PHOTONIC NANO-ANTHENA DEVICES IN LIVE CELLS: INCREASING OUR UNDERSTANDING OF THE MOLECULAR MECHANISMS RESPONSIBLE FOR HEALTH AND DISEASE (Q3184601): Difference between revisions
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(Created claim: summary (P836): THE PRECISE BALANCE BETWEEN THE PROCESS OF ADHESION AND CELLULAR MIGRATION IS RESPONSIBLE FOR A LARGE NUMBER OF PHENOMENES RELATED TO HEALTH, SO THAT ANY SMALL ALTERATION OF THIS BALANCE CAN RESULT IN DEVASTATING DISEASES. MANY OF THE PROTEINS INVOLVED IN THE CELLULAR ADHESION PROCESS ARE LOCATED IN THE PLASMA MEMBRANE, THE PLACE WHERE CELLULAR SIGNALING PROCESSES BEGIN. A LOT OF SCIENTIFIC WORK IN THE LAST FEW YEARS SEEMS TO INDICATE THAT THIS...) |
(Changed label, description and/or aliases in en: translated_label) |
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PHOTONIC NANO-ANTHENA DEVICES IN LIVE CELLS: INCREASING OUR UNDERSTANDING OF THE MOLECULAR MECHANISMS RESPONSIBLE FOR HEALTH AND DISEASE | |||
Revision as of 19:20, 12 October 2021
Project Q3184601 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | PHOTONIC NANO-ANTHENA DEVICES IN LIVE CELLS: INCREASING OUR UNDERSTANDING OF THE MOLECULAR MECHANISMS RESPONSIBLE FOR HEALTH AND DISEASE |
Project Q3184601 in Spain |
Statements
90,750.0 Euro
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181,500.0 Euro
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50.0 percent
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1 January 2015
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31 December 2017
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INSTITUTO DE CIENCIAS FOTONICAS
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41°17'9.96"N, 1°58'56.71"E
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08056
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EL PRECISO BALANCE ENTRE EL PROCESO DE ADHESION Y MIGRACION CELULAR ES RESPONSABLE DE UNA GRAN CANTIDAD DE FENOMENOS RELACIONADOS CON LA SALUD, DE MANERA QUE CUALQUIER PEQUEÑA ALTERACION DE ESTE BALANCE PUEDE RESULTAR EN ENFERMEDADES DEVASTADORAS. MUCHAS DE LAS PROTEINAS INVOLUCRADAS EN EL PROCESO DE ADHESION CELULAR ESTAN UBICADAS EN LA MEMBRANA PLASMATICA, EL LUGAR DONDE SE INICIAN LOS PROCESOS DE SEÑALIZACION CELULAR. UNA GRAN CANTIDAD DE TRABAJOS CIENTIFICOS EN LOS ULTIMOS AÑOS PARECEN INDICAR QUE ESTE PROCESO DE SEÑALIZACION OCURRE A LA ESCALA NANOMETRICA, MUY CERCA DE LA MEMBRANA CELULAR, Y DE UNA MANERA TRANSITORIA PERO TREMENDAMENTE SINCRONIZADA. DESAFORTUNADAMENTE NO EXISTEN HOY EN DIA TECNICAS CON SUFICIENTE RESOLUCION LATERAL Y AXIAL Y RANGO DINAMICO QUE PERMITAN EXPLORAR ESTE TIPO DE PROCESOS. EL PROPOSITO PRINCIPAL DE ESTE PROYECTO ES DESARROLLAR TECNOLOGIAS OPTICAS NOVEDOSAS BASADAS EN ANTENAS FOTONICAS QUE PERMITAN EXPLORAR LOS PRINCIPIOS