Q3209620 (Q3209620): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): THE GROWING REQUIREMENT FOR ANIMAL PROTEIN DUE TO THE INCREASE IN THE WORLD POPULATION, THE RECENT EUROPEAN REGULATIONS ON (DE)MEDICALISATION IN ANIMAL PRODUCTION, AND THE SOCIAL DEMAND FOR HEALTHY ANIMAL PRODUCTS AND SUSTAINABLE PRODUCTION SYSTEMS REPRESENT IMPORTANT CHALLENGES FOR THE PIG INDUSTRY. IN THIS CONTEXT, IMPROVING ANIMAL RESILIENCE AND ROBUSTNESS IN PARALLEL TO IMPROVING PRODUCTIVE YIELDS WOULD CONTRIBUTE TO INCREASING THE SUSTAINAB...) |
||||||||||||||
| Property / summary | |||||||||||||||
THE GROWING REQUIREMENT FOR ANIMAL PROTEIN DUE TO THE INCREASE IN THE WORLD POPULATION, THE RECENT EUROPEAN REGULATIONS ON (DE)MEDICALISATION IN ANIMAL PRODUCTION, AND THE SOCIAL DEMAND FOR HEALTHY ANIMAL PRODUCTS AND SUSTAINABLE PRODUCTION SYSTEMS REPRESENT IMPORTANT CHALLENGES FOR THE PIG INDUSTRY. IN THIS CONTEXT, IMPROVING ANIMAL RESILIENCE AND ROBUSTNESS IN PARALLEL TO IMPROVING PRODUCTIVE YIELDS WOULD CONTRIBUTE TO INCREASING THE SUSTAINABILITY OF PRODUCTION SYSTEMS AND ALSO REDUCING RESISTANCE TO ANTIBIOTICS, BOTH OF WHICH ARE H2020'S PRIORITY CHALLENGES. THE INNATE IMMUNE SYSTEM IS THE GUEST’S FIRST LINE OF DEFENSE AGAINST INFECTIOUS AGENTS, AND RECOGNISES A WIDE RANGE OF PATHOGENS THROUGH A RESTRICTED SET OF PATTERN RECOGNITION RECEPTORS. FOR THIS REASON THE CHARACTERS OF INNATE IMMUNITY ARE PROFILED AS INTERESTING SELECTION TARGETS TO IMPROVE DISEASE RESISTANCE. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO STUDY THE GENETIC DETERMINISM OF IMMUNOCOMPETENCE IN HEALTHY PIGS, AS WELL AS ITS RELATION TO PRODUCTIVE PERFORMANCE AND ANIMAL WELFARE. FOR THIS PURPOSE, A SET OF INNATE IMMUNITY CHARACTERS (IIT) WILL BE ANALYSED IN 450 HEALTHY ANIMALS BELONGING TO A DUROC COMMERCIAL LINE. THE ITIS TO BE ANALYSED INCLUDE IGA SECRETION, ACUTE PHASE PROTEINS, COMPLEMENT PROTEINS, PHAGOCYTOSIS AND NITRIC OXIDE FORMATION, DIFFERENT CLASSES OF CIRCULATING GIS, AND T CELL SUBPOPULATIONS. PHENOTYPIC INFORMATION AND PEDIGRI WILL BE USED TO ESTIMATE INTRA-POPULATION GENETIC VARIABILITY OF ITIS, AS WELL AS THE ASSOCIATION BETWEEN THEM AND WITH THE PRODUCTION CHARACTERS AND STRESS PARAMETERS MEASURED IN THE PROJECT (NEUTRAL PHIL/LYMPHOCYTE RATIO AND CORTISOL LEVELS IN HAIR). IN ADDITION, HIGH DENSITY GENOTYPING (HDS) DATA FROM THE ANALYSED ANIMALS AND NGS DATA FROM OTHER ANIMALS IN THE POPULATION