Q3210193 (Q3210193): Difference between revisions
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(Created claim: summary (P836): CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND V...) |
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CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND VEGETABLES AND CONSEQUENTLY FLAVONOIDS, INCLUDING ANTHOCYANINS, ARE BELOW THE AMOUNTS WITH SIGNIFICANT HEALTH EFFECTS. IN PARTICULAR, ANTHOCYANINS HAVE BEEN INVERSELY RELATED TO THE RISK OF CVD. A LIMITATION OF HUMAN TRIALS CARRIED OUT SO FAR ON FOODS RICH IN ANTHOCYANINS IS THAT THEY CANNOT PROVE THEIR EFFECTS SINCE FOODS CONTAIN OTHER POTENTIALLY BIOACTIVE COMPONENTS, AND THEREFORE CONTROL FOODS ARE DIFFICULT TO OBTAIN. IN THIS FRAMEWORK, THE MAIN OBJECTIVE OF THE COORDINATED PROJECT IS TO ADVANCE KNOWLEDGE OF THE POTENTIALLY BENEFICIAL EFFECTS ON HEALTH AND IN THE MECHANISMS OF ACTION OF THE ANTHOCYANINS IN THE IMPROVEMENT OF MCR FACTORS, FOCUSED ON THE REDUCTION OF THE LDLC AS THE MAIN VARIABLE. TO ACHIEVE THIS OBJECTIVE, A NEW RED PULP APPLE BIOFORTIFIED IN ANTHOCYANINS, OBTAINED BY TECHNIQUES OF TRADITIONAL REPRODUCTION, WILL BE USED AS A SOURCE OF ANTHOCYANINS. AS AN ADVANTAGE, ADEQUATE CONTROL (A VARIETY OF WHITE PULP APPLES WITH A SIMILAR CONTENT OF OTHER PHYTOCHEMICALS) WILL BE OFFERED, WITH ANTHOCYANIN SUPPLEMENTATION BEING THE ONLY DIFFERENCE. THIS APPROACH WILL ALLOW DIRECT LINKAGE OF APPLE ANTHOCYANINS WITH OBSERVED EFFECTS ALLOWING THE STUDY OF UNDERLYING MECHANISMS OF ACTION. The COMPARATION OF the biofortified MANZANA WITH an EXTRACT OF ANTOCIANINS OBTAINS OF THIS MANZANA VARIATE will allow to evaluate the impact of the Food MATRIZ on the OBSERVED EFFECTS OF ANTOCIANINS._x000D_ SPECIFIC OBJECIFIC OBJECTIVES OF Subproject 2 SON:_x000D_ -evaluate the chronic effects of the supplementation of the head in anthocyanins in the course of the red manzan or an extract of variated anthocyanins on LDLC REDUCTION IN HYPERCOLESTEROLEMIA SUJECTS._x000D_ -EVALUATE chronic AND AGUDY EFFECTS of ANTOCIANINS IN A COMPLETE OF RMC FACTORS DESCRITTED BY EFSA AND FDA RELATED TO THE ENDOTELIAL FUNCTION, ARTERIAL PRESSION, LIPIED PERFIL, INFL AND OXIDATION BIOMARKERS._x000D_ -EVALUATE Cronic EFFECTS OF ANTOCIANINS IN FACTORS RCM EMERGENTS AS THE FUNCTIONALITY OF HDL through the efflux of COLESTEROL AND PARAXONASA ACTIVITY (PON) and the NUMBER AND SIZE OF LDL and HDL PARTICULES._x000D_ -SESTING ANTOCIANIN ACTION MECANISMS IN THE RCM CONTROL. IN PARTICULAR, IT IS EXPECTED TO PROVIDE NEW EVIDENCE IN THE REGULATION OF SIGNAGE PATHWAYS THROUGH FUNCTIONAL PROTEOMIC STUDIES, THROUGH PROTEIN-PROTEIN INTERACTIONS AND POST-TRANSLATIONAL MODIFICATIONS, APPLIED IN SAMPLES OF HUMAN PLASMA AND DIANA TISSUES (AORTA AND HEART) IN WISTAR RATS WITH HYPERCHOLESTEROLEMIA. THE DATA OBTAINED WILL CONTRIBUTE SIGNIFICANTLY TO THE ESTABLISHMENT OF SOLID SCIENTIFIC BASES ON THE POTENTIAL EFFECTS OF ANTHOCYANINS AND THEIR MECHANISMS OF ACTION ON THE IMPROVEMENT OF MCR THROUGH A NEW RED RICH PULP APPLE IN ANTOCININAS. (English) | |||||||||||||||
