Development of NMR spectroscopic infrastructure for rational design and production of peptide mimetics, peptide pharmaceuticals and biocompatible nano-systems (Q3958259): Difference between revisions
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The developed infrastructure will be used primarily for basic research on modern clinical, molecular approach therapies, both in academic and KK and large companies (Richter, Sanofi). In our integrated, interdisciplinary projects, we aim not only to better understand the life cycle of proteins, but also to better design molecules as structural materials (winding testing, rational resetting and protein engineering). We can expect a scientific breakthrough in the field of domestic rational drug design (exenatide/diabetes mellitus, active ingredient in-house developed E19 equivalent active ingredient) and the engineering development of biocompatible nanomolecules. As in the structure study of the Ca2+ binder S100A4 protein involved in metastases and chronic inflammations (Gógl et al JBC 2016; Soldier et al FASEB J 2015; Duelli et al, PlosOne 2014), also achieved success in understanding the molecular level of hereditary kidney disease (Tory et al Nature Gen.2014). By revealing structural and dynamic information at the atomic level, we can design peptides that inhibit S100A4 protein-protein interactions, small molecule inhibitors, and perform functional testing. We can build the basis of interdisciplinary translational research in an academic environment that can be relevant in cancer research for the development of anti-metastasis and/or anti-inflammatory drugs, or in the effective treatment of diabetes, which can represent outstanding scientific achievements internationally. The operational background required for the operation is already available, the implementation site is suitable. The three are: The smooth operation of 250, 500 and 700 MHz NMR devices and the related tasks have been successfully performed by professionally committed NMR spectroscopic researchers and doctoral students with international relations, national academic and industrial network for years. The economic background to ensure the smooth operation of the instruments — approx. 3.5 Mt per year — is provided by central targeted support, tender sources and industrial contracts (contracts with small and medium-sized enterprises). We have made considerable efforts to reduce our costs and increase environmentally friendly operation by installing our He recovery system. Presentation of the implementation site: Eötvös Loránd University (ELTE) has participated or coordinated in 48 projects under Article 7 It was funded from the Research Framework Programme and two projects funded by the Competitiveness and Innovation Framework Programme. ELTE is the host institution of two winning ERC projects from H2020. Both young researchers are implementing their project at the Faculty of Science.2 MSCA is an innovative researcher training network (MSCA ITN) member of the University. It also hosts an MSCA individual scholarship project and participates in an MSCA research exchange programme. SECTION 7 In the framework of FP7 and H2020, a total of 7 ERC projects have been implemented or are being carried out at our university, as well as a nationally supported application related to an ERC funded by the NRDI Fund. The University is the host institution of 14 MTA Enduum projects. 13 ERASMUS (Erasmus Mundus, LLP, Jean Monet) is participating in the University, with an ERASMUS MUNDUS coordinated by the University. 6 out of the 7 H2020 projects carried out at the University will be implemented in the Faculty of Natural Sciences. Both winning H2020 ERC projects are hosted by the Faculty of Natural Sciences. In addition to international projects, several projects funded by OTKA, MTA Research Group, MTA Lendület and Richter Foundation are being implemented. Those implementing this project participate in European networks (EAST-NMR FP7) and intercontinental cooperation (Hungarian-US, Hungarian — Yaán, Hungarian — Argentinian). We are part of a winning iNEXT H2020 application. We also have a significant industrial relationship, e.g. Sanofi, Medi-Radiopharma. (English) | |||||||||||||||
| Property / summary: The developed infrastructure will be used primarily for basic research on modern clinical, molecular approach therapies, both in academic and KK and large companies (Richter, Sanofi). In our integrated, interdisciplinary projects, we aim not only to better understand the life cycle of proteins, but also to better design molecules as structural materials (winding testing, rational resetting and protein engineering). We can expect a scientific breakthrough in the field of domestic rational drug design (exenatide/diabetes mellitus, active ingredient in-house developed E19 equivalent active ingredient) and the engineering development of biocompatible nanomolecules. As in the structure study of the Ca2+ binder S100A4 protein involved in metastases and chronic inflammations (Gógl et al JBC 2016; Soldier et al FASEB J 2015; Duelli et al, PlosOne 2014), also achieved success in understanding the molecular level of hereditary kidney disease (Tory et al Nature Gen.2014). By revealing structural and dynamic information at the atomic level, we can design peptides that inhibit S100A4 protein-protein