ROLE OF ADIPOKINES IN INTERVERTEBRAL DISC DEGENERATION (DDIV): A NEW PHSIOPATOLOGICAL APPROACH. (Q3161061): Difference between revisions
Jump to navigation
Jump to search
(Removed claim: summary (P836): The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying t...) |
(Created claim: summary (P836): The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the...) |
||||||||||||||
| Property / summary | |||||||||||||||
The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the molecular bases of disc degeneration exerted by lipocaline-2 (LCN2/NGAL), visfatin, nesfatin-1 (NUCB2), progranulin, serpine-2, chemerin and ghrelin in human intervertebral disc cells. (English) | |||||||||||||||
| Property / summary: The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the molecular bases of disc degeneration exerted by lipocaline-2 (LCN2/NGAL), visfatin, nesfatin-1 (NUCB2), progranulin, serpine-2, chemerin and ghrelin in human intervertebral disc cells. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the molecular bases of disc degeneration exerted by lipocaline-2 (LCN2/NGAL), visfatin, nesfatin-1 (NUCB2), progranulin, serpine-2, chemerin and ghrelin in human intervertebral disc cells. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 16:35, 12 October 2021
Project Q3161061 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | ROLE OF ADIPOKINES IN INTERVERTEBRAL DISC DEGENERATION (DDIV): A NEW PHSIOPATOLOGICAL APPROACH. |
Project Q3161061 in Spain |
Statements
105,600.0 Euro
0 references
132,000.0 Euro
0 references
80.0 percent
0 references
1 January 2018
0 references
31 March 2021
0 references
FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
0 references
42°52'49.51"N, 8°32'45.10"W
0 references
15078
0 references
El objetivo fundamental de este proyecto consiste en profundizar en el conocimiento de los mecanismos moleculares, bioquímicos y celulares implicados en la etiopatogenia de la enfermedad degenerativa del disco intervertebral. En particular, aquellos potencialmente ejercidos por las adipokinas y factores neuroendocrinos que regulan tanto la homeostasis energética y metabólica como la modulación de la respuesta inflamatoria e inmunológica. El estudio estará enfocado a esclarecer las bases moleculares de la degeneración discal ejercidas por la lipocalina-2 (LCN2/NGAL), la visfatina, la nesfatina-1 (NUCB2), la progranulina, la serpina-2, la chemerina y el ghrelin en las células del disco intervertebral humano. (Spanish)
0 references
The fundamental objective of this project is to deepen the knowledge of the molecular, biochemical and cellular mechanisms involved in the etiopathogeny of the degenerative disease of the intervertebral disc. In particular, those potentially exercised by adipokinas and neuroendocrine factors that regulate both energetic and metabolic homeostasis and modulation of the inflammatory and immunological response. The study will focus on clarifying the molecular bases of disc degeneration exerted by lipocaline-2 (LCN2/NGAL), visfatin, nesfatin-1 (NUCB2), progranulin, serpine-2, chemerin and ghrelin in human intervertebral disc cells. (English)
12 October 2021
0 references
Santiago de Compostela
0 references
Identifiers
PI17_00409
0 references