Development of methods of non-invasive genetic diagnosis and prevention of cancer – liquid biopsy. (Q107971): Difference between revisions
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(Removed claim: summary (P836): The project is an attempt to address the problem of cancer diagnosis in a comprehensive way. The current state of medical knowledge makes it possible to treat an increasing number of diseases, but it is often too late to detect them. The development of diagnostic methods makes it possible to use non-invasive methods that use non-invasive methods based on the free, out-of-the-cell DNA in recent years, present in the plasma of every human being,...) |
(Created claim: summary (P836): The presented project is an attempt at a comprehensive approach to the problem of cancer diagnosis. The current state of medical knowledge makes it possible to heal more and more diseases, but it is often too late to detect them. The development of diagnostic methods allows the use of high pass technologies using non-invasive methods based on free, extracellular DNA discovered in recent years, present in the plasma of every human, and in increas...) |
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The presented project is an attempt at a comprehensive approach to the problem of cancer diagnosis. The current state of medical knowledge makes it possible to heal more and more diseases, but it is often too late to detect them. The development of diagnostic methods allows the use of high pass technologies using non-invasive methods based on free, extracellular DNA discovered in recent years, present in the plasma of every human, and in increased amounts and abnormal structure in cancer patients. In addition to the analysis of mutations characterising the tumour tissue, the possibility of analysing changes in the number of copies and structural abberations will be examined on the basis of statistical analysis of abnormalities in the patient’s genome. According to previous studies, changes in the number of copies/abberations present in data from free cancer DNA sequencing may indicate the occurrence of the tumour, its type and progression. Genomed S.A. with its research team comes across the expectations of the market and as part of the project plans to develop an innovative method of genetic profiling of cancers – non-invasive diagnosis of cancers, enabling monitoring of the course of the disease and treatment. The result of the work will be a cost-optimised diagnosis of cancer for the Polish population, with the possibility of making data available via an Internet platform for applications in telemedicine. In the course of research, a method will be developed to detect mutations specific to cancer-specific cancer patients and structural changes specific to cancer patients, based on free, cancerous DNA sequencing of patients. The data thus obtained will allow individual therapy (or inclusion of the patient in clinical trials) and monitoring of the course of treatment without the need for costly and painful biopsy. (English) | |||||||||||||||
| Property / summary: The presented project is an attempt at a comprehensive approach to the problem of cancer diagnosis. The current state of medical knowledge makes it possible to heal more and more diseases, but it is often too late to detect them. The development of diagnostic methods allows the use of high pass technologies using non-invasive methods based on free, extracellular DNA discovered in recent years, present in the plasma of every human, and in increased amounts and abnormal structure in cancer patients. In addition to the analysis of mutations characterising the tumour tissue, the possibility of analysing changes in the number of copies and structural abberations will be examined on the basis of statistical analysis of abnormalities in the patient’s genome. According to previous studies, changes in the number of copies/abberations present in data from free cancer DNA sequencing may indicate the occurrence of the tumour, its type and progression. Genomed S.A. with its research team comes across the expectations of the market and as part of the project plans to develop an innovative method of genetic profiling of cancers – non-invasive diagnosis of cancers, enabling monitoring of the course of the disease and treatment. The result of the work will be a cost-optimised diagnosis of cancer for the Polish population, with the possibility of making data available via an Internet platform for applications in telemedicine. In the course of research, a method will be developed to detect mutations specific to cancer-specific cancer patients and structural changes specific to cancer patients, based on free, cancerous DNA sequencing of patients. The data thus obtained will allow individual therapy (or inclusion of the patient in clinical trials) and monitoring of the course of treatment without the need for costly and painful biopsy. (English) / rank | |||||||||||||||
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| Property / summary: The presented project is an attempt at a comprehensive approach to the problem of cancer diagnosis. The current state of medical knowledge makes it possible to heal more and more diseases, but it is often too late to detect them. The development of diagnostic methods allows the use of high pass technologies using non-invasive methods based on free, extracellular DNA discovered in recent years, present in the plasma of every human, and in increased amounts and abnormal structure in cancer patients. In addition to the analysis of mutations characterising the tumour tissue, the possibility of analysing changes in the number of copies and structural abberations will be examined on the basis of statistical analysis of abnormalities in the patient’s genome. According to previous studies, changes in the number of copies/abberations present