WILL BE USED TO IDENTIFY GENICAS NETWORKS, CANDIDATE GENES AND GENETIC VARIANTS ASSOCIATED WITH PHENOTYPIC VARIATION OF ITIS IN PIGS. IN THE MEDIUM TERM, FUNCTIONAL AND GENETIC VALIDATIONS OF THE IDENTIFIED POLYMORPHISMS WILL BE CARRIED OUT, WITH THE AIM OF SELECTING THE MOST SUITABLE GENETIC VARIANTS TO BE INCLUDED IN GENOMIC SELECTION PROGRAMS. FINALLY, THE LONG-TERM PERSPECTIVE CONTEMPLATES THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN HEALTHY ANIMALS THAT CAN PREDICT IMMUNE RESPONSE TO PATHOGEN INFECTIONS, AND TRANSFER TO THE PORCINE SELECTION INDUSTRY METHODS AND TOOLS (SNP CHIPS) APPLICABLE IN SELECTION SCHEMES AIMED AT IMPROVING IMMUNE CAPACITY IN PARALLEL WITH PRODUCTIVE IMPROVEMENT. THE RESULTS GENERATED REPRESENT AN IMPORTANT ADVANCE IN THE KNOWLEDGE OF GENETIC CONTROL OF CHARACTERS RELATED TO IMMUNITY, AND PROVIDE THE BASIS FOR THE FUTURE IMPLEMENTATION OF GENETIC/GENOMIC SELECTION PROGRAMS THAT INCORPORATE ANIMAL HEALTH AMONG THEIR OBJECTIVES. FINALLY, IT SHOULD BE ADDED THAT THE KNOWLEDGE GENERATED ABOUT THE FUNCTIONAL MECHANISMS UNDERLYING THESE COMPLEX CHARACTERS REPRESENTS A GREAT OPPORTUNITY TO FURTHER DEVELOP THE PIG AS A USEFUL BIOMEDICAL MODEL FOR THE STUDY OF HUMAN IMMUNITY. (English) | |||||||||||||||
| Property / summary: THE GROWING REQUIREMENT FOR ANIMAL PROTEIN DUE TO THE INCREASE IN THE WORLD POPULATION, THE RECENT EUROPEAN REGULATIONS ON (DE)MEDICALISATION IN ANIMAL PRODUCTION, AND THE SOCIAL DEMAND FOR HEALTHY ANIMAL PRODUCTS AND SUSTAINABLE PRODUCTION SYSTEMS REPRESENT IMPORTANT CHALLENGES FOR THE PIG INDUSTRY. IN THIS CONTEXT, IMPROVING ANIMAL RESILIENCE AND ROBUSTNESS IN PARALLEL TO IMPROVING PRODUCTIVE YIELDS WOULD CONTRIBUTE TO INCREASING THE SUSTAINABILITY OF PRODUCTION SYSTEMS AND ALSO REDUCING RESISTANCE TO ANTIBIOTICS, BOTH OF WHICH ARE H2020'S PRIORITY CHALLENGES. THE INNATE IMMUNE SYSTEM IS THE GUEST’S FIRST LINE OF DEFENSE AGAINST INFECTIOUS AGENTS, AND RECOGNISES A WIDE RANGE OF PATHOGENS THROUGH A RESTRICTED SET OF PATTERN RECOGNITION RECEPTORS. FOR THIS REASON THE CHARACTERS OF INNATE IMMUNITY ARE PROFILED AS INTERESTING SELECTION TARGETS TO IMPROVE DISEASE RESISTANCE. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO STUDY THE GENETIC DETERMINISM OF IMMUNOCOMPETENCE IN HEALTHY PIGS, AS WELL AS ITS RELATION TO PRODUCTIVE PERFORMANCE AND ANIMAL WELFARE. FOR THIS PURPOSE, A SET OF INNATE IMMUNITY CHARACTERS (IIT) WILL BE ANALYSED IN 450 HEALTHY ANIMALS BELONGING TO A DUROC COMMERCIAL LINE. THE ITIS TO BE ANALYSED INCLUDE IGA SECRETION, ACUTE PHASE PROTEINS, COMPLEMENT PROTEINS, PHAGOCYTOSIS AND NITRIC OXIDE FORMATION, DIFFERENT CLASSES OF CIRCULATING GIS, AND T CELL SUBPOPULATIONS. PHENOTYPIC INFORMATION AND PEDIGRI WILL BE USED TO ESTIMATE INTRA-POPULATION GENETIC VARIABILITY OF ITIS, AS WELL AS THE ASSOCIATION BETWEEN THEM AND WITH THE PRODUCTION CHARACTERS AND STRESS PARAMETERS MEASURED IN THE PROJECT (NEUTRAL PHIL/LYMPHOCYTE RATIO AND CORTISOL LEVELS IN HAIR). IN ADDITION, HIGH DENSITY GENOTYPING (HDS) DATA FROM THE ANALYSED ANIMALS AND NGS DATA FROM OTHER ANIMALS IN THE POPULATION WILL BE USED TO IDENTIFY GENICAS NETWORKS, CANDIDATE GENES AND GENETIC VARIANTS ASSOCIATED WITH PHENOTYPIC VARIATION OF ITIS IN PIGS. IN THE MEDIUM TERM, FUNCTIONAL AND GENETIC VALIDATIONS OF THE IDENTIFIED POLYMORPHISMS WILL BE CARRIED OUT, WITH THE AIM OF SELECTING THE MOST SUITABLE GENETIC VARIANTS TO BE INCLUDED IN GENOMIC SELECTION PROGRAMS. FINALLY, THE LONG-TERM PERSPECTIVE CONTEMPLATES THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN HEALTHY ANIMALS THAT CAN PREDICT IMMUNE RESPONSE TO PATHOGEN INFECTIONS, AND TRANSFER TO THE PORCINE SELECTION INDUSTRY METHODS AND TOOLS (SNP CHIPS) APPLICABLE IN SELECTION SCHEMES AIMED AT IMPROVING IMMUNE CAPACITY IN PARALLEL WITH PRODUCTIVE IMPROVEMENT. THE RESULTS GENERATED REPRESENT AN IMPORTANT ADVANCE IN THE KNOWLEDGE OF GENETIC CONTROL OF CHARACTERS RELATED TO IMMUNITY, AND PROVIDE THE BASIS FOR THE FUTURE IMPLEMENTATION OF GENETIC/GENOMIC SELECTION PROGRAMS THAT INCORPORATE ANIMAL HEALTH AMONG THEIR OBJECTIVES. FINALLY, IT SHOULD BE ADDED THAT THE KNOWLEDGE GENERATED ABOUT THE FUNCTIONAL MECHANISMS UNDERLYING THESE COMPLEX CHARACTERS REPRESENTS A GREAT OPPORTUNITY TO FURTHER DEVELOP THE PIG AS A USEFUL BIOMEDICAL MODEL FOR THE STUDY OF HUMAN IMMUNITY. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: THE GROWING REQUIREMENT FOR ANIMAL PROTEIN DUE TO THE INCREASE IN THE WORLD POPULATION, THE RECENT EUROPEAN REGULATIONS ON (DE)MEDICALISATION IN ANIMAL PRODUCTION, AND THE SOCIAL DEMAND FOR HEALTHY ANIMAL PRODUCTS AND SUSTAINABLE PRODUCTION SYSTEMS REPRESENT IMPORTANT CHALLENGES FOR THE PIG INDUSTRY. IN THIS CONTEXT, IMPROVING ANIMAL RESILIENCE AND ROBUSTNESS IN PARALLEL TO IMPROVING PRODUCTIVE YIELDS WOULD CONTRIBUTE TO INCREASING THE