Q3189558 (Q3189558): Difference between revisions
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(Created claim: summary (P836): THE INFLAMMATORY RESPONSE PLAYS AN ESSENTIAL ROLE IN PROTECTING THE BODY AFTER AN INJURY OR INVASION BY MICROORGANISMS. THIS PROCESS SHOULD BE VERY FINELY REGULATED, OTHERWISE IT CAN CAUSE TISSUE DAMAGE, OR EVEN GENERATE AN INFLAMMATORY DISEASE. _x000D_ the INFLAMATORY ASSESSMENT A CRUCIAL PAPER TO PROMOT THE AXONAL REGENERATION IN THE NERVIOUS SYSTEM, as it has been shown to be consistent in several models of loss of the peripheric nervium. How...) |
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THE INFLAMMATORY RESPONSE PLAYS AN ESSENTIAL ROLE IN PROTECTING THE BODY AFTER AN INJURY OR INVASION BY MICROORGANISMS. THIS PROCESS SHOULD BE VERY FINELY REGULATED, OTHERWISE IT CAN CAUSE TISSUE DAMAGE, OR EVEN GENERATE AN INFLAMMATORY DISEASE. _x000D_ the INFLAMATORY ASSESSMENT A CRUCIAL PAPER TO PROMOT THE AXONAL REGENERATION IN THE NERVIOUS SYSTEM, as it has been shown to be consistent in several models of loss of the peripheric nervium. However, after the MEDULAR DAY, an ineffective control of the INFLAMATORY RESPONSE, which exacerbates the TISULAR DAMY, and DIFFICULT THE ELIMINATION OF THE MELINE IN DEGENERATION, CONTRIBUTED, the IL-37 Is a cytokin of the FAMILY OF THE IL-1 THAT HAVE UNIQUE CHARACTERISTICS, AND THAT LIKELY LIMITIES INNATED AND ADAPTATIVE INMUNITY. TRANSGENIC MICE FOR IL-37 EXHIBIT LESS SIGNS OF PATHOLOGY IN ANIMAL MODELS OF ENDOTOXAEMIA, ACUTE LUNG INJURY, CHEMICAL COLITIS, MYOCARDIAL ISCHEMIA, METABOLIC SYNDROME AND SLEEP DISORDERS. WE HAVE RECENTLY DEMONSTRATED, FOR THE FIRST TIME, THE ANTI-INFLAMMATORY AND NEUROPROTECTIVE ACTION OF THE IL-37 IN A MODEL OF SPINAL CORD CONTUSION INJURY. THIS CYTOKINE, LIKE IL-1 AND IL-33, CAN TRANSLOCATE TO THE CELL NUCLEUS TO REGULATE THE EXPRESSION OF DIFFERENT INFLAMMATORY FACTORS. THE IL-37 ALSO EXERCISES ITS ANTI-INFLAMMATORY ACTIONS THROUGH THE UNION TO THE IL-1R8 RECEPTOR. However, is unaccounted for in the current situation if the IL-37 MEDIA YOUR ANTI-INFLAMATORY AND neuroprotective actions ARE THE MEDULAR DAYS MEDIANING YOUR NUCLEAR, EXTRAcellular, OR AMBAS._x000D_ THE PRESENT PROJECT PROJECT, PROPOSES PROPOSES TO INDUCTION MEdulary LESIONS IN RATONES DEVELOPMENT OF THE RECEPTOR OF IL-37 (IL-1R8), as well as in transgenic RATONES that an IL-37 MUTED FORM (IL-37D20A), WHEN‘T, CAN’T translocate to the NUCLEO. THE USE OF THESE MICE WILL ALLOW US TO ELUCIDATE A FUNDAMENTAL QUESTION: HOW IMPORTANT IS IL-37'S NUCLEAR AND EXTRACELLULAR ACTION IN THE ANTI-INFLAMMATORY/NEUROPROTECTIVE RESPONSE OF THIS CYTOKINE IN SPINAL INJURY? IN ADDITION, WE