Improving the severity and mortality of life-threatening Acute Diseases in a translational medicine approach — STAY ALIVE (Q3923159): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: add summary) |
(Changed an Item: Adding English translations) |
||||||||||||||
| Property / summary | |||||||||||||||
Our project delivers unique and niche goals in Hungary and Central-East Europe. Among the serious acute life-threatening conditions, many of the illnesses, despite a sufficiently rapid medical intervention, have an unacceptable high mortality rate of 30-50 %. Effective research in these diseases can only be achieved by bringing together basic researchers and clinicians, i.e. through translational medicine. In this consortium, we have set a target in three main areas: Serious necrotising pancreatic inflammation, II) research in cerebral vascular disasters, and III) coordination of research on heart failure by establishing a centre(s), network(s) at international level. Given that acute cell death is common to these diseases, it is more than likely that the translating pathways identified in each area may also improve the distressing severity and mortality indicators in the diseases outlined in the project. In January 2016, the Translation Medicina Centre (TMK) http://www.tm-pte.org/ was established at the University of Pécs for the first time in Central and Eastern Europe, the main objective of which, together with the Hungarian and international centres of excellence, is to achieve serious international results in the above diseases. As a result of the application, not only will we be able to improve the severity and mortality of diseases, but our cost-effectiveness will be improved, new therapies will be introduced into everyday practice. In particular, in the field of basic research, intervention and clinical trials, IV) CORE facilities are also created, thus creating a unique R & D Strategic Workshop, which can lead to the development of high-quality research results that are internationally listed in the long term. The planned research is based on the joint, coordinated work of experts in different fields. One of the major challenges of medicine is the separation of theoretical (e.g. physiology, molecular biology) and clinical sciences (e.g. internal medicine, surgery). In many cases, the two areas no longer understand each other. Despite billions of dollars being spent on theoretical and pharmaceutical research worldwide, the number of products/medicines that can be used in patient care has not increased. Translational medicine was institutionalised for the first time in the last decade at the NIH (the world’s largest research centre with Nobel Prize-winning researchers) and Harvard University. The task of the field of science is to coordinate the different fields of research (informatics, theoretical and clinical research, biostatistics, etc.) to support research in the various medical fields in an operational manner. Linking the excellence of the theoretical and clinical knowledge base in the three areas with serious mortality will significantly stimulate the strengthening of the critical mass of high-quality R & D capacities. Sub-topic I: Based on our basic research results of severe necrotising pancreatic inflammation I.A., the MTE-MTA Multidisciplinary Gastroenterology Research Group confirmed that the intake of ATP into cells significantly reduced cell damage, which raises the possibility of energy replacement. Fundamental research specific topics: I.A1 Cellular examination of mitochondrial damage induced by the most common pancreatitis inducers (alcohol, fatty acid, bile acid) (SZTE-Rakonczay-Maléth working group (mcs)). I.A2 Developing new innovative energy-input pharmaceutical processes (PTE-Local and SZTE-Rakonczay-Maléth mcs). I.A3 In vivo testing of analgesic/anti-inflammatory compounds with various mechanisms of action in AP models (PTE-Local and SZTE-Rakonczay mcs). I.A4 Cell Death Routes were investigated in AP. (De-Flower, SZTE-Maléth mcs). I.B) The intake of energy from KLINIKAI at the PTE Translation Medicine Center in the first three months of 2016 on the early nasogastric probe significantly reduced the number of serious cases and premature deaths. However, late