SUSTAINABILITY OF PRODUCTION SYSTEMS AND ALSO REDUCING RESISTANCE TO ANTIBIOTICS, BOTH OF WHICH ARE H2020'S PRIORITY CHALLENGES. THE INNATE IMMUNE SYSTEM IS THE GUEST’S FIRST LINE OF DEFENSE AGAINST INFECTIOUS AGENTS, AND RECOGNISES A WIDE RANGE OF PATHOGENS THROUGH A RESTRICTED SET OF PATTERN RECOGNITION RECEPTORS. FOR THIS REASON THE CHARACTERS OF INNATE IMMUNITY ARE PROFILED AS INTERESTING SELECTION TARGETS TO IMPROVE DISEASE RESISTANCE. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO STUDY THE GENETIC DETERMINISM OF IMMUNOCOMPETENCE IN HEALTHY PIGS, AS WELL AS ITS RELATION TO PRODUCTIVE PERFORMANCE AND ANIMAL WELFARE. FOR THIS PURPOSE, A SET OF INNATE IMMUNITY CHARACTERS (IIT) WILL BE ANALYSED IN 450 HEALTHY ANIMALS BELONGING TO A DUROC COMMERCIAL LINE. THE ITIS TO BE ANALYSED INCLUDE IGA SECRETION, ACUTE PHASE PROTEINS, COMPLEMENT PROTEINS, PHAGOCYTOSIS AND NITRIC OXIDE FORMATION, DIFFERENT CLASSES OF CIRCULATING GIS, AND T CELL SUBPOPULATIONS. PHENOTYPIC INFORMATION AND PEDIGRI WILL BE USED TO ESTIMATE INTRA-POPULATION GENETIC VARIABILITY OF ITIS, AS WELL AS THE ASSOCIATION BETWEEN THEM AND WITH THE PRODUCTION CHARACTERS AND STRESS PARAMETERS MEASURED IN THE PROJECT (NEUTRAL PHIL/LYMPHOCYTE RATIO AND CORTISOL LEVELS IN HAIR). IN ADDITION, HIGH DENSITY GENOTYPING (HDS) DATA FROM THE ANALYSED ANIMALS AND NGS DATA FROM OTHER ANIMALS IN THE POPULATION WILL BE USED TO IDENTIFY GENICAS NETWORKS, CANDIDATE GENES AND GENETIC VARIANTS ASSOCIATED WITH PHENOTYPIC VARIATION OF ITIS IN PIGS. IN THE MEDIUM TERM, FUNCTIONAL AND GENETIC VALIDATIONS OF THE IDENTIFIED POLYMORPHISMS WILL BE CARRIED OUT, WITH THE AIM OF SELECTING THE MOST SUITABLE GENETIC VARIANTS TO BE INCLUDED IN GENOMIC SELECTION PROGRAMS. FINALLY, THE LONG-TERM PERSPECTIVE CONTEMPLATES THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN HEALTHY ANIMALS THAT CAN PREDICT IMMUNE RESPONSE TO PATHOGEN INFECTIONS, AND TRANSFER TO THE PORCINE SELECTION INDUSTRY METHODS AND TOOLS (SNP CHIPS) APPLICABLE IN SELECTION SCHEMES AIMED AT IMPROVING IMMUNE CAPACITY IN PARALLEL WITH PRODUCTIVE IMPROVEMENT. THE RESULTS GENERATED REPRESENT AN IMPORTANT ADVANCE IN THE KNOWLEDGE OF GENETIC CONTROL OF CHARACTERS RELATED TO IMMUNITY, AND PROVIDE THE BASIS FOR THE FUTURE IMPLEMENTATION OF GENETIC/GENOMIC SELECTION PROGRAMS THAT INCORPORATE ANIMAL HEALTH AMONG THEIR OBJECTIVES. FINALLY, IT SHOULD BE ADDED THAT THE KNOWLEDGE GENERATED ABOUT THE FUNCTIONAL MECHANISMS UNDERLYING THESE COMPLEX CHARACTERS REPRESENTS A GREAT OPPORTUNITY TO FURTHER DEVELOP THE PIG AS A USEFUL BIOMEDICAL MODEL FOR THE STUDY OF HUMAN IMMUNITY. (English) / qualifier | |||||||||||||||
