RED PULP APPLES BIOFORTIFIED WITH ANTHOCYANIANS: EFFECT OF PROCESSING ON PHENOLIC COMPOSITION AND EVALUATION OF BIOAVAILABILITY OF ANTHOCYANINS IN HUMANS. (Q3210672): Difference between revisions
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(Created claim: summary (P836): CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND V...) |
(Changed label, description and/or aliases in en: translated_label) |
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RED PULP APPLES BIOFORTIFIED WITH ANTHOCYANIANS: EFFECT OF PROCESSING ON PHENOLIC COMPOSITION AND EVALUATION OF BIOAVAILABILITY OF ANTHOCYANINS IN HUMANS. | |||
Revision as of 08:27, 14 October 2021
Project Q3210672 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | RED PULP APPLES BIOFORTIFIED WITH ANTHOCYANIANS: EFFECT OF PROCESSING ON PHENOLIC COMPOSITION AND EVALUATION OF BIOAVAILABILITY OF ANTHOCYANINS IN HUMANS. |
Project Q3210672 in Spain |
Statements
78,650.0 Euro
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157,300.0 Euro
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50.0 percent
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30 December 2016
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31 December 2020
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UNIVERSIDAD DE LERIDA
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41°36'53.14"N, 0°37'36.41"E
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25120
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LAS ENFERMEDADES CARDIOVASCULARES (ECV) SON DE LAS MAS PREVALENTES EN EL MUNDO. LA SUMA DE LOS FACTORES DE RIESGO QUE AUMENTAN EL RIESGO DE TENER EVENTOS CARDIOVASCULARES O DESARROLLAR OTRAS ANOMALIAS METABOLICAS SE DENOMINA RIESGO CARDIOMETABOLICO (RCM). EL CONSUMO DE ALIMENTOS DE ORIGEN VEGETAL TIENE UN EFECTO PREVENTIVO CONTRA LAS ECV Y LOS COMPUESTOS FENOLICOS SE CONSIDERAN UNO DE LOS PRINCIPALES MEDIADORES. SIN EMBARGO, EN EUROPA LA DIETA NO GARANTIZA UNA ADECUADA INGESTA DE FRUTAS Y VERDURAS Y, EN CONSECUENCIA, LOS FLAVONOIDES, INCLUYENDO LAS ANTOCIANINAS, ESTAN POR DEBAJO DE LAS CANTIDADES CON EFECTOS SIGNIFICATIVOS SOBRE LA SALUD. EN CONCRETO, LAS ANTOCIANINAS SE HAN RELACIONADO INVERSAMENTE CON EL RIESGO DE ECV. UNA LIMITACION DE LOS ENSAYOS EN HUMANOS REALIZADOS HASTA EL MOMENTO CON ALIMENTOS RICOS EN ANTOCIANINAS, ES QUE NO PUEDEN PROBAR SUS EFECTOS YA QUE LOS ALIMENTOS CONTIENEN OTROS COMPONENTES POTENCIALMENTE BIOACTIVOS, Y POR LO TANTO, LOS ALIMENTOS CONTROL SON DIFICILES DE OBTENER. EN ESTE MARCO, EL OBJETIVO PRINCIPAL DEL PROYECTO COORDINADO ES AVANZAR EN EL CONOCIMIENTO DE LOS EFECTOS POTENCIALMENTE BENEFICIOSOS PARA LA SALUD Y EN LOS MECANISMOS DE ACCION DE LAS ANTOCIANINAS EN LA MEJORA DE LOS FACTORES RCM, FOCALIZADO EN LA REDUCCION DEL LDLC COMO VARIABLE PRINCIPAL._x000D_ PARA LOGRAR