠŪNU KONTEKSTA. PAREIZA ŠO ŠŪNU PROCESU REGULĒŠANA, KO MEDIĒ TP73, IR NEPIECIEŠAMA UN BŪTISKA, LAI PAREIZI ATTĪSTĪTU BIOLOĢISKI SAREŽĢĪTUS PROCESUS, PIEMĒRAM, SOMATISKO CELUALS PĀRPROGRAMMĒŠANU UN AUDU POLARITĀTES VEIDOŠANOS. _x000D_ VISIEM VĒRTĒJOT ŠO PROJEKTS ir izskaidrot funcional INTERACTION darbību un sekas starp TP53 un TP73 PROCESSES, kas attiecas uz EMBRIONAL DEVELOPMENT, AS INICIO un audzēja PROGRESS: SOMATISKO ŠŪNU PĀRPROGRAMMĒŠANA, ŠŪNU NOTEIKŠANA UN ŠŪNU POLARITĀTES PLANĀRA IZVEIDE. VISIEM ŠIEM ŠĶIETAMI DAUDZVEIDĪGAJIEM PROCESIEM IR KOPĪGA CENTRĀLĀ TĒMA: Diferencēšanas regula UN PIEŅEMTS CELULARY INTERACTIONS._x000D_ TO VĒRTĒŠANU HIPOTESIS, MŪSU SPECIFIKĀCIJAS MŪSU SPECIFIKĀCIJAS ARE:_x000D_ 1. P73 ACTION MECHANISM, PRESENCE OR Ausence OF P53 raksturojums SOMATIC CELLS pārprogrammēšanā._x000D_ 2. Pētījums par funcional INTERACTION P53 un P73 AS DO YET MASTERS MESODERMICA_x000D_3 diferenciācijas programmas. PĒTĪJUMS PAR P73’S FUNKCIJU ŠŪNU POLARITĀTES PLANĀRA UN AUDU ARHITEKTŪRAS APZĪMĒJUMOS (Latvian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONÁLNY VÝVOJ A ONKOGENÉZU MOŽNO POVAŽOVAŤ ZA OBE STRANY MINCE. PROCESY STANOVENIA BUNIEK, DIFERENCIÁCIE A MORFOGENÉZY, ROZHODUJÚCE POČAS EMBRYONÁLNEHO VÝVOJA, SÚ ROVNAKÉ PROCESY, KTORÉ SA OBJAVUJÚ DEREGULOVANÉ POČAS PROGRESIE NÁDORU A METASTÁZ. Kontrola týchto procesov sa vykonáva do CABO, aspoň čiastočne, TRANSCRIPCTION FACTORS ako členovia FAMILY P53._x000D_ ANALISIS CONJUNT PROVENENTÝCH DATAS GROUP MULTIPLLES, vrátane NAŠEHO, HODNOTY YIN-YANG INTERACTION BETWEEN TP53 A TP73 bimodálny GEN V biologickej kontexte VARIOS, ako MAINTENANCE NEURAL Troncal CELLS alebo ANGEGENESIS. VÝSLEDOK FUNKČNEJ INTERAKCIE MEDZI TP53 A TP73 JE KONTEXTOVÝ, NIEKEDY SYNERGICKÝ A INÝ, ANTAGONICO. Táto funkčná RELÁCIA musí byť súčasťou EMBRIONAR DEVELOPMENTU a tisulárneho ARCHITEKTÚRA a je možné predstaviť si, ako sa aktivuje v BALANCE DELIKÁCIE, že to môže byť výsledok v GENESIS A nádorový PROGRESS._x000D_Náš Hypotéza pracuje je, že TP73 prináša FUNDAMENTAL PAPEL v STABILITY CELLER INTERACTIONS A CELL DIFFENCREECATION. TÁTO FUNKCIA JE BIMODÁLNA, PRETOŽE VÝSLEDNÁ BUNKOVÁ ODPOVEĎ BUDE ZÁVISIEŤ OD DIFERENCIÁLNEJ EXPRESIE IZOFORIEM TA A DN-P73, A PRETO BUDE ZÁVISIEŤ OD BUNKOVÉHO KONTEXTU. SPRÁVNA REGULÁCIA TÝCHTO BUNKOVÝCH PROCESOV SPROSTREDKOVANÁ TP73 JE NEVYHNUTNÁ A ZÁSADNÁ PRE SPRÁVNY VÝVOJ BIOLOGICKY ZLOŽITÝCH PROCESOV, AKO JE PREPROGRAMOVANIE SOMATICKÝCH CELUALS A STANOVENIE TKANIVOVEJ POLARITY. _x000D_ pre VŠETKY VŠETKY VŠETKY VŠEOBECNÉ OBJEKTY je objasniť fungovanie a dôsledky funcionalálnej interakcie medzi TP53 a TP73 V PROCESSES, ktoré sa týkajú EMBRIONAL DEVELOPMENT, AS FOR INICIO AND tumoral PROGRESS: PREPROGRAMOVANIE SOMATICKÝCH BUNIEK, STANOVENIE BUNIEK A VYTVORENIE ROVINNEJ BUNKOVEJ POLARITY. VŠETKY TIETO ZDANLIVO ROZMANITÉ PROCESY ZDIEĽAJÚ ÚSTREDNÚ TÉMU: Nariadenie o odlíšení a STABILITY PRIJATÝCH CELULARY INTERACTIONS._x000D_ K tomu, aby sa vyriešili tieto HIPOTESIS, NAŠE ŠPECIÚCIU NAŠE ŠPECIFICKÉ OBJEDNÁVKY SÚ:_x000D_ 1. Charakterizácia P73 ACTION MECHANISM, PRESENCE ALEBO P53, v preprogramovaní SOMATIC CELLS._x000D_ 2. Štúdia funkcionality INTERACTION P53 a P73, ako sa vám darí MESODERMICA_x000D_3 Diferencovacie programy. ŠTÚDIUM P73'S FUNKCIE V ZNAČENÍ BUNKOVEJ POLARITY PLANÁRNEJ A TKANIVOVEJ ARCHITEKTÚRY (Slovak)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+IS FÉIDIR FORBAIRT SUTHACH AGUS ONCOGENESIS A MHEAS MAR DHÁ THAOBH MONA. IS IAD NA PRÓISIS A BHAINEANN LE CINNEADH CILLE, DIFREÁIL AGUS MORPHOGENESIS, ATÁ RÍTHÁBHACHTACH LE LINN FORBAIRT SUTHACH, NA PRÓISIS CHÉANNA A BHFUIL CUMA DÍRIALÁILTE ORTHU LE LINN DUL CHUN CINN MEALL AGUS METASTASIS. Déantar rialú na bpróiseas seo chuig CABO, go páirteach ar a laghad, FACTORS TRANSCRITION mar bhaill den P53._x000D Teaghlaigh Teaghlaigh. IS É AN TORADH AR AN IDIRGHNÍOMHAÍOCHT FHEIDHMIÚIL IDIR TP53 AGUS TP73 COMHTHÉACSÚIL, UAIREANTA SINEIRGISTEACHA AGUS DAOINE EILE, ANTAGONICO. [EN] (b) Déanfaidh an Beannacht Chúrsa seo PAPEL CENTRAL i bhForbairt EMBRIONAR AGUS sa Roinn Iompair Turasóireachta agus Spóirt agus go bhfuil sé iomarcach chun a léiriú go bhfuil an obair Hypothesis seo ag dul i léig go dtí go dtugann TP73 PAPEL LEIS AN RIALACHÁN SEO [EN] (b) I Státseirbhís IARNRÓID NA hÉIREANN AGUS AN DEIMHNIÚ CELLEANNA. TÁ AN FHEIDHM SEO DÉMHÓDÚIL ÓS RUD É GO MBEIDH AN FREAGRA CEALLACH MAR THORADH AIR AG BRATH AR LÉIRIÚ DIFREÁLACH AN ISOFORMS TA AGUS DN-P73 AGUS, DÁ BHRÍ SIN, AG BRATH AR AN GCOMHTHÉACS CEALLACH. TÁ AN RIALACHÁN CEART MAIDIR LEIS NA PRÓISIS CHEALLACHA SIN, ARNA IDIRGHABHÁIL AG TP73, RIACHTANACH AGUS BUNÚSACH CHUN PRÓISIS ATÁ CASTA Ó THAOBH NA BITHEOLAÍOCHTA DE A FHORBAIRT I GCEART, AMHAIL ATHCHLÁRÚ CELUALS SÓMACH AGUS BUNÚ POLARAÍOCHT FÍOCHÁN. _x000D_ do GACH, is é an GINEARÁLTA AN PROJECT GINEARÁLTA feidhmiú agus