| Property / summary: CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND VEGETABLES AND CONSEQUENTLY FLAVONOIDS, INCLUDING ANTHOCYANINS, ARE BELOW THE AMOUNTS WITH SIGNIFICANT HEALTH EFFECTS. IN PARTICULAR, ANTHOCYANINS HAVE BEEN INVERSELY RELATED TO THE RISK OF CVD. A LIMITATION OF HUMAN TRIALS CARRIED OUT SO FAR ON FOODS RICH IN ANTHOCYANINS IS THAT THEY CANNOT PROVE THEIR EFFECTS SINCE FOODS CONTAIN OTHER POTENTIALLY BIOACTIVE COMPONENTS, AND THEREFORE CONTROL FOODS ARE DIFFICULT TO OBTAIN. IN THIS FRAMEWORK, THE MAIN OBJECTIVE OF THE COORDINATED PROJECT IS TO ADVANCE KNOWLEDGE OF THE POTENTIALLY BENEFICIAL EFFECTS ON HEALTH AND IN THE MECHANISMS OF ACTION OF THE ANTHOCYANINS IN THE IMPROVEMENT OF MCR FACTORS, FOCUSED ON THE REDUCTION OF THE LDLC AS THE MAIN VARIABLE. TO ACHIEVE THIS OBJECTIVE, A NEW RED PULP APPLE BIOFORTIFIED IN ANTHOCYANINS, OBTAINED BY TECHNIQUES OF TRADITIONAL REPRODUCTION, WILL BE USED AS A SOURCE OF ANTHOCYANINS. AS AN ADVANTAGE, ADEQUATE CONTROL (A VARIETY OF WHITE PULP APPLES WITH A SIMILAR CONTENT OF OTHER PHYTOCHEMICALS) WILL BE OFFERED, WITH ANTHOCYANIN SUPPLEMENTATION BEING THE ONLY DIFFERENCE. THIS APPROACH WILL ALLOW DIRECT LINKAGE OF APPLE ANTHOCYANINS WITH OBSERVED EFFECTS ALLOWING THE STUDY OF UNDERLYING MECHANISMS OF ACTION. The COMPARATION OF the biofortified MANZANA WITH an EXTRACT OF ANTOCIANINS OBTAINS OF THIS MANZANA VARIATE will allow to evaluate the impact of the Food MATRIZ on the OBSERVED EFFECTS OF ANTOCIANINS._x000D_ SPECIFIC OBJECIFIC OBJECTIVES OF Subproject 2 SON:_x000D_ -evaluate the chronic effects of the supplementation of the head in anthocyanins in the course of the red manzan or an extract of variated anthocyanins on LDLC REDUCTION IN HYPERCOLESTEROLEMIA SUJECTS._x000D_ -EVALUATE chronic AND AGUDY EFFECTS of ANTOCIANINS IN A COMPLETE OF RMC FACTORS DESCRITTED BY EFSA AND FDA RELATED TO THE ENDOTELIAL FUNCTION, ARTERIAL PRESSION, LIPIED PERFIL, INFL AND OXIDATION BIOMARKERS._x000D_ -EVALUATE Cronic EFFECTS OF ANTOCIANINS IN FACTORS RCM EMERGENTS AS THE FUNCTIONALITY OF HDL through the efflux of COLESTEROL AND PARAXONASA ACTIVITY (PON) and the NUMBER AND SIZE OF LDL and HDL PARTICULES._x000D_ -SESTING ANTOCIANIN ACTION MECANISMS IN THE RCM CONTROL. IN PARTICULAR, IT IS EXPECTED TO PROVIDE NEW EVIDENCE IN THE REGULATION OF SIGNAGE