NEW EXPERIMENTAL APPROACHES TO SOLVING THE CURRENT LIMITATIONS OF LIQUID CHROMATOGRAPHING/MASS SPECTROMETRY (LC-MS) IN ANALYSIS OF POLLUTANTS OR (Q3166026): Difference between revisions
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(Created claim: summary (P836): ALTHOUGH LIQUID CHROMATOGRAPH/MASS SPECTROMETRY COUPLING (LC-MS) IS REALLY A POWERFUL TOOL FOR APPLICATIONS TO THE ANALYSIS OF ORGANIC COMPOUNDS IN FOOD AND THE ENVIRONMENT, IT STILL HAS CERTAIN LIMITATIONS THAT CONDITION ITS PERFORMANCE. Among THE WE CAN MENCATE THE 5 NEXT:_x000D_ _x000D_ 1. Difficulties IN THE DETECTION OF COMPOSES FOR MATRIZ EFFECTS due to the COMPLEJITY OF THE SARS _x000D_ 2. Difficulties due to the diverging POLARITY and hy...) |
(Changed label, description and/or aliases in en: translated_label) |
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NEW EXPERIMENTAL APPROACHES TO SOLVING THE CURRENT LIMITATIONS OF LIQUID CHROMATOGRAPHING/MASS SPECTROMETRY (LC-MS) IN ANALYSIS OF POLLUTANTS OR | |||
Revision as of 16:31, 12 October 2021
Project Q3166026 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | NEW EXPERIMENTAL APPROACHES TO SOLVING THE CURRENT LIMITATIONS OF LIQUID CHROMATOGRAPHING/MASS SPECTROMETRY (LC-MS) IN ANALYSIS OF POLLUTANTS OR |
Project Q3166026 in Spain |
Statements
54,014.4 Euro
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67,518.0 Euro
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80.0 percent
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1 January 2016
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31 December 2018
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UNIVERSIDAD DE JAEN
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37°57'20.63"N, 3°29'31.42"W
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23050
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PESE A QUE EL ACOPLAMIENTO CROMATOGRAFIA DE LIQUIDOS/ESPECTROMETRIA DE MASAS (LC-MS) ES REALMENTE UN HERRAMIENTA PODEROSA PARA APLICACIONES AL ANALISIS DE COMPUESTOS ORGANICOS EN ALIMENTOS Y MEDIOAMBIENTE, TODAVIA PRESENTA CIERTAS LIMITACIONES QUE CONDICIONAN SU RENDIMIENTO. ENTRE ELLAS PODEMOS MENCIONAR LAS 5 SIGUIENTES:_x000D_ _x000D_ 1. DIFICULTADES EN LA DETECCION DE COMPUESTOS POR EFECTOS MATRIZ DEBIDO A COMPLEJIDAD DE LAS MUESTRAS _x000D_ 2. DIFICULTADES DEBIDAS A LA DIVERSA POLARIDAD E HIDROFOBICIDAD DE LOS ANALITOS Y SU RETENCION EN CROMATOGRAFIA DE LIQUIDOS EN FASE REVERSA._x000D_ 3. LIMITACIONES DE LAS TECNICAS LC-MS PARA LA IONIZACION DE COMPUESTOS APOLARES O CON AUSENCIA DE GRUPOS IONIZABLES._x000D_ 4. ESCASA SENCILLEZ, RAPIDEZ Y PORTABILIDAD QUE PRESENTAN LA TECNICA LC-MS _x000D_ 5. LIMITACIONES EN LOS METODOS DE ADQUISICION Y PROCESADO DE DATOS PARA ANALISIS NO DIRIGIDO EN LC-MS_x000D_ _x000D_ EL OBJETIVO PRINCIPAL DEL PROYECTO ES APORTAR UNA SERIE DE METODOLOGIAS QUE PERMITAN LA MEJORA DE LOS METODOS LC-MS A TRAVES DE SOLUCIONES SENCILLAS QUE SEAN FACILMENTE TRANSFERIBLES A USUARIOS DE LC-MS, CON ESPECIAL