IMMUNE RESPONSE AND MARKERS OF PROTECTION ASSOCIATED WITH VACCINATION IN PARATUBERCULOSIS (Q3185563): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): PARATUBERCULOSIS IS AN INFECTIOUS CHRONIC DISEASE OF MYCOBACTERIAL ETIOLOGY THAT HAS GRANULOMATOUS ENTERITIS, AND IS CONSIDERED A MAJOR HEALTH AND ECONOMIC PROBLEM IN RUMINANT HOLDINGS WORLDWIDE. ALTHOUGH THE FIRST DESCRIPTION OF PARATUBERCULOSIS DATES BACK TO THE END OF THE 19TH CENTURY, THERE IS STILL A GREAT LACK OF KNOWLEDGE OF THE PATOGENICAL MECHANISMS THAT REGULATE HOST-PATHOGEN INTERACTION IN THIS DISEASE. PROBABLY THEIR LONG HATCHING PE...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
IMMUNE RESPONSE AND MARKERS OF PROTECTION ASSOCIATED WITH VACCINATION IN PARATUBERCULOSIS | |||
Revision as of 20:40, 12 October 2021
Project Q3185563 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | IMMUNE RESPONSE AND MARKERS OF PROTECTION ASSOCIATED WITH VACCINATION IN PARATUBERCULOSIS |
Project Q3185563 in Spain |
Statements
96,800.0 Euro
0 references
193,600.0 Euro
0 references
50.0 percent
0 references
1 January 2016
0 references
31 July 2019
0 references
UNIVERSIDAD DE LEON
0 references
42°38'2.94"N, 5°58'17.11"W
0 references
24089
0 references
LA PARATUBERCULOSIS ES UNA ENFERMEDAD INFECCIOSA CRONICA DE ETIOLOGIA MICOBACTERIANA QUE CURSA CON UNA ENTERITIS GRANULOMATOSA, Y QUE ESTA CONSIDERADA COMO UN PROBLEMA SANITARIO Y ECONOMICO DE GRAN IMPORTANCIA EN LAS EXPLOTACIONES DE RUMIANTES EN TODO EL MUNDO. A PESAR DE QUE LA PRIMERA DESCRIPCION DE LA PARATUBERCULOSIS SE REMONTA AL FINAL DEL SIGLO XIX, EXISTE AUN UN GRAN DESCONOCIMIENTO DE LOS MECANISMOS PATOGENICOS QUE REGULAN LA INTERACCION HOSPEDADOR-PATOGENO EN ESTA ENFERMEDAD. PROBABLEMENTE SU LARGO PERIODO DE INCUBACION Y LA FALTA DE UN MODELO EN ANIMALES DE LABORATORIO ECONOMICO Y ADECUADO, HAYAN CONTRIBUIDO A ESTE HECHO. HASTA LA FECHA, LA VACUNACION HA SIDO EL UNICO METODO EFECTIVO PARA CONTROLAR LA ENFERMEDAD, EN LO QUE SE REFIERE A LA REDUCCION DEL NUMERO DE CASOS CLINICOS, YA QUE NO CONFIERE UNA PROTECCION ABSOLUTA EN LOS ANIMALES VACUNADOS, QUE EN ALGUNOS CASOS PUEDEN LLEGAR A DESARROLLAR LA ENFERMEDAD CLINICA. EN ESTE SENTIDO, EL CONOCIMIENTO DE LOS MECANISMOS QUE OPERAN EN LA PROTECCION CONFERIDA POR LA VACUNACION EN LOS ANIMALES ES MUY ESCASO. _x000D_ EL OBJETIVO GLOBAL DE ESTE PROYECTO ES AHONDAR EN EL CONOCIMIENTO DE TODOS ESTOS ASPECTOS, PARA LO QUE SE UTILIZARAN MODELOS ANIMALES DESARROLLADOS ANTERIORMENTE PARA COMPROBAR LAS DISTINTAS HIPOTESIS PLANTEADAS. SE PRETENDE DEMOSTRAR QUE LA VACUNACION CONTRA LA PARATUBERCULOSIS ES CAPAZ DE INDUCIR