Derivatives of salinomycin carbon in item 1 as precursors of cancer therapy (Q81154): Difference between revisions
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(Removed claim: summary (P836): Reference_reference_programme_aids:SA.42799 (2015/X), aid_de_de minimis:Article 42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on the granting of financial assistance by the Polish Agency for Enterprise Development in the framework of the Operational Programme Smart Growth 2014-2020Agenda for procurement is the development by a scientific unit of a new product — the chemical compound, salinomomycin deriv...) |
(Created claim: summary (P836): Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020The subject of the procurement is the development by the Scientific Unit for the micro-entrepreneur Trimen Chemicals SA (Applicant) of a new...) |
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Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020The subject of the procurement is the development by the Scientific Unit for the micro-entrepreneur Trimen Chemicals SA (Applicant) of a new product – a chemical compound, a salinomycin derivative, modified on coal in heading 1, with activity higher than natural salinomycin. Within the framework of the project,........ THIS REQUIREED NAME OF ONE...., (Scientific unit), which was selected in the offer request, will carry out, among others, the following tasks: 1) conduct a State of Technology study to ensure the patent purity developed and supplied to the Applicant concerned carbon modified salinomycin derivative under heading 1. 2)identify operational research fields for the synthesis and modification of salinomycin on carbon in heading 1, with particular regard to the therapeutic potential of modifications, as well as possible difficulties for potential followers. 3) conduct synthesis and characterise at least 24 derivatives from 4 groups differing in the functionality of the modification applied (e.g. esters, amides, urethanes, amino acid amides, aminoalcohol amides, etc.) and determine the physico-chemical properties of derived derivatives, in particular their NMR spectrum. 4) conduct in vitro at least 24 IC50 derivatives using HL-60 cell lines and colon adenocarcinoma L0V0. For at least the two most active derivatives from different groups for functionalisation, an activity scan will be performed on a wider cell panel containing cell lines of breast, ovarian and lung cancer. 5)confirmatory and in vitro test and provide the Applicant with at least 16 IC50 derivatives from use (English) | |||||||||||||||
| Property / summary: Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020The subject of the procurement is the development by the Scientific Unit for the micro-entrepreneur Trimen Chemicals SA (Applicant) of a new product – a chemical compound, a salinomycin derivative, modified on coal in heading 1, with activity higher than natural salinomycin. Within the framework of the project,........ THIS REQUIREED NAME OF ONE...., (Scientific unit), which was selected in the offer request, will carry out, among others, the following tasks: 1) conduct a State of Technology study to ensure the patent purity developed and supplied to the Applicant concerned carbon modified salinomycin derivative under heading 1. 2)identify operational research fields for the synthesis and modification of salinomycin on carbon in heading 1, with particular regard to the therapeutic potential of modifications, as well as possible difficulties for potential followers. 3) conduct synthesis and characterise at least 24 derivatives from 4 groups differing in the functionality of the modification applied (e.g. esters, amides, urethanes, amino acid amides, aminoalcohol amides, etc.) and determine the physico-chemical properties of derived derivatives, in particular their NMR spectrum. 4) conduct in vitro at least 24 IC50 derivatives using HL-60 cell lines and colon adenocarcinoma L0V0. For at least the two most active derivatives from different groups for functionalisation, an activity scan will be performed on a wider cell panel containing cell lines of breast, ovarian and lung cancer. 5)confirmatory and in vitro test and provide the Applicant with at least 16 IC50 derivatives from use (English) / rank | |||||||||||||||
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| Property / summary: Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020The subject of the procurement is the development by the Scientific Unit for the micro-entrepreneur Trimen Chemicals SA (Applicant) of a new product – a chemical compound, a salinomycin derivative, modified on coal in heading 1, with activity higher than natural salinomycin. Within the framework of the project,........ THIS REQUIREED NAME OF ONE...., (Scientific unit), which was selected in the offer request, will carry out, among others, the following tasks: 1) conduct a State of Technology study to ensure the patent purity developed and supplied to the Applicant concerned carbon modified salinomycin derivative under heading 1. 2)identify operational research fields for the synthesis and modification of salinomycin on carbon in heading 1, with particular regard to the therapeutic potential of modifications, as well as possible difficulties for potential followers. 3) conduct synthesis and characterise at least 24 derivatives from 4 groups differing in the functionality of the modification applied (e.g. esters, amides, urethanes, amino acid amides, aminoalcohol amides, etc.) and determine the physico-chemical properties of derived derivatives, in particular their NMR spectrum. 4) conduct in vitro at least 24 IC50 derivatives using HL-60 cell lines and colon adenocarcinoma L0V0. For at least the two most active derivatives from different groups for functionalisation, an activity scan will be performed on a wider cell panel containing cell lines of breast, ovarian and lung cancer. 5)confirmatory and in vitro test and provide the Applicant with at least 16 IC50 derivatives from use (English) / qualifier | |||||||||||||||
