Q3194248 (Q3194248): Difference between revisions
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(Created claim: summary (P836): IN HUMANS, MEDULLARY INJURY (LM) IS ACCOMPANIED BY SCARS AND CAVITIES THAT HAVE SEVERAL CENTIMETRES OF EXTENSION AND WHICH LACK GUIDANCE MECHANISMS FOR CELLS IN REGENERATION. SINCE BOTH NEURONS AND GLIAL CELLS RESPOND INTENSELY TO THE MOLECULAR COMPLEXES ANCHORED TO THE SUBSTRATE ON WHICH THEY GROW, THE MEDULLARY REPAIR COULD BE ENHANCED BY THE IMPLANTATION OF THREE-DIMENSIONAL STRUCTURES THAT PRESENT MOLECULES PROMOTING NEURAL GROWTH WITH TOPOG...) |
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IN HUMANS, MEDULLARY INJURY (LM) IS ACCOMPANIED BY SCARS AND CAVITIES THAT HAVE SEVERAL CENTIMETRES OF EXTENSION AND WHICH LACK GUIDANCE MECHANISMS FOR CELLS IN REGENERATION. SINCE BOTH NEURONS AND GLIAL CELLS RESPOND INTENSELY TO THE MOLECULAR COMPLEXES ANCHORED TO THE SUBSTRATE ON WHICH THEY GROW, THE MEDULLARY REPAIR COULD BE ENHANCED BY THE IMPLANTATION OF THREE-DIMENSIONAL STRUCTURES THAT PRESENT MOLECULES PROMOTING NEURAL GROWTH WITH TOPOGRAPHIC ORGANISATION IN THE AREA OF INJURY. The use of electroconductive MATERIALS to make STRUCTURE DYES will mean an ADDITIONAL AVANCE, and that these will allow the application of elECTRIC STIMULES to enable growth and AXONAL MELINIZACTION, and to control the CELULAR COMPORTATIONS OF THE CELULA/SUSTRATE INTERACTIONS._x000D_ we DEVELOPED microfibers (MFS) biofunctionalised electroconductors FOR THIS APPLICATION. IN CELL CULTURES, MFS PROMOTES AXONAL GROWTH AND MIGRATION OF GLIAL PRECURSORS IN A GUIDED MANNER AND OVER LONG DISTANCES. WHEN IMPLANTED IN AREAS OF SPINAL INJURY IN RAT, MFS HAVE EXCELLENT INTEGRATION WITH NEURAL TISSUE AND ALSO ALLOW CELL MIGRATION AND AXONAL REGENERATION GUIDED THROUGH THE INJURY ZONE. THIS PROJECT AIMS TO INVESTIGATE WHETHER REMEDIAL RESPONSES AND FUNCTIONAL RESULTS AFTER INJURY CAN BE IMPROVED THROUGH THE APPLICATION OF ELECTRIC STIMULI THROUGH THE IMPLANTED SFM. INITIALLY, THE EXPERIMENTS WILL BE PERFORMED IN RATS WITH COMPLETE THORACIC MEDULLARY TRANSECT, IN ORDER TO DETERMINE EFFECTIVE AND NON-HARMFUL ELECTRICAL PARAMETERS THAT INDUCE ACTION POTENTIALS IN AXOTOMISED NEURONS, AND ALSO STUDY THEIR EFFECTS ON AXONAL GROWTH, SENSORY FUNCTION AND MOTORITY. SUBSEQUENTLY, THE SFM WILL BE IMPLANTED IN PIGS WITH CERVICAL SPINAL CORD HEMISECTION, IN WHICH STIMULATION WITH THE PROTOCOL THAT HAS PRODUCED THE BEST RESPONSES IN RATS WILL BE PERFORMED. THE PORCINE MODEL WILL ALLOW TO EVALUATE THE PROPOSED TREATMENT TO IMPROVE TISSUE REPAIR AND FUNCTIONAL RECOVERY IN LESIONS MORE SIMILAR TO THOSE OF HUMANS. WE WILL USE A COMBINATION OF MODERN TECHNIQUES FOR THE ANATOMIC, PHYSIOLOGICAL AND BEHAVIORAL EVALUATION, OBTAINING A DEEP UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF THIS NEW THERAPEUTIC INTERVENTION. _x000D_ our EXPECTATIVE IS THAT THE STIMULATION WITH THE MFS BEFORE WHERE THE AXONAL REGENERATION WITH THE DREAMED AREA AND FUNCIONAL REconnection with NEURONS DESINERVED. IN ADDITION TO THEIR OWN THERAPEUTIC POTENTIAL, ELECTROACTIVE MFS WILL BE A TECHNOLOGY THAT WILL FACILITATE THE SUCCESSFUL APPLICATION OF CELLULAR, GENIC AND PHARMACOLOGICAL THERAPY FOR ML. (English) | |||||||||||||||