WILL EVALUATE THE EFFECTIVENESS OF DIFFERENT RECOMBINANT PROTEINS OF IL-37 IN SPINAL TRAUMA, AS WELL AS ITS THERAPEUTIC APPLICATION WINDOW. Given that the INFLAMACTION NEGATIVELY TO THE MAYORY OF NEURODEGENERATIVE DISEASES, we will also study whether IL-37 has a Therapeutic Potential for the Treatment of Neurological Affinities, focusing on it, in AMIOTROPHICAL LATERAL SCLEROSIS._x000D_ OBTENTED RESULTS in the present project will provide new data with great scientific and CLINICAL RELEVANCY, which can pave the way for the development of a new treatment for the AGUSION OF THE SPINAL MEDULAR, as well as, for a specific enlargement of neurologic diseases, WHERE THE INFLAMACTION CONTRIBUY NEGATIVELY TO PATOLOGY, AND THAT IN THE UPDATE DEAD EFFECENT TREATMENT. (English) | |||||||||||||||
| Property / summary: THE INFLAMMATORY RESPONSE PLAYS AN ESSENTIAL ROLE IN PROTECTING THE BODY AFTER AN INJURY OR INVASION BY MICROORGANISMS. THIS PROCESS SHOULD BE VERY FINELY REGULATED, OTHERWISE IT CAN CAUSE TISSUE DAMAGE, OR EVEN GENERATE AN INFLAMMATORY DISEASE. _x000D_ the INFLAMATORY ASSESSMENT A CRUCIAL PAPER TO PROMOT THE AXONAL REGENERATION IN THE NERVIOUS SYSTEM, as it has been shown to be consistent in several models of loss of the peripheric nervium. However, after the MEDULAR DAY, an ineffective control of the INFLAMATORY RESPONSE, which exacerbates the TISULAR DAMY, and DIFFICULT THE ELIMINATION OF THE MELINE IN DEGENERATION, CONTRIBUTED, the IL-37 Is a cytokin of the FAMILY OF THE IL-1 THAT HAVE UNIQUE CHARACTERISTICS, AND THAT LIKELY LIMITIES INNATED AND ADAPTATIVE INMUNITY. TRANSGENIC MICE FOR IL-37 EXHIBIT LESS SIGNS OF PATHOLOGY IN ANIMAL MODELS OF ENDOTOXAEMIA, ACUTE LUNG INJURY, CHEMICAL COLITIS, MYOCARDIAL ISCHEMIA, METABOLIC SYNDROME AND SLEEP DISORDERS. WE HAVE RECENTLY DEMONSTRATED, FOR THE FIRST TIME, THE ANTI-INFLAMMATORY AND NEUROPROTECTIVE ACTION OF THE IL-37 IN A MODEL OF SPINAL CORD CONTUSION INJURY. THIS CYTOKINE, LIKE IL-1 AND IL-33, CAN TRANSLOCATE TO THE CELL NUCLEUS TO REGULATE THE EXPRESSION OF DIFFERENT INFLAMMATORY FACTORS. THE IL-37 ALSO EXERCISES ITS ANTI-INFLAMMATORY ACTIONS THROUGH THE UNION TO THE IL-1R8 RECEPTOR. However, is unaccounted for in the current situation if the IL-37 MEDIA YOUR ANTI-INFLAMATORY AND neuroprotective actions ARE THE MEDULAR DAYS MEDIANING YOUR NUCLEAR, EXTRAcellular, OR AMBAS._x000D_ THE PRESENT PROJECT PROJECT, PROPOSES PROPOSES TO INDUCTION MEdulary LESIONS IN RATONES DEVELOPMENT OF THE RECEPTOR OF IL-37 (IL-1R8), as well as in transgenic RATONES that an IL-37 MUTED FORM (IL-37D20A), WHEN‘T, CAN’T translocate to the NUCLEO. THE USE OF THESE MICE WILL ALLOW US TO ELUCIDATE A FUNDAMENTAL