FUNDAMENTALES RESPONSABLES DE LA ORGANIZACION NANOMETRICA DE LA MEMBRANA CELULAR. EN GRAN MEDIDA PRETENDEMOS ENTENDER COMO DIFERENTES PROTEINAS IMPLICADAS EN EL PROCESO DE ADHESION CELULAR SE SEGREGAN ESPACIAL Y TEMPORALMENTE EN LA MEMBRANA CELULAR PARA GENERAR DISTINTAS SEÑALIZACIONES. DE ESTA MANERA INTENTAREMOS DISTINGUIR LAS DIFERENCIAS EN LOS PRIMEROS ESTADIOS DE UNA RESPUESTA CELULAR NORMAL Y UNA RESPUESTA MALIGNA._x000D_ _x000D_ PARA ABORDAR LOS RETOS DE ESTE PROYECTO ALTAMENTE DISCIPLINAR HEMOS CONCENTRADO LAS TAREAS EN CUATRO OBJETIVOS PRINCIPALES: _x000D_ 1) LA GENERACION DE ANTENAS FOTONICAS EN SONDAS DE BARRIDO Y COMPATIBLES CON EL ESTUDIO DE PROCESO BIOLOGICOS A NIVEL DE CELULAS VIVAS; _x000D_ 2) LA IMPLEMENTACION DE UN MICROSCOPIO MULTI-COLOR EN EXCITACION Y DETECCION, JUNTO CON LA IMPLEMENTACION DE ESPECTROSCOPIA DE CORRELACION DE FOTONES EN MULTI-COLOR; _x000D_ 3) LA APLICACION DE ESTAS TECNICAS EN EL ESTUDIO DE LOS PRINCIPIOS FUNDAMENTALES DE LA ORGANIZACION DE LA MEMBRANA CELULAR A ESCALA NANOMETRICA, CON UN CLARO ENFASIS EN EL RECEPTOR DE ADHESION DE LEUCOCITOS LFA-1; _x000D_ 4) FINALMENTE, ESTUDIAREMOS EL PAPEL QUE JUEGA ESTA ORGANIZACION EN LA INTEGRINA LFA-1 DE MANERA DE DISTINGUIR POSIBLES PATRONES DE ORGANIZACION RELACIONADOS CON UNA RESPUESTA NORMAL O UNA RESPUESTA CANCERIGENA._x000D_ _x000D_ LA NOVEDAD DE ESTE AMBICIOSO PROYECTO RESIDE EN LA COMBINACION UNICA DE TECNICAS NANOFOTONICAS Y BIOLOGIA CELULAR E INMUNOLOGIA DE MANERA DE INCREMENTAR NUESTRO ENTENDIMIENTO DE LOS ESTADIOS INICIALES DE LA SEÑALIZACION CELULAR Y QUE REGULAN LA RESPUESTA CELULAR (SALUD VS. ENFERMEDAD). EL PROYECTO ESTA COMPLETAMENTE ALINEADO CON UNO DE LOS RETOS DEL PROGRAMA H2020 VINCULADO A TEMAS DE SALUD Y BIENESTAR, CON UN ENFOQUE EN EL ENTENDIMIENTO DE LAS CAUSAS Y MECANISMOS RESPONSABLES DE ENFERMEDADES. ADEMAS, LA TECNOLOGIA QUE DESARROLLAREMOS ESTA RECONOCIDA COMO UNA DE LAS ¿KEY ENABLING TECHNOLOGIES (KET)¿ AL TRATARSE DEL AMBITO DE LA FOTONICA. POR ELLO, ESPERAMOS QUE LOS RESULTADOS DE ESTE PROYECTO TENGAN UN IMPACTO IMPORTANTE EN EL SECTOR TECNOLOGICO DE LA FOTONICA PERO TAMBIEN EN EL SECTOR SALUD, YA QUE EN ESTE CASO ESPERAMOS PODER CONTRIBUIR PROPORCIONANDO GUIAS CLARAS PARA EL DESARROLLO DE NUEVAS TERAPIAS BASADAS EN INMUNOTERAPIAS CONTRA EL CANCER. (Spanish)
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THE PRECISE BALANCE BETWEEN THE PROCESS OF ADHESION AND CELLULAR MIGRATION IS RESPONSIBLE FOR A LARGE NUMBER OF PHENOMENES RELATED TO HEALTH, SO THAT ANY SMALL ALTERATION OF THIS BALANCE CAN RESULT IN DEVASTATING DISEASES. MANY OF THE PROTEINS INVOLVED IN THE CELLULAR ADHESION PROCESS ARE LOCATED IN THE PLASMA MEMBRANE, THE PLACE WHERE CELLULAR SIGNALING PROCESSES BEGIN. A LOT OF SCIENTIFIC WORK IN THE LAST FEW YEARS SEEMS TO INDICATE THAT THIS