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(Created claim: summary (P836): THE MAIN OBJECTIVE OF PRINT4LIFE IS THE DEVELOPMENT OF PERSONALISED SCAFFOLDING FOR THE TREATMENT OF COMPLEX BONE DEFECTS OF CRITICAL SIZE, CAPABLE OF RESPONDING TO THE SPECIFIC NEEDS OF PATIENTS AFFECTED BY PATHOLOGIES THAT COMPROMISE THE CAPACITY FOR BONE REGENERATION, SUCH AS OSTEOPOROSIS, OSTEOMYELITIS OR CANCER. PRIT4LIFE PROPOSES AN APPROACH THAT COMBINES THE LATEST ADVANCES IN 3D PRINTING TECHNOLOGY BY INK INJECTION, WITH ADVANCED PHARMAC...) |
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THE MAIN OBJECTIVE OF PRINT4LIFE IS THE DEVELOPMENT OF PERSONALISED SCAFFOLDING FOR THE TREATMENT OF COMPLEX BONE DEFECTS OF CRITICAL SIZE, CAPABLE OF RESPONDING TO THE SPECIFIC NEEDS OF PATIENTS AFFECTED BY PATHOLOGIES THAT COMPROMISE THE CAPACITY FOR BONE REGENERATION, SUCH AS OSTEOPOROSIS, OSTEOMYELITIS OR CANCER. PRIT4LIFE PROPOSES AN APPROACH THAT COMBINES THE LATEST ADVANCES IN 3D PRINTING TECHNOLOGY BY INK INJECTION, WITH ADVANCED PHARMACO-RELEASE THERAPIES AND TISSUE ENGINEERING. THE PROJECT RANGES FROM THE DEVELOPMENT OF INKS TO THE DIRECT IMPRESSION OF THE PERSONALISED SCAFFOLDING AND INCLUDES THE CHARACTERISATION OF THEIR PHYSICOCHEMICAL PROPERTIES AND THEIR PRECLINICAL EVALUATION. The PROJECT INCLUDED:_x000D_ 1) THE DESIGN OF bioinks WITH DIFFERENT COMPOSICATIONS AND BIOLOGICAL ACTIVITIES, CAPACIES OF PROPORCIONING NECESARIAL Signals to Improve the OSEA REGENERATION, INCLUDING TINT AUTOFRAGUABLE biomimetic CERAMICs, AND HYDROGELES that contain or do not contain MINERAL nanoparticulaes. THE FOLLOWING CHALLENGES WILL BE ADDRESSED: DEVELOPMENT OF BIOMIMETIC CERAMIC INKS CAPABLE OF HARDENING AT LOW TEMPERATURE, WITHOUT SINTERING, IN A CLINICALLY ACCEPTABLE PERIOD OF TIME, WITH HIGH RESOLUTION AND STABILITY AND GOOD REPRODUCIBILITY; DEVELOPMENT OF MULTIFUNCTIONAL HYDROGEL BIOINKS, EQUIPPED WITH CERTAIN BIOLOGICAL FUNCTIONALITIES THROUGH THE INCORPORATION OF GROWTH FACTORS, IONS AND/OR NANOPARTICULAES CAPABLE OF IMPROVING BONE REGENERATION. IN THIS SENSE, A PARTICULAR CHALLENGE THAT WILL BE ADDRESSED IS TO EXPLOIT THE LETHAL EFFECTS FOR CANCER CELLS PRESENTED BY HIGHLY REACTIVE CHEMICAL SPECIES THAT ARE GENERATED BY PLASMA ATMOSPHERIC PRESSURE (PPA) TREATMENTS IN LIQUID ENVIRONMENTS. Development of HYDROGEL THAT ACTS AS VEHICULES FOR SPECY DIY FREEDOM._x000D_ 2) DEVELOPMENT OF STRUCTURES OBTAINED BY IMPRESION 3D WITH COMPLETED ARCHITECTURES AND THE DISTRIBUTION LOCALISED TO BIOLOGICAL COMPONENT DIVERSES, it