QUESTION: HOW IMPORTANT IS IL-37'S NUCLEAR AND EXTRACELLULAR ACTION IN THE ANTI-INFLAMMATORY/NEUROPROTECTIVE RESPONSE OF THIS CYTOKINE IN SPINAL INJURY? IN ADDITION, WE WILL EVALUATE THE EFFECTIVENESS OF DIFFERENT RECOMBINANT PROTEINS OF IL-37 IN SPINAL TRAUMA, AS WELL AS ITS THERAPEUTIC APPLICATION WINDOW. Given that the INFLAMACTION NEGATIVELY TO THE MAYORY OF NEURODEGENERATIVE DISEASES, we will also study whether IL-37 has a Therapeutic Potential for the Treatment of Neurological Affinities, focusing on it, in AMIOTROPHICAL LATERAL SCLEROSIS._x000D_ OBTENTED RESULTS in the present project will provide new data with great scientific and CLINICAL RELEVANCY, which can pave the way for the development of a new treatment for the AGUSION OF THE SPINAL MEDULAR, as well as, for a specific enlargement of neurologic diseases, WHERE THE INFLAMACTION CONTRIBUY NEGATIVELY TO PATOLOGY, AND THAT IN THE UPDATE DEAD EFFECENT TREATMENT. (English) / rank | |||||||||||||||
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| Property / summary: THE INFLAMMATORY RESPONSE PLAYS AN ESSENTIAL ROLE IN PROTECTING THE BODY AFTER AN INJURY OR INVASION BY MICROORGANISMS. THIS PROCESS SHOULD BE VERY FINELY REGULATED, OTHERWISE IT CAN CAUSE TISSUE DAMAGE, OR EVEN GENERATE AN INFLAMMATORY DISEASE. _x000D_ the INFLAMATORY ASSESSMENT A CRUCIAL PAPER TO PROMOT THE AXONAL REGENERATION IN THE NERVIOUS SYSTEM, as it has been shown to be consistent in several models of loss of the peripheric nervium. However, after the MEDULAR DAY, an ineffective control of the INFLAMATORY RESPONSE, which exacerbates the TISULAR DAMY, and DIFFICULT THE ELIMINATION OF THE MELINE IN DEGENERATION, CONTRIBUTED, the IL-37 Is a cytokin of the FAMILY OF THE IL-1 THAT HAVE UNIQUE CHARACTERISTICS, AND THAT LIKELY LIMITIES INNATED AND ADAPTATIVE INMUNITY. TRANSGENIC MICE FOR IL-37 EXHIBIT LESS SIGNS OF PATHOLOGY IN ANIMAL MODELS OF ENDOTOXAEMIA, ACUTE LUNG INJURY, CHEMICAL COLITIS, MYOCARDIAL ISCHEMIA, METABOLIC SYNDROME AND SLEEP DISORDERS. WE HAVE RECENTLY DEMONSTRATED, FOR THE FIRST TIME, THE ANTI-INFLAMMATORY AND NEUROPROTECTIVE ACTION OF THE IL-37 IN A MODEL OF SPINAL CORD CONTUSION INJURY. THIS CYTOKINE, LIKE IL-1 AND IL-33, CAN TRANSLOCATE TO THE CELL NUCLEUS TO REGULATE THE EXPRESSION OF DIFFERENT INFLAMMATORY FACTORS. THE IL-37 ALSO EXERCISES ITS ANTI-INFLAMMATORY ACTIONS THROUGH THE UNION TO THE IL-1R8 RECEPTOR. However, is unaccounted for in the current situation if the IL-37 MEDIA YOUR ANTI-INFLAMATORY AND neuroprotective actions ARE THE MEDULAR DAYS MEDIANING YOUR NUCLEAR, EXTRAcellular, OR AMBAS._x000D_ THE PRESENT PROJECT PROJECT, PROPOSES PROPOSES TO INDUCTION MEdulary