Q2720827 (Q2720827): Difference between revisions
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(Created claim: summary (P836): The object of the proposed project is the creation of a Center for Preclinical Testing and Optimisation of Pharmaceutical Nanoparticles for Cancer. In addition, the Centre will develop specialisation in binding to nanoparticles of anti-fiber substances for which we have recently shown to change the microenvironment of the tumor by increasing its blood supply and hence the transport of nanoparticles in the tumor. Equipment to be acquired includes...) |
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The object of the proposed project is the creation of a Center for Preclinical Testing and Optimisation of Pharmaceutical Nanoparticles for Cancer. In addition, the Centre will develop specialisation in binding to nanoparticles of anti-fiber substances for which we have recently shown to change the microenvironment of the tumor by increasing its blood supply and hence the transport of nanoparticles in the tumor. Equipment to be acquired includes: an advanced ultrasound system for measuring elastic properties and volume perfusion as well as a non-invasive nanoparticle imaging system in animal cancer models to measure particle distribution. The objectives of the Centre shall be: a) finding new solutions to optimise the performance of pharmaceutical nanoparticles, b) transfer of the Centre’s products from preclinical to clinical stage, c) development of collaborations with other research institutes, and d) continued funding of the Centre after the completion of the project. In addition, the Centre will develop commercial partnerships with nano-medical companies to optimise their products. Other specific objectives of the project are the development of two specialised pharmaceutical nanoparticles equipped with anti-fiber and cytotoxic drugs and the creation of a biomarker based on the blood supply of the tumor that will correlate blood supply with the performance of drugs. The blood supply biomarker will be calculated through the development of package software compatible with ultrasonic systems. The ultimate purpose of the software is to develop a clinically relevant biomarker that predicts the outcome of the treatment by dividing the patients into those who will respond or not. The software will also provide guidelines for the drug delivery plan based on the blood supply biomarker. (English) | |||||||||||||||
| Property / summary: The object of the proposed project is the creation of a Center for Preclinical Testing and Optimisation of Pharmaceutical Nanoparticles for Cancer. In addition, the Centre will develop specialisation in binding to nanoparticles of anti-fiber substances for which we have recently shown to change the microenvironment of the tumor by increasing its blood supply and hence the transport of nanoparticles in the tumor. Equipment to be acquired includes: an advanced ultrasound system for measuring elastic properties and volume perfusion as well as a non-invasive nanoparticle imaging system in animal cancer models to measure particle distribution. The objectives of the Centre shall be: a) finding new solutions to optimise the performance of pharmaceutical nanoparticles, b) transfer of the Centre’s products from preclinical to clinical stage, c) development of collaborations with other research institutes, and d) continued funding of the Centre after the completion of the project. In addition, the Centre will develop commercial partnerships with nano-medical companies to optimise their products. Other specific objectives of the project are the development of two specialised pharmaceutical nanoparticles equipped with anti-fiber and cytotoxic drugs and the creation of a biomarker based on the blood supply of the tumor that will correlate blood supply with the performance of drugs. The blood supply biomarker will be calculated through the development of package software compatible with ultrasonic systems. The ultimate purpose of the software is to develop a clinically relevant biomarker that predicts the outcome of the treatment by dividing the patients into those who will respond or not. The software will also provide guidelines for the drug delivery plan based on the blood supply biomarker. (English) / rank | |||||||||||||||
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| Property / summary: The object of the proposed project is the creation of a Center for Preclinical Testing and Optimisation of Pharmaceutical Nanoparticles for Cancer. In addition, the Centre will develop specialisation in binding to nanoparticles of anti-fiber substances for which we have recently shown to change the microenvironment of the tumor by increasing its blood supply and hence the transport of nanoparticles in the tumor. Equipment to be acquired includes: an advanced ultrasound system for measuring elastic properties and volume perfusion as well as a non-invasive nanoparticle imaging system in animal cancer models to measure particle distribution. The objectives of the Centre shall be: a) finding new solutions to optimise the performance of pharmaceutical nanoparticles, b) transfer of the Centre’s products from preclinical to clinical stage, c) development of collaborations with other research institutes, and d) continued funding of the Centre after the completion of the project. In addition, the