death was not affected. The latter can only be achieved through the development of intervention endoscopic interventions (endoscopic necroctomy). Clinical trials are conducted by the Clinical Gastroenterology Units of the PTE-SZTE-DTE. I.B1 We are currently conducting four registered clinical trials (EASY, APPLE, Pineapple, PREPAST) which are still ongoing. Organisation of I.B2 NM-RCT to compare the translational Intervention minimally invasive endoscopic procedure against current radiological and surgical intervention treatment (PTE-Vincze mcs — patients with PTE-SZTE-DTE necrotising AP will be treated in the PTE Intervention Transmission Endoscopy Center (itek) to be developed during the application) I.B3 The implementation of clinical trials of other results (pain relief, etc.) of the basic research. II. Sub-topic 1.2: Stroke The stroke is the 3 rd driver’s death (English) | |||||||||||||||
| Property / summary: Our project delivers unique and niche goals in Hungary and Central-East Europe. Among the serious acute life-threatening conditions, many of the illnesses, despite a sufficiently rapid medical intervention, have an unacceptable high mortality rate of 30-50 %. Effective research in these diseases can only be achieved by bringing together basic researchers and clinicians, i.e. through translational medicine. In this consortium, we have set a target in three main areas: Serious necrotising pancreatic inflammation, II) research in cerebral vascular disasters, and III) coordination of research on heart failure by establishing a centre(s), network(s) at international level. Given that acute cell death is common to these diseases, it is more than likely that the translating pathways identified in each area may also improve the distressing severity and mortality indicators in the diseases outlined in the project. In January 2016, the Translation Medicina Centre (TMK) http://www.tm-pte.org/ was established at the University of Pécs for the first time in Central and Eastern Europe, the main objective of which, together with the Hungarian and international centres of excellence, is to achieve serious international results in the above diseases. As a result of the application, not only will we be able to improve the severity and mortality of diseases, but our cost-effectiveness will be improved, new therapies will be introduced into everyday practice. In particular, in the field of basic research, intervention and clinical trials, IV) CORE facilities are also created, thus creating a unique R & D Strategic Workshop, which can lead to the development of high-quality research results that are internationally listed in the long term. The planned research is based on the joint, coordinated work of experts in different fields. One of the major challenges of medicine is the separation of theoretical (e.g. physiology, molecular biology) and clinical sciences (e.g. internal medicine, surgery). In many cases, the two areas no longer understand each other. Despite billions of dollars being spent on theoretical and pharmaceutical research worldwide, the number of products/medicines that can be used in patient care has not increased. Translational medicine was institutionalised for the first time in the last decade at the NIH (the world’s largest research centre with Nobel Prize-winning researchers) and Harvard University. The task of the field of science is to coordinate the different fields of research (informatics, theoretical and clinical research, biostatistics, etc.) to support research in the various medical fields in an operational manner. Linking the excellence of the theoretical and clinical knowledge base in the three areas with serious mortality will significantly stimulate the strengthening of the critical mass of high-quality R & D capacities. Sub-topic I: Based on our basic research results of severe necrotising pancreatic inflammation I.A., the MTE-MTA Multidisciplinary Gastroenterology Research Group confirmed that the intake of ATP into cells significantly reduced cell damage, which raises the possibility of energy replacement. Fundamental research specific topics: I.A1 Cellular examination of mitochondrial damage induced by the most common pancreatitis inducers (alcohol, fatty acid, bile acid) (SZTE-Rakonczay-Maléth working group (mcs)). I.A2 Developing new innovative energy-input pharmaceutical processes (PTE-Local and SZTE-Rakonczay-Maléth mcs). I.A3 In vivo testing of analgesic/anti-inflammatory compounds with various mechanisms of action in AP models (PTE-Local and SZTE-Rakonczay mcs). I.A4 Cell Death Routes were investigated in AP. (De-Flower, SZTE-Maléth mcs). I.B) The intake of energy from KLINIKAI at the PTE Translation Medicine Center in the first three months of 2016 on the early nasogastric probe significantly reduced the number of serious cases and premature deaths. However, late death was not affected. The latter can only be achieved through the development of intervention endoscopic interventions (endoscopic necroctomy). Clinical trials are conducted by the Clinical Gastroenterology Units of the PTE-SZTE-DTE. I.B1 We are currently conducting four registered clinical trials (EASY, APPLE, Pineapple, PREPAST) which are still ongoing. Organisation of I.B2 NM-RCT to compare the translational Intervention minimally invasive endoscopic procedure against current radiological and surgical intervention treatment (PTE-Vincze mcs — patients with PTE-SZTE-DTE necrotising AP will be treated in the PTE Intervention Transmission Endoscopy Center (itek) to be developed during the application) I.B3 The implementation of clinical trials of other results (pain relief, etc.) of the basic research. II. Sub-topic 1.2: Stroke The stroke is the 3 rd driver’s death (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: Our project delivers unique and niche goals in Hungary and Central-East Europe. Among the serious acute life-threatening conditions, many of the illnesses, despite a sufficiently rapid medical intervention, have an unacceptable high mortality rate of 30-50 %. Effective research in these diseases can only be achieved by bringing together basic researchers and clinicians, i.e. through translational medicine. In this consortium, we have set a target in three main areas: Serious necrotising pancreatic inflammation, II) research in cerebral vascular disasters, and III) coordination of research on heart failure by establishing a centre(s), network(s) at international level. Given that acute cell death is common to these diseases, it is more than likely that the translating pathways identified in each area may also improve the distressing severity and mortality indicators in the diseases outlined in the project. In January 2016, the Translation Medicina Centre (TMK) http://www.tm-pte.org/ was established at the University of Pécs for the first time in Central and Eastern Europe, the main objective of which, together with the Hungarian and international centres of excellence, is to achieve serious international results in the above diseases. As a result of the application, not only will we be able to improve the severity and mortality of diseases, but our cost-effectiveness will be improved, new therapies will be introduced into everyday practice. In particular, in the field of basic research, intervention and clinical trials, IV) CORE facilities are also created, thus creating a unique R & D Strategic Workshop, which can lead to the development of high-quality research results that are internationally listed in the long term. The planned research is based on the joint, coordinated work of experts in different fields. One of the major challenges of medicine is the separation of theoretical (e.g. physiology, molecular biology) and clinical sciences (e.g. internal medicine, surgery). In many cases, the two areas no longer understand each other. Despite billions of dollars being spent on theoretical and pharmaceutical research worldwide, the number of products/medicines that can be used in patient care has not increased. Translational medicine was institutionalised for the first time in the last decade at the NIH (the world’s largest research centre with Nobel Prize-winning researchers) and Harvard University. The task of the field of science is to coordinate the different fields of research (informatics, theoretical and clinical research, biostatistics, etc.) to support research in the various medical fields in an operational manner. Linking the