interactions, small molecule inhibitors, and perform functional testing. We can build the basis of interdisciplinary translational research in an academic environment that can be relevant in cancer research for the development of anti-metastasis and/or anti-inflammatory drugs, or in the effective treatment of diabetes, which can represent outstanding scientific achievements internationally. The operational background required for the operation is already available, the implementation site is suitable. The three are: The smooth operation of 250, 500 and 700 MHz NMR devices and the related tasks have been successfully performed by professionally committed NMR spectroscopic researchers and doctoral students with international relations, national academic and industrial network for years. The economic background to ensure the smooth operation of the instruments — approx. 3.5 Mt per year — is provided by central targeted support, tender sources and industrial contracts (contracts with small and medium-sized enterprises). We have made considerable efforts to reduce our costs and increase environmentally friendly operation by installing our He recovery system. Presentation of the implementation site: Eötvös Loránd University (ELTE) has participated or coordinated in 48 projects under Article 7 It was funded from the Research Framework Programme and two projects funded by the Competitiveness and Innovation Framework Programme. ELTE is the host institution of two winning ERC projects from H2020. Both young researchers are implementing their project at the Faculty of Science.2 MSCA is an innovative researcher training network (MSCA ITN) member of the University. It also hosts an MSCA individual scholarship project and participates in an MSCA research exchange programme. SECTION 7 In the framework of FP7 and H2020, a total of 7 ERC projects have been implemented or are being carried out at our university, as well as a nationally supported application related to an ERC funded by the NRDI Fund. The University is the host institution of 14 MTA Enduum projects. 13 ERASMUS (Erasmus Mundus, LLP, Jean Monet) is participating in the University, with an ERASMUS MUNDUS coordinated by the University. 6 out of the 7 H2020 projects carried out at the University will be implemented in the Faculty of Natural Sciences. Both winning H2020 ERC projects are hosted by the Faculty of Natural Sciences. In addition to international projects, several projects funded by OTKA, MTA Research Group, MTA Lendület and Richter Foundation are being implemented. Those implementing this project participate in European networks (EAST-NMR FP7) and intercontinental cooperation (Hungarian-US, Hungarian — Yaán, Hungarian — Argentinian). We are part of a winning iNEXT H2020 application. We also have a significant industrial relationship, e.g. Sanofi, Medi-Radiopharma. (English) / rank | |||||||||||||||
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| Property / summary: The developed infrastructure will be used primarily for basic research on modern clinical, molecular approach therapies, both in academic and KK and large companies (Richter, Sanofi). In our integrated, interdisciplinary projects, we aim not only to better understand the life cycle of proteins, but also to better design molecules as structural materials (winding testing, rational resetting and protein engineering). We can expect a scientific breakthrough in the field of domestic rational drug design (exenatide/diabetes mellitus, active ingredient in-house developed E19 equivalent active ingredient) and the engineering development of biocompatible nanomolecules. As in the structure study of the Ca2+ binder S100A4 protein involved in metastases and chronic inflammations (Gógl et al JBC 2016; Soldier et al FASEB J 2015; Duelli et al, PlosOne 2014), also achieved success in understanding the molecular level of hereditary kidney disease (Tory et al Nature Gen.2014). By revealing structural and dynamic information at the atomic level, we can design peptides that inhibit S100A4 protein-protein interactions, small molecule inhibitors, and perform functional testing. We can build the basis of interdisciplinary translational research in an academic environment that can be relevant in cancer research for the development of anti-metastasis and/or anti-inflammatory drugs, or in the effective treatment of diabetes, which can represent outstanding scientific achievements internationally. The operational background required for the operation is already available, the implementation site is suitable. The three are: The smooth operation of 250, 500 and 700 MHz NMR devices and the related tasks have been successfully performed by professionally committed NMR spectroscopic researchers and doctoral students with international relations, national academic and industrial network for years. The economic background to ensure the smooth operation of the instruments — approx. 