ESTE OBJETIVO, UNA NUEVA VARIEDAD DE MANZANA DE PULPA ROJA BIOFORTIFICADA EN ANTOCIANINAS, OBTENIDA POR TECNICAS DE MEJORA VARIETAL, SERA UTILIZADA COMO FUENTE DE ANTOCIANINAS. COMO VENTAJA SE OFRECERA UN CONTROL ADECUADO (UNA VARIEDAD DE MANZANA DE PULPA BLANCA CON UN CONTENIDO SIMILAR DE OTROS FITOQUIMICOS) SIENDO LA SUPLEMENTACION ANTOCIANINAS LA UNICA DIFERENCIA. ESTE ENFOQUE PERMITIRA ENLAZAR DIRECTAMENTE LAS ANTOCIANINAS DE LA MANZANA CON LOS EFECTOS OBSERVADOS PERMITIENDO EL ESTUDIO DE LOS MECANISMOS DE ACCION SUBYACENTES. LA COMPARACION DE LA MANZANA BIOFORTIFICADA CON UN EXTRACTO DE ANTOCIANINAS OBTENIDO DE ESTA VARIEDAD DE MANZANA PERMITIRA EVALUAR EL IMPACTO DE LA MATRIZ ALIMENTARIA SOBRE LOS EFECTOS OBSERVADOS DE LAS ANTOCIANINAS._x000D_ LOS OBJETIVOS ESPECIFICOS DEL SUBPROYECTO 1 SON:_x000D_ - SELECCION DE LA VARIEDAD DE MANZANA DE PULPA ROJA CON UN MAYOR CONTENIDO DE ANTOCIANOS Y DE SU CORRESPONDINETE CONTROL (VARIEDAD DE MANZANA DE PULPA BLANCA CARENTE DE ANTOCIANINAS PERO CON UN CONTENIDO SIMILAR EN OTROS FITOQUIMICOS) QUE SE UTILIZARAN PARA LA CONSECUCION DE LOS SIGUIENTES OBJETIVOS._x000D_ - EVALUACION DE LOS EFECTOS DE DIFERENTES PROCESOS TECNOLOGICOS DE DESHIDRATATION (LIOFILIZACION Y SECADO) EN EL CONTENIDO DE FENOLES CON EL FIN DE DESARROLLAR UN PRODUCTO TIPO ¿SNACK¿._x000D_ - DESARROLLO Y VALIDACION DE UN METODO DE DETECCION Y CUANTIFICACION DE METABOLITOS DE ANTOCIANINAS Y OTROS FENOLES EN MUESTRAS DE SANGRE MEDIANTE EL USO DE DRY BLOOD SPOT (DBS) CARDS._x000D_ - DETERMINACION DE LA BIODISPONIBILIDAD DE ANTOCIANINAS MEDIANTE UN ESTUDIO DE INGESTA AGUDA EN HUMANOS ENFOCADO EN EVALUAR EL EFECTO MATRIZ DE LA MANZANA SOBRE SU BIODISPONIBILIDAD._x000D_ - DETERMINACION DE BIOMARCADORES DE CONSUMO DE ANTOCIANINAS Y SUS METABOLITOS BIOLOGICOS EN PLASMA Y ORINA DESPUES DE UNA SUPLEMENTACION SOSTENIDA EN HUMANOS. _x000D_ EL PROYECTO OFRECE UNA OPORTUNIDAD UNICA DE TRANSFERENCIA DE RESULTADOS DESDE INOVACION EN EL CULTIVO, BASADA EN ENRIQUECIMIENTO EN ANOCIANINAS, A LA APLICACION DIRECTA AL CONSUMIDOR EN RELACION CON UNO DE LOS MAYORES RETOS DE LA MEDICINA ACTUAL: EL DESAROLLO DE ESTRATEGIAS SIMPLES, NUTRITICIONALES Y ECONOMICAS PARA LA MEJORA DE LOS FACTORES DE RIESGO CA (Spanish)
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CARDIOVASCULAR DISEASES (CVD) ARE AMONG THE MOST PREVALENT IN THE WORLD. THE SUM OF RISK FACTORS THAT INCREASE THE RISK OF HAVING CARDIOVASCULAR EVENTS OR DEVELOPING OTHER METABOLIC ANOMALIES IS CALLED CARDIOMETABOLIC RISK (CMR). THE CONSUMPTION OF FOOD OF PLANT ORIGIN HAS A PREVENTIVE EFFECT AGAINST CVD AND PHENOLIC COMPOUNDS ARE CONSIDERED ONE OF THE MAIN MEDIATORS. HOWEVER, IN EUROPE THE DIET DOES NOT GUARANTEE ADEQUATE INTAKE OF FRUITS AND VEGETABLES AND CONSEQUENTLY FLAVONOIDS, INCLUDING ANTHOCYANINS, ARE BELOW