OR: Analysis of efficacy and safety of parenteral nutrition formed with two distinct lipids: SMOF lipid (enriched in fatty fish ac) vs Clinoleic (mixture of ac garsos rico oleic (Q3179826): Difference between revisions

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(‎Removed claim: summary (P836): The metabolic effects of lipid emulsions of parenteral nutrition (NP) depend on the composition of fatty acids, which have different action on plasma lipids, inflammatory status and oxidation, thus acting in the clinical course by modulating the immune response. This study compares two different types of lipids (rich in oleic acid vs lipid enriched in fish oil (ClinOleic v SMOF-LIPID) to check the different action on plasma lipids, and in oxid...)
Property / summary
The metabolic effects of lipid emulsions of parenteral nutrition (NP) depend on the composition of fatty acids, which have different action on plasma lipids, inflammatory status and oxidation, thus acting in the clinical course by modulating the immune response. This study compares two different types of lipids (rich in oleic acid vs lipid enriched in fish oil (ClinOleic v SMOF-LIPID) to check the different action on plasma lipids, and in oxidation, clinical course, complications, hospital stay. The objective is to demonstrate non-equality in lipid fractions, and secondaryly difference in biochemical parameters and clinical evolution. Methodology A prospective, randomised, blind study in 80 surgical patients admitted to ICU, with PN: 40 will receive eBao and 40 SMOF lipid. The following shall be analysed: lipid fractions, antioxidants, liver enzymes, nutritional parameters, every 7 days until the completion of parenteral nutrition or up to 28 days, following the study in the Surgery plant. Clinical data on infectious complications (catheter-related infection, surgical wound infection, intraabodominal absceum or peritonitis, pneumonia associated with mechanical ventilation) b.- organ dysfunction and expected mortality shall be collected; c.- side effects, d.- hospital stay. Follow-up to hospital discharge and 6 months post discharge. Multidisciplinary study: Queen Sofia General Hospital. Intensivist: initiates the NP; Pharmacy: randomisation and preparation NP; Nutrition Unit: monitoring in the NP plant; Department of Food Technology (UCAM): Inflammatory status marker analysis. (English)
 
Property / summary: The metabolic effects of lipid emulsions of parenteral nutrition (NP) depend on the composition of fatty acids, which have different action on plasma lipids, inflammatory status and oxidation, thus acting in the clinical course by modulating the immune response. This study compares two different types of lipids (rich in oleic acid vs lipid enriched in fish oil (ClinOleic v SMOF-LIPID) to check the different action on plasma lipids, and in oxidation, clinical course, complications, hospital stay. The objective is to demonstrate non-equality in lipid fractions, and secondaryly difference in biochemical parameters and clinical evolution. Methodology A prospective, randomised, blind study in 80 surgical patients admitted to ICU, with PN: 40 will receive eBao and 40 SMOF lipid. The following shall be analysed: lipid fractions, antioxidants, liver enzymes, nutritional parameters, every 7 days until the completion of parenteral nutrition or up to 28 days, following the study in the Surgery plant. Clinical data on infectious complications (catheter-related infection, surgical wound infection, intraabodominal absceum or peritonitis, pneumonia associated with mechanical ventilation) b.- organ dysfunction and expected mortality shall be collected; c.- side effects, d.- hospital stay. Follow-up to hospital discharge and 6 months post discharge. Multidisciplinary study: Queen Sofia General Hospital. Intensivist: initiates the NP; Pharmacy: randomisation and preparation NP; Nutrition Unit: monitoring in the NP plant; Department of Food Technology (UCAM): Inflammatory status marker analysis. (English) / rank
Normal rank
 