3.5 Mt per year — is provided by central targeted support, tender sources and industrial contracts (contracts with small and medium-sized enterprises). We have made considerable efforts to reduce our costs and increase environmentally friendly operation by installing our He recovery system. Presentation of the implementation site: Eötvös Loránd University (ELTE) has participated or coordinated in 48 projects under Article 7 It was funded from the Research Framework Programme and two projects funded by the Competitiveness and Innovation Framework Programme. ELTE is the host institution of two winning ERC projects from H2020. Both young researchers are implementing their project at the Faculty of Science.2 MSCA is an innovative researcher training network (MSCA ITN) member of the University. It also hosts an MSCA individual scholarship project and participates in an MSCA research exchange programme. SECTION 7 In the framework of FP7 and H2020, a total of 7 ERC projects have been implemented or are being carried out at our university, as well as a nationally supported application related to an ERC funded by the NRDI Fund. The University is the host institution of 14 MTA Enduum projects. 13 ERASMUS (Erasmus Mundus, LLP, Jean Monet) is participating in the University, with an ERASMUS MUNDUS coordinated by the University. 6 out of the 7 H2020 projects carried out at the University will be implemented in the Faculty of Natural Sciences. Both winning H2020 ERC projects are hosted by the Faculty of Natural Sciences. In addition to international projects, several projects funded by OTKA, MTA Research Group, MTA Lendület and Richter Foundation are being implemented. Those implementing this project participate in European networks (EAST-NMR FP7) and intercontinental cooperation (Hungarian-US, Hungarian — Yaán, Hungarian — Argentinian). We are part of a winning iNEXT H2020 application. We also have a significant industrial relationship, e.g. Sanofi, Medi-Radiopharma. (English) / qualifier | |||||||||||||||
point in time: 9 February 2022
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Revision as of 18:46, 9 February 2022
Project Q3958259 in Hungary
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Development of NMR spectroscopic infrastructure for rational design and production of peptide mimetics, peptide pharmaceuticals and biocompatible nano-systems |
Project Q3958259 in Hungary |
Statements
101,578,177 forint
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370,235.607 Euro
0.0027336256 Euro
15 December 2021
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135,437,569.333 forint
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74.999997 percent
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1 January 2017
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31 December 2019
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EÖTVÖS LORÁND TUDOMÁNYEGYETEM
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47°29'30.62"N, 18°58'44.15"E
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A fejlesztett infrastruktúra elsősorban a modern klinikai, molekuláris megközelítésű gyógymódok alapkutatása kapcsán lesznek használhatók mind az akadémiai, mind a KK és nagyvállalatok (Richter, Sanofi) kapcsán. Integrált, interdiszciplináris projektjeinkben nemcsak a fehérjék életciklusának jobb megértését, hanem molekulák - mint szerkezeti anyagok - hatékonyabb tervezését is célozzuk (feltekeredés vizsgálat, racionális átszabás és fehérje-mérnökség). Tudományos áttörést várhatunk a hazai racionális gyógyszertervezés (Exenatid /diabetes mellitus, hatóanyag in-house fejlesztett E19 ekvivalens hatóanyag) és biokompatibilis nanomolekulák mérnöki fejlesztése terén. Ahogy a metasztázisok kialakulásában és a krónikus gyulladásokban szerepet játszó Ca2+-kötő S100A4 fehérje szerkezetvizsgálata kapcsán (Gógl et al JBC 2016; Katona et al Faseb J 2015; Duelli et al, PlosOne 2014), úgy az örökletes vesebetegség molekuláris szintjének megértése terén is (Tory et al Nature Gen.2014) sikereket értünk el. Az atomi szintű szerkezeti, dinamikai információk feltárásával az S100A4 fehérje-fehérje kölcsönhatásokat gátló peptideket, kismolekulás inhibitorokat tudunk tervezni, funkcionálisan vizsgálni. Olyan interdiszciplináris transzlációs kutatások alapját tudjuk akadémiai környezetben kiépíteni, amelyek a rákkutatásban anti-metasztázis és/vagy gyulladásgátló gyógyszerek fejlesztéséhez, vagy éppen a cukorbetegség hatékony kezelésében lehetnek fontosak, jelenthetnek nemzetközileg is kiemelkedő tudományos eredményeket. A működéshez szükséges üzemeltetési háttér már most is rendelkezésre áll, a megvalósítási helyszín alkalmas. A három: 250, 500 és 700 MHz-es NMR készülékek zavartalan működését és az ezekkel kapcsolatos feladatokat szakmailag elkötelezett, nemzetközi kapcsolatrendszerrel, hazai akadémiai és ipari hálózattal bíró NMR spektroszkópus oktató-kutatók és doktoranduszok látják el évek óta eredményesen. A műszerek zavartalan működését biztosító gazdasági hátteret – évi kb. 3,5 MFt-ot – központi céltámogatás, pályázati források, ipari megbízások (kis- és középvállalkozásokkal kötött szerződések) biztosítják. Jelentős erőfeszítéseket tettünk a költségeink csökkentésére és a környezetbarát üzemeltetés fokozására a He visszanyerő rendszerünk beüzemelésével. A megvalósítási helyszín bemutatása: Az ELTE 48 olyan projektben vett részt vagy koordinált, melyek a 7. Kutatási Keretprogramból került finanszírozásra,továbbá kettő, a Versenyképességi és Innovációs Keretprogramból finanszírozott projekt megvalósításában vett részt. H2020-ból két nyertes ERC projekt befogadó intézménye az ELTE. Mindkét fiatal kutató a Természettudományi Karon valósítja meg projektjét.2 MSCA innovatív kutató képzési hálózat (MSCA ITN) tagja az egyetem. Továbbá befogadó intézménye egy MSCA egyéni ösztöndíj projektnek és részt vesz egy MSCA kutatócsere programban. A 7. KP és H2020 keretében összesen 7 ERC projekt valósult illetve valósul meg egyetemünkön, továbbá egy NKFI Alapból finanszírozott ERC-hoz kapcsolódó hazai támogatású pályázat. 