EXPLOSIVE(R+T)BIOTECHNOLOGIC FRAME OF PULMONARY SURFACTANT SHUTTLE, GUARDIAN OF THE BODY/ENVIRONMENT INTERFACE (Q3134953): Difference between revisions
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CADRE BIOTECHNOLOGIQUE EXPLOSIVE(R+T) DE LA NAVETTE TENSIOACTIF PULMONAIRE, GARDIEN DE L’INTERFACE CORPS/ENVIRONNEMENT | |||
Revision as of 09:02, 2 December 2021
Project Q3134953 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | EXPLOSIVE(R+T)BIOTECHNOLOGIC FRAME OF PULMONARY SURFACTANT SHUTTLE, GUARDIAN OF THE BODY/ENVIRONMENT INTERFACE |
Project Q3134953 in Spain |
Statements
193,600.0 Euro
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387,200.0 Euro
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50.0 percent
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1 January 2016
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30 June 2019
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UNIVERSIDAD COMPLUTENSE DE MADRID
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40°25'0.12"N, 3°42'12.89"W
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28079
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EL SURFACTANTE PULMONAR ES UN COMPLEJO LIPOPROTEICO ESENCIAL PARA LA ESTABILIZACION FISICA DE LA SUPERFICIE RESPIRATORIA EN EL PULMON DE LOS MAMIFEROS, Y SU FALTA O DEFICIENCIA ESTA ASOCIADA A SEVERAS PATOLOGIAS RESPIRATORIAS. AUNQUE SU FUNCION PRINCIPAL ES REDUCIR DRASTICAMENTE LA TENSION SUPERFICIAL EN LA INTERFASE AIRE-LIQUIDO ALVEOLAR, LA VISION ACTUAL ES QUE EL SURFACTANTE ESTABLECE UNA COMPLEJA RED DE MEMBRANAS QUE SIMULTANEAMENTE MODULA MECANISMOS DE DEFENSA INNATA FRENTE A PATOGENOS Y PROCESOS DE TRANSPORTE Y DIFUSION DE SOLUTOS Y GASES. LA RED SURFACTANTE ACTUARIA ASI COMO UN AGENTE PROTECTOR PERO TAMBIEN COMO UNA ¿LANZADERA¿ SOBRE LA QUE CONVERGE LA MOVILIZACION DE MULTITUD DE ENTIDADES MOLECULARES Y SUPRAMOLECULARES._x000D_ LA PRESENTE PROPUESTA PARTE DE ESTA VISION INTEGRADA DE LA ESTRUCTURA DE LA RED DEL SURFACTANTE PARA SEGUIR PROFUNDIZANDO EN EL ESTUDIO DE ASPECTOS ESENCIALES PARA LA COMPRENSION DE SUS MECANISMOS MOLECULARES Y PARA EL DESARROLLO DE APLICACIONES BIOTECNOLOGICAS QUE PERMITAN MONITORIZAR, RESTAURAR E INTERVENIR LA RED SURFACTANTE COMO BASE DE MEJORES DIAGNOSTICOS Y TRATAMIENTOS EN MEDICINA RESPIRATORIA._x000D_ OBJETIVOS FUNDAMENTALES DEL PROYECTO SERAN A) LA IDENTIFICACION DE DETERMINANTES ESTRUCTURA-FUNCION EN COMPLEJOS SUPRAMOLECULARES DE LAS PROTEINAS DEL SURFACTANTE, TANTO EN SU ENTORNO NATIVO SANO COMO EN CONDICIONES PATOLOGICAS, B) LA COMPRENSION DE LOS MECANISMOS MOLECULARES Y CELULARES DE ENSAMBLAJE, ALMACENAMIENTO Y SECRECION DEL SURFACTANTE, Y C) EL DESARROLLO DE MATERIALES Y METODOLOGIAS QUE AMPLIEN LAS OPORTUNIDADES DE TRATAMIENTO TERAPEUTICO: PREPARACIONES DE SURFACTANTE RESISTENTES A INACTIVACION Y NUEVAS ESTRATEGIAS