DESIGN, SYNTHESIS AND NANOFORMATION OF SMALL MOLECULES AND METAL COMPLEXES WITH ACTIVITY AGAINST KINETOPLASTIDES. SEARCH FOR THERAPEUTIC TARGETS AND MECHANISMS OF ACTION (Q3191194): Difference between revisions
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(Created claim: summary (P836): KINETOCHEM (HTTP://WWW.UV.ES/~SUPRAMOL/KINETOCHEM) IS A COORDINATED PROJECT THAT COMBINES EXPERTS IN CHEMISTRY, PHARMACEUTICAL TECHNOLOGY AND PARASITOLOGY FROM THE UNIVERSITIES OF VALENCIA (QSM-UV, GHC-UV), GRANADA (BIOKIN-UGR) AND THE INSTITUTE OF TROPICAL HEALTH OF THE UNIVERSITY OF NAVARRA (QMC-UNAV, NONOGUN-UNAV AND NOTTA-UNAV). KINETOCHEM WILL FOCUS ITS RESEARCH ON NEW AND BETTER ORAL THERAPIES FOR THE TREATMENT OF LEISHMANIASIS AND CHAGAS...) |
(Changed label, description and/or aliases in en: translated_label) |
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DESIGN, SYNTHESIS AND NANOFORMATION OF SMALL MOLECULES AND METAL COMPLEXES WITH ACTIVITY AGAINST KINETOPLASTIDES. SEARCH FOR THERAPEUTIC TARGETS AND MECHANISMS OF ACTION | |||
Revision as of 21:44, 12 October 2021
Project Q3191194 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | DESIGN, SYNTHESIS AND NANOFORMATION OF SMALL MOLECULES AND METAL COMPLEXES WITH ACTIVITY AGAINST KINETOPLASTIDES. SEARCH FOR THERAPEUTIC TARGETS AND MECHANISMS OF ACTION |
Project Q3191194 in Spain |
Statements
92,565.0 Euro
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185,130.0 Euro
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50.0 percent
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30 December 2016
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29 December 2020
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UNIVERSIDAD DE VALENCIA
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39°30'14.11"N, 0°26'31.56"W
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46190
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KINETOCHEM (HTTP://WWW.UV.ES/~SUPRAMOL/KINETOCHEM) ES UN PROYECTO COORDINADO QUE COMBINA EXPERTOS EN QUIMICA, TECNOLOGIA FARMACEUTICA Y PARASITOLOGIA DE LAS UNIVERSIDADES DE VALENCIA (QSM-UV, GHC-UV), GRANADA (BIOKIN-UGR) Y DEL INSTITUTO DE SALUD TROPICAL DE LA UNIVERSIDAD DE NAVARRA (QMC-UNAV, NONOGUN-UNAV Y NOTTA-UNAV). KINETOCHEM CENTRARA SU INVESTIGACION EN NUEVAS Y MEJORES TERAPIAS ORALES PARA EL TRATAMIENTO DE LA LEISHMANIASIS Y LA ENFERMEDAD DE CHAGAS. LA INVESTIGACION CUBRIRA TODAS LAS ETAPAS DEL DESARROLLO DE UN FARMACO DESDE LA SINTESIS DE LOS COMPUESTOS HASTA LA FASE PRECLINICA. KINETOCHEM SE OCUPA AREAS DE INVESTIGACION DESTACADAS EN LAS POLITICAS NACIONALES Y EUROPEAS COMO SON: LA APLICACION DE LA NANOTECNOLOGIA PARA EL TRATAMIENTO DE ENFERMEDADES (1.3) Y EL DESARROLLO DE NUEVAS MOLECULAS COMO ARMAS TERAPEUTICAS EN LAS PATOLOGIAS DE ALTA PREVALENCIA EPIDEMIOLOGICA (1.4)._x000D_ COLABORACIONES PREVIAS DE LOS GRUPOS DE KINETOCHEM HAN IDENTIFICADO COMPUESTOS CON ACTIVIDAD PROMETEDORA FRENTE A KINETOPLASTIDOS, QUE SERVIRAN COMO PUNTO DE PARTIDA DEL PROYECTO:_x000D_ O1. SINTESIS DE FAMILIAS DE MOLECULAS ORGANICAS ABIOTICAS (QSM-UV, GMC-UNAV, GHC-UV) QUE CONTENDRAN GENERALMENTE ATOMOS DADORES DE NITROGENO Y PERTENECERAN A LAS CATEGORIAS DE POLIAMINAS, SULFONAMIDAS, TRIAZOLOPIRIDINAS ASI COMO DERIVADOS DE FERROCENO Y COMPUESTOS DE SELENIO _x000D_ O2. ESTUDIO DE LAS PROPIEDADES ACIDO-BASE Y DE LA QUIMICA COORDINACION FRENTE A LOS IONES METALICOS CUI/CUII, ZNII, MNII/ MNIII AND FEII/FEIII (QSM-UV, GHC-UV) QUE PARTICIPAN EN LOS MECANISMOS DE DEFENSA DEL HOSPEDADOR Y DEL PARASITO_x000D_ O3. INTERACCION CON MOLECULAS BIOLOGICAS (QSM-UV, GHC-UV) COMO ANIONES FOSFATO, NUCLEOTIDOS Y ACIDOS NUCLEICOS. SE ANALIZARA TAMBIEN SU ACTIVIDAD COMO NUCLEASAS ABIOTICAS ASI COMO SU POSIBLE ACTUACION FRENTE AL ESTRES OXIDATIVO. _x000D_ O4. ACTIVIDAD/TOXICIDAD DE LAS MOLECULAS ORGANICAS Y COMPLEJOS FRENTE A LAS ENFERMEDADES DE CHAGAS Y A LA LEISHMANIASIS. (GMC-UNAV, BIOKIN-UGR, NANOGUN-UNAV, NOTTA-UNAV) IN VITRO CON CELULAS VERO (T. CRUZI) O CON MACROFAGOS (LEISHMANIA SPP.) E IN VIVO EN MODELO MURINO, EN EL CASO DE T. CRUZI, SE ANALIZARA TANTO LA FASE AGUDA COMO LA CRONICA. SE ANALIZARAN LOS CAMBIOS METABOLICOS POR 1H NMR, MODIFICACIONES ULTRAESTRUCTURALES POR TEM, ETC. SE ESTUDIARA TAMBIEN LA INTERACCION CON BIOMACROMOLECULADS. SE IDENTIFICARAN COMPUESTOS CABEZA DE SERIE_x000D_ O5. APLICACION DE NUEVAS ESTRATEGIAS DE FORMULACION (NANOTECNOLOGIA). (NANOGUN-UNAV), MAS ESPECIFICAMENTE, NANOPARTICULAS (NPS) PENETRANTES DE MUCUS/BIOADHESIVAS COMO ESTRATEGIA PARA: (I) ADMINISTRACION ORAL DE FARMACOS DE USO CORRIENTE FRENTE A KINETOPLASTIDOS QUE ACTUALMENTE SON ADMINISTRADOS MEDIANTE INYECCION (II) RESCATE DE COMPUESTOS SINTETIZADOS POR OTROS GRUPOS DE KINETOCHEM QUE PRESENTEN ALTA EFICACIA IN VITRO PERO DESCARTADOS POR TENER PROPIEDADES ADMET NO ADECUADAS. SE ANALIZARA LA INFLUENCIA DE LA INFECCION DE KINETOPLASTIDOS EN EL COMPORTAMIENTO BIOLOGICO DE LAS NPS A NIVEL CELULAR Y CORPORAL (TECNICAS DE IMAGEN). _x000D_ O6. ANALISIS DE DIANAS TERAPEUTICAS. CARACTERIZACION INMUNOLOGICA Y ANALISIS DEL FENOTIPO INMUNE (NOTTA-UNAV) SE EXPLORARA EL PERFIL DE LAS CELULAS CITOTOXICAS INVOLUCRADAS EN ACTIVAR MECANISMOS INMUNOLOGICOS Y PUEDAN CONDUCIR BIEN A LA CURACION O EL PROGRESO DE LA ENFERMEDAD DESPUES DEL TRATAMIENTO_x000D_ GO7.- ESTUDIOS TEORICOS (QSM-UV, GMC-UNAV, GHC-UV, BIOKIN-UGR) PARA OBTENER INFORMACION SOBRE RELACION ESTRUCTURA/ACTIVIDAD, ENTENDER MECANISMOS DE ACTUACION Y REDISEÑO DE COMPUESTOS. (Spanish)
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KINETOCHEM (HTTP://WWW.UV.ES/~SUPRAMOL/KINETOCHEM) IS A COORDINATED PROJECT THAT COMBINES EXPERTS IN CHEMISTRY, PHARMACEUTICAL TECHNOLOGY AND PARASITOLOGY FROM THE UNIVERSITIES OF VALENCIA (QSM-UV, GHC-UV), GRANADA (BIOKIN-UGR) AND THE INSTITUTE OF TROPICAL HEALTH OF THE UNIVERSITY OF NAVARRA (QMC-UNAV, NONOGUN-UNAV AND NOTTA-UNAV). KINETOCHEM WILL FOCUS ITS RESEARCH ON NEW AND BETTER ORAL THERAPIES FOR THE TREATMENT OF LEISHMANIASIS AND CHAGAS DISEASE. THE INVESTIGATION WILL COVER ALL STAGES OF THE