| Property / summary: IN HUMANS, MEDULLARY INJURY (LM) IS ACCOMPANIED BY SCARS AND CAVITIES THAT HAVE SEVERAL CENTIMETRES OF EXTENSION AND WHICH LACK GUIDANCE MECHANISMS FOR CELLS IN REGENERATION. SINCE BOTH NEURONS AND GLIAL CELLS RESPOND INTENSELY TO THE MOLECULAR COMPLEXES ANCHORED TO THE SUBSTRATE ON WHICH THEY GROW, THE MEDULLARY REPAIR COULD BE ENHANCED BY THE IMPLANTATION OF THREE-DIMENSIONAL STRUCTURES THAT PRESENT MOLECULES PROMOTING NEURAL GROWTH WITH TOPOGRAPHIC ORGANISATION IN THE AREA OF INJURY. The use of electroconductive MATERIALS to make STRUCTURE DYES will mean an ADDITIONAL AVANCE, and that these will allow the application of elECTRIC STIMULES to enable growth and AXONAL MELINIZACTION, and to control the CELULAR COMPORTATIONS OF THE CELULA/SUSTRATE INTERACTIONS._x000D_ we DEVELOPED microfibers (MFS) biofunctionalised electroconductors FOR THIS APPLICATION. IN CELL CULTURES, MFS PROMOTES AXONAL GROWTH AND MIGRATION OF GLIAL PRECURSORS IN A GUIDED MANNER AND OVER LONG DISTANCES. WHEN IMPLANTED IN AREAS OF SPINAL INJURY IN RAT, MFS HAVE EXCELLENT INTEGRATION WITH NEURAL TISSUE AND ALSO ALLOW CELL MIGRATION AND AXONAL REGENERATION GUIDED THROUGH THE INJURY ZONE. THIS PROJECT AIMS TO INVESTIGATE WHETHER REMEDIAL RESPONSES AND FUNCTIONAL RESULTS AFTER INJURY CAN BE IMPROVED THROUGH THE APPLICATION OF ELECTRIC STIMULI THROUGH THE IMPLANTED SFM. INITIALLY, THE EXPERIMENTS WILL BE PERFORMED IN RATS WITH COMPLETE THORACIC MEDULLARY TRANSECT, IN ORDER TO DETERMINE EFFECTIVE AND NON-HARMFUL ELECTRICAL PARAMETERS THAT INDUCE ACTION POTENTIALS IN AXOTOMISED NEURONS, AND ALSO STUDY THEIR EFFECTS ON AXONAL GROWTH, SENSORY FUNCTION AND MOTORITY. SUBSEQUENTLY, THE SFM WILL BE IMPLANTED IN PIGS WITH CERVICAL SPINAL CORD HEMISECTION, IN WHICH STIMULATION WITH THE PROTOCOL THAT HAS PRODUCED THE BEST RESPONSES IN RATS WILL BE PERFORMED. THE PORCINE MODEL WILL ALLOW TO EVALUATE THE PROPOSED TREATMENT TO IMPROVE TISSUE REPAIR AND FUNCTIONAL RECOVERY IN LESIONS MORE SIMILAR TO THOSE OF HUMANS. WE WILL USE A COMBINATION OF MODERN TECHNIQUES FOR THE ANATOMIC, PHYSIOLOGICAL AND BEHAVIORAL EVALUATION, OBTAINING A DEEP UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF THIS NEW THERAPEUTIC INTERVENTION. _x000D_ our EXPECTATIVE IS THAT THE STIMULATION WITH THE MFS BEFORE WHERE THE AXONAL REGENERATION WITH THE DREAMED AREA AND FUNCIONAL REconnection with NEURONS DESINERVED. IN ADDITION TO THEIR OWN THERAPEUTIC POTENTIAL, ELECTROACTIVE MFS WILL BE A TECHNOLOGY THAT WILL FACILITATE THE SUCCESSFUL APPLICATION OF CELLULAR, GENIC AND PHARMACOLOGICAL THERAPY FOR ML. (English) / rank | |||||||||||||||