DE VEHICULIZACION (DE FARMACOS, PROTEINAS, ACIDOS NUCLEICOS, NANOENSAMBLADOS) BASADAS EN SU INTEGRACION EN LA RED SURFACTANTE. ASIMISMO, LA PROPUESTA INTEGRA LA COLABORACION CON VARIOS GRUPOS DE INVESTIGACION EN DIFERENTES MODELOS DE PATOLOGIAS RESPIRATORIAS PARA PERSEGUIR LA ELABORACION DE UN ESQUEMA INTEGRADO QUE INTERPRETE EL PAPEL DEL SURFACTANTE Y SU ALTERACION EN LA PATOGENESIS Y EN LA DETECCION Y TRATAMIENTO EFICACES DE PATOLOGIAS RESPIRATORIAS AGUDAS Y CRONICAS. (Spanish)
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THE PULMONARY SURFACTANT IS AN ESSENTIAL LIPOPROTEIC COMPLEX FOR PHYSICAL STABILISATION OF THE RESPIRATORY SURFACE IN THE LUNGS OF MAMMALS, AND ITS LACK OR DEFICIENCY IS ASSOCIATED WITH SEVERE RESPIRATORY PATHOLOGIES. ALTHOUGH ITS MAIN FUNCTION IS TO DRASTICALLY REDUCE THE SURFACE TENSION IN THE ALVEOLAR AIR-LIQUID INTERFACE, THE CURRENT VISION IS THAT THE SURFACTANT ESTABLISHES A COMPLEX NETWORK OF MEMBRANES THAT SIMULTANEOUSLY MODULATES INNATE DEFENSE MECHANISMS AGAINST POTATOES AND PROCESSES OF TRANSPORT AND DIFUSION OF SOLUTES AND GASES. The surfactant NETWORK ACTUARY AS A PROTECTOR AGENT WILL ALSO AS A WHITE WHAT WHEN THE CONVERING THE MOBILICATION OF MULTITITITY OF MOULCULAR AND SUPRAMOLOLULAR ENTITIES._x000D_ the present PROPOSED PART OF THIS INTEGRATED VISION OF THE Surfactant NETWORK STRUCTURE to follow by deepening the ESSENTIAL ASPECT STUDY FOR THE COMPRENSION OF YOUR MOLECULAR MECHANISMES AND FOR THE DEVELOPMENT OF Biotechnological Applications That Permit to Monitor, Restorate, and Intervene Surfactant Network As Basse of Improved Diagnostic and Treatments in Respirative MEDICINE._x000D_ fundamental OBJECTIVES OF THE PROJECT would be (a) Identification of STRUCTURE-FUNCTURE DETERMINATIONS in supramolecular combinations of surfactant’s PROTEINS, as in their natural environment as well as in pathological conditions, (B) COMPRENSION OF MOLECULAR AND CELULAY MECHANISMES, storage and secretion of the surfactant, and C) the development of materials and methods that expand the opportunities for therapeutic treatment: PREPARATIONS OF SURFACTANT RESISTANT TO INACTIVACION AND NEW STRATEGIES OF VEHICULISATION (FROM PHARMACOS, PROTEINS, NUCLEIC ACIDS, NANOENSAMBLADOS) BASED ON THEIR INTEGRATION INTO THE SURFACTANT NETWORK. ALSO, THE PROPOSAL INTEGRATES COLLABORATION WITH SEVERAL RESEARCH GROUPS IN DIFFERENT MODELS OF RESPIRATORY PATHOLOGIES TO PURSUE THE ELABORATION OF AN INTEGRATED SCHEME THAT INTERPRETS THE ROLE OF SURFACTANT AND ITS ALTERATION IN PATHOGENESIS AND IN THE DETECTION AND TREATMENT OF ACUTE AND CHRONIC RESPIRATORY PATHOLOGIES. (English)
12 October 2021
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Madrid
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Identifiers
BIO2015-67930-R
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