ANALYSIS OF YIN-YANG INTERACTION BETWEEN TP53 AND TP73 IN REPROGRAMMING AND TISSUE ARCHITECTURE: IMPLICATION IN TUMOR ONCOGENESIS (Q3165218): Difference between revisions
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(Removed claim: summary (P836): EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVEN...) |
(Created claim: summary (P836): EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENEN...) |
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| Property / summary | |||||||||||||||
EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English) | |||||||||||||||
| Property / summary: EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English) / rank | |||||||||||||||
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| Property / summary: EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 17:16, 12 October 2021
Project Q3165218 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | ANALYSIS OF YIN-YANG INTERACTION BETWEEN TP53 AND TP73 IN REPROGRAMMING AND TISSUE ARCHITECTURE: IMPLICATION IN TUMOR ONCOGENESIS |
Project Q3165218 in Spain |
Statements
102,850.0 Euro
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205,700.0 Euro
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50.0 percent
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1 January 2016
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31 December 2019
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UNIVERSIDAD DE LEON
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42°38'2.94"N, 5°58'17.11"W
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24089
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EL DESARROLLO EMBRIONARIO Y LA ONCOGENESIS, PUEDEN CONSIDERARSE COMO LAS DOS CARAS DE UNA MONEDA. LOS PROCESOS DE DETERMINACION CELULAR, DIFERENCIACION Y MORFOGENESIS, CRUCIALES DURANTE EL DESARROLLO EMBRIONARIO, SON LOS MISMOS QUE APARECEN DESREGULADOS DURANTE LA PROGRESION Y METASTASIS TUMORAL. EL CONTROL DE ESTOS PROCESOS LO LLEVAN A CABO, AL MENOS EN PARTE, FACTORES DE TRANSCRIPCION COMO LOS MIEMBROS DE LA FAMILIA P53._x000D_ EL ANALISIS CONJUNTO DE DATOS PROVENIENTES DE MULTIPLES GRUPOS, INCLUIDO EL NUESTRO, REVELA UNA INTERACCION YIN-YANG ENTRE TP53 Y EL GEN BIMODAL TP73 EN VARIOS CONTEXTOS BIOLOGICOS, COMO EL MANTENIMIENTO DE LAS CELULAS TRONCALES NEURALES O LA ANGIOGENESIS. EL RESULTADO DE LA INTERACCION FUNCIONAL ENTRE TP53 Y TP73 ES CONTEXTUAL, SIENDO A VECES SINERGICO Y OTRAS, ANTAGONICO. ESTA RELACION FUNCIONAL PARECE LLEVAR A CABO UN PAPEL CENTRAL EN EL DESARROLLO EMBRIONARIO Y LA ARQUITECTURA TISULAR Y ES FACIL IMAGINAR COMO ALTERACIONES EN EL DELICADO BALANCE DE ESTA RED DE CONTROL PUEDE RESULTAR EN LA GENESIS Y PROGRESION TUMORAL._x000D_ NUESTRA HIPOTESIS DE TRABAJO ES QUE TP73 LLEVA A CABO UN PAPEL FUNDAMENTAL EN EL ESTABLECIMIENTO DE LAS INTERACCIONES CELULARES Y LA DIFERENCIACION CELULAR. ESTA FUNCION ES BIMODAL YA QUE LA RESPUESTA CELULAR RESULTANTE DEPENDERA DE LA EXPRESION DIFERENCIAL DE LAS ISOFORMAS TA Y DN-P73 Y, POR TANTO, DEPENDIENTE DEL CONTEXTO CELULAR. LA CORRECTA REGULACION DE ESTOS PROCESOS CELULARES, MEDIADA POR TP73, ES NECESARIA Y FUNDAMENTAL PARA EL CORRECTO DESARROLLO DE PROCESOS BIOLOGICAMENTE COMPLEJOS, COMO LA REPROGRAMACION DE CELUALS SOMATICAS Y EL ESTABLECIMIENTO DE LA POLARIDAD TISULAR. _x000D_ POR TODO ELLO, EL OBJETIVO GENERAL DE ESTE PROYECTO ES EL DE ELUCIDAR LA FUNCION Y CONSECUENCIAS DE LA INTERACCION FUNCIONAL ENTRE TP53 Y TP73 EN PROCESOS QUE SON ESENCIALES TANTO PARA EL DESARROLLO EMBRIONARIO, COMO PARA EL INICIO Y PROGRESION