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| Property / summary: IN HUMANS, MEDULLARY INJURY (LM) IS ACCOMPANIED BY SCARS AND CAVITIES THAT HAVE SEVERAL CENTIMETRES OF EXTENSION AND WHICH LACK GUIDANCE MECHANISMS FOR CELLS IN REGENERATION. SINCE BOTH NEURONS AND GLIAL CELLS RESPOND INTENSELY TO THE MOLECULAR COMPLEXES ANCHORED TO THE SUBSTRATE ON WHICH THEY GROW, THE MEDULLARY REPAIR COULD BE ENHANCED BY THE IMPLANTATION OF THREE-DIMENSIONAL STRUCTURES THAT PRESENT MOLECULES PROMOTING NEURAL GROWTH WITH TOPOGRAPHIC ORGANISATION IN THE AREA OF INJURY. The use of electroconductive MATERIALS to make STRUCTURE DYES will mean an ADDITIONAL AVANCE, and that these will allow the application of elECTRIC STIMULES to enable growth and AXONAL MELINIZACTION, and to control the CELULAR COMPORTATIONS OF THE CELULA/SUSTRATE INTERACTIONS._x000D_ we DEVELOPED microfibers (MFS) biofunctionalised electroconductors FOR THIS APPLICATION. IN CELL CULTURES, MFS PROMOTES AXONAL GROWTH AND MIGRATION OF GLIAL PRECURSORS IN A GUIDED MANNER AND OVER LONG DISTANCES. WHEN IMPLANTED IN AREAS OF SPINAL INJURY IN RAT, MFS HAVE EXCELLENT INTEGRATION WITH NEURAL TISSUE AND ALSO ALLOW CELL MIGRATION AND AXONAL REGENERATION GUIDED THROUGH THE INJURY ZONE. THIS PROJECT AIMS TO INVESTIGATE WHETHER REMEDIAL RESPONSES AND FUNCTIONAL RESULTS AFTER INJURY CAN BE IMPROVED THROUGH THE APPLICATION OF ELECTRIC STIMULI THROUGH THE IMPLANTED SFM. INITIALLY, THE EXPERIMENTS WILL BE PERFORMED IN RATS WITH COMPLETE THORACIC MEDULLARY TRANSECT, IN ORDER TO DETERMINE EFFECTIVE AND NON-HARMFUL ELECTRICAL PARAMETERS THAT INDUCE ACTION POTENTIALS IN AXOTOMISED NEURONS, AND ALSO STUDY THEIR EFFECTS ON AXONAL GROWTH, SENSORY FUNCTION AND MOTORITY. SUBSEQUENTLY, THE SFM WILL BE IMPLANTED IN PIGS WITH CERVICAL SPINAL CORD HEMISECTION, IN WHICH STIMULATION WITH THE PROTOCOL THAT HAS PRODUCED THE BEST RESPONSES IN RATS WILL BE PERFORMED. THE PORCINE MODEL WILL ALLOW TO EVALUATE THE PROPOSED TREATMENT TO IMPROVE TISSUE REPAIR AND FUNCTIONAL RECOVERY IN LESIONS MORE SIMILAR TO THOSE OF HUMANS. WE WILL USE A COMBINATION OF MODERN TECHNIQUES FOR THE ANATOMIC, PHYSIOLOGICAL AND BEHAVIORAL EVALUATION, OBTAINING A DEEP UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF THIS NEW THERAPEUTIC INTERVENTION. _x000D_ our EXPECTATIVE IS THAT THE STIMULATION WITH THE MFS BEFORE WHERE THE AXONAL REGENERATION WITH THE DREAMED AREA AND FUNCIONAL REconnection with NEURONS DESINERVED. IN ADDITION TO THEIR OWN THERAPEUTIC POTENTIAL, ELECTROACTIVE MFS WILL BE A TECHNOLOGY THAT WILL FACILITATE THE SUCCESSFUL APPLICATION OF CELLULAR, GENIC AND PHARMACOLOGICAL THERAPY FOR ML. (English) / qualifier | |||||||||||||||
point in time: 13 October 2021
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Revision as of 23:41, 12 October 2021
Project Q3194248 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3194248 in Spain |
Statements
87,120.0 Euro
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108,900.0 Euro
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80.0 percent
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1 January 2016
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31 December 2018
