Biotechnology for the production of hyaluronic acid, based on a unique moophile strain capable of being used as a source of waste carbon of glycerol. (Q77576): Difference between revisions
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(Removed claim: summary (P836): Reference_reference_programme_aids:SA.41471 (2015/X) _public:Article 25 of Commission Regulation (EC) No 651/2014 of 17 June 2014 declaring certain categories of aid compatible with the internal market in the application of Article 107 and 108 of the Treaty (OJ(OJ LEU L 187/1, 26.06.2014).This project focuses on research and development which will lead to the development of a disruptive technology for the production of hyalonic acid, using was...) |
(Created claim: summary (P836): Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). This project focuses on research and development, which will result in a groundbreaking technology for the production of hyaluronic acid, using w...) |
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Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). This project focuses on research and development, which will result in a groundbreaking technology for the production of hyaluronic acid, using waste in the form of glycerol. Important within the project will be the development of a biotechnology method of transformation of the waste compound – glycerol to hyaluronic acid (HA). The basis for achieving an appropriate way of producing acid will be research into the construction of a unique mutant on a global scale, which will be able to grow in mediums containing high concentrations of glycerol. To this end, extremophilic strains will be selected from micro-organisms in high glycerol environments (>15 %) in order to find osmophils using glycerol for growth and transfer to them hyaluronic synthesis genes, gram-positive Streptococcus membrane proteins. The research hypothesis is based on the possibility of using the metabolic pathways of extremophilic bacteria that can be used as a source of carbon glycerol and after the planned recombinant glucose project as a direct substrate for HA acid biosynthesis. The final result of the project in part of industrial research will be the construction of a new strain with assumed properties, i.e. metabolising glycerol to HA acid and technological assumptions of the HA acid production process, followed by an experimental model under laboratory conditions to test the reliability of the specified process and product parameters. (English) | |||||||||||||||
| Property / summary: Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). This project focuses on research and development, which will result in a groundbreaking technology for the production of hyaluronic acid, using waste in the form of glycerol. Important within the project will be the development of a biotechnology method of transformation of the waste compound – glycerol to hyaluronic acid (HA). The basis for achieving an appropriate way of producing acid will be research into the construction of a unique mutant on a global scale, which will be able to grow in mediums containing high concentrations of glycerol. To this end, extremophilic strains will be selected from micro-organisms in high glycerol environments (>15 %) in order to find osmophils using glycerol for growth and transfer to them hyaluronic synthesis genes, gram-positive Streptococcus membrane proteins. The research hypothesis is based on the possibility of using the metabolic pathways of extremophilic bacteria that can be used as a source of carbon glycerol and after the planned recombinant glucose project as a direct substrate for HA acid biosynthesis. The final result of the project in part of industrial research will be the construction of a new strain with assumed properties, i.e. metabolising glycerol to HA acid and technological assumptions of the HA acid production process, followed by an experimental model under laboratory conditions to test the reliability of the specified process and product parameters. (English) / rank | |||||||||||||||
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| Property / summary: Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). This project focuses on research and development, which will result in a groundbreaking technology for the production of hyaluronic acid, using waste in the form of glycerol. Important within the project will be the development of a biotechnology method of transformation of the waste compound – glycerol to hyaluronic acid (HA). The basis for achieving an appropriate way of producing acid will be research into the construction of a unique mutant on a global scale, which will be able to grow in mediums containing high concentrations of glycerol. To this end, extremophilic strains will be selected from micro-organisms in high glycerol environments (>15 %) in order to find osmophils using glycerol for growth and transfer to them hyaluronic synthesis genes, gram-positive Streptococcus membrane proteins. The research hypothesis is based on the possibility of using the metabolic pathways of extremophilic bacteria that can be used as a source of carbon glycerol and after the planned recombinant glucose project as a direct substrate for HA acid biosynthesis. The final result of the project in part of industrial research will be the construction of a new strain with assumed properties, i.e. metabolising glycerol to HA acid and technological assumptions of the HA acid production process, followed by an experimental model under laboratory conditions to test the reliability of the specified process and product parameters. (English) / qualifier | |||||||||||||||