iarmhairtí na hidirghníomhaíochta fungais idir TP53 agus TP73 I PRÍOMHANNA A DHÉANAMH A DHÉANAMH A DHÉANAMH DÉANAMH MAIDIR LEIS AN GHAIRMIÚIL AGUS GHAIRMIÚIL: ATHCHLÁRÚ CEALLA SÓMACHA, CINNEADH CILLE AGUS PLÁNÓIR POLARAÍOCHT CHEALLACHA A BHUNÚ. GACH NA PRÓISIS COSÚIL GCRUTHAÍONN SÉ ÉAGSÚIL A ROINNT TÉAMA LÁRNACH: Rialáil idirdhealú agus STABILITY INTERACTIONS CELULARY._x000D_ chun measúnú a dhéanamh ar na nithe seo a leanas: _x000D_ 1. Tréithriú P73 GNÍOMH MECHANISM, PRESENCE NÓ ÚSÁID P53, in athchlárú CELLS._x000D_ 2. Staidéar IDIRNÁISIÚNTA P53 agus P73 MAIDIR LEIS AN gCláir Difreálaithe MESODERMICA_x000D_3 STAIDÉAR AR FHEIDHM P73’S I GCOMHARTHAÍOCHT PLANAR POLARAÍOCHT CHEALLACHA AGUS AILTIREACHT FÍOCHÁIN (Irish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONÁLNÍ VÝVOJ A ONKOGENEZE LZE POVAŽOVAT ZA DVĚ STRANY MINCE. PROCESY STANOVENÍ BUNĚK, DIFERENCIACE A MORFOGENEZE, KLÍČOVÉ PŘI EMBRYONÁLNÍM VÝVOJI, JSOU STEJNÉ PROCESY, KTERÉ SE OBJEVUJÍ DEREGULOVÁNY BĚHEM PROGRESE NÁDORU A METASTÁZ. Řízení těchto procesů je přeneseno na CABO, přinejmenším částečně, TRANSCRIPCTION FACTORS jako členové FAMILY P53._x000D_ ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, včetně OURSTER, REVES YIN-YANG INTERACTION BETWEENT TP53 A TP73 bimodální GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE NEURAL Troncal CELLS OR ANGEGENES. VÝSLEDEK FUNKČNÍ INTERAKCE MEZI TP53 A TP73 JE KONTEXTOVÝ, NĚKDY SYNERGICKÝ A DALŠÍ, ANTAGONICO. Tento funcionalní RELATION BETWEEN CENTRAL PAPEL V EMBRIONAR DEVELOPMENT A tisulární ARCHITECTURE a je FACILY oživit AS ALTERATIONS V BALANCE DELIKÁTY tohoto CONTROL RESULT CAN RESULT in GENESIS A tumoral PROGRESS._x000D_Naše hypotéza funguje je, že TP73 přináší FUNDAMENTÁLNÍ PAPEL V STABILITY CELLER INTERACTIONS a CELL DIFFERENCECATION. TATO FUNKCE JE BIMODÁLNÍ, PROTOŽE VÝSLEDNÁ BUNĚČNÁ ODPOVĚĎ BUDE ZÁVISET NA DIFERENCIÁLNÍ EXPRESI IZOFOREM TA A DN-P73, A TEDY ZÁVISÍ NA BUNĚČNÉM KONTEXTU. SPRÁVNÁ REGULACE TĚCHTO BUNĚČNÝCH PROCESŮ, ZPROSTŘEDKOVANÝCH TP73, JE NEZBYTNÁ A ZÁSADNÍ PRO SPRÁVNÝ VÝVOJ BIOLOGICKY SLOŽITÝCH PROCESŮ, JAKO JE PŘEPROGRAMOVÁNÍ SOMATICKÝCH CELUALS A VYTVOŘENÍ TKÁŇOVÉ POLARITY. _x000D_ pro VŠECHNY, GENERÁLNÍ OBJEKT TÉTO PROJEKTU je objasnit fungování a důsledky funcional INTERACTION mezi TP53 a TP73 V PROCESCH, že SESENTIAL PRO EMBRIONAL DEVELOPMENT, AS for THE INICIO AND tumoral PROGRESS: PŘEPROGRAMOVÁNÍ SOMATICKÝCH BUNĚK, STANOVENÍ BUNĚK A VYTVOŘENÍ PLANÁRNÍ BUNĚČNÉ POLARITY. VŠECHNY TYTO ZDÁNLIVĚ ROZMANITÉ PROCESY SDÍLEJÍ ÚSTŘEDNÍ TÉMA: Nařízení o rozlišování A STABILITY PŘIJAŠENÉ CELULARY INTERACTIONS._x000D_ K vyhodnocení tohoto HIPOTESIS, Naše SPECIFIC OUR NAŠE SPECIFICKÉ OBJEKTIVY ARE:_x000D_ 1. Charakterizace P73 AKCE MECHANISM, PRESENCE NEBO použití P53, v přeprogramování SOMATIC CELLS._x000D_ 2. Studie funcional INTERACTION OF P53 a P73 AS DO YOU GET MASTERS of the MESODERMICA_x000D_3 Rozlišení programů. STUDIUM P73’S FUNKCE VE ZNAMENÍ BUNĚČNÉ POLARITY PLANÁRNÍ A TKÁŇOVÉ ARCHITEKTURY (Czech)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+O DESENVOLVIMENTO EMBRIÓNICO E A ONCOGENESE PODEM SER RECONHECIDOS COMO OS DOIS LADOS DE UMA MOEDA. OS PROCESSOS DE DETERMINAÇÃO CELULAR, DIFERENCIAÇÃO E MORFOGENESE, CRUCIAL DURANTE O DESENVOLVIMENTO EMBRIÓNICO, SÃO OS MESMOS PROCESSOS QUE APARECEM DESREGULADOS DURANTE A PROGRESSÃO DO TUMOR E A METASTASE. O controlo destes processos é levado para CABO, pelo menos em parte, FATORES DE TRANSCRIÇÃO como os membros da FAMÍLIA P53._x000D_ O CONJUNTO DE ANÁLISE DE DADOS PROVENIENTES DE MULTIPLES DO GRUPO, incluindo OURSTER, REVISA UMA INTERAÇÃO YIN-YANG ENTRE O TP53 E O GEN bimodal TP73 EM VARIOS DE CONTEXTO BIOLÓGICO, COMO A MANUTENÇÃO DE CÉLULAS TRONCAIS NEURAL OU ANGENESIS. O RESULTADO DA INTERAÇÃO FUNCIONAL ENTRE O TP53 E O TP73 É CONTEXTO, SOMÉTIMOS SINERGISTAS E OUTROS, ANTAGONICO. Esta relação funcional é entre um mapa central do desenvolvimento embrionário e a arquitectura tissular e é fácil de imaginar, uma vez que as alterações no balanço deste controlo podem resultar no progresso genético e no progresso tumoral. ESTA FUNÇÃO É BIMODAL, Uma vez que a RESPOSTA CELULAR RESULTANTE dependerá da EXPRESSÃO DIFERENCIAL DAS ISOFORMAS TA E DN-P73 E, POR ISSO, DEPENDENTE DO CONTEXTO CELULAR. A REGULAMENTAÇÃO CORRETA DOS SEUS PROCESSOS CELULARES, MEDIADOS PELO TP73, É NECESSÁRIA E FUNDAMENTAL PARA O CORRETO DESENVOLVIMENTO DOS PROCESSOS BIOLÓGICOS COMPLETOS, COMO A REPROGRAMAÇÃO DAS CELÉUAS SOMÁTICAS E O ESTABELECIMENTO DA POLARIDADE DOS TECIDOS. _x000D_ para TODOS, o OBJETIVO GERAL DO PRESENTE PROJETO é elucidar o funcionamento e as consequências da INTERAÇÃO FUNCIONAL entre TP53 e TP73 EM PROCESSOS SENSÍVEIS PARA O DESENVOLVIMENTO EMBRIONAL, COMO PARA O PROGRESSO INICIO E TUMORAL: REPROGRAMAÇÃO DAS CÉLULAS SOMÁTICAS, DETERMINAÇÃO CELULAR E