ENFASIS EN LA DETERMINACION DE CONTAMINANTES ORGANICOS EN ALIMENTOS. PARA ELLO, SE PLANTEAN DIVERSAS APROXIMACIONES Y METODOLOGIAS PARA SOLVENTAR, MEJORAR O MINIMIZAR ALGUNAS DE LAS LIMITACIONES ACTUALES DE LOS METODOS LC-MS. SE PLANTEAN 5 PROPUESTAS: _x000D_ (I) EL EMPLEO DE NANOHPLC-HRMS PARA MINIMIZAR LOS PROBLEMAS DEBIDOS A EFECTOS MATRIZ; _x000D_ (II) EL USO DE SISTEMAS DE COLUMNAS HILIC Y FASE REVERSA DE FORMA PARALELA (HILIC/RPLC-HRMS) CON INYECCION DUAL PARA CUBRIR UNA GRAN VARIEDAD DE COMPUESTOS CON DIVERSAS POLARIDADES EN UN UNICO ANALISIS, PARA EVITAR EL EMPLEO DE SINGLE RESIDUE METHODS; _x000D_ (III) EL EMPLEO DE LA FUENTE DE IONIZACION DE DESCARGA DE BARRERA DIELECTRICA (DBDI) CON MICROFLUJOS DE HPLC (CAPLC-µDBDI-MS) PARA MEJORAR LA SENSIBILIDAD Y EXTENDER LA UTILIDAD DE ESTE MODO DE IONIZACION QUE PERMITE EL ANALISIS DE COMPUESTOS CON UN AMPLIO RANGO DE PROPIEDADES Y DEMOSTRAR APLICACIONES DE SU UTILIDAD PARA RESTRINGIR EL USO OBLIGADO DE EQUIPOS GC-MS PARA ANALISIS DE CONTAMINANTES; _x000D_ (IV) LA EVALUACION DE LA TECNICA DE ANALISIS DIRECTO PAPERSPRAY PARA MEJORAR, SIMPLIFICAR Y PERMITIR EL ANALISIS IN SITU DE ALIMENTOS; Y _x000D_ (V) EVALUAR LA POTENCIALIDAD DEL EMPLEO DE MODOS DE ADQUISICION INDEPENDIENTES DE LOS DATOS REGISTRADOS A TIEMPO REAL (DATA INDEPENDENT ACQUISITION) PARA MEJORAR LA ETAPAS DE ADQUISICION Y PROCESADO DE DATOS DE LOS METODOS LC-MS CUALITATIVOS Y COMPARAR SU RENDIMIENTO CON OTROS MODOS DE ADQUISICION._x000D_ _x000D_ EL PROYECTO PROPUESTO ESTA ALINEADO CON VARIOS DE LOS OBJETIVOS TRAZADOS EN EL PLAN ESTATAL DE INVESTIGACION CIENTIFICA Y TECNICA Y DE INNOVACION (2013-2016) Y A SU VEZ CON ALGUNAS DE LAS LINEAS ESTRATEGICAS DEL PROGRAMA MARCO DE INVESTIGACION E INNOVACION DE LA UNION EUROPEA (H2020). TODAS LAS APORTACIONES Y PROPUESTAS DESCRITAS E INCLUIDAS COMO OBJETIVOS DEL PRESENTO PROYECTO VAN ENCAMINADAS A MEJORAR LA CALIDAD Y SEGURIDAD DE LOS ALIMENTOS A TRAVES DE LA MEJORA DE LAS HERRAMIENTAS QUE ACTUALMENTE SE UTILIZAN PARA CONTROLAR SU SEGURIDAD Y TRAZABILIDAD._x000D_ _x000D_ PARA EL DESARROLLO DEL PRESENTE PROYECTO, EL GRUPO DE INVESTIGACION DISPONE DE EXPERIENCIA ACREDITADA POR UN GRAN NUMERO DE PROYECTOS DE INVESTIGACION, CONTRATOS DE I+D Y PUBLICACIONES DE RECONOCIDO PRESTIGIO. ADEMAS, DISPONE DEL EQUIPAMIENTO CIENTIFICO E INFRAESTRUCTURA NECESARIO PARA LA CONSECUCION DE LAS ACTIVIDADES PLANTEADAS. (Spanish)
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ALTHOUGH LIQUID CHROMATOGRAPH/MASS SPECTROMETRY COUPLING (LC-MS) IS REALLY A POWERFUL TOOL FOR APPLICATIONS TO THE ANALYSIS OF ORGANIC COMPOUNDS IN FOOD AND THE ENVIRONMENT, IT STILL HAS CERTAIN LIMITATIONS THAT CONDITION ITS PERFORMANCE. Among THE WE CAN MENCATE THE 5 NEXT:_x000D_ _x000D_ 1. Difficulties IN THE DETECTION OF COMPOSES FOR MATRIZ EFFECTS due to the COMPLEJITY OF THE SARS _x000D_ 2. Difficulties due to the diverging POLARITY and hydrophobicity of analytes and their retension in chromatography of liquids in reversa