DEVELOPMENT OF A PHARMACO FROM THE SYNTHESIS OF THE COMPOUNDS TO THE PRECLINIC PHASE. KINETOCHEM DEALS WITH AREAS OF RESEARCH HIGHLIGHTED IN NATIONAL AND EUROPEAN POLICIES SUCH AS: The application of NANOTECHNOLOGY for the treatment of diseases (1.3) and the development of new ones molecules as terrapeutic arms in high-profile EPIDEMIOLOGICAL PATOLOGIAS (1.4)._x000D_ PREVIED COLABORATIONS OF KINETOCHEM GROUPS have been identified with kinetoplastted protein-producing activity, that they will serve as part of the project:_x000D_ O1. Synthesis OF Abiotic ORGANIC Molecules FAMILYS (QSM-UV, GMC-UNAV, GHC-UV) that contain GENERALLY ATOMES NITROGEN DADORS AND belong to the CATEGORIAS OF POLIMINAS, sulfonamides, TRIAZOLOPIRIDINS as well as ferrocene and SELENIO COMPUESTS _x000D_ O2. Study of the ACIDO-BASE PROPERTY AND THE CHEMICAL COORDINATION FENT TO THE METALIC IONES CUI/Cuii, ZNII, MNII/MnIII AND FEII/FEIII (QSM-UV, GHC-UV) that take place in the defence mechanisms of the host and of the parasito_x000D_ O3. INTERACTION WITH BIOLOGICAL MOLECULES (QSM-UV, GHC-UV) SUCH AS PHOSPHATE ANIONS, NUCLEOTIDES AND NUCLEIC ACIDS. IT WILL ALSO ANALYSE ITS ACTIVITY AS ABIOTIC NUCLEASES AS WELL AS ITS POSSIBLE ACTION AGAINST OXIDATIVE STRESS. _x000D_ O4. ACTIVITY/TOXICITY OF ORGANIC AND COMPLEX MOLECULES AGAINST CHAGAS DISEASES AND LEISHMANIASIS. (GMC-UNAV, BIOKIN-UGR, NANOGUN-UNAV, NOTTA-UNAV) IN VITRO WITH VERO CELLS (T. CRUZI) OR MACROPHAGES (LEISHMANIA SPP.) AND IN VIVO IN MURINO MODEL, IN THE CASE OF T. CRUZI, BOTH THE ACUTE PHASE AND THE CHRONIC PHASE WILL BE ANALYSED. THE METABOLIC CHANGES BY 1H NMR, ULTRASTRUCTURAL MODIFICATIONS BY TEM, ETC. WILL ALSO BE STUDIED THE INTERACTION WITH BIOMACROMOLECULADS. We will identify COMPUESTOS DE SEERIE_x000D_ O5. APPLICATION OF NEW FORMULATION STRATEGIES (NANOTECNOLOGY). (NANOGUN-UNAV), MORE SPECIFICALLY, MUCUS/BIOADHESIVAS PENETRATING NANOPARTICULA (NPS) AS A STRATEGY FOR: (I) ORAL ADMINISTRATION OF COMMONLY USED DRUGS AGAINST KINETOPLASTIDES THAT ARE CURRENTLY ADMINISTERED BY INJECTION (II) RESCUE COMPOUNDS SYNTHESISED BY OTHER KINETOCHEM GROUPS THAT ARE HIGHLY EFFECTIVE IN VITRO BUT RULED OUT BECAUSE THEY HAVE INAPPROPRIATE ADMET PROPERTIES. THE INFLUENCE OF KINETOPLASTIDE INFECTION ON THE BIOLOGICAL BEHAVIOR OF PSCS AT THE CELLULAR AND BODY LEVEL (IMAGE TECHNIQUES) WILL BE ANALYSED. _x000D_ O6. ANALYSIS OF THERAPEUTIC TARGETS. Immunological Characterisation and Analyses of the INMUNE FENOTYPE (Notta-UNAV) PROFILE of cytotoxic CELLS INVOLUCRED IN ACTING immunological mechanisms AND CAN DUCK WORK TO CURACION OR PROGRESS OF DISEASE OF TREATMENT_x000D_ GO7.- TEORIC STUDIES (QSM-UV, GMC-UNAV, GHC-UV, BIOKIN-UGR) FOR INFORMATION ON STRUCTURE RELATION/ACTIVITY, BUYING MECHANISMS OF ACTUATION AND REDISEGNATION OF COMPOSES. (English)
12 October 2021
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Paterna
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Identifiers
CTQ2016-78499-C6-1-R
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