excellence of the theoretical and clinical knowledge base in the three areas with serious mortality will significantly stimulate the strengthening of the critical mass of high-quality R & D capacities. Sub-topic I: Based on our basic research results of severe necrotising pancreatic inflammation I.A., the MTE-MTA Multidisciplinary Gastroenterology Research Group confirmed that the intake of ATP into cells significantly reduced cell damage, which raises the possibility of energy replacement. Fundamental research specific topics: I.A1 Cellular examination of mitochondrial damage induced by the most common pancreatitis inducers (alcohol, fatty acid, bile acid) (SZTE-Rakonczay-Maléth working group (mcs)). I.A2 Developing new innovative energy-input pharmaceutical processes (PTE-Local and SZTE-Rakonczay-Maléth mcs). I.A3 In vivo testing of analgesic/anti-inflammatory compounds with various mechanisms of action in AP models (PTE-Local and SZTE-Rakonczay mcs). I.A4 Cell Death Routes were investigated in AP. (De-Flower, SZTE-Maléth mcs). I.B) The intake of energy from KLINIKAI at the PTE Translation Medicine Center in the first three months of 2016 on the early nasogastric probe significantly reduced the number of serious cases and premature deaths. However, late death was not affected. The latter can only be achieved through the development of intervention endoscopic interventions (endoscopic necroctomy). Clinical trials are conducted by the Clinical Gastroenterology Units of the PTE-SZTE-DTE. I.B1 We are currently conducting four registered clinical trials (EASY, APPLE, Pineapple, PREPAST) which are still ongoing. Organisation of I.B2 NM-RCT to compare the translational Intervention minimally invasive endoscopic procedure against current radiological and surgical intervention treatment (PTE-Vincze mcs — patients with PTE-SZTE-DTE necrotising AP will be treated in the PTE Intervention Transmission Endoscopy Center (itek) to be developed during the application) I.B3 The implementation of clinical trials of other results (pain relief, etc.) of the basic research. II. Sub-topic 1.2: Stroke The stroke is the 3 rd driver’s death (English) / qualifier | |||||||||||||||
point in time: 8 February 2022
| |||||||||||||||
Revision as of 17:46, 8 February 2022
Project Q3923159 in Hungary
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Improving the severity and mortality of life-threatening Acute Diseases in a translational medicine approach — STAY ALIVE |
Project Q3923159 in Hungary |
Statements
1,494,053,285 forint
0 references
4,084,182.308 Euro
0.0027336256 Euro
15 December 2021
0 references
1,494,053,285.0 forint
0 references
100.0 percent
0 references
1 February 2017
0 references
1 May 2021
0 references
PÉCSI TUDOMÁNYEGYETEM
0 references
46°4'35.72"N, 18°13'40.94"E
0 references
Projektünk hazánkban és Közép-Kelet Európában is egyedülálló és hiánypótló célokat valósít meg. A súlyos, akut, életet veszélyeztető állapotok közül, több megbetegedésben is a megfelelően gyors orvosi beavatkozás ellenére is elfogadhatatlanul magas, 30-50%-os a halálozás. Ezen betegségekben történő eredményes kutatás csak az alapkutatók és klinikusok összefogásával, azaz a transzlációs medicina mentén valósíthatóak meg. Jelen konzorciumban célul tűztük ki három fő területen: I) a súlyos nekrotizáló hasnyálmirigy gyulladás, II) agyi érkatasztrófákban történő kutatások és III) a szívelégtelenség kutatásainak összehangolását, nemzetközi szintű centrum(ok), hálózat(ok) kialakításával. Tekintettel arra, hogy a fenti betegségekben közös pont, hogy akut sejthalál alakul ki, több mint valószínű, hogy az egyes területeken azonosított transzlációs útvonalak a projektben felvázolt betegségekben is javíthatnak az elkeserítő súlyossági és halálozási mutatókon. 