LESIONS IN RATONES DEVELOPMENT OF THE RECEPTOR OF IL-37 (IL-1R8), as well as in transgenic RATONES that an IL-37 MUTED FORM (IL-37D20A), WHEN‘T, CAN’T translocate to the NUCLEO. THE USE OF THESE MICE WILL ALLOW US TO ELUCIDATE A FUNDAMENTAL QUESTION: HOW IMPORTANT IS IL-37'S NUCLEAR AND EXTRACELLULAR ACTION IN THE ANTI-INFLAMMATORY/NEUROPROTECTIVE RESPONSE OF THIS CYTOKINE IN SPINAL INJURY? IN ADDITION, WE WILL EVALUATE THE EFFECTIVENESS OF DIFFERENT RECOMBINANT PROTEINS OF IL-37 IN SPINAL TRAUMA, AS WELL AS ITS THERAPEUTIC APPLICATION WINDOW. Given that the INFLAMACTION NEGATIVELY TO THE MAYORY OF NEURODEGENERATIVE DISEASES, we will also study whether IL-37 has a Therapeutic Potential for the Treatment of Neurological Affinities, focusing on it, in AMIOTROPHICAL LATERAL SCLEROSIS._x000D_ OBTENTED RESULTS in the present project will provide new data with great scientific and CLINICAL RELEVANCY, which can pave the way for the development of a new treatment for the AGUSION OF THE SPINAL MEDULAR, as well as, for a specific enlargement of neurologic diseases, WHERE THE INFLAMACTION CONTRIBUY NEGATIVELY TO PATOLOGY, AND THAT IN THE UPDATE DEAD EFFECENT TREATMENT. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 21:56, 12 October 2021
Project Q3189558 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3189558 in Spain |
Statements
96,800.0 Euro
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193,600.0 Euro
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50.0 percent
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30 December 2016
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29 December 2020
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UNIVERSIDAD AUTONOMA DE BARCELONA
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41°29'27.71"N, 2°8'15.00"E
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08266
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LA RESPUESTA INFLAMATORIA JUEGA UN PAPEL ESENCIAL PARA LA PROTECCION DEL ORGANISMO TRAS UNA LA LESION O INVASION POR MICROORGANISMOS. ESTE PROCESO SE DEBE REGULAR MUY FINAMENTE, DE LO CONTRARIO, PUEDE OCASIONAR DAÑOS EN LOS TEJIDOS, O INCLUSO, GENERAR UNA ENFERMEDAD INFLAMATORIA. _x000D_ LA RESPUESTA INFLAMATORIA JUEGA UN PAPEL CRUCIAL PARA PROMOVER LA REGENERACION AXONAL EN EL SISTEMA NERVIOSO, COMO SE HA MOSTRADO DE FORMA CONSISTENTE EN VARIOS MODELOS DE LESION DEL NERVIO PERIFERICO. SIN EMBARGO, TRAS EL DAÑO MEDULAR, SE PRODUCE UN CONTROL INEFICAZ DE LA RESPUESTA INFLAMATORIA, LO QUE EXACERBA EL DAÑO TISULAR, Y DIFICULTA LA ELIMINACION EFICAZ LA MIELINA EN DEGENERACION, CONTRIBUYENDO ASI, A LA AUSENCIA DE LA REGENERACION AXONAL._x000D_ LA IL-37 ES