TUMORAL: LA REPROGRAMACION DE CELULAS SOMATICAS, LA DETERMINACION CELULAR Y EL ESTABLECIMIENTO DE LA POLARIDAD CELULAR PLANAR. TODOS ESTOS PROCESOS, APARENTEMENTE DIVERSOS, COMPARTEN UN TEMA CENTRAL: LA REGULACION DE LA DIFERENCIACION Y EL ESTABLECIMIENTO DE INTERACCIONES CELULARES APROPIADAS._x000D_ PARA EVALUAR ESTA HIPOTESIS, NUESTROS OBJETIVOS ESPECIFICOS SON:_x000D_ 1. CARACTERIZACION DEL MECANISMO DE ACCION DE P73, EN PRESENCIA O AUSENCIA DE P53, EN LA REPROGRAMACION DE CELULAS SOMATICAS._x000D_ 2. ESTUDIO DE LA INTERACCION FUNCIONAL DE P53 Y P73 COMO ¿GATE MASTERS¿ DE LOS PROGRAMAS DE DIFERENCIACION MESODERMICA_x000D_ 3. ESTUDIO DE LA FUNCION DE P73 EN LA SEÑALIZACION DE LA POLARIDAD CELULAR PLANAR Y LA ARQUITECTURA TISULAR (Spanish)
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EMBRYONIC DEVELOPMENT AND ONCOGENESIS CAN BE REGARDED AS THE TWO SIDES OF A COIN. THE PROCESSES OF CELL DETERMINATION, DIFFERENTIATION AND MORPHOGENESIS, CRUCIAL DURING EMBRYONIC DEVELOPMENT, ARE THE SAME PROCESSES THAT APPEAR DEREGULATED DURING TUMOR PROGRESSION AND METASTASIS. The control of these processes is carried to CABO, to the least in part, TRANSCRIPCTION FACTORS as the members of the FAMILY P53._x000D_ THE ANALISIS CONJUNT OF PROVENENT DATAS OF GROUP MULTIPLES, including OURSTER, REVES A YIN-YANG INTERACTION BETWEEN TP53 AND the TP73 bimodal GEN IN BIOLOGIC CONTEXT VARIOS, AS THE MAINTENANCE OF NEURAL TRONCAL CELLS OR ANGEGENESIS. THE RESULT OF THE FUNCTIONAL INTERACTION BETWEEN TP53 AND TP73 IS CONTEXTUAL, SOMETIMES SYNERGISTIC AND OTHERS, ANTAGONICO. This FUNCIONAL RELATION SHALLS BETWEEN A CENTRAL PAPEL IN THE EMBRIONAR DEVELOPMENT AND THE TISULAR ARCHITECTURE AND IS FACILY TO IMAGINATE AS ALTERATIONS IN THE BALANCE DELICATE OF THIS CONTROL RED CAN RESULT IN GENESIS AND TUMORAL PROGRESS._x000D_Our Hypothesis working IS THAT TP73 Brings a FUNDAMENTAL PAPEL IN THE STABILITY OF THE CELLER INTERACTIONS AND THE CELL DIFFERENCECATION. THIS FUNCTION IS BIMODAL SINCE THE RESULTING CELLULAR RESPONSE WILL DEPEND ON THE DIFFERENTIAL EXPRESSION OF THE ISOFORMS TA AND DN-P73 AND, THEREFORE, DEPENDENT ON THE CELLULAR CONTEXT. THE CORRECT REGULATION OF THESE CELLULAR PROCESSES, MEDIATED BY TP73, IS NECESSARY AND FUNDAMENTAL FOR THE CORRECT DEVELOPMENT OF BIOLOGICALLY COMPLEX PROCESSES, SUCH AS THE REPROGRAMMING OF SOMATIC CELUALS AND THE ESTABLISHMENT OF TISSUE POLARITY. _x000D_ for ALL, the GENERAL OBJECTIVE OF THIS PROJECT is to elucidate the functioning and consequences of the FUNCIONAL INTERACTION between TP53 and TP73 IN PROCESSES THAT SESENTIAL FOR EMBRIONAL DEVELOPMENT, AS FOR THE INICIO AND TUMORAL PROGRESS: THE REPROGRAMMING OF SOMATIC CELLS, CELL DETERMINATION AND THE ESTABLISHMENT OF CELLULAR POLARITY PLANAR. ALL THESE SEEMINGLY DIVERSE PROCESSES SHARE A CENTRAL THEME: The REGULATION OF DIFFERENTATION AND THE STABILITY OF ADOPTED CELULARY INTERACTIONS._x000D_ TO EVALUATE THIS HIPOTESIS, OUR SPECIFIC OUR OUR SPECIFIC OBJECTIVES ARE:_x000D_ 1. Characterisation of P73 ACTION MECHANISM, PRESENCE OR AUSENCE OF P53, in the reprogramming of SOMATIC CELLS._x000D_ 2. Study OF THE FUNCIONAL INTERACTION OF P53 and P73 AS DO YOU GET MASTERS OF the MESODERMICA_x000D_3 Differentiation Programmes. STUDY OF P73'S FUNCTION IN THE SIGNAGE OF CELLULAR POLARITY PLANAR AND TISSUE ARCHITECTURE (English)
12 October 2021
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León
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Identifiers
SAF2015-71381-R
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