UNA RESPUESTA INMUNE ¿APRENDIDA¿, ENTENDIDA COMO TAL LA QUE CONFERIRIA AL HOSPEDADOR PROTECCION CONTRA OTROS PATOGENOS DE ORIGEN MICOBACTERIANO O NO, INCLUSO FRENTE A AGENTES DIFERENTES, COMO HONGOS O PROTOZOOS. ESTE OBJETIVO SE EVALUARA PRIMERAMENTE EN CONDICIONES DE CAMPO EN UN REBAÑO DE CABRAS VACUNADO, AFECTADO DE PARATUBERCULOSIS DE FORMA NATURAL, Y YA CONTROLADO, PARA LUEGO SER EVALUADO EN CONDICIONES EXPERIMENTALES EN DOS MODELOS ANIMALES: UNO EN CABRAS Y OTRO EN CONEJOS. EN AMBOS CASOS, SE LLEVARAN A CABO INMUNIZACIONES CON DOS VACUNAS MICOBACTERIANAS UNA DIRIGIDA CONTRA MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS (MAP) Y LA OTRA CONTRA M. BOVIS (MBV), COMO VACUNA HETEROLOGA, PARA EVALUAR LA INMUNIDAD ¿APRENDIDA¿ Y TAMBIEN LA RESPUESTA INMUNE ESPECIFICA CONTRA MAP. ADEMAS, SE BUSCARA LA IDENTIFICACION DE MARCADORES TANTO DE LA INMUNIDAD ¿APRENDIDA¿ COMO DE LA RESPUESTA INMUNE PROTECTORA ESPECIFICA MEDIANTE ANALISIS TRANSCRIPTOMICO. EL HECHO DE REALIZAR LOS EXPERIMENTOS EN PARALELO EN CABRAS Y CONEJOS TENDRIA COMO OBJETIVO EVALUAR SIMILITUDES EN LOS MECANISMOS DE PROTECCION Y VALIDAR EL USO DE ESTE ULTIMO MODELO PARA ENSAYOS DE VACUNACION Y TRATAMIENTOS POR SER MAS ECONOMICO Y DE MAYOR FACLIDAD DE MANEJO. ESTE MODELO HA MOSTRADO SER UTIL AUNQUE POSIBLEMENTE SE PUEDA MEJORAR UTILIZANDO CEPAS DE AISLADAS DE CAMPO DE CONEJOS SILVESTRES. EN ESTE SENTIDO, TAMBIEN SE INTENTARA AISLAR UNA CEPA LEPORINA Y SE EVALUARA SU CAPACIDAD DE PRODUCIR LESIONES EN UN BREVE ESPACIO DE TIEMPO EN COMPARACION CON DOS CEPAS BOVINAS. _x000D_ EL TRABAJO PROPUESTO EN ESTE PROYECTO PROPORCIONARA CONOCIMIENTOS BASICOS DE LA PATOGENIA DE LA PARATUBERCULOSIS QUE PROMOCIONARAN EL PROGRESO EN OTRAS ENFERMEDADES INFLAMATORIAS INTESTINALES Y TAMBIEN INFORMACION MAS AVANZADA SOBRE LOS EFECTOS BENEFICIOSOS DE LA VACUNACION DE LA PARATUBERCULOSIS. LOS RESULTADOS DE ESTE PROYECTO SERVIRAN DE APOYO A LA ESTRATEGIA DE VACUNACION CONTRIBUYENDO A RESOLVER UN PROBLEMA ECONOMICO MUNDIAL. (Spanish)
0 references
PARATUBERCULOSIS IS AN INFECTIOUS CHRONIC DISEASE OF MYCOBACTERIAL ETIOLOGY THAT HAS GRANULOMATOUS ENTERITIS, AND IS CONSIDERED A MAJOR HEALTH AND ECONOMIC PROBLEM IN RUMINANT HOLDINGS WORLDWIDE. ALTHOUGH THE FIRST DESCRIPTION OF PARATUBERCULOSIS DATES BACK TO THE END OF THE 19TH CENTURY, THERE IS STILL A GREAT LACK OF KNOWLEDGE OF THE PATOGENICAL MECHANISMS THAT REGULATE HOST-PATHOGEN INTERACTION IN THIS DISEASE. PROBABLY THEIR LONG HATCHING PERIOD AND THE LACK OF A MODEL IN ECONOMICAL AND ADEQUATE LABORATORY ANIMALS HAVE CONTRIBUTED TO THIS FACT. TO DATE, VACCINATION HAS BEEN THE ONLY