ESTABELECIMENTO DO PLANO DE POLARIDADE CELULAR. Todos estes processos aparentemente diferentes partilham um tema central: A REGULAMENTAÇÃO DA DIFERENCIAÇÃO E A ESTABILIDADE DAS INTERAÇÕES CELULÁRIAS ADOPTADAS._x000D_ PARA AVALIAR ESTA HIPOTESE, NOSSOS OBJETIVOS ESPECÍFICOS SÃO:_x000D_ 1. Caracterização do MECANISMO DE AÇÃO P73, PRESENÇA OU AUSÊNCIA DE P53, na reprogramação de CÉLULAS SOMÁTICAS._x000D_ 2. Estudo da interação funcional de P53 e P73 como obtém mestres dos programas de diferenciação MESODERMICA_x000D_3. ESTUDO DA FUNÇÃO DA P73 NA SINALIZAÇÃO DA POLARIDADE CELULAR PLANAR E DA ARQUITETURA TECIDOSA (Portuguese)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRÜONAALSET ARENGUT JA ONKOGENESI VÕIB PIDADA MÜNDI KAHEKS KÜLJEKS. RAKKUDE MÄÄRAMISE, DIFERENTSEERUMISE JA MORFOGENEESI PROTSESSID, MIS ON EMBRÜO ARENGU AJAL ÜLIOLULISED, ON SAMAD PROTSESSID, MIS NÄIVAD KASVAJA PROGRESSEERUMISE JA METASTAASIDE AJAL DEREGULEERUNUD. Kontrolli nende protsesside üle viiakse CABO-le, vähemalt osaliselt, TRANSCRIPCTION FACTORS liikmetena FAMILY P53._x000D_The ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, sealhulgas OURSTER, A YIN-YANG INTERACTION BETWEEN TP53 JA TP73 bimodaalne GEN IN BIOLOGIC CONTEXT CONTEXT VARIOS, NEURAL Tronkal CELLS’i või ANGEGENESISE MAINTENANCE. TP53 JA TP73 FUNKTSIONAALSE KOOSTOIME TULEMUS ON KONTEKSTUAALNE, MÕNIKORD SÜNERGILINE JA TEISED ANTAGONICO. See funktsioneeriv RELATION on TEENUSED KESKPANNE EMBRIONAR DEVELOPMENT JA Tisular ARCHITECTURE JA on FACILINE KASUTAMINE KESKONNA TÖÖDEVÕTMISE KESKONNA TÖÖDELE TÖÖDE TÖÖDE TÖÖDE TÖÖDEVÕTMISE JA TÖÖDETÖÖ PROGRESS._x000D_Our Hüpoteesi töö ON VÄLJA TP73 Toob FUNDAMENTALAL CELLER INTERACTIONS JA CELL DIFFERENCECATION KOHTA. SEE FUNKTSIOON ON BIMODAALNE, SEST SAADUD RAKU VASTUS SÕLTUB ISOVORMIDE TA JA DN-P73 ERINEVAST EKSPRESSIOONIST NING SÕLTUB SEEGA RAKUKONTEKSTIST. NENDE RAKUPROTSESSIDE ÕIGE REGULEERIMINE, MIDA VAHENDAB TP73, ON VAJALIK JA OLULINE BIOLOOGILISELT KEERUKATE PROTSESSIDE, NÄITEKS SOMAATILISTE CELUALSI ÜMBERPROGRAMMEERIMISE JA KOE POLAARSUSE TEKKEKS. _x000D_ KÕIGI jaoks on THIS PROJECTi ÜLDKOHUSTUSLIK TP53 ja TP73 vahel toimuva funktsioneeriva INTERACTION’i toimimise ja tagajärgede selgitamine TP53 ja TP73 vahel, mida SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS INICIO JA tumoral PROGRESS: SOMAATILISTE RAKKUDE ÜMBERPROGRAMMEERIMINE, RAKKUDE MÄÄRAMINE JA RAKU POLAARSUSE TASAPINNA LOOMINE. KÕIK NEED NÄILISELT ERINEVAD PROTSESSID JAGAVAD KESKSET TEEMAT: Eristamise ja VASTUVÕTMISE VASTUVÕTMISE JA VASTU VÕTNUD KOHTUASI TÄHELEPANU HIPOTESISE, meie SPETSIFIKATSIOONID Meie SPETSIFIKATSIOONID ARE:_x000D_ 1. P73 ACTION MECHANISM, PRESENCE OR ausence of P53 kirjeldus SOMATIC CELLS’i ümberprogrammeerimisel._x000D_ 2. Uuring P53 ja P73 funcional INTERACTION of the MESODERMICA_x000D_3 Eristusprogrammid. UURING P73’S FUNKTSIOONI MÄRKIDES RAKU POLAARSUSE TASAPINNA JA KUDEDE ARHITEKTUURI (Estonian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+AZ EMBRIONÁLIS FEJLŐDÉS ÉS AZ ONKOGENEZIS AZ ÉRME KÉT OLDALÁNAK TEKINTHETŐ. A SEJTEK MEGHATÁROZÁSÁNAK, DIFFERENCIÁLÓDÁSÁNAK ÉS MORFOGENEZISÉNEK FOLYAMATAI, AMELYEK DÖNTŐ FONTOSSÁGÚAK AZ EMBRIONÁLIS FEJLŐDÉS SORÁN, UGYANAZOK A FOLYAMATOK, AMELYEK A TUMOR PROGRESSZIÓJA ÉS METASZTÁZISA SORÁN DEREGULÁLTAK. Ezeknek a folyamatoknak az ellenőrzése a CABO-hoz, legalábbis részben a TRANSCRIPCTION FACTORS-hoz, mint a CSALÁDI P53._x000D_ A CSALÁDI MULTIPLEK ANALISIS CONJUNTjához, beleértve a OURSTER-t is, egy YIN-YANG INTERACTION BETWEEN TP53 ÉS TP73 bimodális GEN BIOLOGIC CONTEXT VARIOS tagjaiként, a NEURAL Troncal CELLS vagy ANGEGENESIS MAINTENANCE-hoz kerül. A TP53 ÉS A TP73 KÖZÖTTI FUNKCIONÁLIS KÖLCSÖNHATÁS EREDMÉNYE KONTEXTUÁLIS, NÉHA SZINERGIKUS ÉS MÁSOK, AZ ANTAGONICO. Ez a funkcional RELATION BETWEEN A CENTRAL PAPELMENT A EMBRIONAR DEVELOPMENT ÉS A TELJES ARCHITECTURE ÉS CSAK, hogy képzelje el, hogy a MEGÁLLAPODÁSOK MEGÁLLAPODÁSI DELICATE EZ ELLENŐRZÉSÉNEK ÉS A daganatos progRESs._x000D_A hipotézis működik, hogy ez a 73 hoz egy FUNDAMENTAL PAPEL A CELLER INTERACTIONS és a CELL DIFFERENCECATION STABILITÁSÁBAN. EZ A FÜGGVÉNY BIMODÁLIS, MIVEL A KAPOTT CELLULÁRIS VÁLASZ A TA ÉS A DN-P73 IZOFORMÁK DIFFERENCIÁL EXPRESSZIÓJÁTÓL FÜGG, ÉS EZÉRT A SEJTHELYZETTŐL FÜGG. A TP73 ÁLTAL KÖZVETÍTETT SEJTFOLYAMATOK HELYES SZABÁLYOZÁSA SZÜKSÉGES ÉS ALAPVETŐ A BIOLÓGIAILAG ÖSSZETETT FOLYAMATOK MEGFELELŐ FEJLŐDÉSÉHEZ, MINT PÉLDÁUL A SZOMATIKUS CELUALS ÁTPROGRAMOZÁSA ÉS A SZÖVET POLARITÁSÁNAK MEGTEREMTÉSE. _x000D_ MINDEN esetében e PROJEKT ÁLTALÁNOS OBJECT IRÁNYELVE, hogy tisztázza a TP53 és TP73 közötti funkcional INTERACTION működését és következményeit az EMBRIONÁLIS FEJLESZTÉSRE, mint az INICIO ÉS tumorprogRESS: A SZOMATIKUS SEJTEK ÁTPROGRAMOZÁSA, A SEJTMEGHATÁROZÁS ÉS A SEJTPOLARITÁS SÍKBARAJZOLÁSA. EZEK A LÁTSZÓLAG SOKSZÍNŰ FOLYAMATOK KÖZPONTI TÉMÁT KÉPVISELNEK: A megkülönböztetésről és a sztereotípiáról szóló rendelet a KÜLÜLÉSI INTERACTIONS._x000D_ EH HIPOTESIS, a mi SPECIFIKAI CÉLKITŰZÉSÉNEK ELŐZETÉRE:_x000D_ 1. A P73 ACTION MECHANISM, PRESENCE VAGY A P53-as fenntartásának jellemzése a SOMATIC CELLS._x000D_ 2. átprogramozásában. A P53 és P73 funcional INTERACTION-jának tanulmányozása a MESODERMICA_x000D_3 Differenciációs programokból. A P73 FUNKCIÓJÁNAK TANULMÁNYOZÁSA A CELLULÁRIS POLARITÁS SÍKBELI ÉS SZÖVETI ARCHITEKTÚRÁJÁNAK JELZÉSÉBEN (Hungarian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+ЕМБРИОНАЛНОТО РАЗВИТИЕ И ОНКОГЕНЕЗАТА МОГАТ ДА СЕ РАЗГЛЕЖДАТ КАТО ДВЕТЕ СТРАНИ НА МОНЕТАТА. ПРОЦЕСИТЕ НА КЛЕТЪЧНО ОПРЕДЕЛЯНЕ, ДИФЕРЕНЦИАЦИЯ И МОРФОГЕНЕЗА, КОИТО СА ОТ РЕШАВАЩО ЗНАЧЕНИЕ ПО ВРЕМЕ НА ЕМБРИОНАЛНОТО РАЗВИТИЕ, СА СЪЩИТЕ ПРОЦЕСИ, КОИТО СЕ ПОЯВЯВАТ ДЕРЕГУЛИРАНИ ПО ВРЕМЕ НА ТУМОРНАТА ПРОГРЕСИЯ И МЕТАСТАЗА. Контролът на тези процеси се извършва в CABO, поне частично, като членове на FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, включително OURSTER, ПРЕДСТАВЯВА ИН-ЯНГ ИНТЕРАКЦИЯ ПО ТР53 И ТР73 бимодални ген в биологичен контекст VARIOS, като ВЪЗЛОЖЕНИЕ НА НЕСТРАЛНИ ТРОНКЦИИ ИЛИ АГЕНТИ. РЕЗУЛТАТЪТ ОТ ФУНКЦИОНАЛНОТО ВЗАИМОДЕЙСТВИЕ МЕЖДУ TP53 И TP73 Е КОНТЕКСТУАЛЕН, ПОНЯКОГА СИНЕРГИЧЕН И ДРУГИ, ANTAGONICO. Тази функционална РЕЛАЦИЯ трябва да бъде по-голяма от една ЦЕНТРАЛНА КАПЕЛА в EMBRIONAR DEVELOPMENT AND THE Tisular ARCHITECTURE AND I е FACILY, за да се представи като АЛТЕРАЦИИ В БАЛАНЦИОННИЯ ДЕЙНОСТ НА ТОВА КОНТРОЛ RED RESULT В GENESIS И туморни PROGRESS._x000D_Нашата Хипотеза работи е, че TP73 Донася FUNDAMENTAL ПАПЕЛ В СТАБИЛНОСТТА НА ПОТРЕБИТЕЛИТЕ И ЗАДЪЛЖИТЕЛНОТО ДИФЕРЕНЦИАЦИЯ. ТАЗИ ФУНКЦИЯ Е БИМОДАЛНА, ТЪЙ КАТО ПОЛУЧЕНИЯТ КЛЕТЪЧЕН ОТГОВОР ЩЕ ЗАВИСИ ОТ ДИФЕРЕНЦИАЛНАТА ЕКСПРЕСИЯ НА ИЗОФОРМИТЕ TA И DN-P73 И СЛЕДОВАТЕЛНО ЗАВИСИ ОТ КЛЕТЪЧНИЯ КОНТЕКСТ. ПРАВИЛНОТО РЕГУЛИРАНЕ НА ТЕЗИ КЛЕТЪЧНИ ПРОЦЕСИ, МЕДИИРАНО ОТ TP73, Е НЕОБХОДИМО И ОТ ОСНОВНО ЗНАЧЕНИЕ ЗА ПРАВИЛНОТО РАЗВИТИЕ НА БИОЛОГИЧНО СЛОЖНИ ПРОЦЕСИ, КАТО НАПРИМЕР ПРЕПРОГРАМИРАНЕТО НА СОМАТИЧНИ CELUALS И УСТАНОВЯВАНЕТО НА ТЪКАННА ПОЛЯРНОСТ. _x000D_ за ВСИЧКИ ОБЕКТИВЕН ОБЕКТИВЕН ОБЕКТ НА ТОЗИ ПРОЕКТ има за цел да изясни функционирането и последиците от функционалната ИНТЕРАКЦИЯ между TP53 и TP73 В ПРОЦЕСИ, ЧЕ СЕЗЕНТИАЛНО ЗА ЕМБРИОНАЛНА РАЗВИТИЕ, СЪОБЩЕНИЕ ЗА ИНИЦИОНЕН И туморен ПРОГРЕС: ПРЕПРОГРАМИРАНЕТО НА СОМАТИЧНИТЕ КЛЕТКИ, ОПРЕДЕЛЯНЕТО НА КЛЕТКИТЕ И УСТАНОВЯВАНЕТО НА ПЛАНАРА НА КЛЕТЪЧНАТА ПОЛЯРНОСТ. ВСИЧКИ ТЕЗИ ПРИВИДНО РАЗНООБРАЗНИ ПРОЦЕСИ СПОДЕЛЯТ ЦЕНТРАЛНА ТЕМА: РЕГЛАМЕНТ НА диференциацията И СТАБИЛНОСТТА НА ПРИЕМАНЕ НА РЕГЛАМЕНТНИТЕ ИНТЕРАКЦИИ._x000D_ ЗА ОЦЕНКА НА НАСТОЯЩИТЕ ХИПОТЕЗИ, НАШИТЕ СПЕЦИФИКАЦИИ НАШИТЕ СПЕЦИФИЧНИ ЦЕЛИ ARE:_x000D_ 1. Характеризиране на P73 ACTION MECHANISM, PRESENCE OR ausence OF P53, в препрограмирането на SOMATIC CELLS._x000D_ 2. Проучване на функционалната ИНТЕРАКЦИЯ на P53 и P73, тъй като вие правите стъпки на програмите за диференциация MESODERMICA_x000D_3. ПРОУЧВАНЕ НА ФУНКЦИЯТА P73'S В ОБОЗНАЧАВАНЕТО НА КЛЕТЪЧНАТА ПОЛЯРНОСТ ПЛАНАРНА И ТЪКАННА АРХИТЕКТУРА (Bulgarian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRIONO VYSTYMASIS IR ONKOGENEZĖ GALI BŪTI LAIKOMI DVIEM MONETOS PUSĖMIS. LĄSTELIŲ NUSTATYMO, DIFERENCIACIJOS IR MORFOGENEZĖS PROCESAI, LABAI SVARBŪS EMBRIONO VYSTYMOSI METU, YRA TIE PATYS PROCESAI, KURIE ATSIRANDA NAVIKO PROGRESAVIMO IR METASTAZIŲ METU. Šių procesų kontrolė yra perduodama CABO, bent iš dalies, TRANSCRIPCTION FACTORS kaip ŠEIMOS P53._x000D_ ANALISIS CONJUNT GROUP MULTIPLES, įskaitant OURSTER, PRIEŽIŪRA YIN-YANG INTERACTION BETWEEN TP53 ir TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, kaip NEURAL Troncal CELLS AR ANGEGENES. TP53 IR TP73 FUNKCINĖS SĄVEIKOS REZULTATAS YRA KONTEKSTINIS, KARTAIS SĄVEIKAUJANTIS IR KT. ANTAGONICO. Šis funcionalinis SANTYKIJIMAS BALŪNINIO PAPELIS EMBRIONARINIO VYRIAUSYBĖS IR TISULINĖS ARCHITEKTŪROS IR ŠEIMOS ĮSIPAREIGOJAMA, kad būtų galima įsivaizduoti, kaip šios KONTROLĖS BALANIJOS DELICIKATAS GENESIS IR naviko PROGRESS._x000D_Mūsų Hipotezė yra ta, kad TP73 suteikia nemokamą PAPELĮ CELLER INTERACIJOS STABILIJOJE ir CELL DIFFERCECATION. ŠI FUNKCIJA YRA BIMODALINĖ, NES GAUTAS LĄSTELINIS ATSAKAS PRIKLAUSYS NUO IZOFORMŲ TA IR DN-P73 DIFERENCINĖS RAIŠKOS IR TODĖL PRIKLAUSYS NUO LĄSTELIŲ KONTEKSTO. TEISINGAS ŠIŲ LĄSTELINIŲ PROCESŲ REGULIAVIMAS, TARPININKAUJANT TP73, YRA BŪTINAS IR ESMINIS SIEKIANT TINKAMAI PLĖTOTI BIOLOGIŠKAI SUDĖTINGUS PROCESUS, PAVYZDŽIUI, SOMATINIŲ CELUALS PERPROGRAMAVIMĄ IR AUDINIŲ POLIARIŠKUMO NUSTATYMĄ. _x000D_ VISI, BENERAL OBJECTIVE ŠIO PROJEKTAS yra išsiaiškinti funcionalinės INTERACTION funkcionavimą ir pasekmes tarp TP53 ir TP73 PROCESSES, KAD EMBRIONAL DEVELOPMENT, AS INICIO ir naviko PROGRESS: SOMATINIŲ LĄSTELIŲ PERPROGRAMAVIMĄ, LĄSTELIŲ NUSTATYMĄ IR