point in time: 14 October 2020
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Revision as of 11:23, 14 October 2020
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Derivatives of salinomycin carbon in item 1 as precursors of cancer therapy |
Project in Poland financed by DG Regio |
Statements
324,836.34 zloty
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382,160.42 zloty
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85.0 percent
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1 December 2017
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31 August 2018
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TRIMEN CHEMICALS SPÓŁKA AKCYJNA
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Numer_referencyjny_programu_pomocowego: SA.42799(2015/X), pomoc_de_minimis: §42 rozporządzenia Ministra Infrastruktury i Rozwoju z dnia 10 lipca 2015 r. w sprawie udzielania przez Polską Agencję Rozwoju Przedsiębiorczości pomocy finansowej w ramach Programu Operacyjnego Inteligentny Rozwój 2014–2020Przedmiotem zamówienia jest opracowanie przez Jednostkę naukową dla mikroprzedsiębiorcy Trimen Chemicals SA (Wnioskodawca) nowego produktu - związku chemicznego, pochodnej salinomycyny, zmodyfikowanej na węglu w pozycji 1, o aktywności wyższej od naturalnej salinomycyny. W ramach projektu, .......TU NAZWA WYBRANEJ JEDNOSTKI....., (Jednostka naukowa), która została wyłoniona w zapytaniu ofertowym, zrealizuje m.in. następujące zadania: 1)przeprowadzi badanie stanu techniki w celu zapewnienia czystości patentowej opracowanej i dostarczonej Wnioskodawcy przedmiotowej pochodnej salinomycyny modyfikowanej na węglu w pozycji 1. 2)określi możliwe do eksploatacji pola badawcze dla syntezy i modyfikacji salinomycyny na węglu w pozycji 1, ze szczególnym uwzględnieniem potencjału terapeutycznego ew. modyfikacji, jak i ewentualnych trudności dla potencjalnych naśladowców. 3)przeprowadzi syntezy i scharakteryzuje co najmniej 24 pochodne z 4 grup różniących się funkcjonalnością zastosowanej modyfikacji (np. estry, amidy, uretany, amidy aminokwasów, amidy aminoalkoholi etc.), a także określi właściwości fizyko-chemiczne uzyskanych pochodnych, w szczególności ich widma NMR. 4)przeprowadzi badanie aktywności in vitro co najmniej 24 pochodnych z wyznaczeniem IC50 z użyciem linii komórkowych białaczki HL-60 oraz gruczolakoraka jelita grubego L0V0. Dla co najmniej dwóch najaktywniejszych pochodnych z różnych grup pod kątem funkcjonalizacji, zostanie wykonany skan aktywności na szerszym panelu komórek, zawierającym linie komórkowe raka piersi, jajnika i płuc. 5)wykona badanie potwierdzające i przebada in vitro i dostarczy Wnioskodawcy co najmniej 16 pochodnych z wyznaczeniem IC50 z uży (Polish)
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Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Regulation of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020The subject of the procurement is the development by the Scientific Unit for the micro-entrepreneur Trimen Chemicals SA (Applicant) of a new product – a chemical compound, a salinomycin derivative, modified on coal in heading 1, with activity higher than natural salinomycin. Within the framework of the project,........ THIS REQUIREED NAME OF ONE...., (Scientific unit), which was selected in the offer request, will carry out, among others, the following tasks: 1) conduct a State of Technology study to ensure the patent purity developed and supplied to the Applicant concerned carbon modified salinomycin derivative under heading 1. 2)identify operational research fields for the synthesis and modification of salinomycin on carbon in heading 1, with particular regard to the therapeutic potential of modifications, as well as possible difficulties for potential followers. 3) conduct synthesis and characterise at least 24 derivatives from 4 groups differing in the functionality of the modification applied (e.g. esters, amides, urethanes, amino acid amides, aminoalcohol amides, etc.) and determine the physico-chemical properties of derived derivatives, in particular their NMR spectrum. 4) conduct in vitro at least 24 IC50 derivatives using HL-60 cell lines and colon adenocarcinoma L0V0. For at least the two most active derivatives from different groups for functionalisation, an activity scan will be performed on a wider cell panel containing cell lines of breast, ovarian and lung cancer. 5)confirmatory and in vitro test and provide the Applicant with at least 16 IC50 derivatives from use (English)
14 October 2020
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Identifiers
POIR.02.03.02-10-0022/17
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