in data from free cancer DNA sequencing may indicate the occurrence of the tumour, its type and progression. Genomed S.A. with its research team comes across the expectations of the market and as part of the project plans to develop an innovative method of genetic profiling of cancers – non-invasive diagnosis of cancers, enabling monitoring of the course of the disease and treatment. The result of the work will be a cost-optimised diagnosis of cancer for the Polish population, with the possibility of making data available via an Internet platform for applications in telemedicine. In the course of research, a method will be developed to detect mutations specific to cancer-specific cancer patients and structural changes specific to cancer patients, based on free, cancerous DNA sequencing of patients. The data thus obtained will allow individual therapy (or inclusion of the patient in clinical trials) and monitoring of the course of treatment without the need for costly and painful biopsy. (English) / qualifier | |||||||||||||||
point in time: 20 October 2020
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Revision as of 09:10, 20 October 2020
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Development of methods of non-invasive genetic diagnosis and prevention of cancer – liquid biopsy. |
Project in Poland financed by DG Regio |
Statements
2,071,253.46 zloty
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3,083,145.41 zloty
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67.18 percent
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1 October 2016
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31 December 2018
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GENOMED SPÓŁKA AKCYJNA
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52°14'1.3"N, 21°4'17.0"E
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Prezentowany projekt stanowi próbę kompleksowego podejścia do problemu diagnostyki chorób nowotworowych. Obecny stan wiedzy medycznej pozwala leczyć coraz większą liczbę chorób, jednakże często ich wykrycie następuje zdecydowanie za późno. Rozwój metod diagnostycznych umożliwia zastosowanie wysokoprzepustowych technologii, wykorzystujących metody nieinwazyjne, oparte na odkrytym w ostatnich latach wolnym, pozakomórkowym DNA, obecnym w osoczu krwi każdego człowieka, a w zwiększonych ilościach i anormalnej strukturze u pacjentów onkologicznych. Oprócz analizy mutacji, charakteryzujących tkankę nowotworową, zostanie zbadana możliwość analizy zmian liczby kopii i abberacji strukturalnych na podstawie statystycznej analizy zaburzeń w pokryciu genomu pacjenta. Jak pokazują dotychczasowe badania, zmiany liczby kopii/ abberacje obecne w danych z sekwencjonowania wolnego nowotworowego DNA mogą świadczyć o występowaniu nowotworu, jego typie i stanie zaawansowania. Genomed S.A. ze swym zespołem badawczym wychodzi naprzeciwko oczekiwaniom rynku i w ramach projektu planuje opracowanie innowacyjnej metody profilowania genetycznego nowotworów - nieinwazyjnej diagnostyki chorób nowotworowych, umożliwiającej monitorowanie przebiegu choroby i leczenia. Efektem prac będzie zoptymalizowana kosztowo diagnostyka chorób nowotworowych dla populacji polskiej, z możliwością udostępnienia danych poprzez platformę internetową do zastosowań w telemedycynie. W toku prac badawczych na podstawie danych z sekwencjonowania wolnego, nowotworowego DNA pacjentów zostanie opracowana metoda umożliwiająca wykrycie mutacji specyficznych dla tkanki nowotworowej pacjentów onkologicznych oraz charakterystycznych dla procesów nowotworowych zmian strukturalnych. Uzyskane w ten sposób dane umożliwią dobranie indywidualnej terapii (czy też włączenie pacjenta w badania kliniczne) i monitorowanie przebiegu leczenia bez konieczności wykonywania kosztownych i bolesnych biopsji. (Polish)
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The presented project is an attempt at a comprehensive approach to the problem of cancer diagnosis. The current state of medical knowledge makes it possible to heal more and more diseases, but it is often too late to detect them. The development of diagnostic methods allows the use of high pass technologies using non-invasive methods based on free, extracellular DNA discovered in recent years, present in the plasma of every human, and in increased amounts and abnormal structure in cancer patients. In addition to the analysis of mutations characterising the tumour tissue, the possibility of analysing changes in the number of copies and structural abberations will be examined on the basis of statistical analysis of abnormalities in the patient’s genome. According to previous studies, changes in the number of copies/abberations present in data from free cancer DNA sequencing may indicate the occurrence of the tumour, its type and progression. Genomed S.A. with its research team comes across the expectations of the market and as part of the project plans to develop an innovative method of genetic profiling of cancers – non-invasive diagnosis of cancers, enabling monitoring of the course of the disease and treatment. The result of the work will be a cost-optimised diagnosis of cancer for the Polish population, with the possibility of making data available via an Internet platform for applications in telemedicine. In the course of research, a method will be developed to detect mutations specific to cancer-specific cancer patients and structural changes specific to cancer patients, based on free, cancerous DNA sequencing of patients. The data thus obtained will allow individual therapy (or inclusion of the patient in clinical trials) and monitoring of the course of treatment without the need for costly and painful biopsy. (English)
20 October 2020
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Identifiers
RPMA.01.02.00-14-6209/16
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