LĄSTELIŲ POLIŠKUMO PLANARĄ. VISI ŠIE IŠ PAŽIŪROS ĮVAIRŪS PROCESAI YRA SUSIJĘ SU PAGRINDINE TEMA: Diferenciacijos REGLAMENTAS IR PRIIMTA IŠLAIDŲ SĄLYGOS._x000D_ Į VERTINTI ŠĮ HIPOTESIS, MŪSŲ SPECIFIKOS JŪSŲ SPECIFIKATAI ARE:_x000D_ 1. P73 VEIKSMŲ MECHANISM, PRESENCE ARBA Ausence OF P53 apibūdinimas perprogramuojant SOMATIC CELLS._x000D_ 2. „P53“ ir „P73“ funcionalinės INTERACIJOS TYRIMAI DĖL MESODERMICA_x000D_3 diferenciacijos programų. P73’S FUNKCIJOS TYRIMAS LĄSTELIŲ POLIŠKUMO PLANO IR AUDINIŲ ARCHITEKTŪROS ŽYMENYJE (Lithuanian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRIONALNI RAZVOJ I ONKOGENEZA MOGU SE SMATRATI DVIJE STRANE KOVANICE. PROCESI ODREĐIVANJA STANICA, DIFERENCIJACIJE I MORFOGENEZE, KLJUČNI TIJEKOM EMBRIONALNOG RAZVOJA, ISTI SU PROCESI KOJI SE POJAVLJUJU DEREGULIRANI TIJEKOM PROGRESIJE TUMORA I METASTAZE. Nadzor nad tim procesima provodi se u CABO-u, najmanje djelomično, TRANSCRIPCTION FACTORS kao članovi OBITELJSKE P53._x000D_ ANALIZI KONJUNT PROVENENTNIH PODATAKA GRUPA MULTIPLES, uključujući i NASTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 I TP73 bimodalni GEN u BIOLOGIC CONTEXT VARIOS, kao MAINTENCE NEURAL Troncal CELLS ili ANGEGENESIS. REZULTAT FUNKCIONALNE INTERAKCIJE IZMEĐU TP53 I TP73 JE KONTEKSTUALNI, PONEKAD SINERGISTIČKI I DRUGI, ANTAGONICO. Ova funcionalna RELATION će BETWEEN CENTRAL PAPEL u EMBRIONAR DEVELOPMENT I tisularna ARCHITECTURE I OBAVIJEST da zamislite kao ALTERACIJE U BALANCE DELICATE OVU KONTROLA RESULT U GENESIS I tumorski PROGRESS._x000D_Our Hypothesis radi JE TOP73 Donosi FUNDAMENTAL PAPEL u STABILNOSTI Interakcija CELLER I PRODAJA DIFFERENCECATION. TA JE FUNKCIJA BIMODALNA JER ĆE DOBIVENI STANIČNI ODGOVOR OVISITI O DIFERENCIJALNOM IZRAŽAVANJU IZOOBLIKA TA I DN-P73 TE STOGA OVISITI O STANIČNOM KONTEKSTU. PRAVILNA REGULACIJA TIH STANIČNIH PROCESA, UZ POSREDOVANJE TP73, NUŽNA JE I TEMELJNA ZA ISPRAVAN RAZVOJ BIOLOŠKI SLOŽENIH PROCESA, KAO ŠTO JE REPROGRAMIRANJE SOMATSKOG CELUALS-A I UTVRĐIVANJE POLARITETA TKIVA. _x000D_ za SVE, OPĆI OBJEKT ovog PROJEKTA je razjasniti funkcioniranje i posljedice funcionalne Interakcije između TP53 i TP73 U PROCESU OBAVIJESTI ZA EMBRIONALnu DEVELOPMENTU, A što za INICIO I tumorski PROGRESS: REPROGRAMIRANJE SOMATSKIH STANICA, ODREĐIVANJE STANICA I USPOSTAVA PLANARA STANIČNE POLARNOSTI. SVI TI NAIZGLED RAZLIČITI PROCESI DIJELE SREDIŠNJU TEMU: Uredba o razlikovanju I STABILNOST ADOPTED CELULARY INTERACTIONS._x000D_ Za EVALUATE OVO HIPOTEZA, NAŠE POSEBNE NAŠE POSEBNE OBJEKTIVE ARE:_x000D_ 1. Karakterizacija P73 ACTION MECHANISM, PRESENCE ILI Auence of P53, u reprogramiranju SOMATIC CELLS._x000D_ 2. Studija funcionalne interakcije P53 i P73 kako biste dobili MASTERS MESODERMICA_x000D_3 Diferencijacijski programi. PROUČAVANJE FUNKCIJE P73-A U ZNAKOVANJU PLANARNE STANIČNE POLARNOSTI I ARHITEKTURE TKIVA (Croatian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRYONAL UTVECKLING OCH ONKOGENES KAN BETRAKTAS SOM DE TVÅ SIDORNA AV ETT MYNT. PROCESSERNA FÖR CELLBESTÄMNING, DIFFERENTIERING OCH MORFOGENES, AVGÖRANDE UNDER EMBRYONAL UTVECKLING, ÄR SAMMA PROCESSER SOM VERKAR AVREGLERADE UNDER TUMÖRPROGRESSION OCH METASTAS. Kontrollen av dessa processer överförs till CABO, till åtminstone delvis, TRANSCRIPCTION FACTORS som medlemmar i FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, inklusive OURSTER, REVES AYIN-YANG INTERACTION BETWEEN TP53 och TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL Troncal CELLS OR ANGEGENIS. RESULTATET AV DET FUNKTIONELLA SAMSPELET MELLAN TP53 OCH TP73 ÄR KONTEXTUELLT, IBLAND SYNERGISTISKT OCH ANDRA, ANTAGONICO. Denna funkional RELATION ska BETWEEN EN CENTRAL PAPEL I EMBRIONAR UTVECKLING OCH den tisulära ARCHITECTURE och är FACILY att föreställa sig som ALTERATIONER I BALANCE DELICATE AV DENNA KONTROLL RED CAN RESULTAT I GENESIS och tumoral PROGRESS._x000D_Our Hypothesis arbete är som TP73 ger en FUNDAMENTAL PAPEL I STABILITET av CELLER INTERACTIONER OCH CELL DIFFERENCECATION. DENNA FUNKTION ÄR BIMODAL EFTERSOM DET RESULTERANDE CELLULÄRA SVARET KOMMER ATT BERO PÅ DIFFERENTIALUTTRYCKET AV ISOFORMERNA TA OCH DN-P73 OCH DÄRFÖR BEROENDE PÅ DET CELLULÄRA SAMMANHANGET. EN KORREKT REGLERING AV DESSA CELLULÄRA PROCESSER, SOM FÖRMEDLAS AV TP73, ÄR NÖDVÄNDIG OCH GRUNDLÄGGANDE FÖR EN KORREKT UTVECKLING AV BIOLOGISKT KOMPLEXA PROCESSER, SÅSOM OMPROGRAMMERING AV SOMATISKA CELUALS OCH FASTSTÄLLANDE AV VÄVNADSPOLARITET. _x000D_ for ALL, GENERAL OBJEKTIV DENNA PROJEKT är att belysa funktionen och konsekvenserna av den funcional INTERACTION mellan TP53 och TP73 I PROCESSES ATT SESENTIAL FÖR EMBRIONAL UTVECKLING, AS FOR THE INICIO OCH tumoral PROGRESS: OMPROGRAMMERING AV SOMATISKA CELLER, CELLBESTÄMNING OCH UPPRÄTTANDE AV CELLPOLARITET PLANAR. ALLA DESSA TILL SYNES OLIKA PROCESSER HAR ETT CENTRALT TEMA: Differentieringens