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FUNDACION DEL HOSPITAL NACIONAL DE PARAPLEJICOS
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39°51'21.85"N, 4°1'26.26"W
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45168
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EN LOS HUMANOS, LA LESION MEDULAR (LM) SE ACOMPAÑA DE CICATRICES Y CAVIDADES QUE TIENEN VARIOS CENTIMETROS DE EXTENSION Y QUE CARECEN DE MECANISMOS DE GUIA PARA LAS CELULAS EN REGENERACION. PUESTO QUE TANTO LAS NEURONAS COMO LAS CELULAS GLIALES RESPONDEN INTENSAMENTE A LOS COMPLEJOS MOLECULARES ANCLADOS AL SUSTRATO SOBRE EL CUAL CRECEN, LA REPARACION MEDULAR PODRIA POTENCIARSE MEDIANTE EL IMPLANTE DE ESTRUCTURAS TRIDIMENSIONALES QUE PRESENTEN MOLECULAS PROMOTORAS DEL CRECIMIENTO NEURAL CON ORGANIZACION TOPOGRAFICA EN LA ZONA DE LESION. EL USO DE MATERIALES ELECTROCONDUCTORES PARA FABRICAR DICHAS ESTRUCTURAS SUPONDRA UN AVANCE ADICIONAL, YA QUE ESTOS PERMITIRAN LA APLICACION DE ESTIMULOS ELECTRICOS PARA POTENCIAR EL CRECIMIENTO Y LA MIELINIZACION AXONAL, Y PARA CONTROLAR EL COMPORTAMIENTO CELULAR A TRAVES DE LAS INTERACCIONES CELULA/SUSTRATO._x000D_ HEMOS DESARROLLADO MICROFIBRAS (MFS) ELECTROCONDUCTORAS BIOFUNCIONALIZADAS PARA ESTA APLICACION. EN CULTIVOS CELULARES, LAS MFS PROMUEVEN EL CRECIENTO AXONAL Y LA MIGRACION DE PRECURSORES GLIALES DE FORMA GUIADA Y POR DISTANCIAS LARGAS. CUANDO SE IMPLANTAN EN ZONAS DE LESION MEDULAR EN RATA, LAS MFS TIENEN UNA INTEGRACION EXCELENTE CON EL TEJIDO NEURAL Y TAMBIEN PERMITEN LA MIGRACION CELULAR Y LA REGENERACION AXONAL GUIADAS A TRAVES DE LA ZONA DE LESION. EL PRESENTE PROYECTO TIENE COMO OBJETIVO INVESTIGAR SI LAS RESPUESTAS REPARATIVAS Y LOS RESULTADOS FUNCIONALES TRAS LA LESION PUEDEN MEJORARSE MEDIANTE LA APLICACION DE ESTIMULOS ELECTRICOS A TRAVES DE LAS MFS IMPLANTADAS. INICIALMENTE, LOS EXPERIMENTOS SE REALIZARAN EN RATAS CON TRANSECCION MEDULAR TORACICA COMPLETA, CON EL FIN DE DETERMINAR PARAMETROS ELECTRICOS EFICACES Y NO LESIVOS QUE INDUZCAN POTENCIALES DE ACCION EN LAS NEURONAS AXOTOMIZADAS, Y TAMBIEN ESTUDIAR SUS EFECTOS SOBRE EL CRECIMIENTO AXONAL, LA FUNCION SENSITIVA Y LA MOTRICIDAD. POSTERIORMENTE, LAS MFS SE IMPLANTARAN EN CERDOS CON HEMISECCION DE LA MEDULA ESPINAL CERVICAL, EN LOS CUALES SE REALIZARA LA ESTIMULACION CON EL PROTOCOLO QUE HAYA PRODUCIDO LAS MEJORES RESPUESTAS EN RATA. EL MODELO PORCINO PERMITIRA EVALUAR EL TRATAMIENTO PROPUESTO PARA MEJORAR LA REPARACION TISULAR Y LA RECUPERACION FUNCIONAL EN LESIONES MAS PARECIDAS A LAS DE LOS HUMANOS. UTILIZAREMOS UNA COMBINACION DE TECNICAS MODERNAS PARA LA EVALUACION ANATOMICA, FISIOLOGICA Y COMPORTAMENTAL, OBTENIENDO UNA COMPRENSION PROFUNDA DE LOS EFECTOS BIOLOGICOS DE ESTA NUEVA INTERVENCION TERAPEUTICA. _x000D_ NUESTRA EXPECTATIVA ES QUE LA ESTIMULACION A TRAVES DE LAS MFS POTENCIE POR SI MISMA LA REGENERACION AXONAL A TRAVES DE LA ZONA DAÑADA Y LA RECONEXION FUNCIONAL CON LAS NEURONAS DESINERVADAS. ADEMAS DE SU PROPIO POTENCIAL TERAPEUTICO, LAS MFS ELECTROACTIVAS SERAN UNA TECNOLOGIA QUE FACILITARA LA APLICACION EXITOSA DE LA TERAPIA CELULAR, GENICA Y FARMACOLOGICA PARA LA LM. (Spanish)