IS TO DECRE, they molecute biologically ACTIVE AND CELLS. SPECIFICALLY, THE AIM IS TO PRODUCE: BIOMIMETIC CERAMIC SCAFFOLDING PRINTED IN SITU (IN-HOSPITAL), FROM BONE DEFECT GEOMETRIES OBTAINED BY CT OR NMR; SCAFFOLDING WITH INTERSPERSED CERAMIC/HYDROGEL STRUCTURES, WHICH WOULD ALLOW TO ADJUST THE MECHANICAL PROPERTIES AND OSTEOGENICA CAPACITY OF 3D STRUCTURES; CORE/SHELL STRUCTURES FOR SEQUANCIAL RELEASE OF PHARMACOS AND ENCAPSULATION OF CELLS. ESPECIALLY RELEVANT WILL BE THE DEVELOPMENT OF PRE-VASCULARISED 3D SCAFFOLDING THROUGH THE SIMULTANEOUS IMPRESSION OF BIOMIMETIC CERAMIC FILAMENTS ALTERNATED WITH TUBULAR HYDROGEL STRUCTURES, INCLUDING ENDOTHELIAL CELLS. (English) | |||||||||||||||
| Property / summary: THE MAIN OBJECTIVE OF PRINT4LIFE IS THE DEVELOPMENT OF PERSONALISED SCAFFOLDING FOR THE TREATMENT OF COMPLEX BONE DEFECTS OF CRITICAL SIZE, CAPABLE OF RESPONDING TO THE SPECIFIC NEEDS OF PATIENTS AFFECTED BY PATHOLOGIES THAT COMPROMISE THE CAPACITY FOR BONE REGENERATION, SUCH AS OSTEOPOROSIS, OSTEOMYELITIS OR CANCER. PRIT4LIFE PROPOSES AN APPROACH THAT COMBINES THE LATEST ADVANCES IN 3D PRINTING TECHNOLOGY BY INK INJECTION, WITH ADVANCED PHARMACO-RELEASE THERAPIES AND TISSUE ENGINEERING. THE PROJECT RANGES FROM THE DEVELOPMENT OF INKS TO THE DIRECT IMPRESSION OF THE PERSONALISED SCAFFOLDING AND INCLUDES THE CHARACTERISATION OF THEIR PHYSICOCHEMICAL PROPERTIES AND THEIR PRECLINICAL EVALUATION. The PROJECT INCLUDED:_x000D_ 1) THE DESIGN OF bioinks WITH DIFFERENT COMPOSICATIONS AND BIOLOGICAL ACTIVITIES, CAPACIES OF PROPORCIONING NECESARIAL Signals to Improve the OSEA REGENERATION, INCLUDING TINT AUTOFRAGUABLE biomimetic CERAMICs, AND HYDROGELES that contain or do not contain MINERAL nanoparticulaes. THE FOLLOWING CHALLENGES WILL BE ADDRESSED: DEVELOPMENT OF BIOMIMETIC CERAMIC INKS CAPABLE OF HARDENING AT LOW TEMPERATURE, WITHOUT SINTERING, IN A CLINICALLY ACCEPTABLE PERIOD OF TIME, WITH HIGH RESOLUTION AND STABILITY AND GOOD REPRODUCIBILITY; DEVELOPMENT OF MULTIFUNCTIONAL HYDROGEL BIOINKS, EQUIPPED WITH CERTAIN BIOLOGICAL FUNCTIONALITIES THROUGH THE INCORPORATION OF GROWTH FACTORS, IONS AND/OR NANOPARTICULAES CAPABLE OF IMPROVING BONE REGENERATION. IN THIS SENSE, A PARTICULAR CHALLENGE THAT WILL BE ADDRESSED IS TO EXPLOIT THE LETHAL EFFECTS FOR CANCER CELLS PRESENTED BY HIGHLY REACTIVE CHEMICAL SPECIES THAT ARE GENERATED BY PLASMA ATMOSPHERIC PRESSURE (PPA) TREATMENTS IN LIQUID ENVIRONMENTS. Development of HYDROGEL THAT ACTS AS VEHICULES FOR SPECY DIY FREEDOM._x000D_ 2) DEVELOPMENT OF STRUCTURES OBTAINED BY IMPRESION 3D WITH COMPLETED ARCHITECTURES AND THE DISTRIBUTION LOCALISED TO BIOLOGICAL COMPONENT DIVERSES, it IS TO DECRE, they molecute biologically ACTIVE AND CELLS. SPECIFICALLY, THE AIM IS TO PRODUCE: BIOMIMETIC CERAMIC SCAFFOLDING PRINTED IN SITU (IN-HOSPITAL), FROM BONE DEFECT GEOMETRIES OBTAINED BY CT OR NMR; SCAFFOLDING WITH INTERSPERSED CERAMIC/HYDROGEL STRUCTURES, WHICH WOULD ALLOW TO ADJUST THE MECHANICAL PROPERTIES AND OSTEOGENICA CAPACITY OF 3D STRUCTURES; CORE/SHELL STRUCTURES FOR SEQUANCIAL RELEASE OF PHARMACOS AND ENCAPSULATION OF CELLS. ESPECIALLY RELEVANT WILL BE THE DEVELOPMENT OF PRE-VASCULARISED 3D SCAFFOLDING THROUGH THE SIMULTANEOUS IMPRESSION OF BIOMIMETIC CERAMIC FILAMENTS ALTERNATED WITH TUBULAR HYDROGEL STRUCTURES, INCLUDING ENDOTHELIAL CELLS. (English) / rank | |||||||||||||||
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| Property / summary: THE MAIN OBJECTIVE OF PRINT4LIFE IS THE DEVELOPMENT OF PERSONALISED SCAFFOLDING FOR THE TREATMENT OF COMPLEX BONE DEFECTS OF CRITICAL SIZE, CAPABLE OF RESPONDING TO THE SPECIFIC NEEDS OF PATIENTS AFFECTED BY PATHOLOGIES THAT COMPROMISE THE CAPACITY FOR BONE REGENERATION, SUCH AS OSTEOPOROSIS, OSTEOMYELITIS OR CANCER. PRIT4LIFE PROPOSES AN APPROACH THAT COMBINES THE LATEST ADVANCES IN 3D PRINTING TECHNOLOGY BY INK INJECTION, WITH ADVANCED PHARMACO-RELEASE THERAPIES AND TISSUE ENGINEERING. THE PROJECT RANGES FROM THE DEVELOPMENT OF INKS TO THE DIRECT IMPRESSION OF THE PERSONALISED SCAFFOLDING AND INCLUDES THE CHARACTERISATION OF THEIR PHYSICOCHEMICAL PROPERTIES AND THEIR PRECLINICAL EVALUATION. The PROJECT INCLUDED:_x000D_ 1) THE DESIGN OF bioinks WITH DIFFERENT COMPOSICATIONS AND BIOLOGICAL ACTIVITIES, CAPACIES OF PROPORCIONING NECESARIAL Signals to Improve the OSEA REGENERATION, INCLUDING TINT AUTOFRAGUABLE biomimetic CERAMICs, AND HYDROGELES that contain or do not contain MINERAL nanoparticulaes. THE FOLLOWING CHALLENGES WILL BE ADDRESSED: DEVELOPMENT OF BIOMIMETIC CERAMIC INKS CAPABLE OF HARDENING AT LOW TEMPERATURE, WITHOUT SINTERING, IN A CLINICALLY ACCEPTABLE PERIOD OF TIME, WITH HIGH RESOLUTION AND STABILITY AND GOOD REPRODUCIBILITY; DEVELOPMENT OF MULTIFUNCTIONAL HYDROGEL BIOINKS, EQUIPPED WITH CERTAIN BIOLOGICAL FUNCTIONALITIES THROUGH THE INCORPORATION OF GROWTH FACTORS, IONS AND/OR NANOPARTICULAES CAPABLE OF IMPROVING BONE REGENERATION. IN THIS SENSE, A PARTICULAR CHALLENGE THAT WILL BE ADDRESSED IS TO EXPLOIT THE LETHAL EFFECTS FOR CANCER CELLS PRESENTED BY HIGHLY REACTIVE CHEMICAL