FÖRORDNING OCH STABILITET AV FÖRESKRIVS KÖLLIGA INTERACTIONS._x000D_ För att genomföra detta, VÅR SÄRSKILDA VÅR VÅRA SÄKERHETSPOLITIK ARE:_x000D_ 1. Karakterisering av P73 ÅTGÄRD MECHANISM, PRESENCE ELLER Ausence OF P53, i omprogrammering av SOMATIC CELLS._x000D_ 2. Studie AV Funcional INTERACTION OF P53 och P73 SOM DU GÖR MASTERS AV MESODERMICA_x000D_3 Differentiationsprogram. STUDIE AV P73’S FUNKTION I SKYLTNING AV CELLPOLARITET PLANAR OCH VÄVNAD ARKITEKTUR (Swedish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+DEZVOLTAREA EMBRIONARĂ ȘI ONCOGENEZA POT FI CONSIDERATE CELE DOUĂ FEȚE ALE UNEI MONEDE. PROCESELE DE DETERMINARE CELULARĂ, DIFERENȚIERE ȘI MORFOGENEZĂ, CRUCIALE ÎN TIMPUL DEZVOLTĂRII EMBRIONARE, SUNT ACELEAȘI PROCESE CARE APAR DEREGLATE ÎN TIMPUL PROGRESIEI TUMORII ȘI METASTAZELOR. Controlul acestor procese este efectuat la CABO, cel puțin parțial, TRANSCRIPCTION FACTORS în calitate de membri ai FAMILIEI P53._x000D_ CONJUNTUL ANALIZĂRILOR DE DATAS PROVENȚIE DE MULTIPLE GROUP, inclusiv OURSTER, REVEZE O INTERACȚIE YIN-YANG BETWEEN TP53 ȘI GEN bimodal TP73 în VARIOSUL CONTEXT BIOLOGIC, ca MAINTENANȚĂ A ANGEGENEREI NEUR a CELE Tronale. REZULTATUL INTERACȚIUNII FUNCȚIONALE DINTRE TP53 ȘI TP73 ESTE CONTEXTUAL, UNEORI SINERGIC ȘI ALTELE, ANTAGONICO. Această RELAȚIE funcională va avea loc într-un plan CENTRAL ÎN DEZVOLTAREA EMBRIONARĂ ȘI ARCHITECTURA tisulară ȘI ESTE FACIALĂ de a imagina sub formă de ALTERAȚII ÎN DELICAREA BALANȚEI DE ACEST CONTROL RED CAN RESULTATE ÎN GENESIS ȘI PROGRESUL tumoral._x000D_Our Ipoteze Lucrându-se este că TP73 aduce un PAL FUNDAMENTAL în STABILITATEA INTERACȚIUNI CELLER și DIFERCEREA CELL. ACEASTĂ FUNCȚIE ESTE BIMODALĂ, DEOARECE RĂSPUNSUL CELULAR REZULTAT VA DEPINDE DE EXPRESIA DIFERENȚIALĂ A IZOFORMELOR TA ȘI DN-P73 ȘI, PRIN URMARE, DEPINDE DE CONTEXTUL CELULAR. REGLEMENTAREA CORECTĂ A ACESTOR PROCESE CELULARE, MEDIATĂ DE TP73, ESTE NECESARĂ ȘI FUNDAMENTALĂ PENTRU DEZVOLTAREA CORECTĂ A PROCESELOR BIOLOGICE COMPLEXE, CUM AR FI REPROGRAMAREA CELUALS SOMATICE ȘI STABILIREA POLARITĂȚII ȚESUTURILOR. _x000D_ pentru TOȚI, OBJECTIVUL GENERAL al acestui proiect trebuie să elucideze funcționarea și consecințele INTERACȚIEI funcționale între TP53 și TP73 în ceea ce privește aspectele legate de dezvoltarea EMBRIONALĂ, precum și pentru PROGRESSUL INICIO ȘI tumoral: REPROGRAMAREA CELULELOR SOMATICE, DETERMINAREA CELULELOR ȘI STABILIREA POLARITĂȚII CELULARE PLANARE. TOATE ACESTE PROCESE APARENT DIVERSE ÎMPĂRTĂȘESC O TEMĂ CENTRALĂ: Regulamentul DE Diferențiere ȘI STABILITATEA INTERACȚIILOR DE CELULARĂ ADOPTATE._x000D_ EVALUAREA ACESTEI HIPOTESIS, SPECIFICUL nostru OBJECTIVE SPECIFICE:_x000D_ 1. Caracterizarea P73 ACTION MECHANISM, PRESENȚA SAU Ausența P53, în reprogramarea CELLS SOMATIC._x000D_ 2. Studiul INTERACȚIEI Funcționale a P53 și P73, astfel încât să obțineți MASTERII MESODERMICA_x000D_3 Programe de diferențiere. STUDIUL FUNCȚIEI P73 ÎN SEMNALIZAREA POLARITĂȚII CELULARE PLANARE ȘI A ARHITECTURII ȚESUTURILOR (Romanian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+EMBRIONALNI RAZVOJ IN ONKOOGENEZA SE LAHKO OBRAVNAVATA KOT OBE STRANI KOVANCA. PROCESI DOLOČANJA CELIC, DIFERENCIACIJE IN MORFOGENEZE, KI SO KLJUČNEGA POMENA MED EMBRIONALNIM RAZVOJEM, SO ISTI PROCESI, KI SE POJAVIJO DEREGULIRANI MED NAPREDOVANJEM TUMORJA IN METASTAZO. Nadzor nad temi procesi se vsaj delno prenese na CABO, in sicer na TRANSCRIPCTION FACTORS kot člani DRUŽINSKE P53._x000D_ ANALISIS KONJUNT PROVENENTNIH DATAS GROUPNIH MULTIPLES, vključno z OURSTERJEM, ZA VARNOSTJO NEURALNIK INTERACTION BETWEEN TP53 IN TP73 bimodalni GEN IN BIOLOGIČNI KONTEXT VARIOS, kot MAINTENANCE NEURAL Troncal CELLS ALI ANGEGENESIS. REZULTAT FUNKCIONALNE INTERAKCIJE MED TP53 IN TP73 JE KONTEKSTUALNA, VČASIH SINERGISTIČNA IN DRUGA, ANTAGONICO. Ta funcional RELATION se bo CENTRALNO PAPEL V EMBRIONAR RAZVOJ IN tisularni ARHITECTURE IN DRUŽNO, da si predstavljate, kot ALTERATIONs v BALANCE DELICATE THIS CONTROL RED CAN RESULT V GENESIS IN tumorski PROGRESS._x000D_Naša hipoteza delo je TP73 Prinaša FUNDAMENTALNO PAPEL v STABILNOSTI CELLER INTERACTIONA IN ODPRTIH PODJETJIH. TA FUNKCIJA JE BIMODALNA, SAJ BO DOBLJENI CELIČNI ODZIV ODVISEN OD DIFERENCIALNEGA IZRAŽANJA IZOOBLIK TA IN DN-P73 IN JE ZATO ODVISEN OD CELIČNEGA KONTEKSTA. PRAVILNA REGULACIJA TEH CELIČNIH PROCESOV, KI JO POSREDUJE TP73, JE POTREBNA IN BISTVENA ZA PRAVILEN RAZVOJ BIOLOŠKO KOMPLEKSNIH PROCESOV, KOT STA REPROGRAMIRANJE SOMATSKIH CELUALS IN VZPOSTAVITEV POLARNOSTI TKIVA. _x000D_ za VSE, GENERAL OBJEKTI TEGA PROJEKTA je, da pojasni delovanje in posledice funcionalne INTERACTION med TP53 in TP73 V POSTOPKIH STROŠKOV ZA EMBRIONALNI RAZVOJ, ZA INICIO IN tumorski PROGRESS: REPROGRAMIRANJE SOMATSKIH CELIC, DOLOČANJE CELIC IN VZPOSTAVITEV CELIČNE POLARNOSTI. VSI TI NAVIDEZNO RAZNOLIKI PROCESI IMAJO OSREDNJO TEMO: Uredba o razlikovanju IN STABILNOST SPELULARNEGA INTERAKCIJE._x000D_ OVILA TEGA HIPOTESA, NAŠE NAŠE SPECIFICIJE NAŠE NAŠE SPECIFIČNE OBJEKTI OBJEKTI:_x000D_ 1. Karakterizacija P73 ACTION MECHANISM, PRESENCE ALI avsenca P53, pri reprogramiranju SOMATIC CELLS._x000D_ 2. Študija funcionalne INTERACCIJE P53 in P73, KI JIH ZAHTEVAte MASTERS MESODERMICA_x000D_3 Diferenciacijskih programov. ŠTUDIJA FUNKCIJE P73 V SIGNALIZACIJI CELIČNE POLARNOSTI PLANARNE IN TKIVNE ARHITEKTURE (Slovenian)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / summary @@