UNA CITOCINA DE LA FAMILIA DE LA IL-1 QUE TIENE CARACTERISTICAS UNICAS, YA QUE LIMITA MARCADAMENTE LA INMUNIDAD INNATA Y ADAPTATIVA. LOS RATONES TRANSGENICOS PARA IL-37 EXHIBEN MENOR SIGNOS DE PATOLOGIA EN MODELOS ANIMALES DE ENDOTOXEMIA, LESION PULMONAR AGUDA, COLITIS QUIMICA, ISQUEMIA DE MIOCARDIO, SINDROME METABOLICO Y TRASTORNOS DEL SUEÑO. RECIENTEMENTE HEMOS DEMOSTRADO, POR PRIMERA VEZ, LA ACCION ANTI-INFLAMATORIA Y NEUROPROTECTORA DE LA IL-37 EN UN MODELO DE LESION POR CONTUSION DE LA MEDULA ESPINAL. ESTA CITOCINA, IGUAL QUE LA IL-1 E IL-33, PUEDE TRANSLOCAR AL NUCLEO CELULAR PARA REGULAR LA EXPRESION DE DIFERENTES FACTORES INFLAMATORIOS. LA IL-37 TAMBIEN EJERCE SUS ACCIONES ANTI-INFLAMATORIAS MEDIANTE LA UNION AL RECEPTOR IL-1R8. SIN EMBARGO, SE DESCONOCE EN LA ACTUALIDAD SI LA IL-37 MEDIA SUS ACCIONES ANTI-INFLAMATORIAS Y NEUROPROTECTORAS TRAS EL DAÑO MEDULAR MEDIANTE SU ACCION NUCLEAR, EXTRACELULAR, O AMBAS._x000D_ EL PRESENTE PROYECTO, PROPONE INDUCIR LESIONES MEDULARES EN RATONES QUE CARECEN DEL RECEPTOR DE LA IL-37 (IL-1R8), ASI COMO EN RATONES TRANSGENICOS QUE LA EXPRESAN UNA FORMA MUTADA DE IL-37 (IL-37D20A), LA CUAL, NO PUEDE TRANSLOCAR AL NUCLEO. EL USO DE ESTOS RATONES NOS PERMITIRA ELUCIDAR UNA CUESTION FUNDAMENTAL: ¿QUE IMPORTANCIA TIENE LA ACCION NUCLEAR Y EXTRACELULAR DE LA IL-37 EN LA RESPUESTA ANTI-INFLAMATORIA/NEUROPROTECTORA DE ESTA CITOCINA EN LA LESION MEDULAR? ADEMAS, EVALUAREMOS LA EFECTIVIDAD DE DISTINTAS PROTEINAS RECOMBINANTES DE IL-37 EN EL TRAUMATISMO MEDULAR, ASI COMO SU VENTANA DE APLICACION TERAPEUTICA. DADO QUE LA INFLAMACION CONTRIBUYE NEGATIVAMENTE A LA MAYORIA DE ENFERMEDADES NEURODEGENERATIVAS, TAMBIEN ESTUDIAREMOS SI IL-37 TIENE UN POTENCIAL TERAPEUTICO PARA EL TRATAMIENTO DE TALES AFECCIONES NEUROLOGICAS, CENTRANDONOS PARA ELLO, EN LA ESCLEROSIS LATERAL AMIOTROFICA._x000D_ LOS RESULTADOS OBTENIDOS EN EL PRESENTE PROYECTO PROPORCIONARAN NUEVOS DATOS CON GRAN RELEVANCIA CIENTIFICA Y CLINICA, QUE PUEDEN ALLANAR EL CAMINO PARA EL DESARROLLO DE UN NUEVO TRATAMIENTO PARA LA LESION AGUDA DE LA MEDULAR ESPINAL, ASI COMO, PARA UN AMPLIO ESPECTRO DE ENFERMEDADES NEUROLOGICAS, DONDE LA INFLAMACION CONTRIBUYE NEGATIVAMENTE A LA PATOLOGIA, Y QUE EN LA ACTUALIDAD CARECEN TRATAMIENTO EFICAZ. (Spanish)
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THE INFLAMMATORY RESPONSE PLAYS AN ESSENTIAL ROLE IN PROTECTING THE BODY AFTER AN INJURY OR INVASION BY MICROORGANISMS. THIS PROCESS SHOULD BE VERY FINELY REGULATED, OTHERWISE IT CAN CAUSE TISSUE DAMAGE, OR EVEN GENERATE AN INFLAMMATORY DISEASE. _x000D_ the INFLAMATORY ASSESSMENT A CRUCIAL PAPER TO PROMOT THE AXONAL REGENERATION IN THE NERVIOUS SYSTEM, as