PATHWAYS THROUGH FUNCTIONAL PROTEOMIC STUDIES, THROUGH PROTEIN-PROTEIN INTERACTIONS AND POST-TRANSLATIONAL MODIFICATIONS, APPLIED IN SAMPLES OF HUMAN PLASMA AND DIANA TISSUES (AORTA AND HEART) IN WISTAR RATS WITH HYPERCHOLESTEROLEMIA. THE DATA OBTAINED WILL CONTRIBUTE SIGNIFICANTLY TO THE ESTABLISHMENT OF SOLID SCIENTIFIC BASES ON THE POTENTIAL EFFECTS OF ANTHOCYANINS AND THEIR MECHANISMS OF ACTION ON THE IMPROVEMENT OF MCR THROUGH A NEW RED RICH PULP APPLE IN ANTOCININAS. (English) / rank | |||||||||||||||
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| Property / summary: CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND VEGETABLES AND CONSEQUENTLY FLAVONOIDS, INCLUDING ANTHOCYANINS, ARE BELOW THE AMOUNTS WITH SIGNIFICANT HEALTH EFFECTS. IN PARTICULAR, ANTHOCYANINS HAVE BEEN INVERSELY RELATED TO THE RISK OF CVD. A LIMITATION OF HUMAN TRIALS CARRIED OUT SO FAR ON FOODS RICH IN ANTHOCYANINS IS THAT THEY CANNOT PROVE THEIR EFFECTS SINCE FOODS CONTAIN OTHER POTENTIALLY BIOACTIVE COMPONENTS, AND THEREFORE CONTROL FOODS ARE DIFFICULT TO OBTAIN. IN THIS FRAMEWORK, THE MAIN OBJECTIVE OF THE COORDINATED PROJECT IS TO ADVANCE KNOWLEDGE OF THE POTENTIALLY BENEFICIAL EFFECTS ON HEALTH AND IN THE MECHANISMS OF ACTION OF THE ANTHOCYANINS IN THE IMPROVEMENT OF MCR FACTORS, FOCUSED ON THE REDUCTION OF THE LDLC AS THE MAIN VARIABLE. TO ACHIEVE THIS OBJECTIVE, A NEW RED PULP APPLE BIOFORTIFIED IN ANTHOCYANINS, OBTAINED BY TECHNIQUES OF TRADITIONAL REPRODUCTION, WILL BE USED AS A SOURCE OF ANTHOCYANINS. AS AN ADVANTAGE, ADEQUATE CONTROL (A VARIETY OF WHITE PULP APPLES WITH A SIMILAR CONTENT OF OTHER PHYTOCHEMICALS) WILL BE OFFERED, WITH ANTHOCYANIN SUPPLEMENTATION BEING THE ONLY DIFFERENCE. THIS APPROACH WILL ALLOW DIRECT LINKAGE OF APPLE ANTHOCYANINS WITH OBSERVED EFFECTS ALLOWING THE STUDY OF UNDERLYING MECHANISMS OF ACTION. The COMPARATION OF the biofortified MANZANA WITH an EXTRACT OF ANTOCIANINS OBTAINS OF THIS MANZANA VARIATE will allow to evaluate the impact of the Food MATRIZ on the OBSERVED EFFECTS OF ANTOCIANINS._x000D_ SPECIFIC OBJECIFIC OBJECTIVES OF Subproject 2 SON:_x000D_ -evaluate the chronic effects of the supplementation of the head in anthocyanins in the course of the red manzan or an extract of variated anthocyanins on LDLC REDUCTION IN HYPERCOLESTEROLEMIA SUJECTS._x000D_ -EVALUATE chronic AND AGUDY EFFECTS of ANTOCIANINS IN A COMPLETE OF RMC FACTORS DESCRITTED BY EFSA AND FDA RELATED TO THE ENDOTELIAL FUNCTION, ARTERIAL PRESSION, LIPIED PERFIL, INFL AND OXIDATION BIOMARKERS._x000D_ -EVALUATE Cronic EFFECTS OF ANTOCIANINS IN FACTORS RCM EMERGENTS AS THE FUNCTIONALITY OF HDL through the efflux of COLESTEROL AND PARAXONASA ACTIVITY (PON) and the NUMBER AND SIZE OF LDL and HDL PARTICULES._x000D_ -SESTING ANTOCIANIN ACTION MECANISMS IN THE RCM CONTROL. IN PARTICULAR, IT IS EXPECTED TO PROVIDE NEW EVIDENCE IN THE REGULATION OF SIGNAGE PATHWAYS THROUGH FUNCTIONAL PROTEOMIC STUDIES, THROUGH PROTEIN-PROTEIN INTERACTIONS AND POST-TRANSLATIONAL MODIFICATIONS, APPLIED IN SAMPLES OF HUMAN PLASMA AND DIANA TISSUES (AORTA AND HEART) IN WISTAR RATS WITH HYPERCHOLESTEROLEMIA. THE DATA OBTAINED WILL CONTRIBUTE SIGNIFICANTLY TO THE ESTABLISHMENT OF SOLID SCIENTIFIC BASES ON THE POTENTIAL EFFECTS OF ANTHOCYANINS AND THEIR MECHANISMS OF ACTION ON THE IMPROVEMENT OF MCR THROUGH A NEW RED RICH PULP APPLE IN ANTOCININAS. (English) / qualifier | |||||||||||||||
point in time: 14 October 2021
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Revision as of 08:28, 14 October 2021
Project Q3210193 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3210193 in Spain |
Statements
75,625.0 Euro
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151,250.0 Euro
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50.0 percent
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30 December 2016
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31 December 2020
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UNIVERSIDAD ROVIRA I VIRGILI
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41°9'20.02"N, 1°6'27.40"E
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43123
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LAS ENFERMEDADES CARDIOVASCULARES (ECV) SON DE LAS MAS PREVALENTES EN EL MUNDO. LA SUMA DE LOS FACTORES DE RIESGO QUE AUMENTAN EL RIESGO DE TENER EVENTOS CARDIOVASCULARES O DESARROLLAR OTRAS ANOMALIAS METABOLICAS SE DENOMINA RIESGO CARDIOMETABOLICO (RCM). EL CONSUMO DE ALIMENTOS DE ORIGEN VEGETAL TIENE UN EFECTO PREVENTIVO CONTRA LAS ECV Y LOS COMPUESTOS FENOLICOS SE CONSIDERAN UNO DE LOS PRINCIPALES MEDIADORES. SIN EMBARGO, EN EUROPA LA DIETA NO GARANTIZA UNA ADECUADA INGESTA DE FRUTAS Y VERDURAS Y, EN CONSECUENCIA, LOS FLAVONOIDES, INCLUYENDO LAS ANTOCIANINAS, ESTAN POR DEBAJO DE LAS CANTIDADES CON EFECTOS SIGNIFICATIVOS SOBRE LA SALUD. EN CONCRETO, LAS ANTOCIANINAS SE HAN RELACIONADO INVERSAMENTE CON EL RIESGO DE ECV. UNA LIMITACION DE LOS ENSAYOS EN HUMANOS REALIZADOS HASTA EL MOMENTO CON ALIMENTOS RICOS EN ANTOCIANINAS, ES QUE NO PUEDEN PROBAR SUS EFECTOS YA QUE LOS ALIMENTOS CONTIENEN OTROS COMPONENTES POTENCIALMENTE BIOACTIVOS, Y POR LO TANTO, LOS ALIMENTOS CONTROL SON DIFICILES DE OBTENER. EN ESTE MARCO, EL OBJETIVO PRINCIPAL DEL PROYECTO COORDINADO ES AVANZAR EN EL CONOCIMIENTO DE LOS EFECTOS POTENCIALMENTE BENEFICIOSOS PARA LA SALUD Y EN LOS MECANISMOS DE ACCION DE LAS