+ROZWÓJ EMBRIONALNY I ONKOGENEZĘ MOŻNA UZNAĆ ZA DWIE STRONY MONETY. PROCESY OZNACZANIA KOMÓREK, RÓŻNICOWANIA I MORFOGENEZY, KLUCZOWE PODCZAS ROZWOJU EMBRIONALNEGO, SĄ TYMI SAMYMI PROCESAMI, KTÓRE POJAWIAJĄ SIĘ DEREGULOWANE PODCZAS PROGRESJI GUZA I PRZERZUTÓW. Kontrola tych procesów jest przeniesiona do CABO, co najmniej w części, TRANSCRIPCTION FACTORS jako członkowie FAMILY P53._x000D_ ANALISIS CONJUNT DANYCH PROVENENTÓW MULTIPLES, w tym OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 ORAZ TP73 bimodalny GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL Troncal CELLS or ANGEGENESIS. WYNIK FUNKCJONALNEJ INTERAKCJI MIĘDZY TP53 I TP73 JEST KONTEKSTOWY, CZASAMI SYNERGISTYCZNY I INNE, ANTAGONICO. To FUNDACJONALNE ZAWIERANIE ŚRODKOWYCH ŚRODKOWYCH W ROZPORZĄDZENIU EMBRIONARU I ARCHITEKTYKTYCZNEJ TYTUŁU W GENESIS I PROGRESSIE nowotworowym._x000D_Nasza Hipoteza pracuje, że TP73 przynosi FUNDAMENTALNY PAPEL W STABILITYCZNOŚCI INTERACTIONS I CELL DIFREKCATION. FUNKCJA TA JEST DWUMODALNA, PONIEWAŻ OTRZYMANA ODPOWIEDŹ KOMÓRKOWA BĘDZIE ZALEŻAŁA OD RÓŻNICOWEGO EKSPRESJI IZOFORM TA I DN-P73, A ZATEM BĘDZIE ZALEŻNA OD KONTEKSTU KOMÓRKOWEGO. PRAWIDŁOWA REGULACJA TYCH PROCESÓW KOMÓRKOWYCH, ZA POŚREDNICTWEM TP73, JEST NIEZBĘDNA I FUNDAMENTALNA DLA PRAWIDŁOWEGO ROZWOJU BIOLOGICZNIE ZŁOŻONYCH PROCESÓW, TAKICH JAK PRZEPROGRAMOWANIE SOMATYCZNYCH CELUALS I USTALENIE POLARYZACJI TKANEK. _x000D_ dla WSZYSTKICH, OGÓLNY OBJĄCY TEGO PROJEKTU polega na wyjaśnieniu funkcjonowania i konsekwencji INTERACTION funcional między TP53 i TP73 W PROCESACH TYSTRYCZNYCH DO ROZPORZĄDZENIA EMBRIONALNEGO, AS FOR THE INICIO AND Gumoral PROGRESS: PRZEPROGRAMOWANIE KOMÓREK SOMATYCZNYCH, OZNACZANIE KOMÓREK I USTANOWIENIE PLANARU POLARYZACJI KOMÓRKOWEJ. WSZYSTKIE TE POZORNIE ZRÓŻNICOWANE PROCESY MAJĄ JEDEN Z GŁÓWNYCH TEMATÓW: Rozporządzenie w sprawie różnicowania i trwałości przyjętych INTERACTIONS CELULARY._x000D_ DO OCHRONY TEGO HIPOTESIS, NASZEJ SPECYFICZNEJ NASZEJ SPECYFIKCJI OBYTUJĄCYCH SZCZEGÓŁÓW:_x000D_ 1. Charakterystyka P73 ACTION MECHANISM, PRESENCE LUB ausence OF P53, w przeprogramowaniu SOMATIC CELLS._x000D_ 2. Badanie INTERACCJI grzybobójczej P53 i P73 AS you GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. BADANIE FUNKCJI P73 W OZNAKOWANIU POLARYZACJI KOMÓRKOWEJ I ARCHITEKTURY TKANKOWEJ (Polish)
+Normal rank
+point in time: 18 August 2022Timestamp +2022-08-18T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2022-08-18T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / location (string) @@
+León
@@ Property / location (string): León / rank @@
+Normal rank
@@ Property / contained in NUTS @@
+León Province
@@ Property / contained in NUTS: León Province / rank @@
+Normal rank
@@ Property / contained in NUTS: León Province / qualifier @@
+inferred from: Local Administrative Unit
@@ Property / contained in Local Administrative Unit @@
+León
@@ Property / contained in Local Administrative Unit: León / rank @@
+Normal rank
@@ Property / coordinate location @@
+°35'17.99"N, 5°34'35.18"WLatitude 42.588333569322
Longitude -5.5764443062967
Precision 1.0E-5
Globe http://www.wikidata.org/entity/Q2
-Latitude
+.588333569322
-Longitude
+-5.5764443062967
-Precision
+.0E-5
-Globe
+http://www.wikidata.org/entity/Q2
@@ Property / coordinate location: 42°35'17.99"N, 5°34'35.18"W / rank @@
+Normal rank
@@ Property / coordinate location: 42°35'17.99"N, 5°34'35.18"W / qualifier @@
+inferred from: Local Administrative Unit
@@ Property / budget @@
+,700.0 EuroAmount 205,700.0 Euro
Unit Euro
-Amount
+,700.0 Euro
-Unit
+Euro
@@ Property / budget: 205,700.0 Euro / rank @@
+Preferred rank
@@ Property / EU contribution @@
+,003.65 EuroAmount 112,003.65 Euro
Unit Euro
-Amount
+,003.65 Euro
-Unit
+Euro
@@ Property / EU contribution: 112,003.65 Euro / rank @@
+Preferred rank
@@ Property / co-financing rate @@
+.45 percentAmount 54.45 percent
Unit percent
-Amount
+.45 percent
-Unit
+percent
@@ Property / co-financing rate: 54.45 percent / rank @@
+Normal rank
@@ Property / date of last update @@
+December 2023Timestamp +2023-12-20T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2023-12-20T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / date of last update: 20 December 2023 / rank @@
+Normal rank

