Q3179762 (Q3179762): Difference between revisions
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(Created claim: summary (P836): Resistant arterial hypertension (HRH) is a frequent, multifactorial etiology clinical problem that is accompanied by a high cardiovascular risk dependent on blood pressure figures and frequent accompanying risk factors. Recent data from the Spanish Registry of Ambulatory Monitoring of Blood Pressure have shown that 12.2 % of the hypertensive population attended in Primary Care presents HTAR in consultation. True HTAR has a worse cardiovascular r...) |
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Resistant arterial hypertension (HRH) is a frequent, multifactorial etiology clinical problem that is accompanied by a high cardiovascular risk dependent on blood pressure figures and frequent accompanying risk factors. Recent data from the Spanish Registry of Ambulatory Monitoring of Blood Pressure have shown that 12.2 % of the hypertensive population attended in Primary Care presents HTAR in consultation. True HTAR has a worse cardiovascular risk profile and a higher degree of cardiovascular disease. These data show the importance of this process in our country and the need for a prevention plan and adequate treatment. On the other hand, there is not much information on the mechanisms that explain differences in response to treatment among patients with HTAR. The identification of new biological markers capable of predicting response to different therapies, either pharmacological, such as aldosterone blockers or invasive techniques such as sympathetic renal denervation, can help optimise the degree of control of these patients. This project aims to improve: 1) knowledge of the detection and treatment of HTAR in the field of Primary Care and its referral to a specialised center, 2) identify biological markers capable of predicting the response to aldosterone block and sympathetic renal denervation in patients with HRH and 3) analyse the changes of these markers in response to different therapeutic options. (English) | |||||||||||||||
| Property / summary: Resistant arterial hypertension (HRH) is a frequent, multifactorial etiology clinical problem that is accompanied by a high cardiovascular risk dependent on blood pressure figures and frequent accompanying risk factors. Recent data from the Spanish Registry of Ambulatory Monitoring of Blood Pressure have shown that 12.2 % of the hypertensive population attended in Primary Care presents HTAR in consultation. True HTAR has a worse cardiovascular risk profile and a higher degree of cardiovascular disease. These data show the importance of this process in our country and the need for a prevention plan and adequate treatment. On the other hand, there is not much information on the mechanisms that explain differences in response to treatment among patients with HTAR. The identification of new biological markers capable of predicting response to different therapies, either pharmacological, such as aldosterone blockers or invasive techniques such as sympathetic renal denervation, can help optimise the degree of control of these patients. This project aims to improve: 1) knowledge of the detection and treatment of HTAR in the field of Primary Care and its referral to a specialised center, 2) identify biological markers capable of predicting the response to aldosterone block and sympathetic renal denervation in patients with HRH and 3) analyse the changes of these markers in response to different therapeutic options. (English) / rank | |||||||||||||||
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| Property / summary: Resistant arterial hypertension (HRH) is a frequent, multifactorial etiology clinical problem that is accompanied by a high cardiovascular risk dependent on blood pressure figures and frequent accompanying risk factors. Recent data from the Spanish Registry of Ambulatory Monitoring of Blood Pressure have shown that 12.2 % of the hypertensive population attended in Primary Care presents HTAR in consultation. True HTAR has a worse cardiovascular risk profile and a higher degree of cardiovascular disease. These data show the importance of this process in our country and the need for a prevention plan and adequate treatment. On the other hand, there is not much information on the mechanisms that explain differences in response to treatment among patients with HTAR. The identification of new biological markers capable of predicting response to different therapies, either pharmacological, such as aldosterone blockers or invasive techniques such as sympathetic renal denervation, can help optimise the degree of control of these patients. This project aims to improve: 1) knowledge of the detection and treatment of HTAR in the field of Primary Care and its referral to a specialised center, 2) identify biological markers capable of predicting the response to aldosterone block and sympathetic renal denervation in patients with HRH and 3) analyse the changes of these markers in response to different therapeutic options. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 18:22, 12 October 2021
Project Q3179762 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3179762 in Spain |
Statements
23,600.0 Euro
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29,500.0 Euro
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80.0 percent
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1 January 2014
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31 March 2017
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FUNDACION DEL HOSPITAL NACIONAL DE PARAPLEJICOS
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39°51'21.85"N, 4°1'26.26"W
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45168
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La hipertensión arterial resistente (HTAR) es un problema clínico frecuente, de etiología multifactorial, que se acompaña de un riesgo cardiovascular elevado dependiente de las cifras de presión arterial y de los frecuentes factores de riesgo acompañantes. Datos recientes del Registro Español de Monitorización Ambulatoria de la Presión Arterial han mostrado que el 12,2% de la población hipertensa atendida en Atención Primaria presenta HTAR en consulta. La HTAR verdadera presenta un peor perfil de riesgo cardiovascular y un mayor grado de enfermedad cardiovascular. Estos datos ponen de manifiesto la importancia que en nuestro país tiene este proceso y la necesidad de un plan de prevención y de un tratamiento adecuado. Por otra parte, no existe mucha información sobre los mecanismos que explican las diferencias en la respuesta al tratamiento entre pacientes con HTAR. La identificación de nuevos marcadores biológicos capaces de predecir la respuesta a distintas terapias, bien farmacológicas, como bloqueantes de la aldosterona o técnicas invasivas como la denervación simpática renal, puede contribuir a optimizar el grado de control de dichos pacientes. Este proyecto pretende mejorar: 1) el conocimiento sobre la detección y tratamiento de la HTAR en el ámbito de la Atención Primaria y su remisión a un centro especializado, 2) identificar marcadores biológicos con capacidad de predecir la respuesta al bloqueo de aldosterona y a la denervación simpática renal en pacientes con HTAR y 3) analizar los cambios de dichos marcadores en respuesta a las diferentes opciones terapéuticas. (Spanish)
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Resistant arterial hypertension (HRH) is a frequent, multifactorial etiology clinical problem that is accompanied by a high cardiovascular risk dependent on blood pressure figures and frequent accompanying risk factors. Recent data from the Spanish Registry of Ambulatory Monitoring of Blood Pressure have shown that 12.2 % of the hypertensive population attended in Primary Care presents HTAR in consultation. True HTAR has a worse cardiovascular risk profile and a higher degree of cardiovascular disease. These data show the importance of this process in our country and the need for a prevention plan and adequate treatment. On the other hand, there is not much information on the mechanisms that explain differences in response to treatment among patients with HTAR. The identification of new biological markers capable of predicting response to different therapies, either pharmacological, such as aldosterone blockers or invasive techniques such as sympathetic renal denervation, can help optimise the degree of control of these patients. This project aims to improve: 1) knowledge of the detection and treatment of HTAR in the field of Primary Care and its referral to a specialised center, 2) identify biological markers capable of predicting the response to aldosterone block and sympathetic renal denervation in patients with HRH and 3) analyse the changes of these markers in response to different therapeutic options. (English)
12 October 2021
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Toledo
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Identifiers
PI13_01581
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