Q3680030 (Q3680030): Difference between revisions
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(Changed an Item: importing one item from France) |
(Created claim: summary (P836): With the development of structural cryo-microscopy in recent years, pharmaceutical companies are very interested in these approaches in order to better characterise the structural organisation of their complex interests. Electron cryo-microscopy has undergone a real revolution in recent years. This makes it possible to obtain the structure of biological complexes at a molecular level from images taken under the electron microscope. The CryoVir p...) |
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With the development of structural cryo-microscopy in recent years, pharmaceutical companies are very interested in these approaches in order to better characterise the structural organisation of their complex interests. Electron cryo-microscopy has undergone a real revolution in recent years. This makes it possible to obtain the structure of biological complexes at a molecular level from images taken under the electron microscope. The CryoVir project will help to understand at the molecular level how molecules of interest interact with their protein targets. This work will also make it possible to see the impact of these molecules on viral particles. The results of this work will allow in the longer term the rational and targeted development of new molecules allowing a better controlled interaction with their protein targets and thus with a better controlled antiviral and anti-inflammatory action. This will make it possible to design inhibitory molecules with a stronger affinity and specificity. The project involves: three academic partners: INSERM (project carrier), CNRS and the University of Montpellier, cotutelles of the CBS laboratory (Centre de Biochemie Structurale). Only INSERM and CNRS will report expenditures on the project and a private partner: ABIVAX company. The project will take place within the PCME Plateau de Cryo-microscopy Electronique. (English) | |||||||||||||||
| Property / summary: With the development of structural cryo-microscopy in recent years, pharmaceutical companies are very interested in these approaches in order to better characterise the structural organisation of their complex interests. Electron cryo-microscopy has undergone a real revolution in recent years. This makes it possible to obtain the structure of biological complexes at a molecular level from images taken under the electron microscope. The CryoVir project will help to understand at the molecular level how molecules of interest interact with their protein targets. This work will also make it possible to see the impact of these molecules on viral particles. The results of this work will allow in the longer term the rational and targeted development of new molecules allowing a better controlled interaction with their protein targets and thus with a better controlled antiviral and anti-inflammatory action. This will make it possible to design inhibitory molecules with a stronger affinity and specificity. The project involves: three academic partners: INSERM (project carrier), CNRS and the University of Montpellier, cotutelles of the CBS laboratory (Centre de Biochemie Structurale). Only INSERM and CNRS will report expenditures on the project and a private partner: ABIVAX company. The project will take place within the PCME Plateau de Cryo-microscopy Electronique. (English) / rank | |||||||||||||||
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| Property / summary: With the development of structural cryo-microscopy in recent years, pharmaceutical companies are very interested in these approaches in order to better characterise the structural organisation of their complex interests. Electron cryo-microscopy has undergone a real revolution in recent years. This makes it possible to obtain the structure of biological complexes at a molecular level from images taken under the electron microscope. The CryoVir project will help to understand at the molecular level how molecules of interest interact with their protein targets. This work will also make it possible to see the impact of these molecules on viral particles. The results of this work will allow in the longer term the rational and targeted development of new molecules allowing a better controlled interaction with their protein targets and thus with a better controlled antiviral and anti-inflammatory action. This will make it possible to design inhibitory molecules with a stronger affinity and specificity. The project involves: three academic partners: INSERM (project carrier), CNRS and the University of Montpellier, cotutelles of the CBS laboratory (Centre de Biochemie Structurale). Only INSERM and CNRS will report expenditures on the project and a private partner: ABIVAX company. The project will take place within the PCME Plateau de Cryo-microscopy Electronique. (English) / qualifier | |||||||||||||||
point in time: 18 November 2021
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Revision as of 16:52, 18 November 2021
Project Q3680030 in France
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3680030 in France |
Statements
778,294.28 Euro
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1,945,735.7 Euro
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40.0 percent
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1 February 2020
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31 December 2022
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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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Avec le développement de la cryo-microscopie structurale ces dernières années, les sociétés pharmaceutiques sont très fortement intéressées par ces approches afin de mieux caractériser l’organisation structurale de leurs complexes d’intérêts. La cryo-microscopie électronique a vécu une véritable révolution ces dernières années. Il devient ainsi possible d'obtenir la structure de complexes biologiques à un niveau moléculaire à partir des images prises au microscope électronique. Le projet CryoVir permettra de comprendre au niveau moléculaire comment se font les interactions de molécules d’intérêts avec leurs cibles protéiques. Ces travaux permettront également de voir l’impact de ces molécules sur les particules virales. Les résultats de ces travaux permettront à plus long terme le développement rationnel et ciblé de nouvelles molécules permettant une interaction mieux contrôlée avec leurs cibles protéiques et donc avec une action antivirale et anti-inflammatoire mieux maîtrisées. Il sera ainsi possible de concevoir des molécules inhibitrices ayant une affinité et une spécificité plus forte. Le projet associe : trois partenaires académiques : l’INSERM (porteur de projet), le CNRS et l’Université de Montpellier, cotutelles du laboratoire CBS (Centre de Biochimie Structurale). Seuls l’INSERM et le CNRS déclareront des dépenses sur le projet et un partenaire privé : l’entreprise ABIVAX. Le projet se déroulera au sein du plateau PCME (Plateau de Cryo-microscopie Electronique). (French)
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With the development of structural cryo-microscopy in recent years, pharmaceutical companies are very interested in these approaches in order to better characterise the structural organisation of their complex interests. Electron cryo-microscopy has undergone a real revolution in recent years. This makes it possible to obtain the structure of biological complexes at a molecular level from images taken under the electron microscope. The CryoVir project will help to understand at the molecular level how molecules of interest interact with their protein targets. This work will also make it possible to see the impact of these molecules on viral particles. The results of this work will allow in the longer term the rational and targeted development of new molecules allowing a better controlled interaction with their protein targets and thus with a better controlled antiviral and anti-inflammatory action. This will make it possible to design inhibitory molecules with a stronger affinity and specificity. The project involves: three academic partners: INSERM (project carrier), CNRS and the University of Montpellier, cotutelles of the CBS laboratory (Centre de Biochemie Structurale). Only INSERM and CNRS will report expenditures on the project and a private partner: ABIVAX company. The project will take place within the PCME Plateau de Cryo-microscopy Electronique. (English)
18 November 2021
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Identifiers
LR0022563
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