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IN HUMANS, MEDULLARY INJURY (LM) IS ACCOMPANIED BY SCARS AND CAVITIES THAT HAVE SEVERAL CENTIMETRES OF EXTENSION AND WHICH LACK GUIDANCE MECHANISMS FOR CELLS IN REGENERATION. SINCE BOTH NEURONS AND GLIAL CELLS RESPOND INTENSELY TO THE MOLECULAR COMPLEXES ANCHORED TO THE SUBSTRATE ON WHICH THEY GROW, THE MEDULLARY REPAIR COULD BE ENHANCED BY THE IMPLANTATION OF THREE-DIMENSIONAL STRUCTURES THAT PRESENT MOLECULES PROMOTING NEURAL GROWTH WITH TOPOGRAPHIC ORGANISATION IN THE AREA OF INJURY. The use of electroconductive MATERIALS to make STRUCTURE DYES will mean an ADDITIONAL AVANCE, and that these will allow the application of elECTRIC STIMULES to enable growth and AXONAL MELINIZACTION, and to control the CELULAR COMPORTATIONS OF THE CELULA/SUSTRATE INTERACTIONS._x000D_ we DEVELOPED microfibers (MFS) biofunctionalised electroconductors FOR THIS APPLICATION. IN CELL CULTURES, MFS PROMOTES AXONAL GROWTH AND MIGRATION OF GLIAL PRECURSORS IN A GUIDED MANNER AND OVER LONG DISTANCES. WHEN IMPLANTED IN AREAS OF SPINAL INJURY IN RAT, MFS HAVE EXCELLENT INTEGRATION WITH NEURAL TISSUE AND ALSO ALLOW CELL MIGRATION AND AXONAL REGENERATION GUIDED THROUGH THE INJURY ZONE. THIS PROJECT AIMS TO INVESTIGATE WHETHER REMEDIAL RESPONSES AND FUNCTIONAL RESULTS AFTER INJURY CAN BE IMPROVED THROUGH THE APPLICATION OF ELECTRIC STIMULI THROUGH THE IMPLANTED SFM. INITIALLY, THE EXPERIMENTS WILL BE PERFORMED IN RATS WITH COMPLETE THORACIC MEDULLARY TRANSECT, IN ORDER TO DETERMINE EFFECTIVE AND NON-HARMFUL ELECTRICAL PARAMETERS THAT INDUCE ACTION POTENTIALS IN AXOTOMISED NEURONS, AND ALSO STUDY THEIR EFFECTS ON AXONAL GROWTH, SENSORY FUNCTION AND MOTORITY. SUBSEQUENTLY, THE SFM WILL BE IMPLANTED IN PIGS WITH CERVICAL SPINAL CORD HEMISECTION, IN WHICH STIMULATION WITH THE PROTOCOL THAT HAS PRODUCED THE BEST RESPONSES IN RATS WILL BE PERFORMED. THE PORCINE MODEL WILL ALLOW TO EVALUATE THE PROPOSED TREATMENT TO IMPROVE TISSUE REPAIR AND FUNCTIONAL RECOVERY IN LESIONS MORE SIMILAR TO THOSE OF HUMANS. WE WILL USE A COMBINATION OF MODERN TECHNIQUES FOR THE ANATOMIC, PHYSIOLOGICAL AND BEHAVIORAL EVALUATION, OBTAINING A DEEP UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF THIS NEW THERAPEUTIC INTERVENTION. _x000D_ our EXPECTATIVE IS THAT THE STIMULATION WITH THE MFS BEFORE WHERE THE AXONAL REGENERATION WITH THE DREAMED AREA AND FUNCIONAL REconnection with NEURONS DESINERVED. IN ADDITION TO THEIR OWN THERAPEUTIC POTENTIAL, ELECTROACTIVE MFS WILL BE A TECHNOLOGY THAT WILL FACILITATE THE SUCCESSFUL APPLICATION OF CELLULAR, GENIC AND PHARMACOLOGICAL THERAPY FOR ML. (English)
13 October 2021
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Toledo
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Identifiers
SAF2015-65236-R
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