Q3192866 (Q3192866): Difference between revisions
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(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): THIS SUBPROJECT (3) FOCUSES ON THE DESIGN OF HIGH SURFACE SOLIDS AND POROSITY AS SUPPORTS FOR THE DESIGN AND CONSTRUCTION OF TERANOSTIC MATERIALS (WHICH COMBINE CAPACITIES IN THERAPY AND DIAGNOSTIC AREAS). THE BASIC STRUCTURE OF THE SUPPORTS IS OF A SILICEA NATURE AND POROSITY IS ACHIEVED BY THE USE OF SURFACTANT MICELLES AS POROGENOS AGENTS. SYNTHESIS PROTOCOLS WILL BE OPTIMISED FROM USUAL REAGENTS (SUCH AS TEOS) AT LABORATORY LEVEL AND ALSO FR...) |
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THIS SUBPROJECT (3) FOCUSES ON THE DESIGN OF HIGH SURFACE SOLIDS AND POROSITY AS SUPPORTS FOR THE DESIGN AND CONSTRUCTION OF TERANOSTIC MATERIALS (WHICH COMBINE CAPACITIES IN THERAPY AND DIAGNOSTIC AREAS). THE BASIC STRUCTURE OF THE SUPPORTS IS OF A SILICEA NATURE AND POROSITY IS ACHIEVED BY THE USE OF SURFACTANT MICELLES AS POROGENOS AGENTS. SYNTHESIS PROTOCOLS WILL BE OPTIMISED FROM USUAL REAGENTS (SUCH AS TEOS) AT LABORATORY LEVEL AND ALSO FROM LOW-COST SILICON SOURCES (SUCH AS SODIUM SILICATE). AMONG THE DESIRED MORPHOLOGIES STAND OUT UNIMODALE MATERIALS WITH LARGE PORES AS WELL AS BI OR MULTIMODAL ORGANISATIONS INCLUDING TOPOLOGIAS TYPE NUCLEO-LAYER OR HOLLOW-LAYER. PARAMETERS SUCH AS THE DISPERSABILITY AND CHEMICAL STABILITY OF THE OBTAINED PARTICLES (ESSENTIAL ASPECTS FOR USE IN BIOMEDICAL APPLICATIONS) WILL ALSO BE OPTIMISED. THE ACCESSIBILITY OF PORE SYSTEMS SHALL BE STUDIED THROUGH THE USE OF MODEL MOLECULES OF DIFFERENT PHARMACO SIZE AND/OR ENZYMES) WITH THE AIM OF ASSESSING THE LOAD CAPACITY (IMPORTANT FOR CONTROLLED DRUG SUPPLY APPLICATIONS). THESE STUDIES WILL INCLUDE CINETICAL ANALYSES OF LOADING AND ELIMINATION PROCESSES. IN ORDER TO INCLUDE TOOLS FOR DIAGNOSIS, SILICEOUS MATERIALS WITH DIFFERENT SPECIES, MAINLY OF INORGANIC NATURE, ARE FUNCIONALISED: GOLD NANOPARTICULATES, OXIDES OF ELEMENTS SUCH AS GADOLINIUM, MANGANESE AND IRON, AND MIXED OXIDES CONTAINING RARE EARTHS (WITH LUMINESCENT PROPERTIES AND ENERGY CONVERTERS). THE INCORPORATION OF THESE PARTICLES WILL ALLOW TO ADAPT OUR POROUS COMPOSITES FOR USE IN BIOIMAGE TECHNIQUES. THE EFFECT OF THE CONCENTRATION AND SIZE OF THESE SPECIES WILL BE STUDIED AND THE PREPARATION AND INCLUSION PROCEDURES ON SILICAS WILL BE OPTIMISED. IMAGING TECHNIQUES INCLUDE RMI, A FIELD IN WHICH EX VIVO AND IN-VIVO TRIALS WERE CARRIED OUT IN CELL CULTURES AND WISTAR RATS WITH THE PARTICIPATION OF STAFF FROM THE VALENCIA CLINICAL HOSPITAL. THE POROUS SUPPORTS OBTAINED WILL BE ADAPTED FOR APPLICATIONS AND TASKS OF SUBPROJECTS 1 AND 2, WHICH WOULD IMPLY AN ADDITIONAL MODIFICATION/FUNCTIONALISATION FOR THE INCORPORATION OF DIFFERENT DOOR-MOLECULAR ENTITIES THAT WOULD PROVIDE THE FINAL MATERIALS WITH PROPERTIES OF INTEREST IN SUPPLY APPLICATIONS AND/OR DETECTION OF SPECIES OF INTEREST IN THE BIOMEDICAL AREA. (English) | |||||||||||||||