SPECIES THAT ARE GENERATED BY PLASMA ATMOSPHERIC PRESSURE (PPA) TREATMENTS IN LIQUID ENVIRONMENTS. Development of HYDROGEL THAT ACTS AS VEHICULES FOR SPECY DIY FREEDOM._x000D_ 2) DEVELOPMENT OF STRUCTURES OBTAINED BY IMPRESION 3D WITH COMPLETED ARCHITECTURES AND THE DISTRIBUTION LOCALISED TO BIOLOGICAL COMPONENT DIVERSES, it IS TO DECRE, they molecute biologically ACTIVE AND CELLS. SPECIFICALLY, THE AIM IS TO PRODUCE: BIOMIMETIC CERAMIC SCAFFOLDING PRINTED IN SITU (IN-HOSPITAL), FROM BONE DEFECT GEOMETRIES OBTAINED BY CT OR NMR; SCAFFOLDING WITH INTERSPERSED CERAMIC/HYDROGEL STRUCTURES, WHICH WOULD ALLOW TO ADJUST THE MECHANICAL PROPERTIES AND OSTEOGENICA CAPACITY OF 3D STRUCTURES; CORE/SHELL STRUCTURES FOR SEQUANCIAL RELEASE OF PHARMACOS AND ENCAPSULATION OF CELLS. ESPECIALLY RELEVANT WILL BE THE DEVELOPMENT OF PRE-VASCULARISED 3D SCAFFOLDING THROUGH THE SIMULTANEOUS IMPRESSION OF BIOMIMETIC CERAMIC FILAMENTS ALTERNATED WITH TUBULAR HYDROGEL STRUCTURES, INCLUDING ENDOTHELIAL CELLS. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
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Revision as of 01:32, 13 October 2021
Project Q3204462 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3204462 in Spain |
Statements
169,400.0 Euro
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338,800.0 Euro
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50.0 percent
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1 January 2016
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31 December 2020
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UNIVERSIDAD POLITECNICA DE CATALUÑA
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41°22'58.40"N, 2°10'38.75"E
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08019
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EL PRINCIPAL OBJETIVO DE PRINT4LIFE ES EL DESARROLLO DE ANDAMIOS PERSONALIZADOS PARA EL TRATAMIENTO DE DEFECTOS OSEOS COMPLEJOS DE TAMAÑO CRITICO, CAPACES DE RESPONDER A LAS NECESIDADES ESPECIFICAS DE PACIENTES AFECTADOS POR PATOLOGIAS QUE COMPROMETEN LA CAPACIDAD DE REGENERACION OSEA, COMO LA OSTEOPOROSIS, LA OSTEOMIELITIS O EL CANCER. PRIT4LIFE PROPONE UN ENFOQUE QUE COMBINA LOS ULTIMOS AVANCES DE LA TECNOLOGIA DE IMPRESION 3D POR INYECCION DE TINTA, CON TERAPIAS AVANZADAS DE LIBERACION DE FARMACOS E INGENIERIA DE TEJIDOS. EL PROYECTO ABARCA DESDE EL DESARROLLO DE LAS TINTAS A LA IMPRESION DIRECTA DE LOS ANDAMIOS PERSONALIZADOS E INCLUYE LA CARACTERIZACION DE SUS PROPIEDADES FISICOQUIMICAS Y SU EVALUACION