phase._x000D_ 3. Limitations OF LC-MS TECHNICAL FOR THE IONISATION OF Apolar COMPOSES OR WITH IONIZABLE GROUPS ASSESSMENT._x000D_ 4. Little SENCILLEZ, RAPIDEZ AND PortABILITY THAT THE TECHNICAL LC-MS _x000D_ 5. Limitations ON THE METHODS OF ADQUISTION AND PROCESSING OF DATA FOR ANALISIS NOT DIRIGITED IN LC-MS_x000D_ _x000D_ THE PRINCIPLE OBJECTIVE OBJECTIVE OF THE PROJECT is to provide a series of methods that permeate the improvement of LC-MS Methods through sensile solutions that are likely to be transferred to LC-MS users, with special emphasis on the determination of organic contaminations in food. FOR THIS PURPOSE, VARIOUS APPROACHES AND METHODS ARE PROPOSED TO SOLVE, IMPROVE OR MINIMISE SOME OF THE CURRENT LIMITATIONS OF LC-MS METHODS. FIVE PROPOSALS ARE PUT FORWARD: _x000D_ (I) the use of nanoHPLC-HRMS to MINIMIZ PROBLEMS due to MATRIZ EFFECTS; _x000D_ (II) The use of HILIC COLUMNAS SYSTEMS AND REVERSE FORMA Parallel Phase (HILIC/RPLC-HRMS) with DUAL INYECTION to cover a great variety of competitions with diversified polarities in a single analysis, to evade the use of SINGLE residue METHODS; _x000D_ (III) EMPLOYMENT OF THE DOWNLOAD SOURCE OF BARRERA dielectrica (DBDI) with HPLC microfluids (CAPLC-µDBDI-MS) to improve sensibility and extend the usefulness of this mode of innovation that will allow the analysis of competitions with a RANGO PROPERTY AMPLY and to devise applications of its utility to reduce the use of GC-MS equipment for pollution analysis; _x000D_ (IV) EVALUATION OF THE DIRECT PAPERSPRAY ANALISIS TECHNICAL TO IMPROVE, SIMPLIFICATE AND PERMIT THE ANALISIS IN FOODS; And _x000D_ (V) EVALUATION OF THE POTENTIALITY OF INDEPENDENT ACQUISITION MODES OF DATA REGISTRED TO REAL TIME (DATA INDEPENDENT ACQUISITION) to improve the acquisition and processing of data from LC-MS QUALITATIVE methods and to buy their money with other modes of acquisition._x000D_ _x000D_ The PROJECT PROPOSED IS ALINEED WITH VARIOS OF OBJECTIVES OF THE STATE PLAN FOR SCIENTIFIC AND TECHNICAL AND INNOVATION RESEARCH AND INNOVATIONS (2013-2016) AND YOUR YOUR WITH THE STRATEGIC LINES OF THE STRATEGIC LINES OF THE PROGRAMME FOR INVESTIGATION AND INNOVATION OF THE EUROPEAN UNION (H2020). All PROJECT REPORTS AND PROPOSES INCLUDED AS OBJECTIVES OF THE PROJECT PRESENTATIONS WITHOUT THE IMPROVEMENTS OF THE QUALITY AND SECURITY OF FOODS WITH THE IMPROVEMENT OF THE TOOLS TO BE UTILY USED TO CONTROL THE SECURITY AND TRACEBILITY._x000D_ _x000D_ FOR THE DEVELOPMENT OF THE PRESENT PROJECT, the RESEARCH GROUP OF EXPERIENCE ACREDITTED BY A GREAT NUMBER OF RESEARCH PROJECTS, R & D CONTRACTS AND PUBLICATIONS OF RECOGNISED PRESTIGIO. IN ADDITION, IT HAS THE NECESSARY SCIENTIFIC EQUIPMENT AND INFRASTRUCTURE FOR THE IMPLEMENTATION OF THE PROPOSED ACTIVITIES. (English)
12 October 2021
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Jaén
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Identifiers
CTQ2015-71321-P
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