| Property / summary: THIS SUBPROJECT (3) FOCUSES ON THE DESIGN OF HIGH SURFACE SOLIDS AND POROSITY AS SUPPORTS FOR THE DESIGN AND CONSTRUCTION OF TERANOSTIC MATERIALS (WHICH COMBINE CAPACITIES IN THERAPY AND DIAGNOSTIC AREAS). THE BASIC STRUCTURE OF THE SUPPORTS IS OF A SILICEA NATURE AND POROSITY IS ACHIEVED BY THE USE OF SURFACTANT MICELLES AS POROGENOS AGENTS. SYNTHESIS PROTOCOLS WILL BE OPTIMISED FROM USUAL REAGENTS (SUCH AS TEOS) AT LABORATORY LEVEL AND ALSO FROM LOW-COST SILICON SOURCES (SUCH AS SODIUM SILICATE). AMONG THE DESIRED MORPHOLOGIES STAND OUT UNIMODALE MATERIALS WITH LARGE PORES AS WELL AS BI OR MULTIMODAL ORGANISATIONS INCLUDING TOPOLOGIAS TYPE NUCLEO-LAYER OR HOLLOW-LAYER. PARAMETERS SUCH AS THE DISPERSABILITY AND CHEMICAL STABILITY OF THE OBTAINED PARTICLES (ESSENTIAL ASPECTS FOR USE IN BIOMEDICAL APPLICATIONS) WILL ALSO BE OPTIMISED. THE ACCESSIBILITY OF PORE SYSTEMS SHALL BE STUDIED THROUGH THE USE OF MODEL MOLECULES OF DIFFERENT PHARMACO SIZE AND/OR ENZYMES) WITH THE AIM OF ASSESSING THE LOAD CAPACITY (IMPORTANT FOR CONTROLLED DRUG SUPPLY APPLICATIONS). THESE STUDIES WILL INCLUDE CINETICAL ANALYSES OF LOADING AND ELIMINATION PROCESSES. IN ORDER TO INCLUDE TOOLS FOR DIAGNOSIS, SILICEOUS MATERIALS WITH DIFFERENT SPECIES, MAINLY OF INORGANIC NATURE, ARE FUNCIONALISED: GOLD NANOPARTICULATES, OXIDES OF ELEMENTS SUCH AS GADOLINIUM, MANGANESE AND IRON, AND MIXED OXIDES CONTAINING RARE EARTHS (WITH LUMINESCENT PROPERTIES AND ENERGY CONVERTERS). THE INCORPORATION OF THESE PARTICLES WILL ALLOW TO ADAPT OUR POROUS COMPOSITES FOR USE IN BIOIMAGE TECHNIQUES. THE EFFECT OF THE CONCENTRATION AND SIZE OF THESE SPECIES WILL BE STUDIED AND THE PREPARATION AND INCLUSION PROCEDURES ON SILICAS WILL BE OPTIMISED. IMAGING TECHNIQUES INCLUDE RMI, A FIELD IN WHICH EX VIVO AND IN-VIVO TRIALS WERE CARRIED OUT IN CELL CULTURES AND WISTAR RATS WITH THE PARTICIPATION OF STAFF FROM THE VALENCIA CLINICAL HOSPITAL. THE POROUS SUPPORTS OBTAINED WILL BE ADAPTED FOR APPLICATIONS AND TASKS OF SUBPROJECTS 1 AND 2, WHICH WOULD IMPLY AN ADDITIONAL MODIFICATION/FUNCTIONALISATION FOR THE INCORPORATION OF DIFFERENT DOOR-MOLECULAR ENTITIES THAT WOULD PROVIDE THE FINAL MATERIALS WITH PROPERTIES OF INTEREST IN SUPPLY APPLICATIONS AND/OR DETECTION OF SPECIES OF INTEREST IN THE BIOMEDICAL AREA. (English) / rank | |||||||||||||||