2016. januárjában Közép és Kelet Európában elsőként a Pécsi Tudományegyetemen megalakult a Transzlációs Medicina Központ (TMK) http://www.tm-pte.org/, melynek fő célkitűzése hogy a magyarországi és nemzetközi kiválósági centrumokkal összefogva komoly nemzetközi visszhangot is kiváltó eredményeket érjen el a fenti betegségekben. A pályázat eredményeként nem csak a betegségek súlyossági és halálozási mutatóinak javítását tudjuk majd elérni, de költséghatékonyságunk jobb lesz, új terápiák kerülnek be a mindennapi gyakorlatba. Külön kiemelendő, hogy mind az alapkutatás, intervenciós beavatkozások és klinikai vizsgálatok területen hosszan fenntartható IV) CORE facilitások is létrejönnek, ezáltal olyan nemzetközi viszonylatban is egyedülálló K+F Stratégiai Műhely alakul ki, mely hosszútávon nemzetközileg jegyzett, magas színvonalú kutatási eredmények megszületéséhez vezethet. A tervezett kutatások a különböző szakterületek szakértőinek közös, összehangolt munkájára épülnek. Az orvostudomány egyik legnagyobb kihívása az elméleti (pl. élettan, molekuláris biológia) és klinikai tudományok (pl. belgyógyászat, sebészet) szétválása. Sok esetben a két terület már nem érti egymást. Annak ellenére, hogy több milliárd dollárral többet költenek elméleti és gyógyszerkutatásra világszerte, a betegellátásban hasznosítható termékek/gyógyszerek száma nem emelkedett. A transzlációs orvostudományt az elmúlt évtizedben az NIH-ben (a világ legnagyobb, Nobel-díjas kutatókkal felálló kutatóközpontja) és a Harvard Egyetemen Intézményesítették először. A tudományterület feladata, hogy a különböző kutatási területeket összehangolva (informatika, elméleti és klinikai kutatás, biostatisztika, stb) az egyes orvostudományi szakterületek kutatását operatív módon segítse. A három komoly halálozással bíró területen az elméleti és klinikai tudásbázis kiválóságainak összekapcsolása jelentősen fogja stimulálni a magas színvonalú K+F kapacitások kritikus tömegének a megerősödését. I. Altéma: Súlyos nekrotizáló hasnyálmirigy gyulladás I.A) ALAPKUTATÁSI eredményeink alapján az SZTE-MTA Multidiszciplináris Gasztroenterológiai Kutatócsoport igazolta, hogy a sejtekbe történő ATP bevitel jelentősen csökkentette a sejtkárosodást, mely felveti az energiapótlás szükségességnek lehetőségét. Alapkutatási specifikus témák: I.A1 A leggyakoribb pancreatitist indukáló anyagok (alkohol, zsírsav, epesav) által kiváltott mitochondriális károsodás sejtszintű vizsgálata (SZTE-Rakonczay-Maléth munkacsoport (mcs)). I.A2 Új, innovatív energiabeviteli gyógyszertechnológiai eljárások kidolgozása (PTE-Helyes és SZTE-Rakonczay-Maléth mcs). I.A3 Különböző hatásmechanizmusú fájdalomcsillapító/gyulladásgátló vegyületek in vivo vizsgálata AP modellekben (PTE-Helyes és SZTE-Rakonczay mcs). I.A4 Sejthalál útvonalak vizsgálta AP-ben. (DE-Virág, SZTE-Maléth mcs). I.B) A KLINIKAI A PTE Transzlációs Medicina Központban, a 2016. év első három hónapjában alkalmazott korai nasogasztrikus szondán történő energia bevitel jelentős mértékben csökkentette a súlyos esetek és korai halálozások számát. A késői halálozásra azonban ez nem volt hatással. Ez utóbbi csak az intervenciós endoszkópos beavatkozások fejlesztésével (endoszkópos nekrektómia) valósítható meg. A klinikai vizsgálatokat a PTE-SZTE-DTE Klinikai Gasztroenterológiai Egységei bonyolítják le. I.B1 Jelenleg négy regisztrált klinikai vizsgálatot vezetünk (EASY, APPLE, PINEAPPLE, PREPAST), melyek lebonyolítása, a betegbevonás jelenleg is folyamatosan zajlik. I.B2 NM-RCT szervezése a transzlációs Intervenciós minimálisan invazív endoszkópos eljárás összehasonlítására a jelenlegi radiológiai és sebészi intervenciós kezeléssel szemben (PTE-Vincze mcs – a PTE-SZTE-DTE nekrotizáló AP-ben szenvedő betegei a pályázat során kialakításra kerülő PTE Intervenciós Transzlációs Endoszkópos Központban (ITEK) kerülnek ellátásra) I.B3 Az alapkutatás során felmerült egyéb eredmények (fájdalomcsillapítás, stb) klinikai vizsgálatainak megvalósítása. II. Altéma: Stroke A stroke a 3. vezető halá (Hungarian)
0 references
Our project delivers unique and niche goals in Hungary and Central-East Europe. Among the serious acute life-threatening conditions, many of the illnesses, despite a sufficiently rapid medical intervention, have an unacceptable high mortality rate of 30-50 %. Effective research in these diseases can only be achieved by bringing together basic researchers and clinicians, i.e. through translational medicine. In this consortium, we have set a target in three main areas: Serious necrotising pancreatic inflammation, II) research in cerebral vascular disasters, and III) coordination of research on heart failure by establishing a centre(s), network(s) at international level. Given that acute