point in time: 14 October 2020
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Revision as of 10:11, 14 October 2020
Project in Poland financed by DG Regio
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Biotechnology for the production of hyaluronic acid, based on a unique moophile strain capable of being used as a source of waste carbon of glycerol. |
Project in Poland financed by DG Regio |
Statements
6,389,466.0 zloty
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8,528,095.0 zloty
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74.92 percent
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1 September 2015
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1 November 2018
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REFIMOL SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ
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51°46'23.2"N, 19°28'42.2"E
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Numer_referencyjny_programu_pomocowego: SA.41471(2015/X) Przeznaczenie_pomocy_publicznej: art. 25 rozporządzenia KE nr 651/2014 z dnia 17 czerwca 2014 r. uznające niektóre rodzaje pomocy za zgodne z rynkiem wewnętrznym w stosowaniu art. 107 i 108 Traktatu (Dz. Urz. UE L 187/1 z 26.06.2014). Niniejszy projekt koncentruje się na przeprowadzeniu prac badawczo – rozwojowych, w wyniku których zostanie opracowana przełomowa technologia produkcji kwasu hialuronowego, wykorzystująca odpad w postaci glicerolu. Istotne w ramach projektu będzie opracowanie biotechnologicznej metody przekształcenia związku odpadowego - glicerolu do kwasu hialuronowego (HA). Podstawą dojścia do odpowiedniego sposobu produkcji kwasu, będzie przeprowadzenie prac badawczych nad skonstruowaniem unikatowego w skali światowej mutanta, który będzie zdolny do wzrostu w pożywkach zawierających wysokie stężenia glicerolu. W tym celu zostanie przeprowadzona selekcja ekstremofilych szczepów spośród drobnoustrojów bytujących w środowiskach o wysokim stężeniu glicerolu (>15%), w celu znalezienia osmofili wykorzystujących glicerol do wzrostu oraz przeniesienie do nich genów syntezy hialuronowej, białka błonowego gram-dodatnich szczepów Streptococcus. Hipoteza badawcza opiera się na możliwości wykorzystania szlaków metabolicznych bakterii ekstremofilnych, które są w stanie wykorzystać, jako źródło węgla glicerol oraz po planowanej w projekcie rekombinacji – glukozę, jako bezpośredni substrat do biosyntezy kwasu HA. Efektem końcowym projektu w ramach części badań przemysłowych będzie konstrukcja nowego szczepu o założonych właściwościach, tj. metabolizującego glicerol do kwasu HA oraz założenia technologiczne procesu wytwarzania kwasu HA, następnie wykonanie modelu eksperymentalnego w warunkach laboratoryjnych w celu zbadania wiarygodności wyznaczonych parametrów procesu i produktu. (Polish)
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Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). This project focuses on research and development, which will result in a groundbreaking technology for the production of hyaluronic acid, using waste in the form of glycerol. Important within the project will be the development of a biotechnology method of transformation of the waste compound – glycerol to hyaluronic acid (HA). The basis for achieving an appropriate way of producing acid will be research into the construction of a unique mutant on a global scale, which will be able to grow in mediums containing high concentrations of glycerol. To this end, extremophilic strains will be selected from micro-organisms in high glycerol environments (>15 %) in order to find osmophils using glycerol for growth and transfer to them hyaluronic synthesis genes, gram-positive Streptococcus membrane proteins. The research hypothesis is based on the possibility of using the metabolic pathways of extremophilic bacteria that can be used as a source of carbon glycerol and after the planned recombinant glucose project as a direct substrate for HA acid biosynthesis. The final result of the project in part of industrial research will be the construction of a new strain with assumed properties, i.e. metabolising glycerol to HA acid and technological assumptions of the HA acid production process, followed by an experimental model under laboratory conditions to test the reliability of the specified process and product parameters. (English)
14 October 2020
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Identifiers
POIR.01.01.01-00-0026/15
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