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| Property / summary: THIS SUBPROJECT (3) FOCUSES ON THE DESIGN OF HIGH SURFACE SOLIDS AND POROSITY AS SUPPORTS FOR THE DESIGN AND CONSTRUCTION OF TERANOSTIC MATERIALS (WHICH COMBINE CAPACITIES IN THERAPY AND DIAGNOSTIC AREAS). THE BASIC STRUCTURE OF THE SUPPORTS IS OF A SILICEA NATURE AND POROSITY IS ACHIEVED BY THE USE OF SURFACTANT MICELLES AS POROGENOS AGENTS. SYNTHESIS PROTOCOLS WILL BE OPTIMISED FROM USUAL REAGENTS (SUCH AS TEOS) AT LABORATORY LEVEL AND ALSO FROM LOW-COST SILICON SOURCES (SUCH AS SODIUM SILICATE). AMONG THE DESIRED MORPHOLOGIES STAND OUT UNIMODALE MATERIALS WITH LARGE PORES AS WELL AS BI OR MULTIMODAL ORGANISATIONS INCLUDING TOPOLOGIAS TYPE NUCLEO-LAYER OR HOLLOW-LAYER. PARAMETERS SUCH AS THE DISPERSABILITY AND CHEMICAL STABILITY OF THE OBTAINED PARTICLES (ESSENTIAL ASPECTS FOR USE IN BIOMEDICAL APPLICATIONS) WILL ALSO BE OPTIMISED. THE ACCESSIBILITY OF PORE SYSTEMS SHALL BE STUDIED THROUGH THE USE OF MODEL MOLECULES OF DIFFERENT PHARMACO SIZE AND/OR ENZYMES) WITH THE AIM OF ASSESSING THE LOAD CAPACITY (IMPORTANT FOR CONTROLLED DRUG SUPPLY APPLICATIONS). THESE STUDIES WILL INCLUDE CINETICAL ANALYSES OF LOADING AND ELIMINATION PROCESSES. IN ORDER TO INCLUDE TOOLS FOR DIAGNOSIS, SILICEOUS MATERIALS WITH DIFFERENT SPECIES, MAINLY OF INORGANIC NATURE, ARE FUNCIONALISED: GOLD NANOPARTICULATES, OXIDES OF ELEMENTS SUCH AS GADOLINIUM, MANGANESE AND IRON, AND MIXED OXIDES CONTAINING RARE EARTHS (WITH LUMINESCENT PROPERTIES AND ENERGY CONVERTERS). THE INCORPORATION OF THESE PARTICLES WILL ALLOW TO ADAPT OUR POROUS COMPOSITES FOR USE IN BIOIMAGE TECHNIQUES. THE EFFECT OF THE CONCENTRATION AND SIZE OF THESE SPECIES WILL BE STUDIED AND THE PREPARATION AND INCLUSION PROCEDURES ON SILICAS WILL BE OPTIMISED. IMAGING TECHNIQUES INCLUDE RMI, A FIELD IN WHICH EX VIVO AND IN-VIVO TRIALS WERE CARRIED OUT IN CELL CULTURES AND WISTAR RATS WITH THE PARTICIPATION OF STAFF FROM THE VALENCIA CLINICAL HOSPITAL. THE POROUS SUPPORTS OBTAINED WILL BE ADAPTED FOR APPLICATIONS AND TASKS OF SUBPROJECTS 1 AND 2, WHICH WOULD IMPLY AN ADDITIONAL MODIFICATION/FUNCTIONALISATION FOR THE INCORPORATION OF DIFFERENT DOOR-MOLECULAR ENTITIES THAT WOULD PROVIDE THE FINAL MATERIALS WITH PROPERTIES OF INTEREST IN SUPPLY APPLICATIONS AND/OR DETECTION OF SPECIES OF INTEREST IN THE BIOMEDICAL AREA. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 21:40, 12 October 2021
Project Q3192866 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3192866 in Spain |
Statements
60,500.0 Euro
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121,000.0 Euro
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50.0 percent
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1 January 2016