PRECLINICA. EL PROYECTO INCLUYE:_x000D_ 1) EL DISEÑO DE BIOTINTAS CON DIFERENTES COMPOSICIONES Y ACTIVIDADES BIOLOGICAS, CAPACES DE PROPORCIONAR LAS SEÑALES NECESARIAS PARA MEJORAR LA REGENERACION OSEA, INCLUYENDO TINTAS CERAMICAS BIOMIMETICOS AUTOFRAGUABLES, E HIDROGELES QUE CONTIENEN O NO NANOPARTICULAS MINERALES. SE ABORDARAN LOS SIGUIENTES DESAFIOS: I) DESARROLLO DE TINTAS CERAMICAS BIOMIMETICAS CAPACES DE ENDURECER A BAJA TEMPERATURA, SIN NECESIDAD DE SINTERIZACION, EN UN PERIODO CLINICAMENTE ACEPTABLE DE TIEMPO, CON ALTA RESOLUCION Y ESTABILIDAD Y BUENA REPRODUCIBILIDAD; II) DESARROLLO DE BIOTINTAS DE HIDROGELES MULTIFUNCIONALES, DOTADOS DE DETERMINADAS FUNCIONALIDADES BIOLOGICAS A TRAVES DE LA INCORPORACION DE FACTORES DE CRECIMIENTO, IONES Y/O NANOPARTICULAS CAPACES DE MEJORAR LA REGENERACION OSEA. EN ESTE SENTIDO, UN RETO PARTICULAR QUE SE ABORDARA ES EL DE EXPLOTAR LOS EFECTOS LETALES PARA LAS CELULAS CANCERIGENAS QUE PRESENTAN LAS ESPECIES QUIMICAS ALTAMENTE REACTIVAS QUE SE GENERAN MEDIANTE TRATAMIENTOS DE PLASMA A PRESION ATMOSFERICA (PPA) EN MEDIOS LIQUIDOS. SE DESARROLLARAN TINTAS DE HIDROGEL QUE ACTUEN COMO VEHICULOS PARA LIBERACION DE DICHAS ESPECIES, CONJUNTAMENTE, SI ES NECESARIO, CON DOSIS COADYUVANTES DE FARMACOS QUIMIOTERAPEUTICOS._x000D_ 2) EL DESARROLLO DE ESTRUCTURAS OBTENIDAS POR IMPRESION 3D CON ARQUITECTURAS COMPLEJAS Y LA DISTRIBUCION LOCALIZADA A MEDIDA DE DIVERSOS COMPONENTES BIOLOGICOS, ES DECIR, MOLECULAS BIOLOGICAMENTE ACTIVAS Y CELULAS. ESPECIFICAMENTE, SE BUSCA PRODUCIR: I) ANDAMIOS CERAMICOS BIOMIMETICOS IMPRESOS IN SITU (EN EL HOSPITAL), A PARTIR DE LA GEOMETRIA DEL DEFECTO OSEO OBTENIDA POR TAC O RMN; II) ANDAMIOS CON ESTRUCTURAS DE CERAMICA / HIDROGEL INTERCALADAS, QUE PERMITIRAN AJUSTAR LAS PROPIEDADES MECANICAS Y LA CAPACIDAD OSTEOGENICA DE LAS ESTRUCTURAS 3D; III) ESTRUCTURAS CORE/SHELL, PARA LA LIBERACION SECUANCIAL DE FARMACOS Y LA ENCAPSULACION DE CELULAS. ESPECIALMENTE RELEVANTE SERA EL DESARROLLO DE LOS ANDAMIOS 3D PRE-VASCULARIZADOS A TRAVES DE LA IMPRESION SIMULTANEA DE FILAMENTOS DE CERAMICA BIOMIMETICOS ALTERNADOS CON ESTRUCTURAS TUBULARES DE HIDROGEL, INCLUYENDO CELULAS ENDOTELIALES. (Spanish)