point in time: 14 October 2021
| |||||||||||||||
Revision as of 08:16, 14 October 2021
Project Q3209620 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3209620 in Spain |
Statements
78,650.0 Euro
0 references
157,300.0 Euro
0 references
50.0 percent
0 references
30 December 2016
0 references
29 June 2021
0 references
INSTITUTO DE INVESTIGACION Y TECNOLOGIA AGROALIMENTARIAS
0 references
41°37'56.17"N, 2°10'3.50"E
0 references
08033
0 references
EL CRECIENTE REQUERIMIENTO DE PROTEINA ANIMAL DEBIDO AL INCREMENTO DE LA POBLACION MUNDIAL, LA RECIENTE NORMATIVA EUROPEA SOBRE (DES)MEDICALIZACION EN PRODUCCION ANIMAL, Y LA DEMANDA SOCIAL DE PRODUCTOS DE ORIGEN ANIMAL SALUDABLES Y DE SISTEMAS DE PRODUCCION SOSTENIBLES REPRESENTAN IMPORTANTES DESAFIOS PARA LA INDUSTRIA PORCINA. EN ESTE CONTEXTO, LA MEJORA DE LA RESILIENCIA Y LA ROBUSTEZ DE LOS ANIMALES EN PARALELO A LA MEJORA DE LOS RENDIMIENTOS PRODUCTIVOS CONTRIBUIRIAN A INCREMENTAR LA SOSTENIBILIDAD DE LOS SISTEMAS DE PRODUCCION Y TAMBIEN A REDUCIR LA RESISTENCIA A ANTIBIOTICOS, AMBOS RETOS PRIORITARIOS DEL H2020. EL SISTEMA INMUNITARIO INNATO ES LA PRIMERA LINEA DE DEFENSA DEL HUESPED CONTRA AGENTES INFECCIOSOS, Y RECONOCE UNA AMPLIA GAMA DE PATOGENOS A TRAVES DE UN CONJUNTO RESTRINGIDO DE RECEPTORES DE RECONOCIMIENTO DE PATRONES. POR ESTE MOTIVO LOS CARACTERES DE INMUNIDAD INNATA SE PERFILAN COMO INTERESANTES OBJETIVOS DE SELECCION PARA MEJORAR LA RESISTENCIA A ENFERMEDADES. EL OBJETIVO GLOBAL DE ESTE PROYECTO ES ESTUDIAR EL DETERMINISMO GENETICO DE LA INMUNOCOMPETENCIA EN CERDOS SANOS, ASI COMO SU RELACION CON EL RENDIMIENTO PRODUCTIVO Y EL BIENESTAR DE LOS ANIMALES. CON ESTE PROPOSITO SE ANALIZARAN UN CONJUNTO DE CARACTERES DE INMUNIDAD INNATA (IIT) EN 450 ANIMALES SANOS PERTENECIENTES A UNA LINEA COMERCIAL DUROC. LOS IIT QUE SE ANALIZARAN INCLUYEN LA SECRECION DE IGA, PROTEINAS DE FASE AGUDA, PROTEINAS DE COMPLEMENTO, FAGOCITOSIS Y FORMACION DE OXIDO NITRICO, DIFERENTES CLASES DE IG CIRCULANTES, Y SUBPOBLACIONES DE CELULAS T. SE UTILIZARA LA INFORMACION FENOTIPICA Y EL PEDIGRI PARA ESTIMAR LA VARIABILIDAD GENETICA INTRA-POBLACIONAL DE LOS IITS, ASI COMO LA ASOCIACION ENTRE ELLOS