cell death is common to these diseases, it is more than likely that the translating pathways identified in each area may also improve the distressing severity and mortality indicators in the diseases outlined in the project. In January 2016, the Translation Medicina Centre (TMK) http://www.tm-pte.org/ was established at the University of Pécs for the first time in Central and Eastern Europe, the main objective of which, together with the Hungarian and international centres of excellence, is to achieve serious international results in the above diseases. As a result of the application, not only will we be able to improve the severity and mortality of diseases, but our cost-effectiveness will be improved, new therapies will be introduced into everyday practice. In particular, in the field of basic research, intervention and clinical trials, IV) CORE facilities are also created, thus creating a unique R & D Strategic Workshop, which can lead to the development of high-quality research results that are internationally listed in the long term. The planned research is based on the joint, coordinated work of experts in different fields. One of the major challenges of medicine is the separation of theoretical (e.g. physiology, molecular biology) and clinical sciences (e.g. internal medicine, surgery). In many cases, the two areas no longer understand each other. Despite billions of dollars being spent on theoretical and pharmaceutical research worldwide, the number of products/medicines that can be used in patient care has not increased. Translational medicine was institutionalised for the first time in the last decade at the NIH (the world’s largest research centre with Nobel Prize-winning researchers) and Harvard University. The task of the field of science is to coordinate the different fields of research (informatics, theoretical and clinical research, biostatistics, etc.) to support research in the various medical fields in an operational manner. Linking the excellence of the theoretical and clinical knowledge base in the three areas with serious mortality will significantly stimulate the strengthening of the critical mass of high-quality R & D capacities. Sub-topic I: Based on our basic research results of severe necrotising pancreatic inflammation I.A., the MTE-MTA Multidisciplinary Gastroenterology Research Group confirmed that the intake of ATP into cells significantly reduced cell damage, which raises the possibility of energy replacement. Fundamental research specific topics: I.A1 Cellular examination of mitochondrial damage induced by the most common pancreatitis inducers (alcohol, fatty acid, bile acid) (SZTE-Rakonczay-Maléth working group (mcs)). I.A2 Developing new innovative energy-input pharmaceutical processes (PTE-Local and SZTE-Rakonczay-Maléth mcs). I.A3 In vivo testing of analgesic/anti-inflammatory compounds with various mechanisms of action in AP models (PTE-Local and SZTE-Rakonczay mcs). I.A4 Cell Death Routes were investigated in AP. (De-Flower, SZTE-Maléth mcs). I.B) The intake of energy from KLINIKAI at the PTE Translation Medicine Center in the first three months of 2016 on the early nasogastric probe significantly reduced the number of serious cases and premature deaths. However, late death was not affected. The latter can only be achieved through the development of intervention endoscopic interventions (endoscopic necroctomy). Clinical trials are conducted by the Clinical Gastroenterology Units of the PTE-SZTE-DTE. I.B1 We are currently conducting four registered clinical trials (EASY, APPLE, Pineapple, PREPAST) which are still ongoing. Organisation of I.B2 NM-RCT to compare the translational Intervention minimally invasive endoscopic procedure against current radiological and surgical intervention treatment (PTE-Vincze mcs — patients with PTE-SZTE-DTE necrotising AP will be treated in the PTE Intervention Transmission Endoscopy Center (itek) to be developed during the application) I.B3 The implementation of clinical trials of other results (pain relief, etc.) of the basic research. II. Sub-topic 1.2: Stroke The stroke is the 3 rd driver’s death (English)
8 February 2022
0 references
Pécs, Baranya
0 references
Identifiers
GINOP-2.3.2-15-2016-00048
0 references