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31 December 2018
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UNIVERSIDAD DE VALENCIA
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39°30'14.11"N, 0°26'31.56"W
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46190
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EL PRESENTE SUBPROYECTO (3) SE CENTRA EN EL DISEÑO DE SOLIDOS DE ALTA SUPERFICIE Y POROSIDAD COMO SOPORTES PARA EL DISEÑO Y CONSTRUCCION DE MATERIALES TERANOSTICOS (QUE COMBINAN CAPACIDADES EN AREAS DE TERAPIA Y DIAGNOSTICO). LA ESTRUCTURA BASICA DE LOS SOPORTES ES DE NATURALEZA SILICEA Y LA POROSIDAD SE CONSIGUE MEDIANTE EL USO DE MICELAS DE SURFACTANTE COMO AGENTES POROGENOS. SE OPTIMIZARAN PROTOCOLOS DE SINTESIS PARTIENDO DE REACTIVOS HABITUALES (COMO EL TEOS) A ESCALA DE LABORATORIO Y TAMBIEN PARTIENDO DE FUENTES DE SILICIO DE BAJO COSTE (COMO EL SILICATO SODICO). ENTRE LAS MORFOLOGIAS DESEADAS DESTACAN MATERIALES UNIMODALES CON POROS DE GRAN TAMAÑO ASI COMO ORGANIZACIONES BI O MULTIMODALES INCLUYENDO TOPOLOGIAS TIPO NUCLEO-CAPA O HUECO-CAPA. SE OPTIMIZARAN TAMBIEN PARAMETROS COMO LA DISPERSABILIDAD Y ESTABILIDAD QUIMICA DE LAS PARTICULAS OBTENIDAS (ASPECTOS FUNDAMENTALES PARA SU USO EN APLICACIONES BIOMEDICAS). SE ESTUDIARA LA ACCESIBILIDAD A LOS SISTEMAS DE PORO MEDIANTE EL USO DE MOLECULAS MODELO DE DISTINTO TAMAÑO FARMACOS Y/O ENZIMAS) CON EL OBJETIVO DE EVALUAR LA CAPACIDAD DE CARGA (DE IMPORTANCIA PARA APLICACIONES DE SUMINISTRO CONTROLADO DE FARMACOS). ESTOS ESTUDIOS INCLUIRAN ANALISIS CINETICOS DE LOS PROCESOS DE CARGA Y ELIMINACION. CON EL OBJETIVO DE INCLUIR HERRAMIENTAS PARA DIAGNOSTICO SE FUNCIONALIZARAN LOS MATERIALES SILICEOS CON DISTINTAS ESPECIES, FUNDAMENTALMENTE DE NATURALEZA INORGANICA: NANOPARTICULAS DE ORO, OXIDOS DE ELEMENTOS COMO GADOLINIO, MANGANESO Y HIERRO, Y OXIDOS MIXTOS CONTENIENDO TIERRAS RARAS (CON PROPIEDADES LUMINISCENTES Y CONVERSORAS DE ENERGIA). LA INCORPORACION DE ESTAS PARTICULAS PERMITIRA ADECUAR NUESTROS COMPOSITES POROSOS PARA SU USO EN TECNICAS DE BIOIMAGEN. SE ESTUDIARA EL EFECTO DE LA CONCENTRACION Y TAMAÑO DE ESTAS ESPECIES Y SE OPTIMIZARAN LOS PROCEDIMIENTOS DE PREPARACION E INCLUSION EN LAS SILICES. ENTRE LAS TECNICAS DE IMAGEN CABE DESTACAR LA RMI, CAMPO EN EL QUE CON LA PARTICIPACION DE PERSONAL DEL HOSPITAL CLINICO DE VALENCIA SE REALIZARAN ENSAYOS EX VIVO E IN-VIVO EN CULTIVOS CELULARES Y RATAS TIPO WISTAR. LOS SOPORTES POROSOS OBTENIDOS SE ADECUARAN PARA APLICACIONES Y TAREAS DE LOS SUBPROYECTOS 1 Y 2, LO QUE SUPONDRA UNA MODIFICACION/FUNCIONALIZACION ADICIONAL PARA LA INCORPORACION DE DISTINTAS ENTIDADES TIPO PUERTA-MOLECULAR QUE PROPORCIONARA A LOS MATERIALES FINALES PROPIEDADES DE INTERES EN APLICACIONES DE SUMINISTRO Y/O DETECCION DE ESPECIES DE INTERES EN EL AREA BIOMEDICA. (Spanish)