Latest revision as of 09:48, 10 October 2024

Project Q3165218 in Spain

Language	Label	Description	Also known as
English	ANALYSIS OF YIN-YANG INTERACTION BETWEEN TP53 AND TP73 IN REPROGRAMMING AND TISSUE ARCHITECTURE: IMPLICATION IN TUMOR ONCOGENESIS	Project Q3165218 in Spain

Statements

contained in NUTS

León Province

inferred from

Local Administrative Unit

0 references

0 references

0 references

0 references

112,003.65 Euro

0 references

budget

205,700.0 Euro

0 references

co-financing rate

54.45 percent

0 references

start time

1 January 2016

0 references

end time

31 December 2019

0 references

beneficiary name (string)

UNIVERSIDAD DE LEON

0 references

beneficiary

University of León

0 references

intervention field

Research and innovation activities in public research centres and centres of competence including networking

0 references

programme

Multi-regional Spain - ERDF

0 references

fund

European Regional Development Fund

0 references

coordinate location

42°35'17.99"N, 5°34'35.18"W

inferred from

Local Administrative Unit

0 references

summary

EL DESARROLLO EMBRIONARIO Y LA ONCOGENESIS, PUEDEN CONSIDERARSE COMO LAS DOS CARAS DE UNA MONEDA. LOS PROCESOS DE DETERMINACION CELULAR, DIFERENCIACION Y MORFOGENESIS, CRUCIALES DURANTE EL DESARROLLO EMBRIONARIO, SON LOS MISMOS QUE APARECEN DESREGULADOS DURANTE LA PROGRESION Y METASTASIS TUMORAL. EL CONTROL DE ESTOS PROCESOS LO LLEVAN A CABO, AL MENOS EN PARTE, FACTORES DE TRANSCRIPCION COMO LOS MIEMBROS DE LA FAMILIA P53._x000D_ EL ANALISIS CONJUNTO DE DATOS PROVENIENTES DE MULTIPLES GRUPOS, INCLUIDO EL NUESTRO, REVELA UNA INTERACCION YIN-YANG ENTRE TP53 Y EL GEN BIMODAL TP73 EN VARIOS CONTEXTOS BIOLOGICOS, COMO EL MANTENIMIENTO DE LAS CELULAS TRONCALES NEURALES O LA ANGIOGENESIS. EL RESULTADO DE LA INTERACCION FUNCIONAL ENTRE TP53 Y TP73 ES CONTEXTUAL, SIENDO A VECES SINERGICO Y OTRAS, ANTAGONICO. ESTA RELACION FUNCIONAL PARECE LLEVAR A CABO UN PAPEL CENTRAL EN EL DESARROLLO EMBRIONARIO Y LA ARQUITECTURA TISULAR Y ES FACIL IMAGINAR COMO ALTERACIONES EN EL DELICADO BALANCE DE ESTA RED DE CONTROL PUEDE RESULTAR EN LA GENESIS Y PROGRESION TUMORAL._x000D_ NUESTRA HIPOTESIS DE TRABAJO ES QUE TP73 LLEVA A CABO UN PAPEL FUNDAMENTAL EN EL ESTABLECIMIENTO DE LAS INTERACCIONES CELULARES Y LA DIFERENCIACION CELULAR. ESTA FUNCION ES BIMODAL YA QUE LA RESPUESTA CELULAR RESULTANTE DEPENDERA DE LA EXPRESION DIFERENCIAL DE LAS ISOFORMAS TA Y DN-P73 Y, POR TANTO, DEPENDIENTE DEL CONTEXTO CELULAR. LA CORRECTA REGULACION DE ESTOS PROCESOS CELULARES, MEDIADA POR TP73, ES NECESARIA Y FUNDAMENTAL PARA EL CORRECTO DESARROLLO DE PROCESOS BIOLOGICAMENTE COMPLEJOS, COMO LA REPROGRAMACION DE CELUALS SOMATICAS Y EL ESTABLECIMIENTO DE LA POLARIDAD TISULAR. _x000D_ POR TODO ELLO, EL OBJETIVO GENERAL DE ESTE PROYECTO ES EL DE ELUCIDAR LA FUNCION Y CONSECUENCIAS DE LA INTERACCION FUNCIONAL ENTRE TP53 Y TP73 EN PROCESOS QUE SON ESENCIALES TANTO PARA EL DESARROLLO EMBRIONARIO, COMO PARA EL INICIO Y PROGRESION TUMORAL: LA REPROGRAMACION DE CELULAS SOMATICAS, LA DETERMINACION CELULAR Y EL ESTABLECIMIENTO DE LA POLARIDAD CELULAR PLANAR. TODOS ESTOS PROCESOS, APARENTEMENTE DIVERSOS, COMPARTEN UN TEMA CENTRAL: LA REGULACION DE LA DIFERENCIACION Y EL ESTABLECIMIENTO DE INTERACCIONES CELULARES APROPIADAS._x000D_ PARA EVALUAR ESTA HIPOTESIS, NUESTROS OBJETIVOS ESPECIFICOS SON:_x000D_ 1. CARACTERIZACION DEL MECANISMO DE ACCION DE P73, EN PRESENCIA O AUSENCIA DE P53, EN LA REPROGRAMACION DE CELULAS SOMATICAS._x000D_ 2. ESTUDIO DE LA INTERACCION FUNCIONAL DE P53 Y P73 COMO ¿GATE MASTERS¿ DE LOS PROGRAMAS DE DIFERENCIACION MESODERMICA_x000D_ 3. ESTUDIO DE LA FUNCION DE P73 EN LA SEÑALIZACION DE LA POLARIDAD CELULAR PLANAR Y LA ARQUITECTURA TISULAR (Spanish)

0 references

EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English)

ANALYSIS OF YIN-YANG INTERACTION BETWEEN TP53 AND TP73 IN REPROGRAMMING AND TISSUE ARCHITECTURE: IMPLICATION IN TUMOR ONCOGENESIS (Q3165218): Difference between revisions

Latest revision as of 09:48, 10 October 2024

Statements

Identifiers

Navigation menu

Search