EFFECTIVE METHOD FOR CONTROLLING THE DISEASE, IN TERMS OF REDUCING THE NUMBER OF CLINICAL CASES, SINCE IT DOES NOT CONFER ABSOLUTE PROTECTION IN VACCINATED ANIMALS, WHICH IN SOME CASES MAY DEVELOP THE CLINICAL DISEASE. IN THIS SENSE, THERE IS VERY LITTLE KNOWLEDGE OF THE MECHANISMS THAT OPERATE IN THE PROTECTION CONFERRED BY VACCINATION IN ANIMALS. _x000D_ the GLOBAL OBJECTIVE OF THIS PROJECT is to delve deeper into the knowledge of all these aspectos, for which ANIMAL MODEL DEVELOPED ANTERIORMENT TO PROVIDED DISTINTS HYPOTESIS were used. IT IS INTENDED TO DEMONSTRATE THAT VACCINATION AGAINST PARATUBERCULOSIS IS CAPABLE OF INDUCING AN IMMUNE RESPONSE, UNDERSTOOD AS SUCH THAT CONFERIRIA TO THE HOST PROTECTED AGAINST OTHER PATHOGENS OF MYCOBACTERIAL ORIGIN OR NOT, EVEN AGAINST DIFFERENT AGENTS, SUCH AS FUNGI OR PROTOZOA. THIS OBJECTIVE WAS FIRST EVALUATED UNDER FIELD CONDITIONS IN A VACCINATED GOAT HERD, NATURALLY AFFECTED BY PARATUBERCULOSIS, AND ALREADY CONTROLLED, AND THEN EVALUATED UNDER EXPERIMENTAL CONDITIONS IN TWO ANIMAL MODELS: ONE IN GOATS AND ONE IN RABBITS. IN BOTH CASES, IMMUNISATIONS WILL BE CARRIED OUT WITH TWO MYCOBACTERIAL VACCINES ONE DIRECTED AGAINST MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS (MAP) AND THE OTHER AGAINST M. BOVIS (MBV), AS A HETEROLOGOUS VACCINE, TO EVALUATE IMMUNITY LEARNED AND THE IMMUNE RESPONSE ALSO SPECIFIES AGAINST MAP. IN ADDITION, THE IDENTIFICATION OF MARKERS OF BOTH IMMUNITY LEARNED AND THE SPECIFIC PROTECTIVE IMMUNE RESPONSE BY TRANSCRIPTOMIC ANALYSIS WILL BE SOUGHT. THE FACT OF CARRYING OUT THE EXPERIMENTS IN PARALLEL IN GOATS AND RABBITS WOULD AIM TO EVALUATE SIMILARITIES IN THE MECHANISMS OF PROTECTION AND VALIDATE THE USE OF THIS LAST MODEL FOR VACCINATION TRIALS AND TREATMENTS BECAUSE IT IS MORE ECONOMICAL AND OF GREATER FACLITY OF MANAGEMENT. THIS MODEL HAS BEEN SHOWN TO BE USEFUL ALTHOUGH IT CAN POSSIBLY BE IMPROVED USING WILD RABBIT FIELD ISOLATES. IN THIS SENSE, AN ATTEMPT WILL ALSO BE MADE TO ISOLATE A LEPORINE STRAIN AND EVALUATE ITS ABILITY TO PRODUCE LESIONS WITHIN A SHORT PERIOD OF TIME COMPARED TO TWO BOVINE STRAINS. _x000D_ the Proposed WORKING IN THIS PROJECT shall provide basic knowledge of the PATOGENIA OF THE PARATUBERCULOSIS that will promote the PROGRESS IN OTHER INTESTINAL INFLAMATORY DISEASES AND ALSO ADVANCED INFORMATION ON THE BENEFITS EFFECTS OF THE PARATUBERCULOSIS VACUNATION. THE RESULTS OF THIS PROJECT WILL SUPPORT THE VACCINATION STRATEGY BY HELPING TO SOLVE A GLOBAL ECONOMIC PROBLEM. (English)
12 October 2021
0 references
León
0 references
Identifiers
AGL2015-66540-C2-1-R
0 references