Centre will develop commercial partnerships with nano-medical companies to optimise their products. Other specific objectives of the project are the development of two specialised pharmaceutical nanoparticles equipped with anti-fiber and cytotoxic drugs and the creation of a biomarker based on the blood supply of the tumor that will correlate blood supply with the performance of drugs. The blood supply biomarker will be calculated through the development of package software compatible with ultrasonic systems. The ultimate purpose of the software is to develop a clinically relevant biomarker that predicts the outcome of the treatment by dividing the patients into those who will respond or not. The software will also provide guidelines for the drug delivery plan based on the blood supply biomarker. (English) / qualifier | |||||||||||||||
point in time: 31 May 2021
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Revision as of 19:26, 31 May 2021
Project Q2720827 in Cyprus
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q2720827 in Cyprus |
Statements
846,440.2 Euro
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995,812.0 Euro
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85.0 percent
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30 March 2017
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20 February 2023
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University of Cyprus
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Αντικείμενο του προτεινόμενου έργου είναι η δημιουργία Κέντρου για Προκλινική Δοκιμή και Βελτιστοποίηση Φαρμακευτικών Νανοσωματιδίων για το Καρκίνο. Επιπρόσθετα το Κέντρο θα αναπτύξει εξειδίκευση στην πρόσδεση στα νανοσωματίδια αντι-ινικών ουσιών για τις οποίες έχουμε δείξει πρόσφατα να αλλάζουν το μικροπεριβάλλον του όγκου αυξάνοντας την αιμάτωση του και επομένως την μεταφορά νανοσωματιδίων στον όγκο. Εξοπλισμός που θα αποκτηθεί περιλαμβάνει: ένα προηγμένο σύστημα υπερήχων για την μέτρηση ελαστικών ιδιοτήτων και της αιμάτωσης του όγκου καθώς και ένα σύστημα μη επεμβατικής απεικόνισης νανοσωματιδίων σε ζωϊκά μοντέλα του καρκίνου για την μέτρηση της κατανομής των σωματιδίων. Στόχοι του Κέντρου αποτελούν: α) εύρεση νέων λύσεων για την βελτιστοποίηση της απόδοσης φαρμακευτικών νανοσωματιδίων, β) μεταφορά των προϊόντων του Κέντρου από το προκλινικό στο κλινικό στάδιο, γ) ανάπτυξη συνεργασιών με άλλα ερευνητικά ινστιτούτα, και δ) συνέχιση χρηματοδότησης του Κέντρου μετά το πέρας του έργου. Επιπρόσθετα το Κέντρο θα αναπτύξει εμπορικές συνεργασίες με εταιρίες νανοϊατρικής για βελτιστοποίηση των προϊόντων τους. Άλλοι συγκεκριμένοι στόχοι του έργου αποτελούν η ανάπτυξη δύο εξειδικευμένων φαρμακευτικών νανοσωματιδίων εξοπλισμένα με αντι-ινικά και κυτταροτοξικά φάρμακα και η δημιουργία ενός Βιοδείκτη βασισμένο στην αιμάτωση του όγκου που θα συσχετίζει την αιμάτωση με την απόδοση των φαρμάκων. Ο Βιοδείκτης Αιμάτωσης θα υπολογίζεται μέσω της ανάπτυξης λογισμικού πακέτου, συμβατού με συστήματα υπερήχων. Ο τελικός σκοπός του λογισμικού είναι να αναπτυχθεί ένας κλινικά σχετικός βιοδείκτης που να προβλέπει το αποτέλεσμα της θεραπείας, χωρίζοντας του ασθενείς σε αυτούς που θα ανταποκριθούν ή όχι. Το λογισμικό θα παρέχει επίσης κατευθυντήριες γραμμές για το σχέδιο χορήγησης των φαρμάκων με βάση των Βιοδείκτη Αιμάτωσης. (Greek)
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The object of the proposed project is the creation of a Center for Preclinical Testing and Optimisation of Pharmaceutical Nanoparticles for Cancer. In addition, the Centre will develop specialisation in binding to nanoparticles of anti-fiber substances for which we have recently shown to change the microenvironment of the tumor by increasing its blood supply and hence the transport of nanoparticles in the tumor. Equipment to be acquired includes: an advanced ultrasound system for measuring elastic properties and volume perfusion as well as a non-invasive nanoparticle imaging system in animal cancer models to measure particle distribution. The objectives of the Centre shall be: a) finding new solutions to optimise the performance of pharmaceutical nanoparticles, b) transfer of the Centre’s products from preclinical to clinical stage, c) development of collaborations with other research institutes, and d) continued funding of the Centre after the completion of the project. In addition, the Centre will develop commercial partnerships with nano-medical companies to optimise their products. Other specific objectives of the project are the development of two specialised pharmaceutical nanoparticles equipped with anti-fiber and cytotoxic drugs and the creation of a biomarker based on the blood supply of the tumor that will correlate blood supply with the performance of drugs. The blood supply biomarker will be calculated through the development of package software compatible with ultrasonic systems. The ultimate purpose of the software is to develop a clinically relevant biomarker that predicts the outcome of the treatment by dividing the patients into those who will respond or not. The software will also provide guidelines for the drug delivery plan based on the blood supply biomarker. (English)
31 May 2021
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*Δεν έχει γεωγραφική διάσταση*
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Identifiers
34535
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