THE AMOUNTS WITH SIGNIFICANT HEALTH EFFECTS. IN PARTICULAR, ANTHOCYANINS HAVE BEEN INVERSELY RELATED TO THE RISK OF CVD. A LIMITATION OF HUMAN TRIALS CARRIED OUT SO FAR ON FOODS RICH IN ANTHOCYANINS IS THAT THEY CANNOT PROVE THEIR EFFECTS SINCE FOODS CONTAIN OTHER POTENTIALLY BIOACTIVE COMPONENTS, AND THEREFORE CONTROL FOODS ARE DIFFICULT TO OBTAIN. In this framework, the primary object of the CoORDINAD project is to anticipate in the knowledge of the potentially beneficial effects for the health and in the mechanisms of action of the anthocyanins in the improvement of the RCM FACTORS, FOCALIZATED IN THE LDLC REDUCTION AS PRINCIPAL VARIABLE._x000D_ To Achieve THIS OBJECTIVE, A NEW VARIED OF MANZANA DE PULPA DE PULPA biofortified IN ANTOCIANINS, OBTENTED BY VARIETAL IMPROVEMENT TECNICATIONS, BE UTILIED AS ANTOCIANIN FUENTS. AS AN ADVANTAGE, ADEQUATE CONTROL (A VARIETY OF WHITE PULP APPLES WITH A SIMILAR CONTENT OF OTHER PHYTOCHEMICALS) WILL BE OFFERED, WITH ANTHOCYANIN SUPPLEMENTATION BEING THE ONLY DIFFERENCE. THIS APPROACH WILL ALLOW DIRECT LINKAGE OF APPLE ANTHOCYANINS WITH OBSERVED EFFECTS ALLOWING THE STUDY OF UNDERLYING MECHANISMS OF ACTION. The COMPARATION OF the biofortified MANZANA WITH an EXTRACT OF ANTOCIANINS OBTAINS OF THIS MANZANA VARIATE will allow to evaluate the impact of the Food MATRIZ on the OBSERVED EFFECTS OF ANTOCIANINS._x000D_ SPECIFIC OBJECIFIC OBJECTIVES OF Subproject 1 SON:_x000D_ — SELECTION OF THE ROAD PULPA MANZANA VARIED WITH A MORE CONTROL CONTROL AND THEIR CONTROL CONTROL (White PULPA MANZANA VARIED IN ANTOCIANIN BUT WITH A SIMILAR CONTENT IN OTHER Phytochemicals) to be used for the consecution of OBJECTIVE NEXTENTS._x000D_ — EVALUATION OF TECHNOLOGIC DESHIDRATATION PROCESSING EFFECTS IN THE CONTENT OF FENOLES WITH THE DEVELOPMENT OF A PRODUCT TYPE SNACK._x000D_ — DEVELOPMENT AND Validation OF A METHODS OF ANTOCIANIN METHODS and other phenols in the use of DRY BLOOD SPOT (DBS) CARDS._x000D_ — DETERMINATION OF THE BIODISPONIBILITY OF ANTOCIANINS FOR ANGESTA STUDY IN HUMANs focussed on assessing the matrix effect of the manzan on its biodisponability._x000D_ — determination of biomarkers for the consumption of anthocyanins and their biologistic metabolites in PLASMA and ORINA aroused by a supplementation sustained in HUMANs. _x000D_ the PROJECT offers a unique opportunity for obtaining results from innovation in the field, based in annoCIANINS, to the implementation of the contract in relation to one of the most current risks: DEVELOPMENT OF SIMPLE, NUTRITIOUS AND ECONOMICAL STRATEGIES FOR IMPROVING CA RISK FACTORS (English)
14 October 2021
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Lleida
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Identifiers
AGL2016-76943-C2-1-R
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