it has been shown to be consistent in several models of loss of the peripheric nervium. However, after the MEDULAR DAY, an ineffective control of the INFLAMATORY RESPONSE, which exacerbates the TISULAR DAMY, and DIFFICULT THE ELIMINATION OF THE MELINE IN DEGENERATION, CONTRIBUTED, the IL-37 Is a cytokin of the FAMILY OF THE IL-1 THAT HAVE UNIQUE CHARACTERISTICS, AND THAT LIKELY LIMITIES INNATED AND ADAPTATIVE INMUNITY. TRANSGENIC MICE FOR IL-37 EXHIBIT LESS SIGNS OF PATHOLOGY IN ANIMAL MODELS OF ENDOTOXAEMIA, ACUTE LUNG INJURY, CHEMICAL COLITIS, MYOCARDIAL ISCHEMIA, METABOLIC SYNDROME AND SLEEP DISORDERS. WE HAVE RECENTLY DEMONSTRATED, FOR THE FIRST TIME, THE ANTI-INFLAMMATORY AND NEUROPROTECTIVE ACTION OF THE IL-37 IN A MODEL OF SPINAL CORD CONTUSION INJURY. THIS CYTOKINE, LIKE IL-1 AND IL-33, CAN TRANSLOCATE TO THE CELL NUCLEUS TO REGULATE THE EXPRESSION OF DIFFERENT INFLAMMATORY FACTORS. THE IL-37 ALSO EXERCISES ITS ANTI-INFLAMMATORY ACTIONS THROUGH THE UNION TO THE IL-1R8 RECEPTOR. However, is unaccounted for in the current situation if the IL-37 MEDIA YOUR ANTI-INFLAMATORY AND neuroprotective actions ARE THE MEDULAR DAYS MEDIANING YOUR NUCLEAR, EXTRAcellular, OR AMBAS._x000D_ THE PRESENT PROJECT PROJECT, PROPOSES PROPOSES TO INDUCTION MEdulary LESIONS IN RATONES DEVELOPMENT OF THE RECEPTOR OF IL-37 (IL-1R8), as well as in transgenic RATONES that an IL-37 MUTED FORM (IL-37D20A), WHEN‘T, CAN’T translocate to the NUCLEO. THE USE OF THESE MICE WILL ALLOW US TO ELUCIDATE A FUNDAMENTAL QUESTION: HOW IMPORTANT IS IL-37'S NUCLEAR AND EXTRACELLULAR ACTION IN THE ANTI-INFLAMMATORY/NEUROPROTECTIVE RESPONSE OF THIS CYTOKINE IN SPINAL INJURY? IN ADDITION, WE WILL EVALUATE THE EFFECTIVENESS OF DIFFERENT RECOMBINANT PROTEINS OF IL-37 IN SPINAL TRAUMA, AS WELL AS ITS THERAPEUTIC APPLICATION WINDOW. Given that the INFLAMACTION NEGATIVELY TO THE MAYORY OF NEURODEGENERATIVE DISEASES, we will also study whether IL-37 has a Therapeutic Potential for the Treatment of Neurological Affinities, focusing on it, in AMIOTROPHICAL LATERAL SCLEROSIS._x000D_ OBTENTED RESULTS in the present project will provide new data with great scientific and CLINICAL RELEVANCY, which can pave the way for the development of a new treatment for the AGUSION OF THE SPINAL MEDULAR, as well as, for a specific enlargement of neurologic diseases, WHERE THE INFLAMACTION CONTRIBUY NEGATIVELY TO PATOLOGY, AND THAT IN THE UPDATE DEAD EFFECENT TREATMENT. (English)
12 October 2021
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Cerdanyola del Vallès
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Identifiers
SAF2016-79774-R
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