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THE MAIN OBJECTIVE OF PRINT4LIFE IS THE DEVELOPMENT OF PERSONALISED SCAFFOLDING FOR THE TREATMENT OF COMPLEX BONE DEFECTS OF CRITICAL SIZE, CAPABLE OF RESPONDING TO THE SPECIFIC NEEDS OF PATIENTS AFFECTED BY PATHOLOGIES THAT COMPROMISE THE CAPACITY FOR BONE REGENERATION, SUCH AS OSTEOPOROSIS, OSTEOMYELITIS OR CANCER. PRIT4LIFE PROPOSES AN APPROACH THAT COMBINES THE LATEST ADVANCES IN 3D PRINTING TECHNOLOGY BY INK INJECTION, WITH ADVANCED PHARMACO-RELEASE THERAPIES AND TISSUE ENGINEERING. THE PROJECT RANGES FROM THE DEVELOPMENT OF INKS TO THE DIRECT IMPRESSION OF THE PERSONALISED SCAFFOLDING AND INCLUDES THE CHARACTERISATION OF THEIR PHYSICOCHEMICAL PROPERTIES AND THEIR PRECLINICAL EVALUATION. The PROJECT INCLUDED:_x000D_ 1) THE DESIGN OF bioinks WITH DIFFERENT COMPOSICATIONS AND BIOLOGICAL ACTIVITIES, CAPACIES OF PROPORCIONING NECESARIAL Signals to Improve the OSEA REGENERATION, INCLUDING TINT AUTOFRAGUABLE biomimetic CERAMICs, AND HYDROGELES that contain or do not contain MINERAL nanoparticulaes. THE FOLLOWING CHALLENGES WILL BE ADDRESSED: DEVELOPMENT OF BIOMIMETIC CERAMIC INKS CAPABLE OF HARDENING AT LOW TEMPERATURE, WITHOUT SINTERING, IN A CLINICALLY ACCEPTABLE PERIOD OF TIME, WITH HIGH RESOLUTION AND STABILITY AND GOOD REPRODUCIBILITY; DEVELOPMENT OF MULTIFUNCTIONAL HYDROGEL BIOINKS, EQUIPPED WITH CERTAIN BIOLOGICAL FUNCTIONALITIES THROUGH THE INCORPORATION OF GROWTH FACTORS, IONS AND/OR NANOPARTICULAES CAPABLE OF IMPROVING BONE REGENERATION. IN THIS SENSE, A PARTICULAR CHALLENGE THAT WILL BE ADDRESSED IS TO EXPLOIT THE LETHAL EFFECTS FOR CANCER CELLS PRESENTED BY HIGHLY REACTIVE CHEMICAL SPECIES THAT ARE GENERATED BY PLASMA ATMOSPHERIC PRESSURE (PPA) TREATMENTS IN LIQUID ENVIRONMENTS. Development of HYDROGEL THAT ACTS AS VEHICULES FOR SPECY DIY FREEDOM._x000D_ 2) DEVELOPMENT OF STRUCTURES OBTAINED BY IMPRESION 3D WITH COMPLETED ARCHITECTURES AND THE DISTRIBUTION LOCALISED TO BIOLOGICAL COMPONENT DIVERSES, it IS TO DECRE, they molecute biologically ACTIVE AND CELLS. SPECIFICALLY, THE AIM IS TO PRODUCE: BIOMIMETIC CERAMIC SCAFFOLDING PRINTED IN SITU (IN-HOSPITAL), FROM BONE DEFECT GEOMETRIES OBTAINED BY CT OR NMR; SCAFFOLDING WITH INTERSPERSED CERAMIC/HYDROGEL STRUCTURES, WHICH WOULD ALLOW TO ADJUST THE MECHANICAL PROPERTIES AND OSTEOGENICA CAPACITY OF 3D STRUCTURES; CORE/SHELL STRUCTURES FOR SEQUANCIAL RELEASE OF PHARMACOS AND ENCAPSULATION OF CELLS. ESPECIALLY RELEVANT WILL BE THE DEVELOPMENT OF PRE-VASCULARISED 3D SCAFFOLDING THROUGH THE SIMULTANEOUS IMPRESSION OF BIOMIMETIC CERAMIC FILAMENTS ALTERNATED WITH TUBULAR HYDROGEL STRUCTURES, INCLUDING ENDOTHELIAL CELLS. (English)
13 October 2021
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Barcelona
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Identifiers
MAT2015-65601-R
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