Y CON LOS CARACTERES DE PRODUCCION Y LOS PARAMETROS DE ESTRES MEDIDOS EN EL PROYECTO (RATIO NEUTROFILOS/LINFOCITOS Y NIVELES DE CORTISOL EN PELO). ASIMISMO, SE UTILIZARAN DATOS DE GENOTIPADO DE ALTA DENSIDAD (SNP) DE LOS ANIMALES ANALIZADOS Y DATOS DE NGS DE OTROS ANIMALES DE LA POBLACION PARA IDENTIFICAR REDES GENICAS, GENES CANDIDATOS Y VARIANTES GENETICAS ASOCIADAS CON LA VARIACION FENOTIPICA DE LOS IITS EN CERDOS. A MEDIO PLAZO, SE REALIZARAN VALIDACIONES FUNCIONALES Y GENETICAS DE LOS POLIMORFISMOS IDENTIFICADOS, CON EL OBJETIVO DE SELECCIONAR AQUELLAS VARIANTES GENETICAS MAS ADECUADAS PARA SER INCLUIDAS EN PROGRAMAS DE SELECCION GENOMICA. POR ULTIMO, LA PERSPECTIVA A LARGO PLAZO CONTEMPLA LA IDENTIFICACION DE BIOMARCADORES MOLECULARES EN ANIMALES SANOS QUE PUEDAN PREDECIR LA CAPACIDAD DE RESPUESTA INMUNE FRENTE A INFECCIONES POR PATOGENOS, Y TRANSFERIR A LA INDUSTRIA DE SELECCION PORCINA METODOLOGIAS Y HERRAMIENTAS (CHIPS DE SNP A MEDIDA) APLICABLES EN ESQUEMAS DE SELECCION DIRIGIDOS A MEJORAR LA CAPACIDAD INMUNE EN PARALELO CON LA MEJORA PRODUCTIVA. LOS RESULTADOS GENERADOS REPRESENTARAN UN AVANCE IMPORTANTE EN EL CONOCIMIENTO SOBRE EL CONTROL GENETICO DE CARACTERES RELACIONADOS CON LA INMUNIDAD, Y APORTAN LAS BASES PARA LA FUTURA IMPLEMENTACION DE PROGRAMAS DE SELECCION GENETICA / GENOMICA QUE INCORPOREN LA SALUD ANIMAL ENTRE SUS OBJETIVOS. CABE POR ULTIMO AÑADIR QUE EL CONOCIMIENTO GENERADO SOBRE LOS MECANISMOS FUNCIONALES QUE SUBYACEN A ESTOS CARACTERES COMPLEJOS REPRESENTA UNA GRAN OPORTUNIDAD PARA DESARROLLAR AUN MAS EL CERDO COMO MODELO BIOMEDICO DE UTILIDAD PARA EL ESTUDIO DE LA INMUNIDAD HUMANA. (Spanish)
0 references
THE GROWING REQUIREMENT FOR ANIMAL PROTEIN DUE TO THE INCREASE IN THE WORLD POPULATION, THE RECENT EUROPEAN REGULATIONS ON (DE)MEDICALISATION IN ANIMAL PRODUCTION, AND THE SOCIAL DEMAND FOR HEALTHY ANIMAL PRODUCTS AND SUSTAINABLE PRODUCTION SYSTEMS REPRESENT IMPORTANT CHALLENGES FOR THE PIG INDUSTRY. IN THIS CONTEXT, IMPROVING ANIMAL RESILIENCE AND ROBUSTNESS IN PARALLEL TO IMPROVING PRODUCTIVE YIELDS WOULD CONTRIBUTE TO INCREASING THE SUSTAINABILITY OF PRODUCTION SYSTEMS AND ALSO REDUCING RESISTANCE TO ANTIBIOTICS, BOTH OF WHICH ARE H2020'S PRIORITY CHALLENGES. THE INNATE IMMUNE SYSTEM IS THE GUEST’S FIRST LINE OF DEFENSE AGAINST INFECTIOUS AGENTS, AND RECOGNISES A WIDE RANGE OF PATHOGENS THROUGH A RESTRICTED SET OF PATTERN RECOGNITION RECEPTORS. FOR THIS REASON THE CHARACTERS OF INNATE IMMUNITY ARE PROFILED AS INTERESTING SELECTION TARGETS TO IMPROVE DISEASE RESISTANCE. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO STUDY THE GENETIC DETERMINISM OF IMMUNOCOMPETENCE IN HEALTHY PIGS, AS WELL AS ITS RELATION TO PRODUCTIVE PERFORMANCE AND ANIMAL WELFARE. FOR THIS PURPOSE, A SET OF INNATE IMMUNITY CHARACTERS (IIT) WILL BE ANALYSED IN 450 HEALTHY ANIMALS BELONGING TO A DUROC COMMERCIAL LINE. THE ITIS TO BE ANALYSED INCLUDE IGA SECRETION, ACUTE PHASE PROTEINS, COMPLEMENT PROTEINS, PHAGOCYTOSIS AND NITRIC OXIDE FORMATION, DIFFERENT CLASSES OF CIRCULATING GIS, AND T CELL SUBPOPULATIONS. PHENOTYPIC INFORMATION AND PEDIGRI WILL BE USED TO ESTIMATE INTRA-POPULATION GENETIC VARIABILITY OF ITIS, AS WELL AS THE ASSOCIATION BETWEEN THEM AND WITH THE PRODUCTION CHARACTERS AND STRESS PARAMETERS MEASURED IN THE PROJECT (NEUTRAL PHIL/LYMPHOCYTE RATIO AND CORTISOL LEVELS IN HAIR). IN ADDITION, HIGH DENSITY GENOTYPING (HDS) DATA FROM THE ANALYSED ANIMALS AND NGS DATA FROM OTHER ANIMALS IN THE POPULATION WILL BE USED TO IDENTIFY GENICAS NETWORKS, CANDIDATE GENES AND GENETIC VARIANTS ASSOCIATED WITH PHENOTYPIC VARIATION OF ITIS IN PIGS. IN THE MEDIUM TERM, FUNCTIONAL AND GENETIC VALIDATIONS OF THE IDENTIFIED POLYMORPHISMS WILL BE CARRIED OUT, WITH THE AIM OF SELECTING THE MOST SUITABLE GENETIC VARIANTS TO BE INCLUDED IN GENOMIC SELECTION PROGRAMS. FINALLY, THE LONG-TERM PERSPECTIVE CONTEMPLATES THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN HEALTHY ANIMALS THAT CAN PREDICT IMMUNE RESPONSE TO PATHOGEN INFECTIONS, AND TRANSFER TO THE PORCINE SELECTION INDUSTRY METHODS AND TOOLS (SNP CHIPS) APPLICABLE IN SELECTION SCHEMES AIMED AT IMPROVING IMMUNE CAPACITY IN PARALLEL WITH PRODUCTIVE IMPROVEMENT. THE RESULTS GENERATED REPRESENT AN IMPORTANT ADVANCE IN THE KNOWLEDGE OF GENETIC CONTROL OF CHARACTERS RELATED TO IMMUNITY, AND PROVIDE THE BASIS FOR THE FUTURE IMPLEMENTATION OF GENETIC/GENOMIC SELECTION PROGRAMS THAT INCORPORATE ANIMAL HEALTH AMONG THEIR OBJECTIVES. FINALLY, IT SHOULD BE ADDED THAT THE KNOWLEDGE GENERATED ABOUT THE FUNCTIONAL MECHANISMS UNDERLYING THESE COMPLEX CHARACTERS REPRESENTS A GREAT OPPORTUNITY TO FURTHER DEVELOP THE PIG AS A USEFUL BIOMEDICAL MODEL FOR THE STUDY OF HUMAN IMMUNITY. (English)
14 October 2021
0 references
Caldes de Montbui
0 references
Identifiers
AGL2016-75432-R
0 references