ANTOCIANINAS EN LA MEJORA DE LOS FACTORES RCM, FOCALIZADO EN LA REDUCCION DEL LDLC COMO VARIABLE PRINCIPAL. PARA LOGRAR ESTE OBJETIVO, UNA NUEVA MANZANA DE PULPA ROJA BIOFORTIFICADA EN ANTOCIANINAS, OBTENIDA POR TECNICAS DE REPRODUCCION TRADICIONAL, SERA UTILIZADA COMO FUENTE DE ANTOCIANINAS. COMO VENTAJA SE OFRECERA UN CONTROL ADECUADO (UNA VARIEDAD DE MANZANA DE PULPA BLANCA CON UN CONTENIDO SIMILAR DE OTROS FITOQUIMICOS) SIENDO LA SUPLEMENTACION ANTOCIANINAS LA UNICA DIFERENCIA. ESTE ENFOQUE PERMITIRA ENLAZAR DIRECTAMENTE LAS ANTOCIANINAS DE LA MANZANA CON LOS EFECTOS OBSERVADOS PERMITIENDO EL ESTUDIO DE LOS MECANISMOS DE ACCION SUBYACENTES. LA COMPARACION DE LA MANZANA BIOFORTIFICADA CON UN EXTRACTO DE ANTOCIANINAS OBTENIDO DE ESTA VARIEDAD DE MANZANA PERMITIRA EVALUAR EL IMPACTO DE LA MATRIZ ALIMENTARIA SOBRE LOS EFECTOS OBSERVADOS DE LAS ANTOCIANINAS._x000D_ LOS OBJETIVOS ESPECIFICOS DEL SUBPROYECTO 2 SON:_x000D_ -EVALUAR LOS EFECTOS CRONICOS DE LA SUPLEMENTACION DE LA DIETA EN ANTOCIANINAS A TRAVES DE LA MANZANA DE PULPA ROJA O UN EXTRACTO DE ANTOCIANINAS DE DICHA VARIEDAD SOBRE LA REDUCCION DEL LDLC EN SUJETOS CON HIPERCOLESTEROLEMIA._x000D_ -EVALUAR LOS EFECTOS CRONICOS Y AGUDOS DE LAS ANTOCIANINAS EN UN CONJUNTO COMPLETO DE FACTORES DE RMC DESCRITOS POR EFSA Y FDA RELACIONADOS CON LA FUNCION ENDOTELIAL, LA PRESION ARTERIAL, EL PERFIL LIPIDICO, LOS BIOMARCADORES DE INFLAMACION Y DE OXIDACION._x000D_ -EVALUAR LOS EFECTOS CRONICOS DE ANTOCIANINAS EN LOS FACTORES EMERGENTES RCM COMO LA FUNCIONALIDAD DE HDL A TRAVES DEL EFLUJO DEL COLESTEROL Y LA ACTIVIDAD PARAXONASA (PON) Y EL NUMERO Y TAMAÑO DE PARTICULAS DE LDL Y HDL._x000D_ -ESTABLECER LOS MECANISMOS DE ACCION DE LAS ANTOCIANINAS EN EL CONTROL DE RCM. EN CONCRETO, SE ESPERA APORTAR NUEVA EVIDENCIA EN LA REGULACION DE LAS VIAS DE SEÑALIZACION A TRAVES DE ESTUDIOS DE PROTEOMICA FUNCIONAL, MEDIANTE LAS INTERACCIONES PROTEINA-PROTEINA Y MODIFICACIONES POST-TRADUCCIONALES, APLICADA EN MUESTRAS DE PLASMA HUMANO Y TEJIDOS DIANA (AORTA Y CORAZON) EN RATAS WISTAR CON HIPERCOLESTEROLEMIA. LOS DATOS OBTENIDOS CONTRIBUIRAN SIGNIFICATIVAMENTE A ESTABLECER BASES CIENTIFICAS SOLIDAS SOBRE LOS EFECTOS POTENCIALES DE LAS ANTOCIANINAS Y SUS MECANISMOS DE ACCION EN LA MEJORA DEL RCM A TRAVES DE UNA NUEVA MANZANA DE PULPA ROJA RICA EN ANTOCININAS. (Spanish)