Property / summary: The metabolic effects of lipid emulsions of parenteral nutrition (NP) depend on the composition of fatty acids, which have different action on plasma lipids, inflammatory status and oxidation, thus acting in the clinical course by modulating the immune response. This study compares two different types of lipids (rich in oleic acid vs lipid enriched in fish oil (ClinOleic v SMOF-LIPID) to check the different action on plasma lipids, and in oxidation, clinical course, complications, hospital stay. The objective is to demonstrate non-equality in lipid fractions, and secondaryly difference in biochemical parameters and clinical evolution. Methodology A prospective, randomised, blind study in 80 surgical patients admitted to ICU, with PN: 40 will receive eBao and 40 SMOF lipid. The following shall be analysed: lipid fractions, antioxidants, liver enzymes, nutritional parameters, every 7 days until the completion of parenteral nutrition or up to 28 days, following the study in the Surgery plant. Clinical data on infectious complications (catheter-related infection, surgical wound infection, intraabodominal absceum or peritonitis, pneumonia associated with mechanical ventilation) b.- organ dysfunction and expected mortality shall be collected; c.- side effects, d.- hospital stay. Follow-up to hospital discharge and 6 months post discharge. Multidisciplinary study: Queen Sofia General Hospital. Intensivist: initiates the NP; Pharmacy: randomisation and preparation NP; Nutrition Unit: monitoring in the NP plant; Department of Food Technology (UCAM): Inflammatory status marker analysis. (English) / qualifier
point in time: 12 October 2021
Timestamp+2021-10-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0
 

Revision as of 19:18, 12 October 2021

Project Q3179826 in Spain
Language Label Description Also known as
English
OR: Analysis of efficacy and safety of parenteral nutrition formed with two distinct lipids: SMOF lipid (enriched in fatty fish ac) vs Clinoleic (mixture of ac garsos rico oleic
Project Q3179826 in Spain

    Statements

    contained in NUTS
    Murcia
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    country
    Spain
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    EU contribution
    19,840.0 Euro
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    budget
    24,800.0 Euro
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    co-financing rate
    80.0 percent
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    start time
    1 January 2014
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    end time
    30 September 2018
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    beneficiary name (string)
    FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA (FFIS)
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    beneficiary
    Q3136857
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    coordinate location

    37°59'32.57"N, 1°7'49.94"W
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    postal code
    30030
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    summary
    Los efectos metabolicos de las emulsiones lipidicas de la nutrición parenteral (NP) dependen de la composición de acidos grasos, que tienen acción distinta sobre los lípidos plasmáticos, el estado inflamatorio y oxidación, actuando así en el curso clínico al modular la respuesta inmune. En este estudio se comparan dos tipos distintos de lipidos (ricos en acido oleico vs lipido enriquecido en aceite de pescado (ClinOleic v SMOF-LIPID) para comprobar la distinta acción sobre los lípidos plasmáticos, y en estado de oxidación, curso clínico, complicaciones, estancia hospitalaria. El objetivo es demostrar la no igualdad en fracciones lipídicas, y de forma secundaria diferencia en parámetros bioquímicos y de evolución clínica . Metodologia Estudio prospectivo, randomizado , ciego en 80 pacientes quirúrgicos ingresados en UCI, con NP: 40 recibirán EBAO y 40 SMOF lipid. Se analizarán: fracciones lipídicas, antioxidantes, enzimas hepáticas, parámetros nutricionales, cada 7 días hasta la terminación de la nutrición parenteral o hasta 28 días, siguiendo el estudio en planta de Cirugía. Se recogerán los datos clínicos de a.- complicaciones infecciosas ( infección relacionada con catéter, infección de herida quirúrgica, absceo intraabodominal y/o peritonitis, neumonía asociada a ventilación mecánica) b.- disfunción de órganos y mortalidad esperada; c.- efectos adversos, d.- estancia hospitalaria. Seguimiento al alta hospitalaria y 6 meses post alta. Estudio multidisciplinar: Hospital General Reina Sofía. Intensivista: inicia la NP; Farmacia: aleatorización y preparación NP; Unidad de Nutrición: seguimiento en planta de NP; Departamento de Tecnología de alimentos (UCAM): Análisis marcadores de estado inflamatorio. (Spanish)
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    location (string)
    Murcia
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    Identifiers

    Spanish Kohesio ID
    PI13_01551
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