14 MTA Lendület programból támogatott projekt befogadó intézménye az egyetem. 13 ERASMUS (Erasmus Mundus, LLP, Jean Monet) pályázatban vesz részt az egyetem, egy ERASMUS MUNDUS-t az egyetem koordinál. Az egyetemen megvalósuló 7 db H2020 projektből 6 a Természettudományi Karon valósul meg. Mindkét nyertes H2020 ERC projektnek a befogadó intézménye szintén a Természettudományi Kar. A nemzetközi projekteken túl számos OTKA, MTA Kutatócsoport, MTA Lendület és Richter Alapítvány által finanszírozott projekt valósul meg. A jelen projektet megvalósítók részt vesznek európai hálózatokban (EAST-NMR FP7) és interkontinentális együttműködésekben (magyar-USA, magyar - jaán, magyar -argentín). Tagjai vagyunk egy elnyert iNEXT H2020 pályázatnak. Továbbá jelentős ipari kapcsolattal is rendelkezünk, pl Sanofi, Medi-Radiopharma. (Hungarian)
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The developed infrastructure will be used primarily for basic research on modern clinical, molecular approach therapies, both in academic and KK and large companies (Richter, Sanofi). In our integrated, interdisciplinary projects, we aim not only to better understand the life cycle of proteins, but also to better design molecules as structural materials (winding testing, rational resetting and protein engineering). We can expect a scientific breakthrough in the field of domestic rational drug design (exenatide/diabetes mellitus, active ingredient in-house developed E19 equivalent active ingredient) and the engineering development of biocompatible nanomolecules. As in the structure study of the Ca2+ binder S100A4 protein involved in metastases and chronic inflammations (Gógl et al JBC 2016; Soldier et al FASEB J 2015; Duelli et al, PlosOne 2014), also achieved success in understanding the molecular level of hereditary kidney disease (Tory et al Nature Gen.2014). By revealing structural and dynamic information at the atomic level, we can design peptides that inhibit S100A4 protein-protein interactions, small molecule inhibitors, and perform functional testing. We can build the basis of interdisciplinary translational research in an academic environment that can be relevant in cancer research for the development of anti-metastasis and/or anti-inflammatory drugs, or in the effective treatment of diabetes, which can represent outstanding scientific achievements internationally. The operational background required for the operation is already available, the implementation site is suitable. The three are: The smooth operation of 250, 500 and 700 MHz NMR devices and the related tasks have been successfully performed by professionally committed NMR spectroscopic researchers and doctoral students with international relations, national academic and industrial network for years. The economic background to ensure the smooth operation of the instruments — approx. 3.5 Mt per year — is provided by central targeted support, tender sources and industrial contracts (contracts with small and medium-sized enterprises). We have made considerable efforts to reduce our costs and increase environmentally friendly operation by installing our He recovery system. Presentation of the implementation site: Eötvös Loránd University (ELTE) has participated or coordinated in 48 projects under Article 7 It was funded from the Research Framework Programme and two projects funded by the Competitiveness and Innovation Framework Programme. ELTE is the host institution of two winning ERC projects from H2020. Both young researchers are implementing their project at the Faculty of Science.2 MSCA is an innovative researcher training network (MSCA ITN) member of the University. It also hosts an MSCA individual scholarship project and participates in an MSCA research exchange programme. SECTION 7 In the framework of FP7 and H2020, a total of 7 ERC projects have been implemented or are being carried out at our university, as well as a nationally supported application related to an ERC funded by the NRDI Fund. The University is the host institution of 14 MTA Enduum projects. 13 ERASMUS (Erasmus Mundus, LLP, Jean Monet) is participating in the University, with an ERASMUS MUNDUS coordinated by the University. 6 out of the 7 H2020 projects carried out at the University will be implemented in the Faculty of Natural Sciences. Both winning H2020 ERC projects are hosted by the Faculty of Natural Sciences. In addition to international projects, several projects funded by OTKA, MTA Research Group, MTA Lendület and Richter Foundation are being implemented. Those implementing this project participate in European networks (EAST-NMR FP7) and intercontinental cooperation (Hungarian-US, Hungarian — Yaán, Hungarian — Argentinian). We are part of a winning iNEXT H2020 application. We also have a significant industrial relationship, e.g. Sanofi, Medi-Radiopharma. (English)
9 February 2022
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Budapest, Budapest
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Identifiers
VEKOP-2.3.3-15-2016-00009
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