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CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND VEGETABLES AND CONSEQUENTLY FLAVONOIDS, INCLUDING ANTHOCYANINS, ARE BELOW THE AMOUNTS WITH SIGNIFICANT HEALTH EFFECTS. IN PARTICULAR, ANTHOCYANINS HAVE BEEN INVERSELY RELATED TO THE RISK OF CVD. A LIMITATION OF HUMAN TRIALS CARRIED OUT SO FAR ON FOODS RICH IN ANTHOCYANINS IS THAT THEY CANNOT PROVE THEIR EFFECTS SINCE FOODS CONTAIN OTHER POTENTIALLY BIOACTIVE COMPONENTS, AND THEREFORE CONTROL FOODS ARE DIFFICULT TO OBTAIN. IN THIS FRAMEWORK, THE MAIN OBJECTIVE OF THE COORDINATED PROJECT IS TO ADVANCE KNOWLEDGE OF THE POTENTIALLY BENEFICIAL EFFECTS ON HEALTH AND IN THE MECHANISMS OF ACTION OF THE ANTHOCYANINS IN THE IMPROVEMENT OF MCR FACTORS, FOCUSED ON THE REDUCTION OF THE LDLC AS THE MAIN VARIABLE. TO ACHIEVE THIS OBJECTIVE, A NEW RED PULP APPLE BIOFORTIFIED IN ANTHOCYANINS, OBTAINED BY TECHNIQUES OF TRADITIONAL REPRODUCTION, WILL BE USED AS A SOURCE OF ANTHOCYANINS. AS AN ADVANTAGE, ADEQUATE CONTROL (A VARIETY OF WHITE PULP APPLES WITH A SIMILAR CONTENT OF OTHER PHYTOCHEMICALS) WILL BE OFFERED, WITH ANTHOCYANIN SUPPLEMENTATION BEING THE ONLY DIFFERENCE. THIS APPROACH WILL ALLOW DIRECT LINKAGE OF APPLE ANTHOCYANINS WITH OBSERVED EFFECTS ALLOWING THE STUDY OF UNDERLYING MECHANISMS OF ACTION. The COMPARATION OF the biofortified MANZANA WITH an EXTRACT OF ANTOCIANINS OBTAINS OF THIS MANZANA VARIATE will allow to evaluate the impact of the Food MATRIZ on the OBSERVED EFFECTS OF ANTOCIANINS._x000D_ SPECIFIC OBJECIFIC OBJECTIVES OF Subproject 2 SON:_x000D_ -evaluate the chronic effects of the supplementation of the head in anthocyanins in the course of the red manzan or an extract of variated anthocyanins on LDLC REDUCTION IN HYPERCOLESTEROLEMIA SUJECTS._x000D_ -EVALUATE chronic AND AGUDY EFFECTS of ANTOCIANINS IN A COMPLETE OF RMC FACTORS DESCRITTED BY EFSA AND FDA RELATED TO THE ENDOTELIAL FUNCTION, ARTERIAL PRESSION, LIPIED PERFIL, INFL AND OXIDATION BIOMARKERS._x000D_ -EVALUATE Cronic EFFECTS OF ANTOCIANINS IN FACTORS RCM EMERGENTS AS THE FUNCTIONALITY OF HDL through the efflux of COLESTEROL AND PARAXONASA ACTIVITY (PON) and the NUMBER AND SIZE OF LDL and HDL PARTICULES._x000D_ -SESTING ANTOCIANIN ACTION MECANISMS IN THE RCM CONTROL. IN PARTICULAR, IT IS EXPECTED TO PROVIDE NEW EVIDENCE IN THE REGULATION OF SIGNAGE PATHWAYS THROUGH FUNCTIONAL PROTEOMIC STUDIES, THROUGH PROTEIN-PROTEIN INTERACTIONS AND POST-TRANSLATIONAL MODIFICATIONS, APPLIED IN SAMPLES OF HUMAN PLASMA AND DIANA TISSUES (AORTA AND HEART) IN WISTAR RATS WITH HYPERCHOLESTEROLEMIA. THE DATA OBTAINED WILL CONTRIBUTE SIGNIFICANTLY TO THE ESTABLISHMENT OF SOLID SCIENTIFIC BASES ON THE POTENTIAL EFFECTS OF ANTHOCYANINS AND THEIR MECHANISMS OF ACTION ON THE IMPROVEMENT OF MCR THROUGH A NEW RED RICH PULP APPLE IN ANTOCININAS. (English)
14 October 2021
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Reus
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Identifiers
AGL2016-76943-C2-2-R
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