‘Quantitative and functional alterations of naïve T lymphocytes in patients with systemic inflammation secondary to chronic heart failure (Q3163151): Difference between revisions

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(‎Changed label, description and/or aliases in en: translated_label)
(‎Removed claim: summary (P836): The main objective of this project is to analyse the alterations associated with the high serum levels of proinflammatory cytokines, which lead to quantitative and functional changes in naïve T lymphocytes in patients with chronic heart failure (CHD). We will study whether these changes affect your functional capacity, and therefore immune responses to re-contact antigens, causing a state of immunocompromise. In addition, we will define the co...)
Property / summary
The main objective of this project is to analyse the alterations associated with the high serum levels of proinflammatory cytokines, which lead to quantitative and functional changes in naïve T lymphocytes in patients with chronic heart failure (CHD). We will study whether these changes affect your functional capacity, and therefore immune responses to re-contact antigens, causing a state of immunocompromise. In addition, we will define the contribution of memory T lymphocytes to systemic inflammation. To this end, patients with CHF will be classified into two groups, one with serum levels =10 pg/mL of IL-1b and the other with levels >10 pg/mL, and compared with each other and with a third group of healthy individuals. Homeostasis and cell repertoire and functional capabilities of T naïve lymphocytes and expression of a wide panel of inflammatory genes in memory T lymphocytes will be studied. The aim is to define the impact of inflammatory status on the efficacy of the adaptive immune response using vaccination against influenza virus as a model of in vivo immunisation, since an adequate response will be decisive in maintaining a stable situation in the context of heart disease, avoiding secondary decompensation to infections, mainly respiratory infections, and associated comorbidities. The study of accelerated immune aging that occurs in CHF will help us to understand the mechanisms involved in age-related aging, as well as to identify possible targets for intervention. (English)
 
Property / summary: The main objective of this project is to analyse the alterations associated with the high serum levels of proinflammatory cytokines, which lead to quantitative and functional changes in naïve T lymphocytes in patients with chronic heart failure (CHD). We will study whether these changes affect your functional capacity, and therefore immune responses to re-contact antigens, causing a state of immunocompromise. In addition, we will define the contribution of memory T lymphocytes to systemic inflammation. To this end, patients with CHF will be classified into two groups, one with serum levels =10 pg/mL of IL-1b and the other with levels >10 pg/mL, and compared with each other and with a third group of healthy individuals. Homeostasis and cell repertoire and functional capabilities of T naïve lymphocytes and expression of a wide panel of inflammatory genes in memory T lymphocytes will be studied. The aim is to define the impact of inflammatory status on the efficacy of the adaptive immune response using vaccination against influenza virus as a model of in vivo immunisation, since an adequate response will be decisive in maintaining a stable situation in the context of heart disease, avoiding secondary decompensation to infections, mainly respiratory infections, and associated comorbidities. The study of accelerated immune aging that occurs in CHF will help us to understand the mechanisms involved in age-related aging, as well as to identify possible targets for intervention. (English) / rank
Normal rank
 
Property / summary: The main objective of this project is to analyse the alterations associated with the high serum levels of proinflammatory cytokines, which lead to quantitative and functional changes in naïve T lymphocytes in patients with chronic heart failure (CHD). We will study whether these changes affect your functional capacity, and therefore immune responses to re-contact antigens, causing a state of immunocompromise. In addition, we will define the contribution of memory T lymphocytes to systemic inflammation. To this end, patients with CHF will be classified into two groups, one with serum levels =10 pg/mL of IL-1b and the other with levels >10 pg/mL, and compared with each other and with a third group of healthy individuals. Homeostasis and cell repertoire and functional capabilities of T naïve lymphocytes and expression of a wide panel of inflammatory genes in memory T lymphocytes will be studied. The aim is to define the impact of inflammatory status on the efficacy of the adaptive immune response using vaccination against influenza virus as a model of in vivo immunisation, since an adequate response will be decisive in maintaining a stable situation in the context of heart disease, avoiding secondary decompensation to infections, mainly respiratory infections, and associated comorbidities. The study of accelerated immune aging that occurs in CHF will help us to understand the mechanisms involved in age-related aging, as well as to identify possible targets for intervention. (English) / qualifier
point in time: 12 October 2021
Timestamp+2021-10-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0
 

Revision as of 17:03, 12 October 2021

Project Q3163151 in Spain
Language Label Description Also known as
English
‘Quantitative and functional alterations of naïve T lymphocytes in patients with systemic inflammation secondary to chronic heart failure
Project Q3163151 in Spain

    Statements

    country
    Spain
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    EU contribution
    124,600.0 Euro
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    budget
    155,750.0 Euro
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    co-financing rate
    80.0 percent
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    start time
    1 January 2018
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    end time
    31 March 2021
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    beneficiary name (string)
    FUNDACION PARA LA INVESTIGACION E INNOVACION BIOSANITARIA EN EL PRINCIPADO DE ASTURIAS
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    beneficiary
    Q3137940
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    coordinate location

    43°21'38.16"N, 5°50'41.64"W
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    postal code
    33044
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    summary
    El objetivo principal de este proyecto es analizar las alteraciones, asociadas a los altos niveles séricos de citocinas proinflamatorias, que conducen a cambios cuantitativos y funcionales en los linfocitos T naïve en los pacientes con insuficiencia cardíaca crónica (ICC). Estudiaremos si estos cambios afectan a su capacidad funcional, y por consiguiente a las respuestas inmunes frente a antígenos de nuevo contacto, ocasionando un estado de inmunocompromiso. Además, definiremos la contribución de los linfocitos T de memoria a la inflamación sistémica. Para ello se clasificará a los pacientes de ICC en dos grupos, uno con niveles séricos =10 pg/mL de IL-1b y otro con niveles >10 pg/mL, y se compararán entre sí y con un tercer grupo de individuos sanos. Se estudiarán la homeostasis y el repertorio celular y las capacidades funcionales de los linfocitos T naïve y la expresión de un amplio panel de genes inflamatorios en linfocitos T de memoria. Se pretende definir la repercusión del estatus inflamatorio en la eficacia de la respuesta inmune adaptativa utilizando la vacunación frente al virus de la gripe como modelo de inmunización in vivo, ya que una adecuada respuesta será decisiva en mantener una situación estable en el contexto de la cardiopatía, evitando la descompensación secundaria a infecciones, principalmente respiratorias, y comorbilidades asociadas. El estudio del envejecimiento inmunológico acelerado que se produce en ICC nos ayudará a conocer los mecanismos implicados en el envejecimiento asociado a la edad, así como a identificar posibles dianas de intervención. (Spanish)
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    location (string)
    Oviedo
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    Identifiers

    Spanish Kohesio ID
    PI17_00714
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