SIGNALING PROCESS OCCURS ON THE NANOMETRIC SCALE, VERY CLOSE TO THE CELL MEMBRANE, AND IN A TRANSIENT BUT TREMENDOUSLY SYNCHRONISED WAY. UNFORTUNATELY THERE ARE NOT TODAY IN TECHNICAL DAYS WITH ENOUGH LATERAL AND AXIAL RESOLUTION AND DYNAMIC RANGE TO EXPLORE THIS TYPE OF PROCESSES. THE MAIN PURPOSE OF THIS PROJECT IS TO DEVELOP NOVEL OPTICAL TECHNOLOGIES BASED ON PHOTONICAL ANTENNAS THAT ALLOW TO EXPLORE THE FUNDAMENTAL PRINCIPLES RESPONSIBLE FOR THE NANOMETRIC ORGANISATION OF THE CELL MEMBRANE. TO A LARGE EXTENT WE INTEND TO UNDERSTAND HOW DIFFERENT PROTEINS INVOLVED IN THE PROCESS OF CELLULAR ADHESION ARE SEGREGATED SPATIALLY AND TEMPORARILY IN THE CELL MEMBRANE TO GENERATE DIFFERENT SIGNS. From this will we try to identify the differences in the first stages of a NORMAL CELULAR AND MALIGNA RESPERTY._x000D_ _x000D_ to abrogate the risks of this high disciplining project we have agreed on the amounts in question as follows: _x000D_ 1) GENERATION OF PHOTONICAL ANTENAS IN BARRIDO SOUNDS AND COMPATIBLE WITH THE BIOLOGICAL PROCESS STUDIO OF LIVE CELLS; _x000D_ 2) IMPLEMENTATION OF A MULTI-COLOR MICROSCOPY IN excitation AND DETECTION, together with the IMPLEMENTATION OF SPECTROSCOPY OF MULTI-COLOR photon correlation; _x000D_ 3) the implementation of these technical specifications in the FUNDAMENTAL PRINCIPES STUDY OF THE ORGANISATION OF THE CELLING MEMBER to nanometric ESCALA, with a clear emphasis on the LFA-1 LEUCOCIT ADHESION RECEPTOR; _x000D_ 4) FINALENT, we will study the PAPEL THIS ORGANISATION IN THE INTEGRINE LFA-1 OF DYSTEMING POSSIBLE PATRONS OF ORGANISATION RELATED WITH A NORMAL RESPONSE OR A CANCERIGEN RESPONSE._x000D_ _x000D_ AMBICIOSO PROJECT is contained in the UN COMBINEMENT OF NANOFOTONIC TECHNICAL TECHNICAL AND CELL BIOLOGY AND WARNING Immunologic IMPLEMENTATION OF OUR ACCOUNTING OF THE INICIAL STATEMENT OF THE CELLAR SYNALISATION AND REGULATION OF THE CELLAR RESPONSE (HALDE VS. DISEASE). THE PROJECT IS FULLY ALIGNED WITH ONE OF THE CHALLENGES OF THE H2020 PROGRAMME LINKED TO HEALTH AND WELL-BEING ISSUES, WITH A FOCUS ON UNDERSTANDING THE CAUSES AND MECHANISMS RESPONSIBLE FOR DISEASES. IN ADDITION, THE TECHNOLOGY THAT WE WILL DEVELOP IS RECOGNISED AS ONE OF THE KEY ENABLING TECHNOLOGIES (KET) AS IT IS THE FIELD OF PHOTONICS. THEREFORE, WE HOPE THAT THE RESULTS OF THIS PROJECT WILL HAVE AN IMPORTANT IMPACT ON THE TECHNOLOGY SECTOR OF PHOTONICA BUT ALSO IN THE HEALTH SECTOR, SINCE IN THIS CASE WE HOPE TO CONTRIBUTE BY PROVIDING CLEAR GUIDELINES FOR THE DEVELOPMENT OF NEW THERAPIES BASED ON IMMUNOTHERAPIES AGAINST CANCER. (English)
12 October 2021
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Castelldefels
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Identifiers
FIS2014-56107-R
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