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THIS SUBPROJECT (3) FOCUSES ON THE DESIGN OF HIGH SURFACE SOLIDS AND POROSITY AS SUPPORTS FOR THE DESIGN AND CONSTRUCTION OF TERANOSTIC MATERIALS (WHICH COMBINE CAPACITIES IN THERAPY AND DIAGNOSTIC AREAS). THE BASIC STRUCTURE OF THE SUPPORTS IS OF A SILICEA NATURE AND POROSITY IS ACHIEVED BY THE USE OF SURFACTANT MICELLES AS POROGENOS AGENTS. SYNTHESIS PROTOCOLS WILL BE OPTIMISED FROM USUAL REAGENTS (SUCH AS TEOS) AT LABORATORY LEVEL AND ALSO FROM LOW-COST SILICON SOURCES (SUCH AS SODIUM SILICATE). AMONG THE DESIRED MORPHOLOGIES STAND OUT UNIMODALE MATERIALS WITH LARGE PORES AS WELL AS BI OR MULTIMODAL ORGANISATIONS INCLUDING TOPOLOGIAS TYPE NUCLEO-LAYER OR HOLLOW-LAYER. PARAMETERS SUCH AS THE DISPERSABILITY AND CHEMICAL STABILITY OF THE OBTAINED PARTICLES (ESSENTIAL ASPECTS FOR USE IN BIOMEDICAL APPLICATIONS) WILL ALSO BE OPTIMISED. THE ACCESSIBILITY OF PORE SYSTEMS SHALL BE STUDIED THROUGH THE USE OF MODEL MOLECULES OF DIFFERENT PHARMACO SIZE AND/OR ENZYMES) WITH THE AIM OF ASSESSING THE LOAD CAPACITY (IMPORTANT FOR CONTROLLED DRUG SUPPLY APPLICATIONS). THESE STUDIES WILL INCLUDE CINETICAL ANALYSES OF LOADING AND ELIMINATION PROCESSES. IN ORDER TO INCLUDE TOOLS FOR DIAGNOSIS, SILICEOUS MATERIALS WITH DIFFERENT SPECIES, MAINLY OF INORGANIC NATURE, ARE FUNCIONALISED: GOLD NANOPARTICULATES, OXIDES OF ELEMENTS SUCH AS GADOLINIUM, MANGANESE AND IRON, AND MIXED OXIDES CONTAINING RARE EARTHS (WITH LUMINESCENT PROPERTIES AND ENERGY CONVERTERS). THE INCORPORATION OF THESE PARTICLES WILL ALLOW TO ADAPT OUR POROUS COMPOSITES FOR USE IN BIOIMAGE TECHNIQUES. THE EFFECT OF THE CONCENTRATION AND SIZE OF THESE SPECIES WILL BE STUDIED AND THE PREPARATION AND INCLUSION PROCEDURES ON SILICAS WILL BE OPTIMISED. IMAGING TECHNIQUES INCLUDE RMI, A FIELD IN WHICH EX VIVO AND IN-VIVO TRIALS WERE CARRIED OUT IN CELL CULTURES AND WISTAR RATS WITH THE PARTICIPATION OF STAFF FROM THE VALENCIA CLINICAL HOSPITAL. THE POROUS SUPPORTS OBTAINED WILL BE ADAPTED FOR APPLICATIONS AND TASKS OF SUBPROJECTS 1 AND 2, WHICH WOULD IMPLY AN ADDITIONAL MODIFICATION/FUNCTIONALISATION FOR THE INCORPORATION OF DIFFERENT DOOR-MOLECULAR ENTITIES THAT WOULD PROVIDE THE FINAL MATERIALS WITH PROPERTIES OF INTEREST IN SUPPLY APPLICATIONS AND/OR DETECTION OF SPECIES OF INTEREST IN THE BIOMEDICAL AREA. (English)
12 October 2021
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Paterna
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Identifiers
MAT2015-64139-C4-2-R
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